96,943 results match your criteria critically ill


Leveraging Surveillance and Evidence: Preventing Adverse Childhood Experiences Through Data to Action.

Am J Prev Med 2022 Jun;62(6S1):S24-S30

Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.

Adverse childhood experiences are potentially traumatic events that occur in childhood that have been associated with lifelong chronic health problems, mental illness, substance misuse, and decreased life opportunities. Therefore, preventing adverse childhood experiences is critical to improving health and socioeconomic outcomes throughout the lifespan. The Preventing Adverse Childhood Experiences: Data to Action (CDC-RFA-CE20-2006) funding initiative is a comprehensive public health approach to adverse childhood experience prevention that aims to understand the prevalence of and risk factors for adverse childhood experiences among youth, track changes in adverse childhood experience prevalence over time, focus prevention strategies, and ultimately measure the success of those evidence-based prevention strategies. Read More

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Differentiating autoimmune encephalitis from schizophrenia spectrum disorders among patients with first-episode psychosis.

J Psychiatr Res 2022 May 13;151:419-426. Epub 2022 May 13.

Department of Neuropsychiatry, Ashikaga Red Cross Hospital, Ashikaga, Tochigi, 326-0843, Japan; Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan. Electronic address:

Background: Although differential diagnosis between autoimmune encephalitis and schizophrenia spectrum disorders is crucial for a good outcome, the psychiatric symptoms that distinguish these two conditions have not been identified even though psychiatric symptoms are often the main manifestation of autoimmune encephalitis. Also, there are many situations in clinical psychiatry in which laboratory testing and imaging studies are not available. Because no comparative study of the psychiatric symptoms between these two conditions has been carried out, we explored diagnostically useful psychiatric symptoms in a retrospective case-control study. Read More

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The application of pediatric early warning score (PEWS) in emergency observation room.

J Pediatr Nurs 2022 May 18;66:1-5. Epub 2022 May 18.

Department of Pediatric Emergency Medicine and Critical Care Medicine, Children's Hospital of Fudan University, Shanghai 201102, PR China. Electronic address:

Objective: To explore the value of pediatric early warning scoring system (PEWS) in an emergency observation room in China.

Methods: The children who had been admitted consecutively to the emergency observation room from Jan, 2019 to Aug, 2020 were selected. Three most important time-points including the first value (admission value), the highest value during the observation (highest value), and final value (discharge value) of Brighton Pediatric Early Warning Score (PEWS) was evaluated in all patients. Read More

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Usefulness of lung ultrasound for early detection of hospital-acquired pneumonia in cardiac critically ill patients on venoarterial extracorporeal membrane oxygenation.

Ann Intensive Care 2022 May 21;12(1):43. Epub 2022 May 21.

Sorbonne Université, GRC 29, AP-HP, DMU DREAM, Department of Anesthesiology and Critical Care, Institute of Cardiology, Pitié-Salpêtrière Hospital, 47-83 boulevard de l'Hôpital, 75651, Paris Cedex 13, France.

Background: Hospital-acquired pneumonia (HAP) is the most common and severe complication in patients treated with venoarterial extracorporeal membrane oxygenation (VA ECMO) and its diagnosis remains challenging. Nothing is known about the usefulness of lung ultrasound (LUS) in early detection of HAP in patients treated with VA ECMO. Also, LUS and chest radiography were performed when HAP was suspected in cardiac critically ill adult VA ECMO presenting with acute respiratory failure. Read More

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Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study.

Intensive Care Med 2022 May 21. Epub 2022 May 21.

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, Italy.

Purpose: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients.

Methods: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020. Read More

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Knowledge, attitudes, and practices toward cancer pain management amongst healthcare workers (physicians, pharmacists, and nurses): a cross-sectional study from first-tier cities in China.

Support Care Cancer 2022 May 20. Epub 2022 May 20.

Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Purpose: China is currently one of the countries with the largest increased number of new cancer cases in the world, but cancer pain management (CPM) is still inadequate. This study uses a questionnaire to demonstrate the status and differences in knowledge, attitude and practice (KAP) of CPM among healthcare workers (HCWs) in developed regions of China, to find deficiencies and priorities for improvement, from which areas and advantages of the role of pharmacists and mobile devices can be explored.

Methods: This study used data from a questionnaire on CPM from March to June 2019. Read More

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The effect of intermittent pneumatic compression on deep-vein thrombosis and ventilation-free days in critically ill patients with heart failure.

Sci Rep 2022 May 20;12(1):8519. Epub 2022 May 20.

Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.

