19,729 results match your criteria critical covid-19


High intelligence may exacerbate paediatric inflammatory response to SARS-CoV-2 infection.

Med Hypotheses 2021 Sep 9;155:110677. Epub 2021 Sep 9.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

The body's innate and acquiredimmunesystems are critical in responses to a wide spectrum of assaults, including SARS-CoV-2 infection. We identify studies of autoimmunity to support our hypothesis that a high intelligence quotient (IQ) may put children at increased risk for severe COVID-19 sequelae; especially those whose viral load is high and/or who develop multisystem inflammatory syndrome in children (MIS-C). MIS-C is associated with a higher risk of COVID-19 morbidity and death, even in otherwise healthy children. Read More

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September 2021

Comparing the diagnostic accuracy of rapid antigen detection tests to real time polymerase chain reaction in the diagnosis of SARS-CoV-2 infection: A systematic review and meta-analysis.

J Clin Virol 2021 Sep 16;144:104985. Epub 2021 Sep 16.

Department of Preventive Medicine, Korea University College of Medicine, Seoul, Republic of Korea.

Background: Timely and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is crucial to reduce the risk of viral transmission. We investigated the diagnostic accuracy of rapid antigen detection tests (RADTs) in the diagnosis of SARS-CoV-2 infection.

Methods: A systematic literature search was performed using Pubmed, Embase, and the Cochrane Central Register. Read More

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September 2021

Query bot for retrieving patients' clinical history: a COVID-19 use-case.

J Biomed Inform 2021 Sep 21:103918. Epub 2021 Sep 21.

Department of Radiology, Mayo Clinic, Arizona, AZ, USA 85054; School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, AZ USA 85281.

Objective: With increasing patient complexity whose data are stored in fragmented health information systems, automated and time-efficient ways of gathering important information from the patients' medical history are needed for effective clinical decision making. Using COVID-19 as a case study, we developed a query-bot information retrieval system with user-feedback to allow clinicians to ask natural questions to retrieve data from patient notes.

Materials And Methods: We applied clinicalBERT, a pre-trained contextual language model, to our dataset of patient notes to obtain sentence embeddings, using K-Means to reduce computation time for real-time interaction. Read More

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September 2021

Analytical and clinical performance of cPass neutralizing antibodies assay.

Clin Biochem 2021 Sep 21. Epub 2021 Sep 21.

Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, 77030, United States; Section of Clinical Chemistry, Division of Laboratory Medicine, Department of Pathology, Texas Children's Hospital, Houston, TX, 77030, United States. Electronic address:

Serological tests for SARS-CoV-2 are a critical component of disease control strategies. SARS-CoV-2 serology tests used in clinical diagnostic should not accurately evaluate total levels the antibodies but also closely correlate with neutralizing antibodies titers. However, only limited data is available reporting correlation of neutralization antibody assays with commercial high-throughput serological assays widely used in clinical laboratories. Read More

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September 2021

eARDS: A multi-center validation of an interpretable machine learning algorithm of early onset Acute Respiratory Distress Syndrome (ARDS) among critically ill adults with COVID-19.

PLoS One 2021 24;16(9):e0257056. Epub 2021 Sep 24.

Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, United States of America.

We present an interpretable machine learning algorithm called 'eARDS' for predicting ARDS in an ICU population comprising COVID-19 patients, up to 12-hours before satisfying the Berlin clinical criteria. The analysis was conducted on data collected from the Intensive care units (ICU) at Emory Healthcare, Atlanta, GA and University of Tennessee Health Science Center, Memphis, TN and the Cerner® Health Facts Deidentified Database, a multi-site COVID-19 EMR database. The participants in the analysis consisted of adults over 18 years of age. Read More

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September 2021

The PUPPY Study: Protocol for a Longitudinal Mixed Methods Study Exploring Problems Coordinating and Accessing Primary Care for Attached and Unattached Patients Exacerbated During the COVID-19 Pandemic Year.

