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The effect of on obesity related metabolic disorders: a systematic review of randomized controlled trials.

J Complement Integr Med 2021 May 5. Epub 2021 May 5.

Nutrition Research Center, Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: (CV) as a unicellular algae is a dietary supplement with beneficial nutritious content, used for decades in some countries. Positive effects for CV supplementation on metabolic parameters has been established in animal and human studies. However there is a gap for this results summary for a definite conclusion announce. Read More

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Antipsychotics are related to psychometric conversion to psychosis in ultra-high-risk youth.

Early Interv Psychiatry 2021 May 5. Epub 2021 May 5.

Programma2000 - Center for Early Detection and Intervention in Psychosis, Department of Mental Health, Niguarda Ca' Granda Hospital, Milan, Italy.

Background: The prescription of antipsychotics outside overt psychotic conditions remains controversial, especially in youth where it is relatively widespread. Furthermore, some studies seem to indicate that antipsychotic exposure in individuals at ultra-high-risk (UHR) for psychosis is associated with higher conversion rates. This study was set up to test whether the inter-current prescription of antipsychotics in UHR patients was related to the psychometric threshold for a diagnosis of psychosis. Read More

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Ultrasonography Grading of Internal Carotid Artery Disease: Multiparametric German Society of Ultrasound in Medicine (DEGUM) versus Society of Radiologists in Ultrasound (SRU) Consensus Criteria.

Ultraschall Med 2021 May 5. Epub 2021 May 5.

Department of Neurology, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.

Purpose:  We sought to determine the diagnostic agreement between the revised ultrasonography approach by the German Society of Ultrasound in Medicine (DEGUM) and the established Society of Radiologists in Ultrasound (SRU) consensus criteria for the grading of carotid artery disease.

Materials And Methods:  Post-hoc analysis of a prospective multicenter study, in which patients underwent ultrasonography and digital subtraction angiography (DSA) of carotid arteries for validation of the DEGUM approach. According to DEGUM and SRU ultrasonography criteria, carotid arteries were independently categorized into clinically relevant NASCET strata (normal, mild [1-49 %], moderate [50-69 %], severe [70-99 %], occlusion). Read More

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The Use of Prophylactic Foam Dressings for Prevention of Hospital-Acquired Pressure Injuries: A Systematic Review.

J Wound Ostomy Continence Nurs 2021 May-Jun 01;48(3):211-218

Katherine Sillmon, ACNP, MSN, CCRN, The University of North Carolina at Charlotte.

Purpose: The purpose of this systematic review was to identify and evaluate the use of prophylactic foam dressings for prevention of hospital-acquired pressure injuries (HAPIs).

Methods: A systematic review was conducted in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-analysis Statement (PRISMA).

Search Strategy: Four researchers independently conducted searches in Health Source, Cochrane of Systematic Reviews, CINAHL, and PubMed. Read More

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Short-term Outcomes of Day-Case Stoma Closure: A Prospective, Observational Study.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Department of Digestive Surgery, Amiens University Hospital, Amiens, France SSPC (Simplification of Surgical Patients Care) Clinical Research Unit, University of Picardie Jules Verne, Amiens, France Department of Anaesthesia, Amiens University Hospital, Amiens, France.

Background: Elective stoma closure is a common, standardized procedure in digestive surgery.

Objective: To evaluate the feasibility of day-case surgery for elective stoma closure.

Design: A prospective, single-center, non-randomized study of consecutive patients undergoing day-case elective stoma closure. Read More

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Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in the Adjuvant Setting for Patients with Resected Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer: A Meta-Analysis with 11 Trials.

Oncol Res Treat 2021 May 5:1-9. Epub 2021 May 5.

Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, China.

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have recently become the standard first-line therapy for advanced non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. This study aimed to define the role of EGFR-TKI treatment in the adjuvant setting of patients with resected EGFR-mutant NSCLC.

Methods: Three online databases (PubMed, Embase, and the Cochrane Library) were used to conduct systematic research to search for studies published before June 1, 2020. Read More

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Bulbar Urethral Stents for Bulbar Urethral Strictures: Long-Term Follow-Up after Stent Removal.

Urol Int 2021 May 5:1-6. Epub 2021 May 5.

Department of Urology, Kocaeli University School of Medicine, Kocaeli, Turkey.

Background/aim: The aim of this study was to assess long-term clinical efficacy of temporary bulbar urethral stent (BUS) used for treatment of recurrent bulbar urethral stricture (US).

Materials And Methods: A total of 168 patients with recurrent bulbar US who underwent BUS placement after internal urethrotomy between 2009 and 2019 were enrolled. An indwelling time of 12 months was planned for the stents. Read More

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Sextant Biopsy-Based Criteria for Clinically Insignificant Prostate Cancer Are Also Valid for the 12-Core Prostate Biopsy Scheme: A Multicenter Study of Urooncology Association, Turkey.

