58,559 results match your criteria crohn's disease


Comparative Efficacy and Rapidity of Action for Infliximab vs. Ustekinumab in Biologic Naive Crohn's Disease.

Clin Gastroenterol Hepatol 2021 Apr 7. Epub 2021 Apr 7.

Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, Austria.

Background And Aims: Comparative effectiveness have become increasingly important to help position therapies for inflammatory bowel disease. We compared the efficacy and rapidity of onset of action of infliximab vs. ustekinumab induction therapy for moderate to severe biologic-naïve Crohn's disease (CD) using patient-level data from randomized controlled trials. Read More

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Distinct clinical phenotypes for Crohn's disease derived from patient surveys.

BMC Gastroenterol 2021 Apr 9;21(1):160. Epub 2021 Apr 9.

Department of Bioengineering, Stanford University, Shriram Room 209, MC: 4245, 443 Via Ortega Drive, Stanford, CA, 94305-4145, USA.

Background: Defining clinical phenotypes provides opportunities for new diagnostics and may provide insights into early intervention and disease prevention. There is increasing evidence that patient-derived health data may contain information that complements traditional methods of clinical phenotyping. The utility of these data for defining meaningful phenotypic groups is of great interest because social media and online resources make it possible to query large cohorts of patients with health conditions. Read More

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Trends in paediatric inflammatory bowel disease-attributable direct costs: a population-based analysis.

Aliment Pharmacol Ther 2021 Apr 9. Epub 2021 Apr 9.

IBD Clinical and Research Center, University of Manitoba, Winnipeg, MB, Canada.

Background: In addition to its morbidities, inflammatory bowel disease (IBD) has a major financial burden on patients and healthcare systems. However, there is a paucity of evidence on IBD-attributable costs in children.

Aims: To determine the trends of IBD-attributable direct costs over time using a population-based analysis. Read More

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CEing More-Assessing Small Bowel Crohn's with Capsule Endoscopy (CE).

Dig Dis Sci 2021 Apr 9. Epub 2021 Apr 9.

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy.

Introduction: Small bowel involvement is very common in Crohn's disease. Ileocolonoscopy, cross-sectional imaging modalities, and video capsule endoscopy are the tools currently used to investigate such involvement.

Areas Covered: Herein we report the case of a 47-year-old man with a history of ileocolic Crohn's disease and persistent, unexplained iron deficiency anemia. Read More

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Anti-Tumor Necrosis Factor-Alpha Withdrawal in Children With Inflammatory Bowel Disease in Endoscopic and Histologic Remission.

Inflamm Bowel Dis 2021 Apr 9. Epub 2021 Apr 9.

Gastroenterology and Nutrition Unit, Meyer Children's Hospital, Florence, Italy.

Background: The aim of the present study was to investigate outcomes of anti-TNF-alpha (ATA) withdrawal in selected pediatric patients with inflammatory bowel disease who achieved clinical remission and mucosal and histological healing (MH and HH).

Methods: A retrospective analysis was performed on children and adolescents affected by Crohn disease (CD) and ulcerative colitis (UC) who were followed up at 2 tertiary referral centers from 2008 through 2018. The main outcome measure was clinical relapse rates after ATA withdrawal. Read More

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Association between Fecal Calprotectin and Mucosal Healing in Pediatric Patients with Crohn's Disease Who Have Achieved Sustained Clinical Remission with Anti-Tumor Necrosis Factor Agents.

Gut Liver 2021 Apr 9. Epub 2021 Apr 9.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.

Background/aims: : Although mucosal healing (MH) is acknowledged as the treatment target in the treat-to-target era, there are limitations on repeated endoscopic examinations, especially in pediatric patients. We aimed to investigate whether fecal calprotectin (FC) could serve as a surrogate marker for the assessment of MH in pediatric patients with Crohn's disease (CD) who have achieved sustained clinical remission (CR) while treated with anti-tumor necrosis factor (TNF) agents.