JMIR Res Protoc 2021 Sep 9. Epub 2021 Sep 9.

Queen's University, Kingston, CA.

Background: The COVID-19 pandemic significantly disrupted primary care in Canada, with many walk-in clinics and family practices initially closing or being perceived as inaccessible, pharmacies remaining open with restrictions on patient interactions, rapid uptake of virtual care, and reduced referrals for lab tests, diagnostics, and specialist care. The PUPPY Study (Problems Coordinating and Accessing Primary Care for Attached and Unattached Patients Exacerbated During the COVID-19 Pandemic Year) seeks to understand the impact of COVID-19 across the quadruple aim of primary care, with particular focus on the impacts on patients without attachment to a regular provider and those with chronic health conditions.

Objective: The PUPPY Study objective is to understand the impact of COVID-19 across the quadruple aim of primary care. Read More

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September 2021

Analyses of Original and Computationally-Derived Electronic Health Record Data: The National COVID Cohort Collaborative.

J Med Internet Res 2021 Sep 12. Epub 2021 Sep 12.

Department of Biomedical and Medical Education, School of Medicine, University of Washington, Seattle, US.

Background: Computationally-derived ("synthetic") data can enable the creation and analysis of clinical, laboratory, and diagnostic data as if they were the original electronic health record (EHR) data. Synthetic data can support data sharing to answer critical research questions to address the COVID-19 pandemic.

Objective: We aimed to (1) compare the results from analyses of synthetic data to those from original data, and (2) assess the strengths and limitations of leveraging computationally-derived data for research purposes. Read More

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September 2021

Do High Dose Corticosteroids Improve Outcomes in Hospitalized COVID-19 Patients?

J Med Virol 2021 Sep 24. Epub 2021 Sep 24.

Associate Professor, Division of Hematology/Oncology, Georgia Cancer Center, Augusta University, Augusta, GA, 30909.

Problem: COVID-19 is characterized by dysregulated hyperimmune response and steroids have been shown to decrease mortality. However, whether higher dosing of steroids results in better outcomes have been debated.

Methods: This was a retrospective observational of COVID-19 admissions between March 1 2020 and March 10 2021. Read More

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September 2021

Birth Satisfaction During the Early Months of the COVID-19 Pandemic in the United States.

MCN Am J Matern Child Nurs 2021 Sep 23. Epub 2021 Sep 23.

Elizabeth Mollard, Assistant Professor, University of Nebraska Medical Center, College of Nursing - Lincoln Division, Lincoln, NE. Dr. Mollard can be reached via email at Kevin Kupzyk, Assistant Professor, University of Nebraska Medical Center, College of Nursing - Omaha Division, 985330 Nebraska Medical Center, Omaha, NE.

Abstract: Purpose: The purpose of this study was to describe birth satisfaction in women who gave birth in U.S. hospitals during the earliest months of the COVID-19 pandemic (March-July 2020). Read More

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September 2021

The role of the cord blood platelet gel in the management of a diabetic foot with tendon exposure.

Regen Med 2021 Sep 24. Epub 2021 Sep 24.

Unit of Vascular & Endovascular Surgery, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, 89124, Italy.

Diabetic foot infection is frequent in diabetic patients and is due to neuropathy, trauma or peripheral arterial disease. The presence of an abscess requires urgent drainage and specific antibiotic therapy. Patients with critical limb ischemia need revascularization and, subsequently the intervention of a plastic surgeon is often required in cases of exposure of tendons and ligaments. Read More

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September 2021

Nationwide Social Distancing and the Epidemiology of Severe Acute Respiratory Infections.

Yonsei Med J 2021 Oct;62(10):954-957

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Nonpharmaceutical interventions (e.g., social distancing) are recommended to prevent the spread of respiratory viruses. Read More

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October 2021

Dynamic changes in human single-cell transcriptional signatures during fatal sepsis.

