4,440 results match your criteria crevicular fluid


Impact of chronic gingivitis management on the cytokine and anti-PPAD expressions in juvenile systemic lupus erythematosus: A six-month follow-up.

J Periodontal Res 2021 Sep 12. Epub 2021 Sep 12.

Department of Periodontology, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Objective: To evaluate how chronic gingivitis treatment impacts the oral and circulating cytokine expressions after six-month follow-up in patients with juvenile systemic lupus erythematosus (jSLE) and also to evaluate the circulating expression of anti-Porphyromonas gingivalis peptidylarginine deiminase antibodies (anti-PPAD) before and after treatment.

Background: Juvenile systemic lupus erythematosus patients present a worse periodontal condition associated with higher gingival crevicular fluid (GCF) levels of interleukin (IL)-1β, IL-8, granulocyte colony-stimulating factor (G-CSF), interferon-γ and monocyte chemoattractant protein (MCP)-1.

Materials And Methods: Twenty-one adolescents with jSLE (mean age: 16. Read More

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September 2021

Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid.

Clin Oral Investig 2021 Sep 10. Epub 2021 Sep 10.

Araçatuba School of Dentistry, São Paulo State University, José Bonifácio St, 1193, Araçatuba, SP, 16015-050, Brazil.

Objectives: To evaluate different restorative techniques for non-carious cervical lesions (NCCLs) and the activity of matrix metalloproteinases (MMPs) in gingival crevicular fluid.

Materials And Methods: Two hundred restorations were performed in 50 patients using resin composite restorative system without (I) and with selective enamel conditioning (II) and resin-modified glass-ionomer cement without (III) and with EDTA pretreatment (IV). Gingival crevicular fluid samples were collected in 15 patients. Read More

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September 2021

Allicin May Promote Reversal of T-Cell Dysfunction in Periodontitis via the Pathway.

Int J Mol Sci 2021 Aug 25;22(17). Epub 2021 Aug 25.

Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India.

We evaluated the role of allicin in periodontitis using an in silico and in vitro design. An in silico docking analysis was performed to assess the plausible interactions between allicin and . The cytokine profile of gingival crevicular fluid (GCF) samples obtained from periodontitis patients was estimated by cytometric bead array. Read More

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Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review.

Int J Environ Res Public Health 2021 Aug 25;18(17). Epub 2021 Aug 25.

School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia.

This systematic review assessed studies that evaluated the immunological traits of patients with both inflammatory bowel disease (IBD) and periodontal disease. An electronic search for literature was conducted on PubMed, Embase, Scopus, Cochrane and Web of Science. Studies that evaluated the immunological response in patients with IBD and periodontal disease were considered eligible for inclusion. Read More

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Effects of submucosally administered platelet-rich plasma on the rate of tooth movement.

Angle Orthod 2021 Sep 7. Epub 2021 Sep 7.

Objectives: To evaluate the effects of submucosally administered platelet-rich plasma (PRP) on the rate of maxillary canine retraction. Levels of soluble receptor activator of nuclear factor-κb ligand (sRANKL) and osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) were also measured over 2 months.

Materials And Methods: This split-mouth trial involved 20 sites in 10 subjects randomly assigned to PRP (experimental) side and control side. Read More

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September 2021

Increased risk of periodontitis occurrence in patients with rheumatoid arthritis and its association with the levels of IL-1β and TNF-α in gingival crevicular fluid.

Ann Palliat Med 2021 Aug;10(8):9078-9087

Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: Periodontitis (PD) is a chronic inflammatory disease caused by infection of the periodontal supporting tissues. Clinical studies have reported that rheumatoid arthritis (RA) patients have a higher prevalence of PD. This study aimed to explore the correlation between RA and PD. Read More

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Non-invasive methods for the assessment of biomarkers and their correlation with radiographic maturity indicators - a scoping review.

Prog Orthod 2021 Sep 6;22(1):26. Epub 2021 Sep 6.

Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Sciences, Bahadur Shah Zafar Marg, New Delhi, 110002, India.

