1,034 results match your criteria cres


Cloud Occurrences and Cloud Radiative Effects (CREs) from CCCM and CloudSat Radar-Lidar Products.

J Geophys Res Atmos 2017 Aug 18;122(16):8852-8884. Epub 2017 Aug 18.

Science Systems and Applications Inc. (SSAI), Hampton, Virginia, USA.

Two kinds of radar-lidar synergy cloud products are compared and analyzed in this study; CERES-CALIPSO-CloudSat-MODIS (CCCM) product and CloudSat radar-lidar (RL) product such as GEOPROF-LIDAR and FLXHR-LIDAR. Compared to GEOPROF-LIDAR, CCCM has more low-level (< 1 km) clouds over tropical oceans because CCCM uses a more relaxed threshold of Cloud-Aerosol Discrimination (CAD) score for Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) vertical feature mask (VFM) product. In contrast, GEOPROF-LIDAR has more mid-level (1-8 km) clouds than CCCM at high latitudes (> 40°). Read More

View Article and Full-Text PDF

Making Biological Sense of Genetic Studies of Age-Related Macular Degeneration.

Adv Exp Med Biol 2021 ;1256:201-219

Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Age-related macular degeneration (AMD) is a major cause of blindness in older individuals worldwide. The disease is characterized by deposition of drusen between the retinal pigment epithelium (RPE) and Bruch's membrane, RPE atrophy and death of photoreceptors. AMD is a complex disease with multiple genetic and non-genetic risk factors. Read More

View Article and Full-Text PDF

Comparative Study of Effect of Different Lever Arm Positions and Lengths on Transverse and Vertical Bowing in Lingual Orthodontics-An FEM Study.

Int Orthod 2021 Apr 9. Epub 2021 Apr 9.

Department of Orthodontics and Dentofacial Orthopedics, K.L.E. Society's Institute of Dental Sciences, Bangalore, Karnataka, India.

Objective: To assess the influence of changing the size and position of lever arm on transverse and vertical bowing effects on application of retraction forces in lingual biomechanics.

Methods: A 3D finite element method was used to simulate en masse anterior teeth retraction using lingual appliance with sliding mechanics. Two groups were made, 1st group had lever arm mesial to canine while 2nd group had distal to canine. Read More

View Article and Full-Text PDF

Super-Enhancers and CTCF in Early Embryonic Cell Fate Decisions.

Front Cell Dev Biol 2021 25;9:653669. Epub 2021 Mar 25.

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States.

Cell fate decisions are the backbone of many developmental and disease processes. In early mammalian development, precise gene expression changes underly the rapid division of a single cell that leads to the embryo and are critically dependent on autonomous cell changes in gene expression. To understand how these lineage specifications events are mediated, scientists have had to look past protein coding genes to the regulatory elements (CREs), including enhancers and insulators, that modulate gene expression. Read More

View Article and Full-Text PDF

Intervention factors associated with environmental stressors resulting from cross-provincial transfers by coal resource-based enterprises.

Environ Geochem Health 2021 Apr 9. Epub 2021 Apr 9.

School of Business, Jiangsu Normal University, No. 101 Shanghai Road, Copper Mt. District, Xuzhou, Jiangsu, China.

The environmental stressors associated with the cross-provincial transfer of coal resource-based enterprises (CREs) have become a critical concern for the green, sustainable, and high-quality development of resource-rich areas in central and western regions. This study referred to socioeconomic statistics and carried out an interview survey, literature review, and systematic analysis to clarify the mechanism underlying environmental stressors arising from the cross-provincial transfer of CREs. The intervention factors associated with such environmental stressors were identified, and the study conducted an empirical analysis of relevant data related to the coal-resources industry in three central and western provinces in China for the period 1997-2016. Read More

View Article and Full-Text PDF

Novel Specific Metallo-ß-lactamase Inhibitor, ANT2681, Restores Meropenem Activity to Clinically Effective Levels Against NDM-Positive Enterobacterales.

Antimicrob Agents Chemother 2021 Apr 5. Epub 2021 Apr 5.

Antabio SAS, Labège, France.

The global dissemination of metallo-ß-lactamase (MBL)-producing carbapenem resistant Enterobacterales (CRE) is a serious public health concern. Specifically, NDM (New Delhi MBL) has been a major cause of carbapenem therapy failures in recent years, particularly as effective treatments for serine-ß-lactamase (SBL)-producing Enterobacterales are now commercially available. Since the NDM gene is carried on promiscuous plasmids encoding multiple additional resistance determinants, a large proportion of NDM-CREs are also resistant to many commonly used antibiotics, resulting in limited and sub-optimal treatment options. Read More

View Article and Full-Text PDF

Prescription of blood pressure lowering treatment after intracerebral haemorrhage: Prospective, population-based cohort study.