J Leukoc Biol 2021 Sep 24. Epub 2021 Sep 24.

Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California, USA.

Systemic infections, especially in patients with chronic diseases, may result in sepsis: an explosive, uncoordinated immune response that can lead to multisystem organ failure with a high mortality rate. Patients with similar clinical phenotypes or sepsis biomarker expression upon diagnosis may have different outcomes, suggesting that the dynamics of sepsis is critical in disease progression. A within-subject study of patients with Gram-negative bacterial sepsis with surviving and fatal outcomes was designed and single-cell transcriptomic analyses of peripheral blood mononuclear cells (PBMC) collected during the critical period between sepsis diagnosis and 6 h were performed. Read More

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September 2021

Nonverbal closed loop communication during COVID-19 pandemic - Proposal of four tick technique.

Indian J Public Health 2021 Jul-Sep;65(3):315-317

Consultant Psychiatrist, Manam Behavioural Medicine Clinic, Coimbatore, Tamil Nadu, India.

This COVID-19 pandemic has posed difficulty in verbal communication among health-care workers with usage of respirators and personal protective equipments. We propose a four tick technique for the nonverbal closed loop communication in health-care settings with limited resources such as low and middle-income countries. It is simple, easy to learn, train, effective, ensuring patient safety and can be extended to nonhealth-care settings and in electronic form. Read More

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September 2021

COVID-19 vaccine and the cold chain implications for global adoption.

Authors:
Manoja Kumar Das

Indian J Public Health 2021 Jul-Sep;65(3):307-310

Director Projects, The INCLEN Trust International, New Delhi, India.

The COVID-19 pandemic has spread globally with 190.8 million infected cases and 4.1 million deaths as of July 18, 2021. Read More

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September 2021

Late-presenting Plasmodium falciparum Malaria in a Non-Endemic Setting During COVID-19 Travel Restrictions.

Mil Med 2021 Sep 24. Epub 2021 Sep 24.

Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

We report a case of febrile Plasmodium falciparum malaria in a 36-year-old male patient occurring 14 years after immigration from and more than 12 months since a return visit to the endemic area. The critical need for awareness regarding late presentations of P. falciparum is discussed. Read More

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September 2021

The clinical correlates of vaccine-induced immune thrombotic thrombocytopenia after immunisation with adenovirus vector-based SARS-CoV-2 vaccines.

Immunother Adv 2021 Jan 17;1(1):ltab019. Epub 2021 Aug 17.

The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

We are at a critical stage in the COVID-19 pandemic where vaccinations are being rolled out globally, in a race against time to get ahead of the SARS-CoV-2 coronavirus and the emergence of more highly transmissible variants. A range of vaccines have been created and received either emergency approval or full licensure. To attain the upper hand, maximum vaccine synthesis, deployment, and uptake as rapidly as possible is essential. Read More

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January 2021

Different spreading dynamics throughout Germany during the second wave of the COVID-19 pandemic: a time series study based on national surveillance data.

Lancet Reg Health Eur 2021 Jul 27;6:100151. Epub 2021 Jun 27.

Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS and ECMO centre, Kliniken der Stadt Köln, Witten/Herdecke University Hospital, Cologne, Germany.

Background: The second wave of the COVID-19 pandemic led to substantial differences in incidence rates across Germany.

Methods: Assumption-free k-nearest neighbour clustering from the principal component analysis of weekly incidence rates of German counties groups similar spreading behaviour. Different spreading dynamics was analysed by the derivative plots of the temporal evolution of tuples [x(t),x'(t)] of weekly incidence rates and their derivatives. Read More

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Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar Lavage.

Front Med (Lausanne) 2021 7;8:690523. Epub 2021 Sep 7.

Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China.

