4,923 results match your criteria creation functional

Unraveling Impacted Maxillary Incisors: The Why, When, and How.

Int J Clin Pediatr Dent 2021 Jan-Feb;14(1):149-157

Department of Orthodontics and Dentofacial Orthopaedics, ITS Center for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India.

Failure of eruption of maxillary incisors requires careful diagnosis and treatment planning. The cause of impaction may vary from physical obstruction in the path of eruption, tooth material arch length discrepancy to malformation of the tooth. General principles of management of the condition include removal of physical obstruction, creation of space, and surgical exposure with or without traction. Read More

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Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Department of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel;

The lymphatic system is involved in various biological processes, including fluid transport from the interstitium into the venous circulation, lipid absorption, and immune cell trafficking. Despite its critical role in homeostasis, lymphangiogenesis (lymphatic vessel formation) is less widely studied than its counterpart, angiogenesis (blood vessel formation). Although the incorporation of lymphatic vasculature in engineered tissues or organoids would enable more precise mimicry of native tissue, few studies have focused on creating engineered tissues containing lymphatic vessels. Read More

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Creation of a vascular inducing device using mesenchymal stem cells to induce angiogenesis.

J Biosci Bioeng 2021 Jul 26. Epub 2021 Jul 26.

Department of Cell and Developmental Biology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Givat Ram Campus, Jerusalem 91904, Israel. Electronic address:

Conventional treatments of peripheral vascular disease and coronary artery disease have partial success but are still limited. Methods to deliver angiogenic factors into ischemic areas using gene, protein and cell therapies are faced with difficult issues such a delivery, effective concentration and duration of action. Tissue engineering offers the possibility of creating a functional self-contained three-dimensional (3D) unit that works as a coordinated biological pump that can secrete a whole range of angiogenic factors. Read More

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High Interfacial-Energy and Lithiophilic Janus Interphase Enables Stable Lithium Metal Anodes.

Small 2021 Jul 29:e2102196. Epub 2021 Jul 29.

College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

The stability of solid electrolyte interphase (SEI) layers is critical for developing lithium (Li) metal batteries. However, the fabrication of stable SEI layers is plagued by un-controlled structures, properties, and functions. Here a controllable design of an ordered LiF-rich and lithiophilic hybrid Janus interphase (LiF-HJI) is reported using organic fluorination reagent as a functional SEI precursor. Read More

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Inhibition of Lysyl Oxidase with β-aminopropionitrile Improves Venous Adaptation after Arteriovenous Fistula Creation.

Kidney360 2021 Feb;2(2):270-278

DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.

Background: The arteriovenous fistula (AVF) is the preferred hemodialysis access for end-stage renal disease (ESRD) patients. Yet, establishment of a functional AVF presents a challenge, even for the most experienced surgeons, since postoperative stenosis frequently occludes the AVF. Stenosis results from the loss of compliance in fibrotic areas of the fistula which turns intimal hyperplasia into an occlusive feature. Read More

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February 2021

Multicenter European Real-World Utilization of VasQ™ Anastomotic External Support Device for Arteriovenous Fistulae.

J Vasc Surg 2021 Jul 24. Epub 2021 Jul 24.

Department of Angiology and Vascular Surgery, Clinica Sagrada Familia, Barcelona, Spain.

Objectives: To evaluate the outcomes of arteriovenous fistulae (AVF), created with VasQ™ external support device under standard clinical practice across three vascular access clinics.

Methods: This was a multi-national, retrospective study to evaluate prospectively collected clinical outcomes of both forearm and upper-arm brachiocephalic AVF (BCAVF) created using the VasQ™ device. 51 AVF patients were pooled from three different vascular access centers in Germany, Italy and Spain. Read More

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Deep Brain Stimulation of Caudal Zona Incerta for Parkinson's Disease: One-Year Follow-Up and Electric Field Simulations.

Neuromodulation 2021 Jul 27. Epub 2021 Jul 27.

Department of Clinical Science, Neuroscience, Umeå University, Umeå, Sweden.

Objective: To evaluate the effects of bilateral caudal zona incerta (cZi) deep brain stimulation (DBS) for Parkinson's disease (PD) one year after surgery and to create anatomical improvement maps based on patient-specific simulation of the electric field.

Materials And Methods: We report the one-year results of bilateral cZi-DBS in 15 patients with PD. Patients were evaluated on/off medication and stimulation using the Unified Parkinson's Disease Rating Scale (UPDRS). Read More

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Utilization of Nanotechnology to Improve the Application and Bioavailability of Phytochemicals Derived from Waste Streams.

J Agric Food Chem 2021 Jul 26. Epub 2021 Jul 26.

Department of Food Engineering, Faculty of Engineering, Yeditepe University, Istanbul 34755, Turkey.

Phytochemicals are relatively small molecular species found in edible plants that may exhibit a diverse range of techno- and biofunctional attributes. In particular, there has been great interest in the identification, isolation, and utilization of dietary phytochemicals that can be used as natural pigments, antioxidants, or antimicrobials or that may improve human health and wellbeing by preventing chronic diseases, such as cardiovascular diseases, diabetes, obesity, and cancer. Relatively high levels of these phytochemicals are often present in the waste streams produced by the food and agriculture industry, such as the peels, stems, roots, or leaves of plants, that are normally discarded or turned into animal foods. Read More

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Study on the assessment of humification processes during biodegradation of heavy residual fuel oil.

