J Breath Res 2016 Apr 19;10(2):021001. Epub 2016 Apr 19.
Department of Pediatrics, University Children's Hospital, Technical University Dresden, Dresden, Germany. Division of Pulmonary Medicine, University Children's Hospital, Technical University Dresden, Dresden, Germany. These authors contributed equally to this work.
We aimed to evaluate the fraction of exhaled nitric oxide (FENO50) and deaerated exhaled breath condensate pH (dEBCpH) as non-invasive markers of subclinical airway inflammation in pediatric patients with rheumatologic disorders. We determined FENO50 and dEBCpH in a prospective study spanning at least 12 months, comprising 85 pediatric patients with rheumatologic disorders, including juvenile idiopathic arthritis (JIA, n = 63), chronic recurrent multifocal osteomyelitis (CRMO, n = 6), systemic lupus erythematosus (SLE, n = 3), juvenile dermatomyositis (JDM, n = 1) and other rheumatic disorders (n = 12). dEBCpH was determined once in a group of children without evidence of rheumatologic or pulmonary disease (controls, n = 90). Read More