There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in critically ill patients with HF. Read More

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Mechanical Circulatory Support: Primer for Consultant Specialists.

Clin J Am Soc Nephrol 2022 May 20. Epub 2022 May 20.

Department of Anesthesiology, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York.

Mechanical life support therapies exist in many forms to temporarily replace the function of vital organs. Generally speaking, these tools are supportive therapy to allow for organ recovery but, at times, require transition to long-term mechanical support. This review will examine nonrenal extracorporeal life support for cardiac and pulmonary support as well as other mechanical circulatory support options. Read More

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Perioperative Risk Stratification and Modification.

Anesthesiol Clin 2022 Mar;40(1S):e1-e23

Perioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Tremona Road, Southampton SO16 6YD, United Kingdom; Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

This article discusses the important topic of perioperative risk stratification and the interventions that can be used in the perioperative period for risk modification. It begins with a brief overview of the commonly used scoring systems, risk-prediction models, and assessments of functional capacity and discusses some of the evidence behind each. It then moves on to examine how perioperative risk can be modified through the use of shared decision making, management of multimorbidity, and prehabilitation programs, before considering what the future of risk stratification and modification may hold. Read More

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The Science of Context: Transforming Serious Illness Care Though In Situ Observation.

J Pain Symptom Manage 2022 Jun;63(6):e651-e653

Department of Surgery (M.L.S), Division of Vascular Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

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Sunset and the Birth of New Ideas.

J Pain Symptom Manage 2022 Jun;63(6):e643-e644

Grant W. Liddle Professor of Medicine & Critical Care, Vanderbilt University Medical Center, Tennessee Valley Veteran's Affairs GRECC, Nashville, Tennessee, USA. Electronic address:

We met each other through academic medicine, in search for answers, and found friendship. Its value in my life was abundant, unearned grace. In Dr. Read More

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Surrogates of Patients With Severe Acute Brain Injury Experience Persistent Anxiety and Depression Over the 6 Months After ICU Admission.

J Pain Symptom Manage 2022 Jun;63(6):e633-e639

Division of Pulmonary Diseases and Critical Care Medicine (B.W., A.C., S.S.C.), University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Context: Severe Acute Brain Injury (SABI) is neurologically devastating, and surrogates for these patients may struggle with particularly complex decisions due to substantial prognostic uncertainty.

Objectives: To compare anxiety and depression symptoms over time between SABI surrogates and non-SABI surrogates for patients requiring prolonged mechanical ventilation (PMV).

Methods: We conducted a secondary analysis of the data from a multicenter randomized trial of a decision aid intervention for surrogates of adults experiencing PMV. Read More

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Evolution of Investigating Informed Assent Discussions about CPR in Seriously Ill Patients.

J Pain Symptom Manage 2022 Jun;63(6):e621-e632

Pulmonary, Critical Care & Sleep Medicine, Cambia Palliative Care Center of Excellence at UW Medicine (R.A.E.), University of Washington, Seattle, Seattle, Washington, USA.

Context: Outcomes after cardiopulmonary resuscitation (CPR) remain poor. We have spent 10 years investigating an "informed assent" (IA) approach to discussing CPR with chronically ill patients/families. IA is a discussion framework whereby patients extremely unlikely to benefit from CPR are informed that unless they disagree, CPR will not be performed because it will not help achieve their goals, thus removing the burden of decision-making from the patient/family, while they retain an opportunity to disagree. Read More

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Utilization and Delivery of Specialty Palliative Care in the ICU: Insights from the Palliative Care Quality Network.

J Pain Symptom Manage 2022 Jun;63(6):e611-e619

Division of Palliative Medicine, Department of Medicine (A.C.C., J.A.L., J.L., D.L.O.R., S.Z.P.), University of California San Francisco, San Francisco, California.

Context: Palliative care (PC) benefits critically ill patients but remains underutilized. Important to developing interventions to overcome barriers to PC in the ICU and address PC needs of ICU patients is to understand how, when, and for which patients PC is provided in the ICU.

Objectives: Compare characteristics of specialty PC consultations in the ICU to those on medical-surgical wards. Read More

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ProPACC: Protocol for a Trial of Integrated Specialty Palliative Care for Critically Ill Older Adults.

J Pain Symptom Manage 2022 Jun;63(6):e601-e610

Program on Ethics and Decision Making, The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine (S.K.A., G.V., R.A.B., E.H.P.B., D.M., S.K., R.O., J.S., D.B.W.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Palliative Research Center (PaRC) (R.A.B., J.R., K.B.B., A.T., L.A.K., J.S., R.A., Y.S., D.B.W.), University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

Background: Each year, approximately one million older adults die in American intensive care units (ICUs) or survive with significant functional impairment. Inadequate symptom management, surrogates' psychological distress and inappropriate healthcare use are major concerns. Pioneering work by Dr. Read More

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Improving Outcomes Measurement in Palliative Care: The Lasting Impact of Randy Curtis and his Collaborators.