Urol Int 2021 May 5:1-9. Epub 2021 May 5.

Department of Urology, Altunizade Hospital, Mehmet Ali Aydınlar Acıbadem University, Istanbul, Turkey.

Background: Epstein criteria based on sextant biopsy are assumed to be valid for 12-core biopsies. However, very scarce information is present in the current literature to support this view.

Objectives: To investigate the validity of Epstein criteria for clinically insignificant prostate cancer (PCa) in a cohort of the currently utilized 12-core prostate biopsy (TRUS-Bx) scheme in patients with low-risk and intermediate-risk PCa. Read More

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Influence of Gestational Age and Mode of Delivery on Neonatal Outcomes in Prenatally Diagnosed Isolated Congenital Diaphragmatic Hernia.

Fetal Diagn Ther 2021 May 5:1-9. Epub 2021 May 5.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Aim: The optimal gestational age (GA) at delivery and mode of delivery (MoD) for pregnancies with fetal congenital diaphragmatic hernia (CDH) is undetermined. The impact of early term (37-38 weeks 6 days) versus full term (39-40 weeks 6 days) and MoD on immediate neonatal outcomes in prenatally diagnosed isolated CDH cases was evaluated.

Material And Methods: A retrospective chart review of pregnancies evaluated and delivered with the prenatal diagnosis of CDH between July 1, 2008, and December 31, 2018. Read More

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Oral Desogestrel as Endometrial Preparation before Operative Hysteroscopy: A Systematic Review.

Gynecol Obstet Invest 2021 May 5:1-9. Epub 2021 May 5.

Obstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.

The pharmacologic preparation of the endometrium before hysteroscopy may be achieved with the use of various drugs. This systematic review aims to summarize the available evidence regarding the use of desogestrel for endometrial preparation before hysteroscopic procedures. A literature search for suitable articles published in English language from inception of the database until August 2019 was performed using the following databases: PubMed/MEDLINE, EMBASE, the Cochrane Library, and Google Scholar. Read More

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Efficacy and one-year outcomes of Luminor® paclitaxel-coated drug-eluting balloon in the treatment of popliteal artery atherosclerosis lesions.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

University of Palermo - Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), Palermo, Italy; Vascular Surgery Unit, AOUP "P. Giaccone", Palermo, Italy.

Purpose: Reporting outcomes with a new generation paclitaxel eluting balloon (Luminor®; iVascular, Vascular, S.L.U. Read More

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Aspiration Thrombectomy with the Indigo System for Acute Lower Limb Ischemia: preliminary experience and analysis of parameters affecting the outcome.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Department of Surgical and Medical Sciences and Translational Medicine, "Sapienza" - University of Rome, Italy. Radiology and Interventional Radiology Unit, Sant'Andrea University Hospital.

Purpose: The purpose of our study is to assess the short-term technical success and the safety of the Indigo System in a series of patients undergoing vacuum-assisted catheter direct thrombus aspiration (IS-CDTA) for acute lower limb ischemia (ALLI) and to evaluate which parameters may affect the outcome.

Materials And Methods: All procedures using the IS-CDTA for ALLI, performed in a single-centre Interventional Radiology Unit from February 2016 to March 2020, were retrospectively analysed. Technical success was defined as the achievement of nearly-complete or complete revascularization (TIPI grade 2/3) and considered as a good outcome. Read More

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Aortic neck IFU violations during EVAR for ruptured infrarenal aortic aneurysms are associated with increased in-hospital mortality.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Division of Vascular Surgery and Endovascular Therapy, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Objective: Vascular surgeons treating patients with ruptured abdominal aortic aneurysm (rAAA) must make rapid treatment decisions and sometimes lack immediate access to endovascular devices meeting the anatomic specifications of the patient at hand. We hypothesized that endovascular treatment of rAAA (rEVAR) outside manufacturer instructions-for-use (IFU) guidelines would have similar in-hospital mortality compared to patients treated on-IFU or with an infrarenal clamp during open repair (rOAR).

Methods: Vascular Quality Initiative (VQI) datasets for endovascular and open aortic repair were queried for patients presenting with ruptured infrarenal AAA between 2013-2018. Read More

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Comparison of Myeloablative Versus Reduced-Intensity Conditioning Regimens in Allogeneic Stem Cell Transplant Recipients with Acute Myelogenous Leukemia with MRD Negative Disease at the Time of Transplant: A Retrospective Cohort Study.

Transplant Cell Ther 2021 May 2. Epub 2021 May 2.