Eur Stroke J 2021 Mar 3;6(1):44-52. Epub 2020 Dec 3.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Introduction: Blood pressure (BP) lowering reduces the risk of recurrent stroke after intracerebral haemorrhage (ICH). However, implementation of BP lowering in clinical practice in the UK is unknown.

Patients And Methods: We identified adults with first-ever incident ICH to quantify the proportion who survived >14 days after hospital discharge and were prescribed BP-lowering medication in a prospective, population-based, inception cohort study in the Lothian region of Scotland during June 2010-May 2012 and January-December 2019. Read More

View Article and Full-Text PDF

Cooperative -Regulatory Elements in Intestinal Cells.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Univ. Brest, Inserm, EFS, UMR 1078, GGB, F-29200 Brest, France.

About 8% of the human genome is covered with candidate -regulatory elements (cCREs). Disruptions of CREs, described as "-ruptions" have been identified as being involved in various genetic diseases. Thanks to the development of chromatin conformation study techniques, several long-range cystic fibrosis transmembrane conductance regulator () regulatory elements were identified, but the regulatory mechanisms of the gene have yet to be fully elucidated. Read More

View Article and Full-Text PDF

Possibility for Transcriptional Targeting of Cancer-Associated Fibroblasts-Limitations and Opportunities.

Int J Mol Sci 2021 Mar 24;22(7). Epub 2021 Mar 24.

Department of Genomics and Postgenomic Technologies, Gene Immunooncotherapy Group, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.

Cancer-associated fibroblasts (CAF) are attractive therapeutic targets in the tumor microenvironment. The possibility of using CAFs as a source of therapeutic molecules is a challenging approach in gene therapy. This requires transcriptional targeting of transgene expression by cis-regulatory elements (CRE). Read More

View Article and Full-Text PDF

Microstructural White Matter Alterations in Cognitively Impaired Patients at Early Stages of Multiple Sclerosis.

Clin Neuroradiol 2021 Mar 31. Epub 2021 Mar 31.

Institute of Neuroradiology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany.

Purpose: As conventional quantitative magnetic resonance imaging (MRI) parameters are weakly associated with cognitive impairment (CI) in early multiple sclerosis (MS), we explored microstructural white matter alterations in early MS or clinically isolated syndrome (CIS) comparing patients with or without CI.

Methods: Based on a preceding tract-based spatial statistics analysis (3 Tesla MRI) which contrasted 106 patients with early MS or CIS and 49 healthy controls, diffusion metrics (fractional anisotropy, FA, mean diffusivity, MD) were extracted from significant clusters using an atlas-based approach. The FA and MD were compared between patients with (Ci_P n = 14) and without (Cp_P n = 81) cognitive impairment in a subset of patients who underwent CI screening. Read More

View Article and Full-Text PDF

Incidence and Management of Effusions Before and After CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy in Large B Cell Lymphoma.

Transplant Cell Ther 2021 Mar 27;27(3):242.e1-242.e6. Epub 2020 Dec 27.

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, Florida; Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida. Electronic address:

In patients with lymphoma, third-space fluid accumulations may develop or worsen during cytokine release syndrome (CRS) associated with chimeric antigen receptor (CAR) T cell therapy. Pre-existing symptomatic pleural effusions were excluded by the ZUMA-1 trial of axicabtagene ciloleucel for large B cell lymphoma (LBCL) and variants. The incidence and management of effusions during CAR T cell therapy for LBCL are unknown. Read More

View Article and Full-Text PDF

Socioeconomic, comorbidity, lifestyle, and quality of life comparisons between chronic rhinosinusitis phenotypes.

Laryngoscope 2021 Mar 26. Epub 2021 Mar 26.

Norwich Medical School, University of East Anglia, Norfolk, UK.

Background: Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory sinonasal disorders with key defining symptoms, but traditionally separated into phenotypes by clinical/endoscopic findings. It is not known whether the two phenotypes have differing socioeconomic, comorbidity, and lifestyle differences. This analysis of the Chronic Rhinosinusitis Epidemiology Study (CRES) database sought to analyze any key differences in the socioeconomic variables between those with CRS with nasal polyps (CRSwNPs) and those without nasal polyps (CRSsNPs). Read More

View Article and Full-Text PDF

The dynamics of satisfaction in surgical and non-surgical adult spinal deformity patients.

