J Rheumatol 2021 Mar 1. Epub 2021 Mar 1.
TSS was supported by the University of Iowa's Department of Radiology and Divisions of Pediatric Radiology and Neuroradiology. PJF was supported by NIH/NIAMS R01AR059703 and The Marjorie K. Lamb Professorship at the University of Iowa Carver College of Medicine. T.S. Sato, Clinical Assistant Professor, Divisions of Pediatric Radiology and Neuroradiology, Department of Radiology, Carver College of Medicine, University of Iowa; P.J. Ferguson, Professor, Division of Pediatric Rheumatology, Allergy and Immunology, Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. Address correspondence to Dr. P. Ferguson, University of Iowa, 200 Hawkins Dr., Iowa City, IA 52240, USA. Email:
From the first description in 1972 as "subacute and chronic recurrent osteomyelitis" to the currently recognized chronic recurrent multifocal osteomyelitis (CRMO) or chronic nonbacterial osteitis (CNO), diagnosis and monitoring of patients with this disease has been and continues to be a challenge While the most common presenting symptom is focal bone pain, its waxing and waning nature tends to contribute to the diagnostic odyssey that many patients must endure. Read More