Methods: This multicenter retrospective cross-sectional study included pediatric CD patients who had sustained a CR for at least 6 months with anti-TNF agents and who simultaneously underwent ileocolonoscopy and FC tests during follow-up. Read More

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Risk Factors for Disease Behavior Evolution and Efficacy of Biologics in Reducing Progression in Pediatric Patients with Nonstricturing, Nonpenetrating Crohn's Disease at Diagnosis: A Single-Center Experience in Korea.

Gut Liver 2021 Apr 9. Epub 2021 Apr 9.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Background/aims: : Recently, the treatment of Crohn's disease (CD) has changed to a treat-totarget strategy, in which disease progression is prevented with early intervention. We analyzed the long-term evolution of nonstricturing, nonpenetrating (B1) disease at diagnosis and factors related to disease evolution in pediatric CD.

Methods: We retrospectively analyzed 402 patients between 2000 and 2013 who were younger than 18 years and had B1 disease at CD diagnosis. Read More

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One-year real life data of our patients with moderate-severe Crohn's disease who underwent ustekinumab therapy.

Scott Med J 2021 Apr 9:369330211008587. Epub 2021 Apr 9.

Professor of Gastroenterology, Department of Gastroenterology, Ankara City Hospital, Ankara, Turkey.

Aim: The aim of this study was to present one-year real-life data of our patients with CD who showed unresponsiveness and/or intolerance to biological agents and then received ustekinumab treatment through an early access program.

Materials And Methods: The retrospective study reviewed the 52-week clinical data of 10 patients with moderate or severe CD who underwent ustekinumab therapy.

Results: The 10 patients comprised 7 (70%) men and 3 (30%) women with a mean age of 38 ± 11. Read More

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What are the predictors for recurrence of Crohn's disease after surgery?

Medicine (Baltimore) 2021 Apr;100(14):e25340

Gastrointestinal Surgery Unit, Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University.

Abstract: Surgical resection is an unavoidable part of the current treatment options for Crohn's disease (CD), and more than half of patients develop recurrence. The aim of this study was to investigate the predictors for recurrence in the long-term follow-up of CD patients after surgery.Medical records of consecutive CD patients who were operated on between January 2003 and January 2015 were retrospectively analyzed. Read More

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Accuracy of the highly sensitive C-reactive protein/albumin ratio to determine disease activity in inflammatory bowel disease.

Medicine (Baltimore) 2021 Apr;100(14):e25200

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract: Persistent disease activity is associated with a poor prognosis in patients with inflammatory bowel disease (IBD). This study aims to explore the accuracy of the highly sensitive C-reactive protein/albumin ratio (CAR) in determining IBD activity.The clinical data of 231 IBD patients treated at Peking Union Medical College Hospital from 2012 to 2018 were analyzed retrospectively. Read More

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Stable and scalable SERS tags conjugated with neutravidin for the detection of Fibroblast Activation Protein (FAP) in primary fibroblasts.

Nanotechnology 2021 Apr 8. Epub 2021 Apr 8.

Chemistry, University of Pavia, Pavia, Lombardia, ITALY.

SERS tags are a class of nanoparticles with great potential in advanced imaging experiments. The preparation of SERS tags however is complex, as they suffer from the high variability of the SERS signals observed even at the slightest sign of aggregation. Here, we developed a method for the preparation of SERS tags based on the use of gold nanostars (GNS) conjugated with neutravidin. Read More

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The value of magnetic resonance enterography in diagnostic difficulties associated with Crohn's disease.

Pol J Radiol 2021 3;86:e143-e150. Epub 2021 Mar 3.