Eur Spine J 2021 Mar 22. Epub 2021 Mar 22.

Spine Unit, Vall d'Hebron University Hospital, Barcelona, Spain.

Purpose: For adult spinal deformity (ASD) patients receiving operative (op) and non-operative (non-op) treatment, the relationship between HRQoL measures, complications and self-reported satisfaction remains unclear. The objective of this analysis is to study nonlinear association dynamics between ASD patient satisfaction, HRQoL, and complications over a two-year follow-up period.

Methods: From a prospective multicenter international adult spinal deformity database, all patients with 2-year follow-up data on satisfaction (21st question of SRS-22r) were identified and included. Read More

View Article and Full-Text PDF

'Enhancing' red cell fate through epigenetic mechanisms.

Curr Opin Hematol 2021 May;28(3):129-137

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge.

Purpose Of Review: Transcription of erythroid-specific genes is regulated by the three-dimensional (3D) structure and composition of chromatin, which dynamically changes during erythroid differentiation. Chromatin organization and dynamics are regulated by several epigenetic mechanisms involving DNA (de-)methylation, posttranslational modifications (PTMs) of histones, chromatin-associated structural proteins, and higher-order structural changes and interactions. This review addresses examples of recent developments in several areas delineating the interface of chromatin regulation and erythroid-specific lineage transcription. Read More

View Article and Full-Text PDF

Genome-wide identification of CLE gene family and their potential roles in bolting and fruit bearing in cucumber (Cucumis sativus L.).

BMC Plant Biol 2021 Mar 19;21(1):143. Epub 2021 Mar 19.

College of Horticulture, Shanxi Agricultural University, Taigu, China.

Background: Signal peptides are essential for plant growth and development. In plants, biological processes including cell-cell communication, cellular proliferation and differentiation, cellular determination of self-incompatibility, and defensive responses, all depend heavily on peptide-signaling networks such as CLE (CLAVATA3/Embryo surrounding region-related). The CLEs are indispensable in different periods of plant growth and development, especially in maintaining the balance between proliferation and differentiation of stem cells in various meristematic tissues. Read More

View Article and Full-Text PDF

In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes.

J Gen Physiol 2021 Apr;153(4)

Department of Cellular Cardiology, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.

The dyads of cardiac myocytes contain ryanodine receptors (RYRs) that generate calcium sparks upon activation. To test how geometric factors of RYR distribution contribute to the formation of calcium sparks, which cannot be addressed experimentally, we performed in silico simulations on a large set of models of calcium release sites (CRSs). Our models covered the observed range of RYR number, density, and spatial arrangement. Read More

View Article and Full-Text PDF

Clinical Outcomes in Carbapenem-Resistant Enterobacteriaceae Infections Treated With Ceftazidime-Avibactam: A Single-Center Observational Study.

Cureus 2021 Feb 2;13(2):e13081. Epub 2021 Feb 2.

Clinical Microbiology, Aster Medcity, Kochi, IND.

Introduction Among the several newer beta lactam+beta lactase inhibitors (BL/BLI), ceftazidime-avibactam is the only drug showing activity against OXA-48-like producers. Hence, it is being increasingly used in India to treat infections caused by carbapenem-resistant Enterobacteriaceae (CRE), especially as a colistin-sparing agent. We have used ceftazidime-avibactam in patients suspected and confirmed to have CRE infections in our center, and present a retrospective analysis of our experience. Read More

View Article and Full-Text PDF
February 2021

A survey of International Health Regulations National Focal Points experiences in carrying out their functions.

Global Health 2021 03 6;17(1):25. Epub 2021 Mar 6.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, 1053 Carling Avenue, Ottawa, ON, K1Y 4E9, Canada.

Background: The 2005 International Health Regulations (IHR (2005)) require States Parties to establish National Focal Points (NFPs) responsible for notifying the World Health Organization (WHO) of potential events that might constitute public health emergencies of international concern (PHEICs), such as outbreaks of novel infectious diseases. Given the critical role of NFPs in the global surveillance and response system supported by the IHR, we sought to assess their experiences in carrying out their functions.

