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Critical measurement issues in the assessment of social media influence on body image.

Body Image 2022 Jan 12;40:225-236. Epub 2022 Jan 12.

School of Psychology, Deakin University, 1 Gheringhap Street, Geelong, Victoria, Australia; Centre for Social and Early Emotional Development, School of Psychology, Deakin University, Burwood, Australia.

Progress towards understanding how social media impacts body image hinges on the use of appropriate measurement tools and methodologies. This review provides an overview of common (qualitative, self-report survey, lab-based experiments) and emerging (momentary assessment, computational) methodological approaches to the exploration of the impact of social media on body image. The potential of these methodologies is detailed, with examples illustrating current use as well as opportunities for expansion. Read More

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January 2022

Retrosigmoid Vestibular Neurectomy for Meniere's Disease: a technical note.

World Neurosurg 2022 Jan 12. Epub 2022 Jan 12.

Department of Neurosurgery - Emory University, Atlanta, Georgia, United States of America. Electronic address:

Background And Objective: Meniere's disease (MD) is an idiopathic peripheral pathology involving the acoustic apparatus. One of the most critical challenges in managing MD is intractable vertigo. In this context, the retrosigmoid vestibular neurectomy (RVN) has been described as a safe and effective technique to manage this symptom when resistant to first- and second-line treatments. Read More

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January 2022

Impacts of COVID-19 on Sustainable Development Goals and effective approaches to maneuver them in the post-pandemic environment.

Environ Sci Pollut Res Int 2022 Jan 15. Epub 2022 Jan 15.

The Institute of the Middle and Far East, Jagiellonian University, Oleandry 2a, 30-063, Kraków, Poland.

In the pursuit of constructing a sustainable world for all through the instrumental seventeen Sustainable Development Goals, the COVID-19 pandemic emerged and affected the efforts concentrated on these goals. Therefore, there is a pressing need to analyze the extent of the impact that unfolded from the pandemic on each Sustainable Development Goal and further to direct the post-pandemic situation to accelerate the progress in every goal. Besides, there exists a knowledge gap in understanding the Sustainable Development Goals and its interaction with each goal through synergic and trade-off effects. Read More

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January 2022

A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level.

J Comput Neurosci 2022 Jan 15. Epub 2022 Jan 15.

Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Aix Marseille University, Marseille, France.

The majority of seizures recorded in humans and experimental animal models can be described by a generic phenomenological mathematical model, the Epileptor. In this model, seizure-like events (SLEs) are driven by a slow variable and occur via saddle node (SN) and homoclinic bifurcations at seizure onset and offset, respectively. Here we investigated SLEs at the single cell level using a biophysically relevant neuron model including a slow/fast system of four equations. Read More

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January 2022

Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing.

Mol Metab 2022 Jan 11:101441. Epub 2022 Jan 11.

Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, United States; Knight Cancer Institute, Oregon Health & Science University, Portland, United States; Brenden-Colson Center for Pancreatic Care, Oregon Health and & Science University Portland, Portland, United States. Electronic address:

Objective: Cancer cachexia is a devastating chronic condition characterized by involuntary weight loss, muscle wasting, abnormal fat metabolism, anorexia, and fatigue. However, the molecular mechanisms underlying this syndrome remain poorly understood. In particular, the hypothalamus may play a central role in cachexia, given that it has direct access to peripheral signals due to its anatomical location and attenuated blood-brain barrier. Read More

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January 2022

Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761.

Bioengineered 2022 Feb;13(2):2028-2043

Department of Orthopedics, The Fifth People's Hospital of Jinan, Shandong China.

An increasing number of studies have supported the critical regulatory actions of long noncoding RNAs (lncRNAs) in osteosarcoma (OS). However, the detailed roles of adipogenesis regulatory factor-antisense RNA 1 (ADIRF-AS1) in OS have not been comprehensively described. Hence, we first detected ADIRF-AS1 expression in OS and evaluated its clinical significance. Read More

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February 2022

Localization and spin dynamics of spin-orbit-coupled Bose-Einstein condensates in deep optical lattices.