The longitudinal characterization and risk of poor outcomes related to cytokine overproduction in critical coronavirus disease 2019 (COVID-19) patients with hyperinflammation in bronchoalveolar lavage requires further investigation. We enrolled two critically ill patients with comorbidities diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detected by RT-PCR during hospitalization. Clinical characteristics, longitudinal immunological, and biochemical parameters of each critical COVID-19 case were collected. Read More

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September 2021

Genomic analysis of early transmissibility assessment of the D614G mutant strain of SARS-CoV-2 in travelers returning to Taiwan from the United States of America.

PeerJ 2021 2;9:e11991. Epub 2021 Sep 2.

Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Taipei city, Taiwan.

Background: There is a global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Information on viral genomics is crucial for understanding global dispersion and for providing insight into viral pathogenicity and transmission. Here, we characterized the SARS-CoV-2 genomes isolated from five travelers who returned to Taiwan from the United States of America (USA) between March and April 2020. Read More

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September 2021

Expert consensus on the procedure of interventional diagnosis and treatment of cancer patients during the COVID-19 epidemic.

J Interv Med 2020 May 31;3(2):61-64. Epub 2020 Mar 31.

Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing, 100034, China.

Since December 2019, coronavirus disease (COVID-19) has spread rapidly from Wuhan, Hubei province, to other regions of China. To reduce and prevent cross-over infections in the interventional diagnosis and treatment of tumor patients. The Interventional Oncology Branch of the China Anti-Cancer Association organized specialists to compile the corresponding expert consensus. Read More

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From Infection to Immunity: Understanding the Response to SARS-CoV2 Through Modeling.

Front Immunol 2021 7;12:646972. Epub 2021 Sep 7.

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Background: Immune system conditions of the patient is a key factor in COVID-19 infection survival. A growing number of studies have focused on immunological determinants to develop better biomarkers for therapies.

Aim: Studies of the insurgence of immunity is at the core of both SARS-CoV-2 vaccine development and therapies. Read More

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September 2021

The Impact of COVID-19 on Cancer.

Infect Drug Resist 2021 17;14:3809-3816. Epub 2021 Sep 17.

Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, People's Republic of China.

Since late December 2019, the 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid international spread have posed a global health threat. The World Health Organization has declared the outbreak of COVID-19 as "public health emergency of international concern". COVID-19 not only brings tremendous pressure to the medical system but also brings new challenges to the global economy. Read More

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September 2021

Communicating COVID-19 Vaccine Safety: Knowledge and Attitude Among Residents of South East, Nigeria.

Infect Drug Resist 2021 16;14:3785-3794. Epub 2021 Sep 16.

Department of Mass Communication, University of Nigeria, Nsukka, Nigeria.

Background: The fight against the coronavirus disease (COVID-19), which has continued to threaten human existence globally, has led to the development of vaccines in order to control the rate of infection and death associated with the disease. Media messages on the COVID-19 vaccine are geared towards raising audience awareness and understanding of health risks, knowledge and attitudes about the vaccine safety.

Objective: The study examined the knowledge and attitude towards COVID-19 vaccine safety media messages amongst residents of South East, Nigeria. Read More

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September 2021

COVID-19 Vaccine: Side Effects After the First Dose of the Oxford AstraZeneca Vaccine Among Health Professionals in Low-Income Country: Ethiopia.

J Multidiscip Healthc 2021 16;14:2577-2585. Epub 2021 Sep 16.

Department of Pathology, School of Medicine, Debre Markos University, Debre Markos, Ethiopia.

Purpose: The Oxford-AstraZeneca is one of COVID-19 vaccine which is expected to be mass-produced and plays a critical role in controlling the pandemic that the globe faced. Ethiopia launched the AstraZeneca vaccination and planned to vaccinate 20% of the population by the end of 2021. Health care professionals are one of the eligible groups of the community to receive the vaccine with priority. Read More

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September 2021

Factors associated with the difference between the incidence and case-fatality ratio of coronavirus disease 2019 by country.

Sci Rep 2021 Sep 23;11(1):18938. Epub 2021 Sep 23.