Blood and Marrow Transplant Center, AdventHealth Orlando Hospital, Orlando, FL 32804, USA. Electronic address:

Background/objective: The ideal conditioning intensity in allogeneic hematopoietic stem cell transplantation (HSCT) is evolving. Previous prospective studies comparing myeloablative versus reduced intensity conditioning regimens in adults with acute myelogenous leukemia (AML) have shown mixed results. In many of these studies, patients were not stratified based on measurable residual disease (MRD). Read More

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Population Pharmacokinetics-Pharmacodynamics of Ceftazidime in Neonates and Young Infants: Dosing Optimization for Neonatal Sepsis.

Eur J Pharm Sci 2021 May 2:105868. Epub 2021 May 2.

Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Department of Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China; Department of Pediatrics, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan 250000, China; Clinical Research Center, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250000, China. Electronic address:

Ceftazidime is a third-generation cephalosporin with high activity against many pathogens. But the ambiguity and diversity of the dosing regimens in neonates and young infants impair access to effective treatment. Thus, we conducted a population pharmacokinetic study of ceftazidime in this vulnerable population and recommended a model-based dosage regimen to optimize sepsis therapy. Read More

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Primary squamous cell carcinoma, breast: A challenging diagnosis.

Cancer Rep (Hoboken) 2021 May 5:e1391. Epub 2021 May 5.

Department of Endocrine surgery, King George's Medical University, Lucknow, India.

Background: Primary squamous cell carcinoma of the breast is an extremely rare malignancy constituting less than 0.1% of all breast cancers with very few cases reported in literature. It is an aggressive, triple-hormone negative tumor, and its appropriate management is still debated. Read More

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Genetic testing results of children suspected to have Stickler syndrome type collagenopathy after ocular examination.

Mol Genet Genomic Med 2021 May 5:e1628. Epub 2021 May 5.

Department of Genetics, KFSHRC, Riyadh, Saudi Arabia.

Purpose: Stickler syndrome is a collagenopathy that is typically COL2A1-related (autosomal dominant) and less commonly related to other collagen gene mutations. Diagnosis is straightforward when a child has myopia or retinal detachment in the setting of classic diagnostic criteria such as hearing impairment, midfacial hypoplasia, and arthropathy. However, some children have primarily ocular disease with mild or no extraocular features. Read More

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Sarcopenia as a predictor of initial administration dose of afatinib in patients with advanced non-small cell lung cancer.

Thorac Cancer 2021 May 5. Epub 2021 May 5.

Department of Medical Oncology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Background: Sarcopenia has recently emerged as a new condition with increasing importance in lung cancer patients. The aim of this study was to investigate the influence of sarcopenia on tolerance and efficacy of afatinib.

Methods: We retrospectively evaluated 35 patients with epidermal growth factor receptor (EGFR) mutant advanced non-small cell lung cancer (NSCLC) treated with first-line afatinib. Read More

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Dubiofossils from a Mars-analogue subsurface palaeoenvironment: The limits of biogenicity criteria.

Geobiology 2021 May 5. Epub 2021 May 5.

Department of Earth & Planetary Science, University of California, Berkeley, CA, USA.

The search for a fossil record of Earth's deep biosphere, partly motivated by potential analogies with subsurface habitats on Mars, has uncovered numerous assemblages of inorganic microfilaments and tubules inside ancient pores and fractures. Although these enigmatic objects are morphologically similar to mineralized microorganisms (and some contain organic carbon), they also resemble some abiotic structures. Palaeobiologists have responded to this ambiguity by evaluating problematic filaments against checklists of "biogenicity criteria". Read More

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Experiences of fathers regarding the diagnosis of their child with autism spectrum disorder: A narrative review of the international research.

J Clin Nurs 2021 May 5. Epub 2021 May 5.

School of Nursing and Midwifery, University of Dublin, Trinity College, Dublin, Ireland.

Aim And Objectives: The aim of this systematic review was to identify the views and experiences of fathers regarding their child's Autism Spectrum Disorder diagnosis.

Background: The diagnosis of a child's Autism Spectrum Disorder may be a stressful experience, creating uncertainty for parents. There has been a limited research focus on the views and experiences of fathers in relation to the diagnosis of Autism Spectrum Disorder of their child. Read More

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Factors associated with psychological distress for couples facing head and neck cancer: A systematic literature review.

Psychooncology 2021 Apr 9. Epub 2021 Apr 9.

King's Mill Hospital, Nottinghamshire Healthcare NHS Foundation Trust, Sutton-in-Ashfield, UK.

Objectives: Cancer patients in supportive relationships display improved health and survival outcomes. Identifying factors that might respond to intervention for Head and Neck Cancer (HNC) dyads is important as HNC patients and their partners experience heightened distress. This article systematically reviewed and evaluated the research findings and methodological quality of studies which identified factors influencing psychological distress for couples facing HNC. Read More

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Paying for performance to improve the delivery of health interventions in low- and middle-income countries.

