57,017 results match your criteria crp


Usage of C-Reactive Protein Testing in the Diagnosis and Monitoring of Psoriatic Arthritis (PsA): Results from a Real-World Survey in the USA and Europe.

Rheumatol Ther 2022 Jan 15. Epub 2022 Jan 15.

University of Oxford, Oxford, UK.

Introduction: C-reactive protein (CRP) is an important non-specific marker of both acute and chronic inflammation and can be elevated in patients with psoriatic arthritis (PsA). However, the use of CRP testing in the management of PsA can vary. This study investigated how CRP testing is implemented in real-world clinical practice for disease management of PsA. Read More

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January 2022

Non-specific spondylodiscitis: a new perspective for surgical treatment.

Eur Spine J 2022 Jan 15. Epub 2022 Jan 15.

Clinica Ortopedica dell'Adulto e Pediatrica, AOU "Ospedali Riuniti di Ancona", Ancona, Italy.

Purpose: Pyogenic spondylodiscitis is a relatively rare spinal disease; non-specific spondylodiscitis (NSS) cases are increasing. This study aims to identify if changes of inflammatory markers under antibiotic therapy can be used to determine which NSS patients can benefit from surgical indication earlier than others.

Methods: Two groups of patients with NSS were examined. Read More

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January 2022

Multisystem inflammatory syndrome in neonates (MIS-N) associated with SARS-CoV2 infection: a case series.

Eur J Pediatr 2022 Jan 14. Epub 2022 Jan 14.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Multisystem inflammatory syndrome in neonates (MIS-N) is hypothesised to be caused either following transplacental transfer of SARS-CoV2 antibodies or antibodies developed in the neonate after infection with SARS-CoV-2. In this paper, we aim to discuss the clinical manifestations, laboratory features, and management of neonates diagnosed with MIS-N. We collated information from five participating hospitals in western India. Read More

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January 2022

Dexamethasone Attenuate the Perioperative Acute Phase Response for Simultaneous Bilateral Total Hip Arthroplasty.

J Arthroplasty 2022 Jan 11. Epub 2022 Jan 11.

Department of Orthopaedic surgery, West China Hospital, Sichuan University, ChengDu, SiChuan Province, People's Republic of China.

Background: This study aimed to evaluate the effect of perioperative dexamethasone on acute phase response (APR) after simultaneous bilateral total hip arthroplasty (SimBTHA).

Methods: A retrospective case-control study was performed on 177 SimBTHA procedures. The patients were divided into 2 cohorts: patients receiving perioperative dexamethasone and patients in whom no dexamethasone was administered. Read More

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January 2022

Simple and effective serum biomarkers potential for predicting status epilepticus in anti-N-methyl-D-aspartate receptor encephalitis.

BMC Neurol 2022 Jan 14;22(1):27. Epub 2022 Jan 14.

Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.

Background: Patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis who also present with status epilepticus (SE) often have a poor prognosis. The aim of this study is to explore simple and effective predictors for anti-NMDAR encephalitis accompanied with SE.

Methods: We retrospectively analyzed 65 anti-NMDAR encephalitis patients from January 2015 to December 2018 who admitted to the Third Affiliated Hospital of Sun Yat-sen University. Read More

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January 2022

Chronic and acute hypervitaminosis A are associated with suboptimal anthropometric measurements in a cohort of South African preschool children.

Am J Clin Nutr 2022 Jan 14. Epub 2022 Jan 14.

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

Background: Excessive vitamin A (VA) can cause bone resorption and impair growth. Government-mandated VA supplementation (VAS) and adequate intake through dietary fortification and liver consumption led to excessive VA in South African children.

Objectives: We evaluated the relationship of VAS and underlying hypervitaminosis A assessed by retinol isotope dilution (RID) with measures of growth and bone turnover in this cohort. Read More

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January 2022

Nanoceria-based lateral flow immunoassay for hydrogen peroxide-free colorimetric biosensing for C-reactive protein.