Methods: In collaboration with WHO officials, we administered a voluntary online survey to all 196 States Parties to the IHR (2005) in Africa, Asia, Europe, and South and North America, from October to November 2019. Read More

View Article and Full-Text PDF

Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells.

Cells 2021 Feb 15;10(2). Epub 2021 Feb 15.

Endocrine Signalling Group, Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.

C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production in neurons, astrocytes and endothelial cells. CNP is implicated in the regulation of neurogenesis, axonal bifurcation, as well as learning and memory. Several neurological disorders result in toxic concentrations of ammonia (hyperammonaemia), which can adversely affect astrocyte function. Read More

View Article and Full-Text PDF
February 2021

CRISPR Deletion of a SVA Retrotransposon Demonstrates Function as a -Regulatory Element at the Intergenic Region.

Int J Mol Sci 2021 Feb 15;22(4). Epub 2021 Feb 15.

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK.

SINE-VNTR- (SVA) retrotransposons are a subclass of transposable elements (TEs) that exist only in primate genomes. TE insertions can be co-opted as -regulatory elements (CREs); however, the regulatory potential of SVAs has predominantly been demonstrated using bioinformatic approaches and reporter gene assays. The objective of this study was to demonstrate SVA -regulatory activity by CRISPR (clustered regularly interspaced short palindromic repeats) deletion and subsequent measurement of direct effects on local gene expression. Read More

View Article and Full-Text PDF
February 2021

Percutaneous fixation of acute scaphoid waist fractures: Long-term patient-reported functional outcomes and satisfaction at a mean of 11 years following surgery.

Hand Surg Rehabil 2021 Feb 27. Epub 2021 Feb 27.

Edinburgh Orthopaedics - Trauma, Royal Infirmary of Edinburgh, 51 Little France Cres, Edinburgh EH16 4SA, United Kingdom; Usher Institute, University of Edinburgh, NINE Edinburgh BioQuarter, Edinburgh. Electronic address:

The aim of this study was to report the long-term functional outcomes and complication rates following early percutaneous fixation of acute fractures of the scaphoid. A trauma database was searched to identify all skeletally-mature patients with an undisplaced or minimally-displaced scaphoid waist fracture managed with early percutaneous retrograde screw fixation over a thirteen-year period from 1997-2010. Medical records were retrospectively reviewed, and complications documented. Read More

View Article and Full-Text PDF
February 2021

Safety evaluation of recycling process used to produce recycled pulp for adult paper diapers.

Regul Toxicol Pharmacol 2021 Feb 27;122:104909. Epub 2021 Feb 27.

Unicharm Corporation, Japan.

Eight contaminants were used to perform a surrogate contamination test to evaluate safety of the process for producing recycled pulp for adult paper diapers. We performed a safety evaluation of the recycling process for producing recycled pulp following the European Food Safety Authority safety assessment for polyethylene terephthalate (PET) bottles using recycled PET. We also compared the first tier safety limit established on the basis of TTC (C) in the pulp that contained recycled pulp with residual contaminant concentrations (C). Read More

View Article and Full-Text PDF
February 2021

Mortality Associated with Bushfire Smoke Inhalation in a Captive Population of the Smoky Mouse (Pseudomys fumeus), a Threatened Australian Rodent.

J Wildl Dis 2021 Jan;57(1):199-204

Priam Psittaculture Centre, 2 Australis Place, Queanbeyan, NSW 2620, Australia.

A mortality event of nine threatened smoky mice (Pseudomys fumeus) occurred in January 2020 at a captive breeding facility in southeastern Australia that was affected at the time by hazardous levels of bushfire smoke, despite being more than 20 km from the nearest fire. Pathologic and clinical observations indicated smoke inhalation was the cause of death. All animals had significant pulmonary lesions, notably pulmonary edema and congestion, and moderate amounts of dark brown to black pigmented intracellular and extracellular particles from <0. Read More

View Article and Full-Text PDF
January 2021

Characterising open chromatin in chick embryos identifies cis-regulatory elements important for paraxial mesoderm formation and axis extension.

Nat Commun 2021 02 19;12(1):1157. Epub 2021 Feb 19.

School of Biological Sciences, Cell and Developmental Biology, University of East Anglia, Norwich Research Park, Norwich, UK.

Somites arising from paraxial mesoderm are a hallmark of the segmented vertebrate body plan. They form sequentially during axis extension and generate musculoskeletal cell lineages. How paraxial mesoderm becomes regionalised along the axis and how this correlates with dynamic changes of chromatin accessibility and the transcriptome remains unknown. Read More

View Article and Full-Text PDF
February 2021

Interrogating the Accessible Chromatin Landscape of Eukaryote Genomes Using ATAC-seq.