Cochrane Database Syst Rev 2021 May 5;5:CD007899. Epub 2021 May 5.

Institute for Global Health and Development, Queen Margaret University, Edinburgh, UK.

Background: There is growing interest in paying for performance (P4P) as a means to align the incentives of healthcare providers with public health goals. Rigorous evidence on the effectiveness of these strategies in improving health care and health in low- and middle-income countries (LMICs) is lacking; this is an update of the 2012 review on this topic.

Objectives: To assess the effects of paying for performance on the provision of health care and health outcomes in low- and middle-income countries. Read More

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Advance care planning by proxy in German nursing homes: Descriptive analysis and policy implications.

J Am Geriatr Soc 2021 May 5. Epub 2021 May 5.

Institute of Ethics, History and Theory of Medicine, Ludwig Maximilian University of Munich, Munich, Germany.

Background: Legally recognized advance directives (ADs) have to be signed by the person to whom the decisions apply. In practice, however, there are also ADs written and signed by legal proxies (surrogates) on behalf of patients who lack decision-making capacity. Given their practical relevance and substantial ethical and legal implications, ADs by proxy (AD-Ps) have received surprisingly little scientific attention so far. Read More

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A prospective trial of abiraterone acetate plus prednisone in Black and White men with metastatic castrate-resistant prostate cancer.

Cancer 2021 May 5. Epub 2021 May 5.

Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina.

Background: Retrospective analyses of randomized trials suggest that Black men with metastatic castration-resistant prostate cancer (mCRPC) have longer survival than White men. The authors conducted a prospective study of abiraterone acetate plus prednisone to explore outcomes by race.

Methods: This race-stratified, multicenter study estimated radiographic progression-free survival (rPFS) in Black and White men with mCRPC. Read More

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Occlusal Disorders in Patients with Sickle Cell Disease: Critical Literature Review.

J Clin Pediatr Dent 2021 Apr;45(2):117-122

Objective: To identify the association of occlusal disorders in patients with sickle cell disease (SCD).

Study Design: A literature review was conducted, and articles published between 2010 and 2019 were searched on Bireme and PubMed websites and in MEDLINE and LILACS databases, in English, Portuguese, and Spanish, using the keywords "malocclusion," "sickle cell disease," and "cephalometry," combined by Boolean operators AND and OR. One of the criteria for the selection of articles was the presence of adolescents in the sample. Read More

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Inspiratory muscle training for improving inspiratory muscle strength and functional capacity in older adults: a systematic review and meta-analysis.

Age Ageing 2021 May;50(3):716-724

Department of Sport, Exercise and Rehabilitation, School Health & Life Sciences, Northumbria University, Newcastle, Upon Tyne, UK.

Background: The ageing process can result in the decrease of respiratory muscle strength and consequently increased work of breathing and associated breathlessness during activities of daily living in older adults.

Objective: This systematic review and meta-analysis aims to determine the effects of inspiratory muscle training (IMT) in healthy older adults.

Methods: A systematic literature search was conducted across four databases (Medline/Pubmed, Web of Science, Cochrane Library CINAHL) using a search strategy consisting of both MeSH and text words including older adults, IMT and functional capacity. Read More

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Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? A systematic review.

Age Ageing 2021 May;50(3):725-732

Department of Cardiology, Blacktown Hospital, Western Sydney Local Health District, Sydney, Australia.

Background: Frailty is strongly associated with adverse cardiovascular outcomes; however, the underlying pathophysiological processes are largely unknown. Vascular endothelial dysfunction (VED) is the earliest stage of cardiovascular disease (CVD) progression and predicts long-term CVD outcomes. Both these conditions share an elevated inflammatory state as a common pathological factor. Read More

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Prevalence of atrial fibrillation and outcomes in older long-term care residents: a systematic review.

Age Ageing 2021 May;50(3):744-757

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Background: anticoagulation is integral to stroke prevention for atrial fibrillation (AF), but there is evidence of under-treatment in older people in long-term care (LTC).

Objective: to synthesise evidence on the prevalence and outcomes (stroke, mortality or bleeding) of AF in LTC and the factors associated with the prescription of anticoagulation.

Methods: studies were identified from Medline, CINAHL, PsycINFO, Scopus and Web of Science from inception to 31 October 2019. Read More

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Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis.

Age Ageing 2021 May;50(3):733-743

School of Allied Health, Faculty of Education and Health Sciences, Ageing Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland.

Objective: Detection of delirium in hospitalised older adults is recommended in national and international guidelines. The 4 'A's Test (4AT) is a short (<2 minutes) instrument for delirium detection that is used internationally as a standard tool in clinical practice. We performed a systematic review and meta-analysis of diagnostic test accuracy of the 4AT for delirium detection. Read More

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