J Pain Symptom Manage 2022 Jun;63(6):e579-e586

Cambia Palliative Care Center of Excellence (N.K., R.A.E.), University of Washington, Harborview Medical Center, Seattle, Washington, USA; University of Washington, Department of Medicine (R.A.E.), Division of Pulmonary, Critical Care and Sleep Medicine, Seattle, Washington, USA.

Palliative care research is deeply challenging for many reasons, not the least of which is the conceptual and operational difficulty of measuring outcomes within a seriously ill population such as critically ill patients and their family members. This manuscript describes how Randy Curtis and his network of collaborators successfully confronted some of the most vexing outcomes measurement problems in the field, and by so doing, have enhanced clinical care and research alike. Beginning with a discussion of the clinical challenges of measurement in palliative care, we then discuss a selection of the novel measures developed by Randy and his collaborators and conclude with a look toward the future evolution of these concepts. Read More

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To J.R.C. with L.O.V.E.

J Pain Symptom Manage 2022 Jun;63(6):e577-e578

Palliative and Advanced Illness Research (PAIR) Center, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Department of Medical Ethics and Health Policy (S.D.H.),University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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Repatriation of a Critically Ill Coronavirus Disease 2019-Positive Patient Across Closed Borders.

Air Med J 2022 May-Jun;41(3):323-325. Epub 2022 Feb 10.

Royal Darwin Hospital, Tiwi, Northern Territory, Australia; Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory, Australia.

We report on the international retrieval of a critically ill, ventilated, coronavirus disease 2019-positive patient from Dili, East Timor, into the intensive care unit of the Royal Darwin Hospital in Australia. The patient had severe respiratory failure, and the medical team in Dili was struggling to maintain adequate oxygenation with a fraction of inspired oxygen of 1 most of the time. This occurred during an outbreak of coronavirus disease 2019 in East Timor, placing strain on the local health system. Read More

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February 2022

Investigation of Possible Preventable Causes of COVID-19 Deaths in the Kampala Metropolitan Area, Uganda, 2020-2021.

Int J Infect Dis 2022 May 17. Epub 2022 May 17.

Centers for Disease Control and Prevention, Kampala, Uganda.

Background: Identifying preventable causes of COVID-19 deaths is key to reducing mortality. We investigated possible preventable causes of COVID-19 deaths over a 6-month period in Uganda.

Methods: A case-patient was a person testing RT-PCR-positive for SARS-CoV-2 who died in Kampala Metropolitan Area hospitals during August 2020-February 2021. Read More

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Molecular mechanism of Pulmonary diseases caused by exposure to urban PM in Chengdu-Chongqing Economic Circle, China.

Environ Int 2022 May 11;165:107292. Epub 2022 May 11.

Research Center for Atmospheric Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China. Electronic address:

Chengdu-Chongqing Economic Circle (CD-CQ Economic Circle) is one of China's four major economic circles and five major urban agglomerations located in Southwest China's Sichuan Basin. The CD-CQ Economic Circle, with its strong economic development and dense population, suffers from severe PM pollution, which is known to cause chronic and acute respiratory ailments. This study examined the lung disease-related hub genes, functions, and pathways that are affected by PM in summer and winter in the two central megacities of Chengdu and Chongqing. Read More

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Ralstonia pickettii and Pseudomonas aeruginosa Bloodstream Infections Associated with Contaminated Extracorporeal Membrane Oxygenation Water Heater Devices.

Clin Infect Dis 2022 May 20. Epub 2022 May 20.

Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA, USA.

We report on probable factory-based contamination of portable water heaters with waterborne pathogens and two bloodstream infections potentially attributable to off-label use of these water heaters to warm extracorporeal membrane oxygenation circuits. Great caution is warranted when using water-based devices to care for critically ill patients. Read More

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Association between skeletal muscle changes, anthropometric measurements, and clinical outcomes in critically ill trauma and surgical patients: A prospective observational study.

Nutr Clin Pract 2022 May 20. Epub 2022 May 20.

Department of Anesthesiology and Reanimation, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Background: Acute skeletal muscle wasting may predict clinical outcomes in critically ill patients. This study aimed to assess acute muscle loss, changes in anthropometric measurements, and the relationship between muscle loss and clinical outcomes in critically ill trauma and surgical patients.