Department of Diagnostic Imaging, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

Purpose: The diagnosis of Crohn's disease (CD), one of the inflammatory bowel diseases (IBD), along with ulcerative colitis (UC), is often challenging due to the limitations of small intestine visualisation. Magnetic resonance enterography (MRE) enables imaging of intraluminal and extraintestinal complications without ionizing radiation. The objective of this study is to select CD-related MRE features and determine the feasibility of this technique to indicate a group of patients that should be subjected to more invasive diagnostic procedures. Read More

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Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases.

Front Neurosci 2021 22;15:650971. Epub 2021 Mar 22.

Laboratoire Inter-Universitaire de Psychologie Personnalité, Cognition, Changement Social, University Grenoble Alpes, University Savoie Mont Blanc, Grenoble, France.

The vagus nerve is a mixed nerve, comprising 80% afferent fibers and 20% efferent fibers. It allows a bidirectional communication between the central nervous system and the digestive tract. It has a dual anti-inflammatory properties via activation of the hypothalamic pituitary adrenal axis, by its afferents, but also through a vago-vagal inflammatory reflex involving an afferent (vagal) and an efferent (vagal) arm, called the cholinergic anti-inflammatory pathway. Read More

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Risk stratification and geographical mapping of Brazilian inflammatory bowel disease patients during the COVID-19 outbreak: Results from a nationwide survey.

World J Gastroenterol 2021 Mar;27(12):1226-1239

Health Sciences Postgraduate Program, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80440-220, PR, Brazil.

Background: Coronavirus disease 2019 (COVID-19) pandemic is still evolving globally, and Brazil is currently one of the most affected countries. It is still debated whether patients with inflammatory bowel disease (IBD) are at a higher risk for developing COVID-19 or its complications.

Aim: To assess geographical distribution of IBD patients at the highest risk and correlate these data with COVID-19 mortality rates in Brazil. Read More

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CAR directs T cell adaptation to bile acids in the small intestine.

Nature 2021 Apr 7. Epub 2021 Apr 7.

Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.

Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small intestine. As detergents, bile acids can cause toxicity and inflammation in enterohepatic tissues. Nuclear receptors maintain bile acid homeostasis in hepatocytes and enterocytes, but it is unclear how mucosal immune cells tolerate high concentrations of bile acids in the small intestine lamina propria (siLP). Read More

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Improved Smoking Cessation Rates in a Pharmacist-Led Program Embedded in an Inflammatory Bowel Disease Specialty Medical Home.

J Pharm Pract 2021 Apr 8:8971900211000682. Epub 2021 Apr 8.

Mount Sinai Hospital, New York, NY, USA.

Background: Cigarette smoking is associated with disease progression, poor outcomes, and increased biologic use in Crohn's Disease (CD). In this prospective study, we describe the structure and results of a pharmacist-driven smoking cessation program in an Inflammatory Bowel Disease (IBD) Specialty Medical Home.

Methods: One pharmacist designed and implemented a collaborative drug therapy management (CDTM) program, which allowed the pharmacist to initiate and modify smoking cessation aids, monitor medication safety and efficacy, and provide behavioral counseling. Read More

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Inflammatory bowel disease-related economic costs due to presenteeism and absenteeism.

Scand J Gastroenterol 2021 Apr 7:1-6. Epub 2021 Apr 7.

Department of Internal Medicine, Turku University Hospital, University of Turku, Turku, Finland.

Background: Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis, can be a lifelong burden generating high costs to an economic system. Data regarding the cost of workplace presenteeism and absenteeism in workers with IBD are limited. Our objective was to assess these costs in employed adults. Read More

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NRG4-ErbB4 signaling represses pro-inflammatory macrophage activity.

Am J Physiol Gastrointest Liver Physiol 2021 Apr 7. Epub 2021 Apr 7.

Biochemistry and Molecular Biology, University of Southern California, United States.

Macrophages are critical mediators of intestinal defense and homeostasis. However, uncontrolled pro-inflammatory macrophage activity may contribute to chronic conditions such as inflammatory bowel disease. Currently, the regulatory feedback mechanisms restraining pro-inflammatory cytokine production in activated macrophages are not well understood. Read More

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Potential Role of Epithelial Endoplasmic Reticulum Stress and Anterior Gradient Protein 2 Homolog in Crohn's Disease Fibrosis.