Background: Detection of skeletal maturity is vital in orthodontic treatment timing and planning. Traditional methods include hand-wrist radiography and cervical vertebral maturation index (CVMI). Though the radiographic methods are well established and routinely used to assess skeletal maturation, they carry the drawback of subjective perception and low reproducibility. Read More

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September 2021

() as a Potential Driver of Molecular Mimicry and Inflammation in Rheumatoid Arthritis.

Front Med (Lausanne) 2021 17;8:671018. Epub 2021 Aug 17.

Università Cattolica del Sacro Cuore, Rome, Italy.

(; now ) is an infectious agent that causes severe arthritis in swines and shares sequence similarity with residues 261-273 of collagen type 2 (Coll), a possible autoantigen in rheumatoid arthritis (RA). We tested the presence of sequencing 16S ribosomal RNA in crevicular fluid, synovial fluids, and tissues in patients with arthritis (RA and other peripheral arthritides) and in healthy controls. Moreover, we examined the cross-recognition of by Coll-specific T cells in HLA-DRB104 RA patients, by T-cell receptor (TCR) beta chain spectratyping and T-cell phenotyping. Read More

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A qualitative and quantitative analysis of the human gingival crevicular fluid proteome and metaproteome.

Proteomics 2021 Aug 31:e2000321. Epub 2021 Aug 31.

Core Facility of Instrument, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.

Gingival crevicular fluid (GCF) is an integral part of oral fluid that plays a special role in maintaining the structure of junctional epithelium and defending against bacterial infection. In this study, we comprehensively analysed the composition of the human GCF proteome and metaproteome simultaneously to obtain multidimensional information about GCF. A total of 3680 human proteins (2540 with at least two unique peptides) were identified in the normal GCF sample, and their functions were mainly associated with immune function and inflammation. Read More

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Impact of calorie restriction and intermittent fasting on periodontal health.

Authors:
Sameena Parveen

Periodontol 2000 2021 Oct;87(1):315-324

Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

The scientific evidence indicates that calorie restriction and intermittent fasting are among the appropriate strategies targeting factual causative factors of various inflammatory and lifestyle-related disorders. Periodontitis is a common oral inflammatory disease leading to bone loss that is associated with various systemic problems. Previous studies suggest that calorie restriction may dampen inflammation and concomitant tissue damage under inflammatory conditions, such as periodontal diseases in nonhuman primates. Read More

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October 2021

Impact of interproximal composite restorations on periodontal tissues health. Clinical and cytokine profiles from a pre-post quasi-experimental study.

J Periodontol 2021 Aug 28. Epub 2021 Aug 28.

Unit of Endodontics and Restorative Dentistry, Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Background: to clinically and molecularly evaluate the effect of an interproximal iuxta/subgingival direct composite restoration on periodontal tissues healing.

Methods: Individuals in need of a posterior iuxta/subgingival interproximal restoration were consecutively enrolled. After enrollment, a Test (site with tooth decay) and a Control site (intact contralateral tooth) were identified. Read More

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Cross-sectional comparisons of subgingival microbiome and gingival fluid inflammatory cytokines in periodontally healthy vegetarians versus non-vegetarians.

J Periodontal Res 2021 Aug 27. Epub 2021 Aug 27.

Department of Preventive Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA.

Background: Vegetarian diets are known to reduce inflammation. The objective of this study was to test the hypothesis that reduced inflammation associated with a vegetarian diet would promote a more commensal subgingival bacterial profile.

Methods: A total of 39 periodontally healthy subjects (PD ≤3 mm, bleeding on probing <10%) were enrolled. Read More

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Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial.

Nutrients 2021 Jul 28;13(8). Epub 2021 Jul 28.

Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03722, Korea.

Background: Mangosteen and propolis extracts (MAEC) have been potential therapeutic agents known to exhibit powerful antioxidant and anti-inflammatory properties. The aim of the current study was to evaluate the clinical and immunological efficacy of MAEC as well as safety and patient-reported outcomes (PROMs) on gingivitis and incipient periodontitis.