Anal Bioanal Chem 2022 Jan 14. Epub 2022 Jan 14.

Department of BioNano Technology, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam, Gyeonggi, 13120, Republic of Korea.

During the recent several decades, lateral flow immunoassay (LFIA) constructed with gold nanoparticle (AuNP) has been widely utilized to conveniently detect target analyte. However, AuNP-based LFIA has limitations, such as limited detection sensitivity and quantification capability. Herein, to overcome these constraints, we have developed cerium oxide nanoparticle (nanoceria)-based LFIA for C-reactive protein (CRP) detection in human serum samples. Read More

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January 2022

Early use of tocilizumab in solid organ transplant recipients with COVID-19: A retrospective cohort study in Saudi Arabia.

Immun Inflamm Dis 2022 Jan 14. Epub 2022 Jan 14.

Research Center, Almoosa Specialist Hospital, Al-ahsa, Saudi Arabia.

Background: Tocilizumab was studied to reduce cytokine syndrome in patients with severe COVID-19 pneumonia in solid organ transplant (SOT) recipients with conflicting results. We aim to study the early use of tocilizumab in SOT with COVID-19 pneumonia on low flow oxygen.

Methods: This is a retrospective cohort study that was conducted in two transplant centers in Saudi Arabia among 46 SOT with COVID-19 comparing 21 patients who received tocilizumab to 25 patients who received standard of care. Read More

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January 2022

Resolution of iron deficiency following successful eradication of Helicobacter pylori in children.

Acta Paediatr 2022 Jan 13. Epub 2022 Jan 13.

The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

Aim: We aimed to assess correlation between successful Helicobacter-Pylori (HP) eradication and resolution of iron deficiency in children, without iron supplementation.

Methods: Medical records of children diagnosed with HP infection based on endoscopy, were retrospectively reviewed. Among those with non-anemic iron deficiency (NAID) or iron deficiency anemia (IDA), hemoglobin, ferritin and CRP levels were compared prior and 6-9 months' post successful HP eradication. Read More

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January 2022

The association of anxiety and stress-related disorders with C-reactive protein (CRP) within UK Biobank.

Brain Behav Immun Health 2022 Feb 27;19:100410. Epub 2021 Dec 27.

Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, G12 8RZ, Glasgow, Scotland, UK.

Anxiety and stress-related disorders are both common and disabling psychiatric conditions. There are a number of hypotheses suggesting the underlying pathophysiology of these disorders, however, the exact mechanism is unknown. Inflammation has previously been linked with depression and has more recently been suggested as a possible link to anxiety aetiology. Read More

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February 2022

Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB.

Biomed Res Int 2022 4;2022:5984184. Epub 2022 Jan 4.

Blood Purification Centre, Weifang People's Hospital, Weifang 261041, Shandong Province, China.

Aim: This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions.

Materials And Methods: Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Read More

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January 2022

Scanner-Assisted CO Laser Fissurectomy: A Pilot Study.

Front Surg 2021 28;8:799607. Epub 2021 Dec 28.

SOSD Proctologia, USL Toscana Centro, Florence, Italy.

Surgery for chronic anal fissure is challenging for every proctologist. Solving the pain by guaranteeing rapid and effective healing is the objective, but what is the price to pay today in functional terms? Though this result is nowadays partially achievable through interventions that include the execution of an internal sphincterotomy among the procedures, it is necessary to underline the high rate of patients who can present faecal incontinence. The aim of this study is to explore the effectiveness of scanner-assisted CO laser fissurectomy. Read More

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December 2021

Peripheral NF-κB dysregulation in people with schizophrenia drives inflammation: putative anti-inflammatory functions of NF-κB kinases.

Transl Psychiatry 2022 Jan 13;12(1):21. Epub 2022 Jan 13.

Neuroscience Research Australia, Sydney, New South Wales, Australia.