Phys Rev E 2021 Dec;104(6-1):064215

College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou 730070, China.

We analytically and numerically discuss the dynamics of two pseudospin components Bose-Einstein condensates (BECs) with spin-orbit coupling (SOC) in deep optical lattices. Rich localized phenomena, such as breathers, solitons, self-trapping, and diffusion, are revealed and strongly depend on the strength of the atomic interaction, SOC, Raman detuning, and the spin polarization (i.e. Read More

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December 2021

Observational study of changes in utilization and outcomes in mechanical ventilation in COVID-19.

PLoS One 2022 14;17(1):e0262315. Epub 2022 Jan 14.

Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS and ECMO Center, Kliniken der Stadt Köln, Witten/Herdecke University Hospital, Cologne, Germany.

Background: The role of non-invasive ventilation (NIV) in severe COVID-19 remains a matter of debate. Therefore, the utilization and outcome of NIV in COVID-19 in an unbiased cohort was determined.

Aim: The aim was to provide a detailed account of hospitalized COVID-19 patients requiring non-invasive ventilation during their hospital stay. Read More

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January 2022

Why did hunting weapon design change at Abri Pataud? Lithic use-wear data on armature use and hafting around 24,000-22,000 BP.

PLoS One 2022 14;17(1):e0262185. Epub 2022 Jan 14.

TraceoLab / Prehistory, University of Liège, Liège, Belgium.

Projectile technology is commonly viewed as a significant contributor to past human subsistence and, consequently, to our evolution. Due to the allegedly central role of projectile weapons in the food-getting strategies of Upper Palaeolithic people, typo-technological changes in the European lithic record have often been linked to supposed developments in hunting weaponry. Yet, relatively little reliable functional data is currently available that would aid the detailed reconstruction of past weapon designs. Read More

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January 2022

Medical Oxygen: A Lifesaving Drug During the COVID-19 Pandemic-Source and Distribution.

Indian J Pediatr 2022 Jan 14. Epub 2022 Jan 14.

Pediatric Emergency and Critical Care Unit, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Oxygen is an essential lifesaving medicine used for several indications at all levels of health care. The COVID-19 pandemic and its recent second wave have resulted in a surge in demand for necessary resources, including trained staff, hospital beds, and medical supplies like oxygen. Limited availability of these resources resulted in added risk of adverse outcomes. Read More

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January 2022

Simplified Model-Dependent and Model-Independent Approaches for Dissolution Profile Comparison for Oral Products: Regulatory Perspective for Generic Product Development.

AAPS PharmSciTech 2022 Jan 13;23(1):53. Epub 2022 Jan 13.

Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Bachupally, Medchal Malkajgiri District, Hyderabad, Telangana, 500 090, India.

Dissolution profile comparison among different formulations plays a critical role during new drug as well as generic product development. In the generic product development, dissolution profile comparison is a mandate for biowaivers (BCS-based, for lower strengths and IVIVC-based biowaivers) and also from quality control perspective. Even though traditionally similarity factor or f2 is used as a metric for dissolution profile comparison, it comes with multiple limitations and requirements (e. Read More

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January 2022

Rewards of divergence in sequences, 3-D structures and dynamics of yeast and human spliceosome SF3b complexes.

Curr Res Struct Biol 2021 15;3:133-145. Epub 2021 Jun 15.

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, 560012, India.

The evolution of homologous and functionally equivalent multiprotein assemblies is intriguing considering sequence divergence of constituent proteins. Here, we studied the implications of protein sequence divergence on the structure, dynamics and function of homologous yeast and human SF3b spliceosomal subcomplexes. Human and yeast SF3b comprise of 7 and 6 proteins respectively, with all yeast proteins homologous to their human counterparts at moderate sequence identity. Read More

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Driving Performance in Older Adults: Current Measures, Findings, and Implications for Roadway Safety.

Innov Aging 2022 7;6(1):igab051. Epub 2022 Jan 7.

Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA.

Background And Objectives: Over 10,000 people a day turn 65 in the United States. For many older adults, driving represents an essential component of independence and is one of the most important factors in overall mobility. Recent survey studies in older adults suggest that up to 60% of older adult drivers with mild cognitive impairment, and up to 30% with dementia, continue to drive. Read More

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January 2022

Epidemiology of Intensive Care Unit-acquired Infections in a Tertiary Care Hospital of North India.

Indian J Crit Care Med 2021 Dec;25(12):1427-1433

Indian Council of Medical Research, New Delhi, India.

Background: The majority of nosocomial infections in the hospital setting are found in intensive care units (ICUs). The present study was undertaken to determine the incidence, risk factors, causative microorganisms, and outcome of various ICU-acquired infections.

Materials And Methods: The patients admitted to the ICU of a teaching hospital in North India were prospectively studied. Read More

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December 2021

Monitoring Antibiotic Consumption in Pediatrics. How Close to Reality Are Days of Therapy and Recommended Daily Dose Methods?

Pediatr Infect Dis J 2022 Jan 10. Epub 2022 Jan 10.

From the Department for Operative and Nonoperative Pediatrics and Adolescent Medicine, Section for Neonatology and Pediatric Critical Care, University Hospital, Halle, Germany Institute for Medical Epidemiology, Biometry and Informatics, Medical Faculty, Martin Luther University of Halle-Wittenberg, Halle, Germany University Pharmacy Section of Clinical Infectious Diseases, University Hospital, Halle, Germany.

Background: Hospitals are advised to monitor antibiotic use. Several approximation methods do exist to perform this task. Adult cohorts can easily be monitored using the defined daily dose method, or its German adaption recommended daily doses (RDD) method, that seems inapplicable in pediatric cohorts due to body weight variations. Read More

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January 2022

Interaction of membrane-embedded cytochrome b-complexes with quinols: Classical Q-cycle and murburn model.

Cell Biochem Funct 2022 Jan 13. Epub 2022 Jan 13.

Karel de Grote University College, Antwerp University Association, Campus Hoboken, Hoboken, Belgium.

We recently proposed a diffusible reactive (oxygen) species (DRS/DROS) based function for cytochrome b complexes (CBC) and quinones (Q)/quinols (QH ) in the murburn model of bioenergetics. This proposal is in direct conflict with the classical purview of Q-cycle. Via extensive analyses of the structure-function correlations of membrane-quinones/quinols and proteins, we present qualitative and quantitative arguments to infer that the classical model cannot explain the energetics, kinetics, mechanism and probabilistic considerations. Read More

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January 2022

A comprehensive techno-economic analysis of income-generating sources on the conversion of real sheep slaughterhouse waste stream into valorized by-products.

J Environ Manage 2022 Jan 11;306:114464. Epub 2022 Jan 11.

School of Chemical and Bioprocess Engineering, Faculty of Architecture and Engineering, University College Dublin, Belfiled, Dublin 4, Ireland. Electronic address:

The present analysis was conducted as the first research to assess the techno-economic viability of the value-added by-products (struvite, blood meal, bone meal, and raw sheepskin) from a medium-scale sheep slaughterhouse facility with a slaughtering capacity of 300 sheep per day. For this aim, a comparative technical and economic feasibility analysis was performed to assess the synergistic use of slaughterhouse-oriented rendering wastes and struvite recovery from real sheep abattoir effluent within the framework of detailed cost breakdown, break-even point, and payback period analyses. The experimental findings clearly showed that under the optimal conditions (chemical combination of MgCl. Read More

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January 2022

Critical factors that affect the functioning of a research and evaluation capacity building partnership: A causal loop diagram.

PLoS One 2022 13;17(1):e0262125. Epub 2022 Jan 13.

Collaboration for Evidence, Research and Impact in Public Health, School of Population Health, Curtin University, Perth, Western Australia, Australia.