J Crohns Colitis 2021 Apr 2. Epub 2021 Apr 2.

Laboratory of Translational Gastroenterology, University of Liège, Liège, Belgium.

Background And Aims: Intestinal fibrosis is a common complication of Crohn's disease (CD). It is characterised by an accumulation of fibroblasts differentiating into myofibroblasts secreting excessive extracellular matrix. The potential role of the intestinal epithelium in this fibrotic process remains poorly defined. Read More

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Care of inflammatory bowel disease patients during coronavirus disease-19 pandemic using digital health-care technology.

JGH Open 2021 Jan 29. Epub 2021 Jan 29.

School of Telemedicine and Biomedical Informatics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India.

Background And Aim: Although telemedicine is an option for the care of inflammatory bowel disease (IBD) patients during the Coronavirus Disease (COVID)-19 pandemic, its feasibility and acceptability data are scant. Data on the frequency of COVID-19 among patients with IBD, quality of life (QOL), access to health care, psychological stress, and anxiety during the COVID-19 pandemic are scant.

Methods: Video/audio consultation for IBD patients was undertaken after a web-based appointment, and data on acceptability, IBD control, Hospital Anxiety Depression Scale (HADS), and World Health Organization Quality of Life questionnaire (WHOQOL-Bref) were obtained electronically. Read More

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January 2021

A nationwide real-world study on dynamic ustekinumab dosing and concomitant medication use among Crohn's disease patients in Finland.

Scand J Gastroenterol 2021 Apr 5:1-10. Epub 2021 Apr 5.

Medical Affairs, Espoo, Finland.

Background: Real-world evidence to support optimal ustekinumab dosing for refractory Crohn's disease (CD) patients remains limited. Data from a retrospective nationwide chart review study was utilized to explore ustekinumab dosing dynamics and optimization, identify possible clinical predictors of dose intensification, and to evaluate ustekinumab trough concentrations (TCs) and concomitant medication use in Finland.

Methods: Information gathered from17 Finnish hospitals included clinical chart data from 155 adult CD patients who received intravenous ustekinumab induction during 2017-2018. Read More

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Perspectives of health care use and access to care for individuals living with inflammatory bowel disease in rural Canada.

Rural Remote Health 2021 Apr 6;21(2):6358. Epub 2021 Apr 6.

4342-104 Clinic Place, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with no known cure. Management of IBD is complex and requires those with IBD to have lifelong interactions with the healthcare system. Individuals with IBD who live in rural areas are at risk of poorer health outcomes due to their limited access to care. Read More

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Recombinant antimicrobial peptide microcin J25 alleviates DSS-induced colitis via regulating intestinal barrier function and modifying gut microbiota.

Biomed Pharmacother 2021 Apr 2;139:111127. Epub 2021 Apr 2.

State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, China Agricultural University, Beijing 100193, PR China; Beijing Bio-Feed Additives Key Laboratory, Beijing 100193, PR China. Electronic address:

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is rising constantly all over the world. However, current medical treatments are not universally practical. Microcin J25 (MccJ25), a member of the lasso peptides class, has excellent antimicrobial activity both in vitro and in vivo. Read More

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Advances In The Comprehensive Management of Post-Operative Crohn's Disease.

Clin Gastroenterol Hepatol 2021 Apr 2. Epub 2021 Apr 2.

Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.

Patients with post-operative Crohn's disease are difficult to manage due to their risk of experiencing a more severe course, multiple symptom confounders and poor sensitivity of symptomatic remission to rule out intestinal inflammation. In this group, data are lacking on biologic therapeutic efficacy and recommendations are lacking for those with multiple medication failures. Novel non-invasive testing can simultaneously exclude alternate causes of symptoms (serum C4, fecal fat, SIBO breath testing) and assess intestinal inflammation (fecal calprotectin, endoscopic healing index). Read More

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The cumulative effects of MEFV gene polymorphisms and mutations in patients with inflammatory bowel diseases.