Elevations in plasma levels of pro-inflammatory cytokines and C-reactive protein (CRP) in patient blood have been associated with impairments in cognitive abilities and more severe psychiatric symptoms in people with schizophrenia. The transcription factor nuclear factor kappa B (NF-κB) regulates the gene expression of pro-inflammatory factors whose protein products trigger CRP release. NF-κB activation pathway mRNAs are increased in the brain in schizophrenia and are strongly related to neuroinflammation. Read More

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January 2022

Association between serum amyloid A and rheumatoid arthritis: A systematic review and meta-analysis.

Semin Arthritis Rheum 2021 Dec 30:151943. Epub 2021 Dec 30.

Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui 230032,China; Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address:

Backgrounds: Consistent correlation of serum amyloid A (SAA) to rheumatoid arthritis (RA) is not completely established. The present study is to systematically summarize their relationship.

Methods: Publications up to may 2021 were examined using key terms in the PubMed, Cochrane Library, Embase and China national knowledge infrastructure (CNKI) databases. Read More

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December 2021

Inpatient COVID-19 mortality has reduced over time: Results from an observational cohort.

PLoS One 2022 13;17(1):e0261142. Epub 2022 Jan 13.

Centre for Rheumatic Diseases, King's College London, London, United Kingdom.

Background: The Covid-19 pandemic in the United Kingdom has seen two waves; the first starting in March 2020 and the second in late October 2020. It is not known whether outcomes for those admitted with severe Covid were different in the first and second waves.

Methods: The study population comprised all patients admitted to a 1,500-bed London Hospital Trust between March 2020 and March 2021, who tested positive for Covid-19 by PCR within 3-days of admissions. Read More

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January 2022

The impact of physical activity on blood inflammatory cytokines and neuroprotective factors in individuals with mild cognitive impairment: a systematic review and meta-analysis of randomized-controlled trials.

Aging Clin Exp Res 2022 Jan 13. Epub 2022 Jan 13.

National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology & Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.

Background: Accumulated evidence has proved that both neuroinflammation and neuroprotection existing at the stage of mild cognitive impairment (MCI) may mediate its progression, which can conversely be modulated by physical activity (PA). However, further research is needed to clarify which factors are involved in that process.

Objectives: To identify the impact of PA on inflammatory cytokines and neuroprotective factors in individuals with MCI. Read More

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January 2022

Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects.

Rom J Morphol Embryol 2021 Apr-Jun;62(2):509-515

Department of Internal Medicine, Medical Semiology, University of Medicine and Pharmacy of Craiova, Romania; Department of Nursing, Faculty of Nursing, Târgu Jiu Subsidiary, Titu Maiorescu University, Bucharest, Romania;

Introduction: Non-alcoholic steatohepatitis (NASH) is a progressive form of liver steatosis that involves a risk of progression towards fibrosis, cirrhosis, and end-stage liver disease. Low-grade inflammation is recognized to be involved in non-alcoholic fatty liver disease (NAFLD) pathogeny. Additionally, adipose tissue dysfunction plays an important role in the development of metabolic diseases. Read More

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January 2022

Safety and Efficacy of Tocilizumab 4 or 8 mg/kg in Hospitalized Patients With Moderate to Severe Coronavirus Disease 2019 Pneumonia: A Randomized Clinical Trial.

Open Forum Infect Dis 2022 Jan 4;9(1):ofab608. Epub 2021 Dec 4.

Genentech, Inc, South San Francisco, California, USA.

Background: Tocilizumab, an interleukin 6 receptor (IL-6R) antagonist monoclonal antibody, has shown efficacy in patients with coronavirus disease 2019 (COVID-19) pneumonia, but the optimal dose is unknown.