Methods: This single-center, prospective observational study was conducted in critically ill trauma and surgical patients who were expected to stay in the intensive care unit (ICU) for at least 7 days. Read More

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Analgosedation in Critically Ill Adults Receiving Extracorporeal Membrane Oxygenation Support.

ASAIO J 2022 May 20. Epub 2022 May 20.

Neurocritical Care Division, Departments of Neurology, Neurosurgery, and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Extracorporeal membrane oxygenation (ECMO) is an increasingly utilized intervention for cardiopulmonary failure. Analgosedation during ECMO support is essential to ensure adequate pain and agitation control and ventilator synchrony, optimize ECMO support, facilitate patient assessment, and minimize adverse events. Although the principles of analgosedation are likely similar for all critically ill patients, ECMO circuitry alters medication pharmacodynamics and pharmacokinetics. Read More

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Chronic Critical Illness in Patients With Sepsis is Associated With Persistent Anemia, Inflammation, and Impaired Functional Outcomes.

Am Surg 2022 May 20:31348221104252. Epub 2022 May 20.

Department of Surgery and Sepsis and Critical Illness Research Center, 3463University of Florida Health, Gainesville, FL, USA.

Introduction: Survivors of sepsis will progress towards rapid recovery (RAP) or enter a state of persistent organ dysfunction and chronic critical illness (CCI). Independently, anemia is known to be a significant factor in functional recovery of hospitalized patients. This study aims to analyze long-term hemoglobin levels and functional outcomes following RAP and CCI. Read More

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Posttraumatic Stress Symptoms, Physical Illness, and Social Adjustment Among Disaster Victims.

Disaster Med Public Health Prep 2022 May 20:1-7. Epub 2022 May 20.

Division of Disaster Mental Health Services, National Center for Mental Health, Seoul, Republic of Korea.

Objective: Posttraumatic stress disorder is one of the most studied outcomes after a disaster. Posttraumatic stress symptoms (PTSS) are maladaptive and disabling and can severely impair affected individuals' psychosocial functioning and quality of life. Consequently, the objective of this research is to investigate the prevalence of PTSS and physical illness among disaster victims. Read More

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Acute Stress in Parents of Patients Admitted to the Pediatric Intensive Care Unit: A Two-Center Cross-Sectional Observational Study.

J Intensive Care Med 2022 May 20:8850666221100482. Epub 2022 May 20.

Department of Pediatrics, Division of Pediatric Critical Care, 25044Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Objective: To examine medical and psychosocial risk factors associated with the development of acute stress in parents of patients unexpectedly admitted to the PICU.

Design: Cross-sectional observational study.

Setting: Two tertiary care children's hospitals with mixed medical/surgical/cardiac PICU. Read More

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Clustered restricted mean survival time regression.

Biom J 2022 May 20. Epub 2022 May 20.

Department of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.

For multicenter randomized trials or multilevel observational studies, the Cox regression model has long been the primary approach to study the effects of covariates on time-to-event outcomes. A critical assumption of the Cox model is the proportionality of the hazard functions for modeled covariates, violations of which can result in ambiguous interpretations of the hazard ratio estimates. To address this issue, the restricted mean survival time (RMST), defined as the mean survival time up to a fixed time in a target population, has been recommended as a model-free target parameter. Read More

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Activities of daily living and psychiatric symptoms after intensive care unit discharge among critically ill patients with or without tracheostomy: a single center longitudinal study.

Acute Med Surg 2022 Jan-Dec;9(1):e753. Epub 2022 May 11.

Department of Emergency and Critical Care Medicine Wakayama Medical University Wakayama Japan.

Aim: Tracheostomy is widely performed in critically ill patients who require prolonged mechanical ventilation. Long-term morbidity (post-intensive care syndrome) in tracheostomized patients is not widely reported, however, so we evaluate it here.

Methods: This is a sub-analysis of a single center prospective longitudinal study, which assessed activities of daily living (ADL) and psychiatric symptoms in adult patients emergently admitted to the intensive care unit (ICU). Read More

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Chyloabdomen in critically ill patient after Hartmann's procedure.

J Surg Case Rep 2022 May 17;2022(5):rjac150. Epub 2022 May 17.

Hospital Episcopal San Lucas, General Surgery, Ponce, Puerto Rico.

Post-surgical chylous ascites (CA) is extremely rare in colon surgery, known as the extravasation of creamy fluid rich in triglycerides accumulating in the peritoneal cavity. The incidence of CA after colorectal surgery remains between 1 and 6.5%. Read More

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