J Pak Med Assoc 2021 02;71(2(A)):479-483

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cukurova University, Turkey.

Objective: To determine the cumulative effects of Mediterranean fever gene polymorphisms and mutations in patients with ınflammatory bowel diseases.

Methods: The case-control study was conducted from January, 2012, to January, 2016,at Cukurova University, Turkey, and comprised patients diagnosed with inflammatory bowel diseases and followed up at the Children Gastroenterology Department. By using molecular methods, 12 Mediterranean fevergene variants most frequently observed in the country were examined in all the diagnosed cases. Read More

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February 2021

Vulvar edema: diagnostic clue to Crohn disease.

Dermatol Online J 2021 Feb 15;27(2). Epub 2021 Feb 15.

Hospital Clínico Universitario de Valladolid. Calle Ramón y Cajal 3, Valladolid.

Vulvar lesions are clinically challenging for physicians because the differential diagnosis may include many entities. Vulvar edema is one of the most frequent symptoms and is normally attributed to a local cause. Herein, we present a case report of vulvar Crohn disease (VCD) in a 9-year-old girl, in which skin lesions preceded the systemic gastrointestinal symptoms. Read More

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February 2021

Poor Concordance Between Clinical Activity and Endoscopic Severity in Pediatric Crohn's Disease: Before and After Induction Therapy.

Dig Dis Sci 2021 Apr 5. Epub 2021 Apr 5.

Department of Gastroenterology, The Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, 3333 Bin Sheng Road, Binjiang District, Hangzhou City, 310051, Zhejiang Province, China.

Objectives And Study: Endoscopic assessments of disease activity are important to diagnose and evaluate treatment responses in patients with Crohn's disease (CD). However, the invasiveness of endoscopy limits the application of this technique in routine examination. Thus, interest has been increasing in identifying noninvasive surrogate markers to predict endoscopic CD activity. Read More

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The role of hyperbaric oxygen therapy in inflammatory bowel disease: a narrative review.

Med Gas Res 2021 Apr-Jun;11(2):66-71

Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Inflammatory bowel disease is a group of chronic recurrent diseases in the digestive tract, including ulcerative colitis and Crohn's disease. Over the past few decades, the treatment of IBD has made great progress but there is still a lot of room for improvement. Hyperbaric oxygen therapy (HBOT) was defined as the therapeutic effect of inhaling 100% oxygen higher than one atmosphere and reported to be used in stroke, decompression sickness and wound healing. Read More

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The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats.

Physiol Genomics 2021 Apr 5. Epub 2021 Apr 5.

Veterinary Pathobiology, University of Missouri, United States.

ATG16L1 is a ubiquitous autophagy gene responsible, in part, for formation of the double-membrane bound autophagosome that delivers unwanted cellular debris and intracellular pathogens to the lysosome for degradation. A single, nonsynonymous adenine to guanine polymorphism resulting in a threonine to alanine amino acid substitution (T300A) directly preceded by a caspase cleavage site (DxxD) causes an increased susceptibility to Crohn's disease (CD) in humans. The mechanism behind this increased susceptibility is still being elucidated, however, the amino acid change caused by this point mutation results in increased ATG16L1 protein sensitivity to caspase 3-mediated cleavage. Read More

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Risk mitigation in Crohn's disease and ulcerative colitis: Session four summary.

Authors:
Rupert W Leong

J Gastroenterol Hepatol 2021 Apr;36 Suppl 1:27-28

Department of Gastroenterology and Hepatology, Concord General Repatriation Hospital, Sydney, Australia and the University of Sydney, Sydney, Australia.

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