Introduction: Public health policy and practice is strengthened by the application of quality evidence to decision making. However, there is limited understanding of how initiatives that support the generation and use of evidence in public health are operationalised. This study examines factors that support the internal functioning of a partnership, the Western Australian Sexual Health and Blood-borne Virus Applied Research and Evaluation Network (SiREN). Read More

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January 2022

Livedoid vasculopathy: A multidisciplinary clinical approach to diagnosis and management.

Int J Womens Dermatol 2021 Dec 2;7(5Part A):588-599. Epub 2021 Sep 2.

Akdeniz University School of Medicine, Department of Dermatology and Venereology, Antalya, Turkey.

Livedoid vasculopathy (LV) is a rare, chronic, and occlusive disease of the veins supplying the upper parts of the skin. The pathogenesis of the disease is not precisely understood, and its attacks are often unpredictable but tend to worsen during the summer. LV affects women more often. Read More

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December 2021

Tuning Precursor-Amine Interactions for Light-Emitting Lead Bromide Perovskites.

J Phys Chem Lett 2022 Jan 13:704-710. Epub 2022 Jan 13.

State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou, 310027, China.

Organic additives with amino moieties are effective in improving the properties of archetypical formamidinium (FA)-based hybrid perovskites for photovoltaic and light-emitting applications. However, a detailed understanding of how amino additives affect the perovskite materials is lacking, impeding developments in this area. Here, by investigating the interactions of lead bromide perovskite precursors with phenethylamine (PEA) and its derivatives with small variations in chemical structure, we reveal that only the secondary amine (-methyl-2-phenylethylamine (N-PEA)) results in strengthened hydrogen bonds with FABr in precursor solutions, allowing the formation of high-quality perovskite films. Read More

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January 2022

Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway.

Cell Commun Signal 2022 Jan 12;20(1). Epub 2022 Jan 12.

Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200072, China.

Background: Glioblastomas are lethal brain tumors under the current combinatorial therapeutic strategy that includes surgery, chemo- and radio-therapies. Extensive changes in the tumor microenvironment is a key reason for resistance to chemo- or radio-therapy and frequent tumor recurrences. Understanding the tumor-nontumor cell interaction in TME is critical for developing new therapy. Read More

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January 2022

Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study.

BMC Med Genomics 2022 Jan 12;15(1). Epub 2022 Jan 12.

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.

Background: Pain is a complex polygenic trait whose common genetic underpinnings are relatively ill-defined due in part to challenges in measuring pain as a phenotype. Pain sensitivity can be quantified, but this is difficult to perform at the scale required for genome wide association studies (GWAS). Existing GWAS of pain have identified surprisingly few loci involved in nociceptor function which contrasts strongly with rare monogenic pain states. Read More

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January 2022

Full Width at Half Maximum of Nanopore Current Blockage Controlled by a Single-Biomolecule Interface.

Langmuir 2022 Jan 12. Epub 2022 Jan 12.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People's Republic of China.

A biological nanopore is one of the predominant single-molecule approaches as a result of its controllable single-biomolecule interface, which could reflect the "intrinsic" information on an individual molecule in a label-free way. Because the current blockage is normally treated as the most important parameter for nanopore identification of every single molecule, the fluctuation of current blockage for certain types of molecules, defined as full width at half maximum (fwhm) of current blockage, actually owns a dominant influence on nanopore resolution. Therefore, controlling the fwhm of current blockage of molecules is critical for the sensing capability of the nanopore. Read More

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January 2022

MDM4 alternative splicing and implication in MDM4 targeted cancer therapies.

Am J Cancer Res 2021 15;11(12):5864-5880. Epub 2021 Dec 15.

Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center Buffalo, NY, USA.

The oncogenic MDM4, initially named MDMX, has been identified as a p53-interacting protein and a key upstream negative regulator of the tumor suppressor p53. Accumulating evidence indicates that MDM4 plays critical roles in the initiation and progression of multiple human cancers. MDM4 is frequently amplified and upregulated in human cancers, contributing to overgrowth and apoptosis inhibition by blocking the expression of downstream target genes of p53 pathway. Read More

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December 2021

Robust ultrathin nanoporous MOF membrane with intra-crystalline defects for fast water transport.

