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[DEVELOPMENT OF FORMULATIONS FOR THE PRODUCTION OF MEDICINAL - COMETIC PREPARATIONS USING PLANT, MINERAL AND ANIMAL RESOURCES OF GEORGIA].

Georgian Med News 2021 Mar(312):150-156

Tbilisi State Medical University, Institute of Pharmacochemistry I. Kutateladze, Georgia.

The purpose of the study was to develop cosmetic products using the natural resources of Georgia As components, the therapeutic mud of Akhtala, bentonite clay, perlite, liver oil of the sea cartilaginous fish katran, habitat of coastal waters were used. From the Black Sea, oils and extracts from plants in large numbers growing in Georgia. When studying the physicochemical characteristics of the products obtained and their compliance with standards, tests according to GOST 31460-2012 were used. Read More

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MORPHOMETRIC ASSESSMENT OF STRUCTURAL CHANGES IN THE VASCULAR BED OF DUODENUM IN ANIMALS WITH OBSTRUCTIVE CHOLESTASIS.

Georgian Med News 2021 Mar(312):105-113

I. Horbachevsky Ternopil National Medical University, Ukraine.

Aim of the research - comprehensive morphometric assessment of the structural and spatial organization of the circulatory system of the duodenum in obstructive cholestasis in intact animals. Three days after the simulated obstructive cholestasis in 3 experimental animals, on examination of radiographs there is a tendency to reorient the arterial and venous bed of the duodenum. Analysis of morphometric parameters also showed a tendency to constriction of arteries and varicose veins. Read More

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Comparison in detection of prodromal Parkinson's disease patients using original and updated MDS research criteria in two independent cohorts.

Parkinsonism Relat Disord 2021 Apr 30;87:48-55. Epub 2021 Apr 30.

Department of Neurology, P. J. Safarik University, Trieda SNP 1, 04011, Kosice, Slovak Republic; Department of Neurology, University Hospital L. Pasteur, Rastislavova 43, 04190, Kosice, Slovak Republic.

Introduction: MDS research criteria for prodromal Parkinson's disease (pPD) were published in 2015 and updated in 2019. We aimed to determine the difference in pPD patient detection rates in two cohorts recruited via gastrointestinal symptoms (PARCAS study) and the presence of a probable REM sleep behaviour disorder (PDBIOM study) using the original and updated criteria.

Methods: We evaluated all risk and prodromal markers, except genetic testing, plasma urate and physical inactivity, in both cohorts and DaT scan, diabetes mellitus type II and cognitive deficit in the PARCAS cohort. Read More

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Introducing intense rainfall and snowmelt variables to implement a process-related non-stationary shallow landslide susceptibility analysis.

Sci Total Environ 2021 Apr 27;786:147360. Epub 2021 Apr 27.

Dipartimento di Scienze della Terra "A. Desio", Università degli Studi di Milano, Milan, Italy.

The study objective was to derive a susceptibility model for shallow landslides that could include process-related non-stationary variables, to be adaptable to climate changes. We selected the territory of the Mont-Emilius and Mont-Cervin Mountain Communities (northern Italy) as the study area. To define summary variables related to landslide predisposing and triggering processes, we investigated the relationships between landslide occurrences and intense rainfall and snowmelt events (period 1991-2020). Read More

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LCA and economic study on the local oxygen supply in Central Europe during the COVID-19 pandemic.

Sci Total Environ 2021 Apr 29;786:147401. Epub 2021 Apr 29.

AGH University of Science and Technology, Faculty of Energy and Fuels, Department of Coal Chemistry and Environmental Sciences, Al. Mickiewicza 30, 30-059 Kraków, Poland. Electronic address:

Medical oxygen is the key to survival for COVID-19 patients. To meet the pandemic-driven oxygen demand spike, local hospitals began searching for a suitable medical oxygen delivery system. Among the studies published on the impact of COVID-19 on a range of aspects, including the global economy and the environment, no study has been conducted on the environmental impact of medical oxygen supply to hospitals under epidemic conditions. Read More

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g-CN/MoS based floating solar still for clean water production by thermal/light activation of persulfate.

Chemosphere 2021 Apr 27;280:130618. Epub 2021 Apr 27.

Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, College of Civil Engineering and Architecture, Zhejiang University, Hangzhou, 310058, PR China. Electronic address:

Currently, seawater desalination based on air-water interface solar heating has triggered significant research interests because it effectively makes use of the solar energy and avoids fossil fuel consumption. However, to prevent the volatile organic compounds (VOCs) from volatilizing with water vapor which later will liquefy and enter the condensed freshwater is still a challenge. In this work, a g-CN/MoS based floating solar still (CM-FSS) combined with thermal/light activation of persulfate (PS) at air-water interface was applied for clean freshwater production for the first time. Read More

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Development of an analytical method for the determination of pimavanserin and its impurities applying analytical quality by design principles as a risk-based strategy.

J Pharm Biomed Anal 2021 Apr 24;201:114091. Epub 2021 Apr 24.

Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, 10000, Zagreb, Croatia. Electronic address:

Pimavanserin is an atypical antipsychotic indicated for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. As it is a relatively new drug on the market, limited number of pharmacokinetic information and analytical methods are available. This paper presents an ultra-high performance chromatography for the simultaneous determination of pimavanserin and its four process impurities. Read More

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Ambient fine particulate matter air pollution and the risk of hospitalization among COVID-19 positive individuals: Cohort study.

Environ Int 2021 Apr 9;154:106564. Epub 2021 Apr 9.

Clinical Epidemiology Center, Research and Development Service, VA Saint Louis Health Care System, 501 N Grand Blvd, Suite 300, Saint Louis, MO 63103, United States; Veterans Research & Education Foundation of Saint Louis, 501 N Grand Blvd, Suite 300, Saint Louis, MO 63103, United States; Department of Medicine, Washington University in Saint Louis, 4921 Parkview Pl, Saint Louis, MO 63110, United States; Nephrology Section, Medicine Service, VA Saint Louis Health Care System, 915 N Grand Blvd, Saint Louis, MO 63106, United States; Institute for Public Health, Washington University in Saint Louis, 600 S Taylor Ave, Saint Louis, MO 63110, United States. Electronic address:

Background: Ecologic analyses suggest that living in areas with higher levels of ambient fine particulate matter air pollution (PM) is associated with higher risk of adverse COVID-19 outcomes. Studies accounting for individual-level health characteristics are lacking.

Methods: We leveraged the breadth and depth of the US Department of Veterans Affairs national healthcare databases and built a national cohort of 169,102 COVID-19 positive United States Veterans, enrolled between March 2, 2020 and January 31, 2021, and followed them through February 15, 2021. Read More

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Are they too perfect to eat healthy? Association between eating disorder symptoms and perfectionism in adolescent rhythmic gymnasts.

Eat Behav 2021 May 1;41:101514. Epub 2021 May 1.

School of Physical Education & Sport Science, National & Kapodistrian University of Athens, Greece.

Objective: Eating disorders are associated with perfectionism in adults, but evidence is lacking in adolescent competitive athletes. This study examined eating disorder symptoms and perfectionism in a sample of 13-15 years old, adolescent rhythmic gymnasts.

Methods: Eighty-nine female rhythmic gymnasts (41 international and 48 recreational level gymnasts), completed the Eating Attitudes Tests 26 (EAT-26), the Sport Perfectionism Questionnaire (SPQ), the Social Desirability Scale (SDS) and provided information on their training. Read More

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Methods and techniques for in vitro subcellular localization of radiopharmaceuticals and radionuclides.

Nucl Med Biol 2021 Apr 22;98-99:18-29. Epub 2021 Apr 22.

Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, United Kingdom. Electronic address:

In oncology, the holy grail of radiotherapy is specific radiation dose deposition in tumours with minimal healthy tissue toxicity. If used appropriately, injectable, systemic radionuclide therapies could meet these criteria, even for treatment of micrometastases and single circulating tumour cells. The clinical use of α and β particle-emitting molecular radionuclide therapies is rising, however clinical translation of Auger electron-emitting radionuclides is hampered by uncertainty around their exact subcellular localisation, which in turn affects the accuracy of dosimetry. Read More

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The impact on health outcomes of implementing electronic health records to support the care of older people in residential aged care: A scoping review.