Department of Preventive Medicine, Korea University College of Medicine, Seoul, Republic of Korea.

Coronavirus disease (COVID-19) has been spreading all over the world; however, its incidence and case-fatality ratio differ greatly between countries and between continents. We investigated factors associated with international variation in COVID-19 incidence and case-fatality ratio (CFR) across 107 northern hemisphere countries, using publicly available COVID-19 outcome data as of 14 September 2020. We included country-specific geographic, demographic, socio-economic features, global health security index (GHSI), healthcare capacity, and major health behavior indexes in multivariate models to explain this variation. Read More

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September 2021

A new qualitative RT-PCR assay detecting SARS-CoV-2.

Sci Rep 2021 Sep 23;11(1):18955. Epub 2021 Sep 23.

Department of Experimental Medicine, "Tor Vergata" University, Via Montpellier 1, 00133, Rome, Italy.

The world is facing an exceptional pandemic caused by SARS-CoV-2. To allow the diagnosis of COVID-19 infections, several assays based on the real-time PCR technique have been proposed. The requests for diagnosis are such that it was immediately clear that the choice of the most suitable method for each microbiology laboratory had to be based, on the one hand, on the availability of materials, and on the other hand, on the personnel and training priorities for this activity. Read More

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September 2021

Impact of restricted visitation policies in hospitals on patients, family members and healthcare providers during the COVID-19 pandemic: a scoping review protocol.

BMJ Open 2021 Sep 23;11(9):e048227. Epub 2021 Sep 23.

Critical Care Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada

Introduction: Flexible visitation policies in hospitals are an important component of care that contributes to reduced stress and increased satisfaction among patients and their family members. Early evidence suggests restricted visitation policies enacted in hospitals during the COVID-19 pandemic are having unintended consequences on patients, family members and healthcare providers. There is a need for a comprehensive summary of the impacts of restricted visitation policies on key stakeholders and approaches to mitigate that impact. Read More

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September 2021

Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis.

BMJ 2021 Sep 23;374:n2231. Epub 2021 Sep 23.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada.

Objective: To evaluate the efficacy and safety of antiviral antibody therapies and blood products for the treatment of novel coronavirus disease 2019 (covid-19).

Design: Living systematic review and network meta-analysis, with pairwise meta-analysis for outcomes with insufficient data.

Data Sources: WHO covid-19 database, a comprehensive multilingual source of global covid-19 literature, and six Chinese databases (up to 21 July 2021). Read More

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September 2021

The effects of Alzheimer's and Parkinson's disease on 28-day mortality of COVID-19.

Rev Neurol (Paris) 2021 Sep 13. Epub 2021 Sep 13.

Critical Care Quality Improvement Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Health Management and Economics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. Electronic address:

We compared the prognosis of inpatients with a known diagnosis of Alzheimer's or Parkinson's disease who have COVID-19 infection with other hospitalized patients with COVID-19. Our cohort study started in October 2020 and ended in May 2021 and included inpatients with COVID-19 infection who were admitted to hospitals. From a total of 67,871 patients with a confirmed diagnosis of COVID-19, a sample of 3732 individuals were selected of which 363 had Alzheimer's, and 259 had Parkinson's disease. Read More

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September 2021

Association between COVID-19 and angiotensin-converting enzyme inhibitors with the spotlight on zinc: an opinion.

Ann Med 2021 Dec;53(1):1673-1675

Program Director, Internal Medicine Department, Community Memorial Hospital, Ventura, CA, USA.

In the setting of the raging COVID-19 pandemic, the search for innovative therapeutics is desperately sought after. As we learn more about the characteristics and metabolic health of patients and as our understanding of COVID-19 pathophysiology and treatment progresses, so is our understanding of medication effects that might increase disease severity. As of late, ACE inhibitors have been under investigation for a potential increase in illness severity due to ACE2 upregulation. Read More

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December 2021