Methods: This study was performed on 104 patients diagnosed with gingivitis or incipient periodontitis. Read More

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Active MMP-8 Quantitative Test as an Adjunctive Tool for Early Diagnosis of Periodontitis.

Diagnostics (Basel) 2021 Aug 20;11(8). Epub 2021 Aug 20.

Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago 8380544, Chile.

Periodontitis is a host-mediated bacterial disease that affects the tooth attachment apparatus. Metalloproteinase-8 (MMP-8), a validated biomarker, could aid in clinical diagnosis. This study aimed to evaluate the diagnostic performance of active (a) MMP-8 immunotest versus total (t) MMP-8 ELISA for quantitative real-time diagnosis and assessment of periodontitis severity at the site level. Read More

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WNT-5a and SOST Levels in Gingival Crevicular Fluid Depend on the Inflammatory and Osteoclastogenic Activities of Periodontal Tissues.

Medicina (Kaunas) 2021 Jul 31;57(8). Epub 2021 Jul 31.

Division of Periodontology, Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA.

Wnt signaling leads to stimulation of osteoblasts and it reduces osteoclastogenesis and bone resorption via the regulation of the osteprotegrin and receptor activator of nuclear factor kappa-Β ligan (RANKL). Wnt signaling pathways are regulated by their physiological antagonists such as sclerostin (SOST) as well as WNT-5a. The aim of this study was to determine the total amount of Sclerostin and WNT-5a in the gingival crevicular fluid (GCF) in sites with a continuum from a healthy to diseased periodontium. Read More

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Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels.

Biomolecules 2021 08 19;11(8). Epub 2021 Aug 19.

Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago 8380544, Chile.

Cardiovascular diseases (CVD) are highly prevalent non-communicable diseases worldwide. Periodontitis may act as a non-traditional cardiovascular risk (CVR) factor, linked by a low-grade systemic inflammation mediated by C-reactive protein (CRP). Patients with periodontitis reported higher serum CRP levels; however, a CRP systemic and periodontal correlation in gingival crevicular fluid (GCF) and its CVR impact have been barely studied. Read More

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Interleukin-1β activity in gingival crevicular fluid of abutment teeth with temporary fixed restorations versus final fixed restorations: Prospective observational study.

Saudi Dent J 2021 Sep 6;33(6):322-327. Epub 2021 Jun 6.

Lecturer of Oral Medicine, Oral diagnosis and Periodontology, Faculty of Dentistry, Beni-Suef University, 62511 Beni Suef, Egypt.

Objective: To compare the effect of temporary fixed restorations to final fixed restorations on gingival health of abutment tooth by evaluating the level of IL-1β in gingival crevicular fluid (GCF) as an inflammatory biomarker.

Subjects And Methods: It was a nonrandomized prospective observational study. Samples of GCF were collected from 24 participants with provisional and permanent definitive full-coverage restorations with subgingival margin placements at three intervals for each participant: Interval 1, after preparation and immediately before cementation of temporary fixed restoration. Read More

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September 2021

Evaluation of periostin levels in gingival crevicular fluid in association between coronary heart disease and chronic periodontitis.

Dent Res J (Isfahan) 2021 22;18:46. Epub 2021 Jun 22.

Department of Periodontics, School of Dentistry, Arak University of Medical Sciences, Arak, Iran.

Background: Periostin is a protein, which is essential for periodontal tissue integrity, development and maturity. The aim of this study was to evaluate the role of gingival crevicular fluid (GCF) periostin levels in the association between coronary heart disease (CHD) and chronic periodontitis (CP).

Materials And Methods: This matched case-control study was conducted on 116 participants. Read More

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Early soft tissue response to zirconium oxide and titanium healing abutments in vivo: a study in dogs.

BMC Oral Health 2021 Aug 24;21(1):416. Epub 2021 Aug 24.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education and Department of Oral Implantology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

Background: This study aimed to investigate the clinical characteristics and early soft tissue response to zirconium oxide (Zr) and titanium (Ti) healing abutments in dogs.