Int J Med Inform 2021 Apr 24;151:104471. Epub 2021 Apr 24.

Center for Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Aim: The implementation of electronic health records (EHRs) in the aged care sector has been shown to improve efficiency and quality of care, administrative and funding processes. The aim of this study was to examine whether implementing EHRs and/or interventions leveraging EHRs in residential aged care facilities has any impact on health outcomes for residents and to review and summarise any published evidence.

Methods: Using the Joanna Briggs Institute guidelines for conducting scoping reviews, we searched PubMed, CINAHL, Embase, Cochrane and Scopus databases for articles describing the impact of EHRs and/or EHR-based interventions on health outcomes for residents in residential aged care. Read More

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Content validation and usability of a chatbot of guidelines for wound dressing.

Int J Med Inform 2021 Apr 29;151:104473. Epub 2021 Apr 29.

Nursing Department of the Catholic University of Pernambuco, Pernambuco, Brazil. Electronic address:

Introduction: The growing demand from patients with wounds from various causes has significantly challenged primary care nurses. A chatbot, with duly validated evidence-based content, can assist both nurses and patients in managing care. This work describes the development process of such a chatbot (BOTCURATIVO) that aims to help the treatment of wounds by non-specialists, by giving guidelines about the recommended wound dressing procedures for each type of wound. Read More

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Parental and provider perspectives on social media about ankyloglossia.

Int J Pediatr Otorhinolaryngol 2021 Apr 28;146:110741. Epub 2021 Apr 28.

Department of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA; Division of Pediatric Otolaryngology, Children's Wisconsin, Milwaukee, WI, USA.

Objectives: To investigate and identify the concerns and opinions expressed in both parental and provider posts on social media about ankyloglossia.

Methods: In this study, posts on Twitter between 1/1/2008 and 12/31/2018 were collected using search terms and hashtags specific to pediatric ankyloglossia. The search terms included a primary phrase to indicate ankyloglossia along with a pediatric identifier. Read More

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Word class and word frequency in the MMN looking glass.

Brain Lang 2021 May 5;218:104964. Epub 2021 May 5.

Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary; Institute of Psychology, Károli Gáspár University of the Reformed Church in Hungary, Budapest, Hungary.

The effects of lexical meaning and lexical familiarity on auditory deviance detection were investigated by presenting oddball sequences of words, while participants ignored the stimuli. Stimulus sequences were composed of words that were varied in word class (nouns vs. functions words) and frequency of language use (high vs. Read More

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Clinical characteristics of paediatric Hashimoto's encephalopathy.R2 clean.

Eur J Paediatr Neurol 2021 Apr 30;32:122-127. Epub 2021 Apr 30.

Department of Paediatrics, Medical Centre Leeuwarden, P.O. Box 888, 8901, BR, Leeuwarden, the Netherlands. Electronic address:

Background: Hashimoto's encephalopathy, also known as steroid responsive encephalopathy, is associated with thyroid antibodies (SREAT) and is a rare but serious form of encephalopathy. In this paper, we describe the signs, symptoms, outcome, and treatments as noted in the case reports reviewed.

Methods: We searched PubMed, Embase, and the Cochrane library for articles in which cases of Hashimoto's encephalopathy were described. Read More

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Discordance in Appendicitis Grading and the Association with Outcomes: A Post-Hoc Analysis of an EAST Multicenter Study.

J Surg Res 2021 May 5;265:259-264. Epub 2021 May 5.

Division of Trauma and Surgical Critical Care, DeWitt Daughtry Family Department of Surgery, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, Florida.

Background: The American Association for the Surgery of Trauma (AAST) appendicitis severity grading criteria use independent subscales for radiologists (Rad), surgeons (Surg), and pathologists (Path). We reviewed the EAST Multicenter Study of the Treatment of Appendicitis in America: Acute, Perforated, and Gangrenous (MUSTANG) database to determine rates of discordance and clinical consequences of inaccuracy.

Materials And Methods: A confusion matrix was constructed for pairs among Rad, Surg, and Path. Read More

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Sensitivity of bovine tuberculosis surveillance through intradermal tests in cattle in France: An evaluation of different scenarios.