Methods Mol Biol 2021 ;2243:183-226

Department of Genetics, Stanford University, Stanford, CA, USA.

The ATAC-seq assay has emerged as the most useful, versatile, and widely adaptable method for profiling accessible chromatin regions and tracking the activity of cis-regulatory elements (cREs) in eukaryotes. Thanks to its great utility, it is now being applied to map active chromatin in the context of a very wide diversity of biological systems and questions. In the course of these studies, considerable experience working with ATAC-seq data has accumulated and a standard set of computational tasks that need to be carried for most ATAC-seq analyses has emerged. Read More

View Article and Full-Text PDF

The effect of prophylaxis with ertapenem versus cefuroxime/metronidazole on intestinal carriage of carbapenem-resistant or third-generation-cephalosporin-resistant Enterobacterales after colorectal surgery.

Clin Microbiol Infect 2021 Feb 12. Epub 2021 Feb 12.

Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; National Institute for Antibiotic Resistance and Infection Control, Israel Ministry of Health, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objectives: Compared to cephalosporin-based prophylaxis, ertapenem prophylaxis lowers the risk of surgical site infection among carriers of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PEs) undergoing colorectal surgery. We aimed to determine whether ertapenem prophylaxis leads to increased postoperative colonization with carbapenem-resistant Enterobacterales (CREs) and third-generation-cephalosporin-resistant Enterobacterales (3GCR-Es).

Methods: This study was nested within a quality improvement study of prophylaxis for ESBL-PE carriers undergoing colorectal surgery. Read More

View Article and Full-Text PDF
February 2021

The -regulatory codes of response to combined heat and drought stress in .

NAR Genom Bioinform 2020 Sep 21;2(3):lqaa049. Epub 2020 Jul 21.

Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA.

Plants respond to their environment by dynamically modulating gene expression. A powerful approach for understanding how these responses are regulated is to integrate information about regulatory elements (CREs) into models called regulatory codes. Transcriptional response to combined stress is typically not the sum of the responses to the individual stresses. Read More

View Article and Full-Text PDF
September 2020

ADAP is a possible negative regulator of glucosinolate biosynthesis in Arabidopsis thaliana based on clustering and gene expression analyses.

J Plant Res 2021 Mar 8;134(2):327-339. Epub 2021 Feb 8.

Centre for Bioinformatics Research, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.

Glucosinolates (GSLs) are plant secondary metabolites consisting of sulfur and nitrogen, commonly found in Brassicaceae crops, such as Arabidopsis thaliana. These compounds are known for their roles in plant defense mechanisms against pests and pathogens. 'Guilt-by-association' (GBA) approach predicts genes encoding proteins with similar function tend to share gene expression pattern generated from high throughput sequencing data. Read More

View Article and Full-Text PDF

Expanding health care coverage in Canada: a dramatic shift in the debate.

Health Econ Policy Law 2021 Feb 8:1-7. Epub 2021 Feb 8.

Professor Emeritus of Political Science and Distinguished Fellow, Munk School of Global Affairs and Public Policy, 14 Queen's Park Cres. W., 3rd Floor, Toronto, ON, CanadaM5S 3K9.

The coronavirus disease 2019 (COVID-19) pandemic has shifted the health policy debate in Canada. While the pre-pandemic focus of policy experts and government reports was on the question of whether to add outpatient pharmaceuticals to universal health coverage, the clustering of pandemic deaths in long-term care facilities has spurred calls for federal standards in long-term care (LTC) and its possible inclusion in universal health coverage. This has led to the probability that the federal government will attempt to expand medicare as Canadians have known it for the first time in over a half century. Read More

View Article and Full-Text PDF
February 2021

Enhancer-mediated reporter gene expression in Arabidopsis thaliana: a forward genetic screen.

Plant J 2021 Feb 6. Epub 2021 Feb 6.

Department of Plant Biology, Michigan State University, East Lansing, MI, 48824, USA.

Gene expression is controlled and regulated by interactions between cis-regulatory DNA elements (CREs) and regulatory proteins. Enhancers are one of the most important classes of CREs in eukaryotes. Eukaryotic genes, especially those related to development or responses to environmental cues, are often regulated by multiple enhancers in different tissues and/or at different developmental stages. Read More

View Article and Full-Text PDF
February 2021