Methods: Eight implants (four at each hemi-mandible) were inserted after bilateral mandibular third and fourth premolars and first molar extraction in dogs. Then, two Zr and two Ti healing abutments were connected to each unilateral mandible eight weeks later. Read More

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Expression Level and Clinical Significance of Inflammatory Cytokines and Biochemical Markers in Gingival Crevicular Fluid During Different Crown Adhesion Patterns of Dental Implant.

Niger J Clin Pract 2021 Aug;24(8):1181-1187

Department of Stomatology, The Third Hospital of Hebei Medical University, Hebei, China.

Objective: The aim of this study was to investigate the expression level and clinical significance of inflammatory factors and biochemical markers in gingival crevicular fluid during different crown-binding styles in dental implant patients.

Methods: A total of 38 patients with posterior tooth loss and implant repair were recruited and divided into two groups according to the different ways of crown bonding, including 19 prostheses (19 patients) in the adhesive retainer group and 19 prostheses (19 patients) in the modified adhesive retainer group. Moreover, the peri-implant gingival sulcus fluids of each group of patients were collected at 7, 15, 30, 60, and 90 d of post-treatment, and the expression level of each cytokine as well as biochemical marker were analyzed by enzyme-linked adsorption method, respectively. Read More

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Clinical, radiographic, and immunological evaluation of angulated screw-retained and cemented single-implant crowns in the esthetic region: A 1-year randomized controlled clinical trial.

Clin Implant Dent Relat Res 2021 Aug 14. Epub 2021 Aug 14.

Department of Oral and Maxillo-facial Implantology, Shanghai Key Laboratory of Stomatology, National Clinical Research Center for Stomatology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Screw-retained implant crowns are considered more biologically compatible than cemented crowns due to the absence of excess cement. However, traditional screw-retained implant crowns are not viable when the access hole of the screw channel would need to be located in an esthetic area, which would compromise the esthetic outcome of the treatment.

Purpose: To evaluate the clinical, radiographic, and immunological outcomes of angulated screw-retained and cemented single-implant crowns in the esthetic region. Read More

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Salivary and gingival CXCL8 correlation with periodontal status, periodontal pathogens and smoking.

Oral Dis 2021 Aug 13. Epub 2021 Aug 13.

Department of Conservative Dentistry and Periodontology, University Hospital, LMU Munich, Germany.

Objectives: Neutrophil granulocytes have been proposed to play a major role in the mediation of periodontitis-associated tissue destruction. Their recruitment and activation are regulated by the chemokine CXCL8. This study aimed to delineate the dependency of CXCL8-expression in gingival crevicular fluid (GCF) and saliva on periodontal status, bacterial infection and smoking, in patients with periodontitis. Read More

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A single application of chlorhexidine gel reduces gingival inflammation and interleukin 1-β following one-stage implant placement: A randomized controlled study.

Clin Implant Dent Relat Res 2021 Aug 11. Epub 2021 Aug 11.

Department of Periodontology, Rambam Health Care Campus, Haifa, Israel.

Background: Chlorhexidine (CHX) is a broad-spectrum antimicrobial agent commonly used in medicine. Application of (CHX) during abutment connection reduced the bacterial load at the implant-abutment interface. We hypothesize this treatment may consequently reduce peri-implant soft tissue inflammation and marginal bone loss. Read More

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The curative effect of ultrasonic subgingival curettage combined with Xipayi gingival rinse on patients with chronic periodontitis.

Am J Transl Res 2021 15;13(7):8094-8101. Epub 2021 Jul 15.

Department of Stomatology, Haikou Longhua Mai Yamei Dental Clinic Haikou 570105, Hainan, China.

Objectives: We explored and analyzed the effect and masticatory function of ultrasonic subgingival curettage combined with rinsing and gargling of Xipayi gingival rinse on patients with moderate to severe chronic periodontitis.

Methods: We selected 98 patients with moderate to severe chronic periodontitis admitted to our hospital, and randomly divided them into observation group and control group (n=49 in each group). The control group was treated with ultrasonic subgingival curettage. Read More

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S100A8 and S100A9 in saliva, blood and gingival crevicular fluid for screening established periodontitis: a cross-sectional study.