Prev Vet Med 2021 Apr 24;191:105364. Epub 2021 Apr 24.

INRAE, Oniris, BIOEPAR, 44300, Nantes, France. Electronic address:

The current situation regarding bovine tuberculosis (bTB) in Europe is spatially heterogeneous, with stagnating or increasing trends in bTB prevalence in many European regions, underlying the challenge in controlling this disease. In France, in spite of the implementation of two control programs in 2010-2012 to eradicate the disease and maintain the bTB-free status, bTB prevalence has continued to increase, underlying the need to reinforce and adapt surveillance measures. The goal of this study was to evaluate the effectiveness of bTB surveillance in high-risk areas in metropolitan France, with an emphasis on the criteria to select herds and animals within herds in the context of programmed surveillance and movement testing. Read More

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Temporal trends in the incidence and prevalence of Multiple Sclerosis in the Northwest of Spain.

Mult Scler Relat Disord 2021 Apr 24;52:102979. Epub 2021 Apr 24.

Neurology Department, Hospital Clínico Universitario, Travesía da Choupana s/n, 15706, Santiago de Compostela, (A Coruña), Spain.

Background: During the last decades, the frequency of multiple sclerosis (MS) is increasing worldwide. Nevertheless, the higher sensibility of the new diagnostic criteria obscures the comparison between studies performed in different decades.

Methods: The evolution of the frequency of MS in Santiago de Compostela (North-West of Spain) between 2003 and 2015 was analyzed using Poisson regression. Read More

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Alpha 1 adrenoceptor expression in skin, nerves and blood vessels of patients with painful diabetic neuropathy.

Auton Neurosci 2021 May 3;234:102814. Epub 2021 May 3.

College of Science, Health, Engineering and Education, Murdoch University, Perth, Western Australia, Australia.

Diabetic neuropathy (dNP) patients often suffer from severe neuropathic pain. It was suggested that alpha-1 adrenoceptor (α-AR) hyperresponsiveness contributes to pain in dNP. The aim of our study was to quantify α-AR expression using immunohistochemistry in skin biopsies of nine patients with painful diabetic neuropathy compared to 10 healthy controls. Read More

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A generic curriculum development model for the biomedical physics component of the educational and training programmes of the non-physics healthcare professions.

Phys Med 2021 May 5;85:32-41. Epub 2021 May 5.

Medical Physics Department, prof. Franciszek Lukaszczyk Memorial Oncology Centre & Collegium Medicum Nicholas Copernicus University, Bydgoszcz, Poland.

The objective of the study was the construction of a generic curriculum development model for the use of biomedical physics (BMP) educators teaching the non-physics healthcare professions (HCP) in Europe. A comprehensive, qualitative cross-sectional Europe-wide survey of the curricula delivered by BMP in Faculties of Medicine and Health Sciences (FMHS) was carried out. Curricular content was collected from faculty web-sites, curricular documents and textbooks. Read More

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A Systematic Review of the Effect of Physical Activity on Asthma Outcomes.

J Allergy Clin Immunol Pract 2021 May 5. Epub 2021 May 5.

Department of Medicine, University of Illinois at Chicago, Chicago, USA. Electronic address:

Background: Asthma is a chronic respiratory disease that affects millions worldwide. Medication management is the current mainstay of treatment; however, there is evidence to suggest additional benefit with lifestyle changes, particularly with increased physical activity.

Objective: Our systematic review aims to discover and evaluate the effects of physical activity on asthma outcomes. Read More

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Encephalocele-Associated Drug Resistant Epilepsy of Adult-Onset: Diagnosis, Management, and Outcomes.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Epileptogenic encephaloceles, most frequently located in the temporal lobe, are a known lesional cause of focal epilepsy. Data are limited regarding diagnosis, management, and outcomes of patients with epilepsy in the setting of an encephalocele, as the literature is mostly comprised of case reports, case series, and retrospective studies. We conducted a broad literature review for manuscripts related to encephaloceles and epilepsy regardless of level of evidence. Read More

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Clinical presentation, diagnostic findings, and long-term survival time in 182 dogs with meningoencephalitis of unknown origin from Central Europe that were administered glucocorticosteroid monotherapy.