Methods: Patients hospitalized for moderate to severe COVID-19 pneumonia were randomized 1:1 to receive standard of care treatment and 1-2 doses of intravenous tocilizumab 4 mg/kg or 8 mg/kg (open-label). Primary pharmacokinetic and pharmacodynamic end points were serum concentrations of tocilizumab and soluble interleukin 6 receptor (sIL-6R), IL-6, ferritin, and C-reactive protein (CRP), from baseline to day 60. Read More

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January 2022

Application Value of Blood Heparin-Binding Protein in the Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Contrast Media Mol Imaging 2021 22;2021:3800211. Epub 2021 Dec 22.

Affiliated Hospital of China University of Mining and Technology, Xuzhou, Jiangsu 221000, China.

Objective: To investigate the expression and clinical significance of serum heparin-binding protein (HBP), C-reactive protein (CRP), and white blood cell count (WBC) in an acute exacerbation of chronic obstructive pulmonary disease (COPD).

Methods: A prospective research model was used to select 63 patients with acute exacerbation of chronic obstructive pulmonary disease who were hospitalized in Xuzhou First People's Hospital from January 2020 to June 2020, and among the chronic obstructive pulmonary disease patients who were followed up in our hospital during the same period, 18 patients were in the stable phase, and 43 healthy patients in our hospital during the same period were selected as the healthy control group. 18 patients with stable chronic obstructive pulmonary disease were selected as the observation group, and 43 healthy people who underwent examination at the same time as the control group. Read More

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December 2021

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Infection, Ethiopia.

Int J Gen Med 2022 6;15:271-278. Epub 2022 Jan 6.

Department of Medical Biochemistry, School of Medicine, Debre Tabor University, Debre Tabor, Ethiopia.

Introduction: are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. Read More

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January 2022

Platelet Parameters, C-Reactive Protein, and Depression: An Association Study.

Int J Gen Med 2022 6;15:243-251. Epub 2022 Jan 6.

Department of General, Qiaokou Han Jia Dun Street Community Health Service Center, Wuhan, 430000, Hubei, People's Republic of China.

Objective: This study aims to investigate the correlation of platelet parameters and C-reactive protein (CRP) with depression.

Methods: The clinical data of 61 patients with depression and 30 healthy control subjects were collected to compare the platelet parameters, CRP levels, and Hamilton Depression Rating Scale (HAMD) scores of the two groups for correlation analysis.

Results: The results revealed that the body mass index (BMI) of patients with depression was lower (P < 0. Read More

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January 2022

Management of Descending Necrotizing Mediastinitis, a Severe Complication of Deep Neck Infection, Based on Multidisciplinary Approaches and Departmental Co-Ordination.

Ear Nose Throat J 2022 Jan 13:1455613211068575. Epub 2022 Jan 13.

School of Medicine, Chang Gung University, Taoyuan, Taiwan.

Objectives: Descending necrotizing mediastinitis (DNM) developing after deep neck infection (DNI) is a potentially lethal disease of the mediastinum with a mortality rate as high as 40% prior to the 1990s. No standard treatment protocol is available. Here, we present the outcomes of our multidisciplinary approaches for treating DNM originating from a DNI. Read More

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January 2022

Matrix Metalloproteinase 3: a Novel Effective Biomarker for Predicting the Mortality and the Severity of Pneumonia.

Clin Lab 2022 Jan;68(1)

Background: Matrix metalloproteinase 3 (MMP3) is known as an inflammatory factor; however, the effectiveness of MMP3 for diagnosis of pneumonia and predicting outcomes is unclear. We evaluated the diagnostic and prognostic value of serum MMP3 in patients with pneumonia.

Methods: One hundred and eighty-five patients with pneumonia and 52 healthy controls were enrolled. Read More

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January 2022

Can B-Type Natriuretic Peptide (BNP) Levels Serve as an Early Predictor of Clinical Severity in Patients with COVID-19 Pneumonia?

Clin Lab 2022 Jan;68(1)

Background: COVID-19 has continued to aggressively spread and kill. The incidence of complications and associated mortality rates are high. Cardiac damage, which is related to survival, is one of these. Read More

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January 2022

Caloric adequacy of parenteral nutrition and its influence on the clinical outcome of hospitalised patients.