BMC Oral Health 2021 Aug 9;21(1):388. Epub 2021 Aug 9.

Dental Research Institute, Seoul National University, Seoul, Korea.

Background: Periodontitis is one of major oral diseases, which has no consensus on early screening tool. This study aimed to compare the association and screening ability of S100A8 and S100A9 in saliva, blood and gingival crevicular fluid (GCF) for periodontitis status.

Methods: We recruited 149 community Korean adults, 50 no or initial periodontitis (NIPERIO) and 99 established periodontitis (PERIO). Read More

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Sphingosine kinase activity and sphingosine-1-phosphate in the inflamed human periodontium.

Oral Dis 2021 Aug 9. Epub 2021 Aug 9.

Department of Dental Clinical Sciences, Division of Periodontics, Faculty of Dentistry, Dalhousie University, Halifax, NS, Canada.

Objectives: This study evaluated changes in the levels of Sphingosine-1-Phosphate (S1P) and Sphingosine Kinase (SPHK) activity in response to non-surgical periodontal treatment in humans.

Methods: Diseased (n = 65) and healthy sites (n = 72) were screened in 18 patients with localized periodontitis stage II or III. Periodontal clinical parameters were recorded, and the gingival crevicular fluid (GCF) collected at baseline, 30 and 90 days of non-surgical treatment. Read More

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Clinical effects of the exposure to red wine during at-home bleaching.

Quintessence Int 2021 Aug 9;0(0):2-11. Epub 2021 Aug 9.

Objectives: This clinical trial evaluated the effects of red wine exposure on the effectiveness of at-home bleaching with 10% carbamide peroxide, degree of tooth sensitivity, and levels of periodontal inflammatory markers.

Method And Materials: Eighty participants were assigned to two groups, namely, those who drank red wine (experimental group), and those who did not drink red wine (control group). The experimental group participants rinsed their mouths with 25 mL of red wine four times a day during the bleaching period. Read More

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Impact of Smoking on Neutrophil Enzyme Levels in Gingivitis: A Case-Control Study.

Int J Environ Res Public Health 2021 07 30;18(15). Epub 2021 Jul 30.

Periodontology Department, Faculty of Dentistry, University of Istanbul, Istanbul 34093, Turkey.

Background: The determination of the impact of risk factors such as smoking in periodontal disease development is of importance to better characterize the disease. However, its impact on host response remains unclear. This study aimed to evaluate the effects of tobacco smoking on GCF levels of neutrophil enzymes (myeloperoxidase (MPO), beta-glucuronidase (BGD), neutrophil elastase (NE) and periodontal parameters in healthy young adults with dental plaque biofilm-induced gingivitis. Read More

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[Diagnostic value of biomarkers of bone metabolism in the gingival fluid in inflammatory-destructive and tumor oral pathology].

Stomatologiia (Mosk) 2021 ;100(4):31-36

National Medical Research Centre for Oncology, Rostov-on-Don, Russia.

Objective: The aim of the work was to determine the informativeness of the assessment of biochemical markers in the gingival fluid with destructive bone changes in the peri-implantation area, primary tumor lesion of the alveolar processes of the jaws and metastatic destruction of the jaw bone tissue in cancer of the large salivary glands. The study included 51 patients aged 30 to 75 years of both sexes. Depending on the genesis of destruction of the bone tissue of the lower jaw, three groups of patients were identified. Read More

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An Evaluation of Microbial Flora, Alkaline Phosphatase and IL-8 Levels in GCF of Orthodontic Patients with Self-Ligating and Conventional Brackets.

Clin Cosmet Investig Dent 2021 30;13:343-352. Epub 2021 Jul 30.

Department of oral Medicine and Periodontology, College of Dentistry, Al-Azhar University, Assiut, Egypt.

Purpose: To compare the microbial flora, alkaline phosphatase (ALP) and interleukin-8 (IL-8) levels during orthodontic treatment with self-ligating brackets versus conventional brackets.

Patients And Methods: Forty patients were included in this study and distributed equally between two groups. One group received conventional edgewise brackets while the other group received DAMON self-ligating brackets. Read More

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