Top Companion Anim Med 2021 May 5:100539. Epub 2021 May 5.

Institute of Mathematics and Statistics, Masaryk University, Brno, 60200 Czech Republic.

Canine non-infectious inflammatory meningoencephalomyelitis is termed meningoencephalomyelitis of unknown origin (MUO) and may affect dogs of every breed at any age. Treatment with immunosuppressive medication, the survival time based on MRI, and cerebrospinal fluid (CSF) findings has been widely reported; however, these studies only included a small number of patients, or they are summaries from the literature. Therefore, the aim of this study was to compare the clinical presentation, diagnostic findings, treatment protocol and long-term survival time in many dogs diagnosed with MUO in one clinic with previously published studies. Read More

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Clinical validation of Whole Genome Sequencing for cancer diagnostics.

J Mol Diagn 2021 May 5. Epub 2021 May 5.

Hartwig Medical Foundation, Science Park 408, 1098 XH Amsterdam, the Netherlands; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.

Whole genome sequencing (WGS) using fresh frozen tissue and matched blood samples from cancer patients is becoming in reach as the most complete genetic tumor test. With a trend towards the availability of small biopsies and the need to screen an increasing number of (complex) biomarkers, the use of a single all-inclusive test is preferred over multiple consecutive assays. To meet high-quality diagnostics standards, we optimized and clinically validated WGS sample and data processing procedures resulting in a technical success rate of 95. Read More

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Diagnostic accuracy of rapid nucleic acid tests for group A streptococcal pharyngitis: systematic review and meta-analysis.

Clin Microbiol Infect 2021 May 5. Epub 2021 May 5.

Université de Paris, Centre of Research in Epidemiology and Statistics (CRESS), INSERM, F-75004, Paris, France; Necker-Enfants malades Hospital, APHP, Université de Paris, Department of General Pediatrics and Pediatric Infectious Diseases, Paris, France. Electronic address:

Background: Acute pharyngitis is one of the most common conditions in outpatient settings and an important source of inappropriate antibiotic prescribing. Rapid antigen detection tests (RADTs) offer diagnosis of group A streptococcus (GAS) at the point of care but have limited sensitivity. Rapid nucleic acid tests (RNATs) are now available; a systematic review of their accuracy is lacking. Read More

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What's the choice for goji: Lycium barbarum L. or L. chinense Mill.?

J Ethnopharmacol 2021 May 5:114185. Epub 2021 May 5.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China. Electronic address:

Ethnopharmacological Relevance: For over one millennium, goji berries have been used traditionally as food and medicine in eastern Asia. In recent decades, it has become increasingly popular globally. However, the biocultural development of goji is poorly known. Read More

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Effects of brain radiotherapy on cognitive performance in adult low-grade glioma patients: A Systematic Review.

Radiother Oncol 2021 May 5. Epub 2021 May 5.

Department of Neurosurgery, Leeds General Infirmary, Great George Street, Leeds, UK.

Grade II gliomas are slow growing tumours that usually affect younger patients. The mainstream treatment modality at present is surgical. The role of radiation therapy in the management of grade II gliomas has been the subject of considerable debate. Read More

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Effect of regular resistance training on memory in older adults: A systematic review.

Exp Gerontol 2021 May 5:111396. Epub 2021 May 5.

Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; College of Nursing and Health Management, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China. Electronic address:

The purpose of this study was to evaluate the effect of regular resistance training on memory in older adults.

Methods: Eight databases (PubMed, Cochrane Library, EMBASE, Web of Science, SinoMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP) and Wanfang) were searched from their inception to March 24, 2021. The data included in the study were analysed according to the Cochrane handbook using Review Manager 5. Read More

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Structural determination of the sheath-forming polysaccharide of Sphaerotilus montanus using thiopeptidoglycan lyase which recognizes the 1,4 linkage between α-d-GalN and β-d-GlcA.

Int J Biol Macromol 2021 May 5. Epub 2021 May 5.

Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama 240-8501, Japan. Electronic address:

Sphaerotilus natans is a filamentous sheath-forming bacterium commonly found in activated sludge. Its sheath is assembled from a thiolic glycoconjugate called thiopeptidoglycan. S. Read More

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