Nutr Health 2022 Jan 13:2601060211070108. Epub 2022 Jan 13.

73076Faculty of Pharmacy, Universidad Complutense de Madrid, Madrid, Spain.

The adaptation of Parenteral Nutrition (PN) to actual energy requirements of hospitalised patients is essential, since excessive and insufficient nutritional intake have been associated with poor clinical outcomes. To evaluate the adaptation of prescribed PN to the estimated nutritional requirements using three predictive equations and the influence of excessive/insufficient nutrient intake on patient clinical outcomes (nutritional parameters, metabolic and infectious complications). Prospective, observational study in hospitalised patients nutritionally assessed. Read More

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January 2022

Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial.

Phytother Res 2022 Jan 12. Epub 2022 Jan 12.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

It has been more than a year since the outbreak of COVID-19, and it is still the most critical issue of the healthcare system. Discovering effective strategies to treat infected patients is necessary to decrease the mortality rate. This study aimed to determine the effects of nanocurcumin on the severity of symptoms and length of hospital stay (LOS) in COVID-19 patients. Read More

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January 2022

The Role of Inflammatory Biomarkers as a Diagnostic Tool for Possible Late-Life Cognitive Decline and Dementias.

Adv Exp Med Biol 2021 ;1339:39-46

Department of Physiotherapy, School of Health Rehabilitation Sciences, University of Patras, Aigio, Greece.

The objective of this paper was to explore whether inflammatory biomarkers, especially C-reactive protein (CRP) and high-sensitivity CRP (hsCRP), can be used as a diagnostic tool for possible late-life cognitive decline and dementias. Twelve studies were identified since 2010 involving 13,174 subjects, and one study recruited only healthy population. Inflammatory biomarkers CRP and hsCRP were obtained from blood plasma. Read More

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January 2022

The blood sugar level can predict preoperative shock in patients with a ruptured abdominal aortic aneurysm even when the patient's condition appears stable.

Surg Today 2022 Jan 13. Epub 2022 Jan 13.

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, 6-1 Kishibeshinmachi, Suita, Osaka, 564-8565, Japan.

Purpose: This observational retrospective study aimed to identify preoperative blood test data capable of predicting preoperative shock in ruptured abdominal aortic aneurysm (rAAA).

Methods: A total of 104 patients who underwent surgery for rAAA between 2007 and 2018 were reviewed. Preoperative shock, defined as a shock index (heart rate/blood pressure) exceeding 1. Read More

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January 2022

Bacteremic and Nonbacteremic Brucellosis in Children in Turkey.

J Trop Pediatr 2022 Jan;68(1)

Department of Pediatric Infectious Disease, SBU Ankara Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara 06080, Turkey.

Introduction: Human brucellosis is one of the most common zoonotic infections in the world. The definitive diagnosis of brucellosis is based on cultured Brucella organisms from blood or other tissue samples. We aimed to compare bacteremic and nonbacteremic brucellosis patients with demographical, epidemiological, clinical and laboratory features and determine the predictive factors affecting blood culture positivity. Read More

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January 2022

Increased Circulating PD-1 hi CXCR5 - Peripheral T Helper Cells are Associated with Disease Activity of ANCA-Associated Vasculitis.

Clin Exp Immunol 2022 Jan 12. Epub 2022 Jan 12.

Department of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, P.R. China.

Newly identified PD-1 hiCXCR5 -CD4 + T cells, termed as peripheral helper T cells (Tph), have been found elevated and playing pathogenic role in some autoimmune diseases like systemic lupus erythematosus (SLE) and rheumatic arthritis (RA). However, the potential role of Tph cells in Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) remains unclear. Here, we explored the potential clinical significance of circulating Tph cells in the pathogenesis of AAV. Read More

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January 2022