Nat Commun 2022 Jan 11;13(1):266. Epub 2022 Jan 11.

Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education, MOE), School of Environmental Science and Technology, Dalian University of Technology, Liaoning, 116024, Dalian, China.

Rational design of high-performance stable metal-organic framework (MOF) membranes is challenging, especially for the sustainable treatment of hypersaline waters to address critical global environmental issues. Herein, a molecular-level intra-crystalline defect strategy combined with a selective layer thinning protocol is proposed to fabricate robust ultrathin missing-linker UiO-66 (ML-UiO-66) membrane to enable fast water permeation. Besides almost complete salt rejection, high and stable water flux is achieved even under long-term pervaporation operation in hash environments, which effectively addresses challenging stability issues. Read More

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January 2022

Critical review of microplastics removal from the environment.

Chemosphere 2022 Jan 8;293:133557. Epub 2022 Jan 8.

School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL, 36849, United States. Electronic address:

Globally, microplastics pollution has become a serious environmental threat due to their multitude sources, widespread occurrence, persistence, and adverse effects to ecosystem and the human health. Addressing this multifaceted threat requires innovative technologies that can efficiently remove microplastics from the environment. In this review, we first overviewed the source, occurrence, and potential adverse impacts of microplastics to human health. Read More

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January 2022

Dynamics and mechanism of dimer dissociation of photoreceptor UVR8.

Nat Commun 2022 Jan 10;13(1):93. Epub 2022 Jan 10.

Department of Physics, Department of Chemistry and Biochemistry, Programs of Biophysics, Chemical Physics and Biochemistry, The Ohio State University, Columbus, OH, 43210, USA.

Photoreceptors are a class of light-sensing proteins with critical biological functions. UVR8 is the only identified UV photoreceptor in plants and its dimer dissociation upon UV sensing activates UV-protective processes. However, the dissociation mechanism is still poorly understood. Read More

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January 2022

Development and evaluation of an electronic nursing documentation system.

BMC Nurs 2022 Jan 10;21(1):15. Epub 2022 Jan 10.

Department of Health Information Technology, Abadan University of Medical Sciences, Abadan, Iran.

Background: Nursing documentation is a critical aspect of the nursing care workflow. There is a varying degree in how detailed nursing reports are described in scientific literature and care practice, and no uniform structured documentation is provided. This study aimed to describe the process of designing and evaluating the content of an electronic clinical nursing documentation system (ECNDS) to provide consistent and unified reporting in this context. Read More

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January 2022

Mode Coupling at around M-Point in PZT.

Materials (Basel) 2021 Dec 23;15(1). Epub 2021 Dec 23.

European Synchrotron Radiation Facility (ESRF), 38000 Grenoble, France.

The question of the microscopic origin of the M-superstructure and additional satellite peaks in the Zr-rich lead zirconate-titanate is discussed for nearly 50 years. Clear contradiction between the selection rules of the critical scattering and the superstructure was found preventing unambiguous attributing of the observed superstructure either to the rotation of the oxygen octahedra or to the antiparallel displacements of the lead cations. Detailed analysis of the satellite pattern explained it as the result of the incommensurate phase transition rather than antiphase domains. Read More

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December 2021

Systematic Review of Potential Anticancerous Activities of .

Plants (Basel) 2021 Dec 22;11(1). Epub 2021 Dec 22.

Faculty of Health Sciences, Saint Thomas d'Aquin University, Ouagadougou P.O. Box 10212, Burkina Faso.

The objective of this study was to carry out a systematic review of the substances isolated from the African medicinal plant focusing on compounds harboring activities against cancer models detailed in depth herein at both in vitro and in vivo preclinical levels. The review was conducted through Pubmed and Google Scholar. Nineteen out of the forty-two secondary metabolites isolated to date from displayed interesting in vitro and/or in vivo antitumor activities. Read More

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December 2021