Sci Total Environ 2021 Jul 17;797:149099. Epub 2021 Jul 17.

BREM GROUP Ltd., Oslobođenja 39b, 11090 Belgrade, Serbia.

The aim of this study was to investigate the creation of humic substances during biodegradation of heavy residual fuel oil, because there are indications that substances similar to humic substances are generated during biodegradation of polycyclic aromatic hydrocarbons. In the study, which lasted for 110 days, biodegradation of heavy residual fuel oil was carried out in a layer of artificial soil substrate. The initial concentration of the total petroleum hydrocarbon in the prepared artificial soil substrate (biopile) was 23. Read More

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A Comparison of Outcomes Between Open and Endovascular Arteriovenous Access Creation for Hemodialysis.

J Vasc Surg 2021 Jul 22. Epub 2021 Jul 22.

Division of Vascular Surgery, Department of Surgery, Vancouver General Hospital, Vancouver, BC, Canada.

Objective: Preliminary outcomes for percutaneous endovascular autogenous access (endoAVF) have shown promising results; however, comparisons with surgical cohorts in dialysis populations are lacking. This study compares autogenous arteriovenous access created with the EverlinQ endoAVF system with accesses created by conventional surgical technique with respect to functional and patency related outcomes.

Methods: This is a multicenter, retrospective review of autogenous arteriovenous accesses entered into a prospective database. Read More

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Binding mode transformation and biological activity on the Ru(II)-DMSO complexes bearing heterocyclic pyrazolyl ligands.

J Inorg Biochem 2021 Jul 16;223:111545. Epub 2021 Jul 16.

Department of Medicinal and Applied Chemistry, Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address:

Three Ru(II)-DMSO complexes (1-3) containing 2-(3-pyrazolyl)pyridine (PzPy), 2-pyrazol-3-ylfuran (PzO), or 2-pyrazol-3-ylthiophene (PzS) ligand, were synthesized and characterized. The monodentate coordination of the heterocyclic pyrazolyl ligand (Pz) with Ru(II) ion via N atom was confirmed by single crystal X-ray diffraction. Complex 1 could be converted to the known η-bidentate Pz complex cis(Cl), cis(S)-[RuCl(Pz)(DMSO)] (4) under reflux conditions. Read More

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Deep Learning Method to Accelerate Discovery of Hybrid Polymer-Graphene Composites.

Sci Rep 2021 Jul 23;11(1):15111. Epub 2021 Jul 23.

C-Crete Technologies LLC, Stafford, TX, 77477, USA.

Interfacial encoded properties of polymer adlayers adsorbed on the graphene (GE) and silicon dioxide (SiO) have been constituted a scaffold for the creation of new materials. The holistic understanding of nanoscale intermolecular interaction of 1D/2D polymer assemblies on substrate is the key to bottom-up design of molecular devices. We develop an integrated multidisciplinary approach based on electronic structure computation [density functional theory (DFT)] and big data mining [machine learning (ML)] in parallel with neural network (NN) and statistical analysis (SA) to design hybrid polymers from assembly on substrate. Read More

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Shadow Burden of Undiagnosed Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) on Society: Retrospective and Prospective-In Light of COVID-19.

J Clin Med 2021 Jul 6;10(14). Epub 2021 Jul 6.

Institute of Microbiology and Virology, Riga Stradins University, 5 Ratsupites Str, LV-1067 Riga, Latvia.

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a poorly understood, complex, multisystem disorder, with severe fatigue not alleviated by rest, and other symptoms, which lead to substantial reductions in functional activity and quality of life. Due to the unclear aetiology, treatment of patients is complicated, but one of the initial problems is the insufficient diagnostic process. The increase in the number of undiagnosed ME/CFS patients became specifically relevant in the light of the COVID-19 pandemic. Read More

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Oncolytic Virus-Induced Autophagy in Glioblastoma.

Cancers (Basel) 2021 Jul 12;13(14). Epub 2021 Jul 12.

Group of Experimental Biotherapy and Diagnostic, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.

Autophagy is a catabolic process that allows cells to scavenge damaged organelles and produces energy to maintain cellular homeostasis. It is also an effective defense method for cells, which allows them to identify an internalized pathogen and destroy it through the fusion of the autophagosome and lysosomes. Recent reports have demonstrated that various chemotherapeutic agents and viral gene therapeutic vehicles provide therapeutic advantages for patients with glioblastoma as monotherapy or in combination with standards of care. Read More

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biotransformation of tea using tannase produced by 41.

J Food Sci Technol 2021 Aug 21;58(8):3235-3242. Epub 2021 Feb 21.

Laboratory of Bio-Pesticide Creation and Application of Guangdong Province, College of Agriculture, South China Agricultural University, Guangzhou, 510642 People's Republic of China.

Tannase is a widely used enzyme that improves the quality of tea by facilitating the release of water-soluble polyphenolic compounds, as well as reduces the formation of tea creams. The microbial tannase enzymes are often employed for tea biotransformation by hydrolyses esters of phenolic acids, including the gallated polyphenols found in blacks teas. The study was focused to investigate the tannase enzyme mediated biotransformation of black tea such as CTC-(Crush, tear, curl) & Kangra orthodox which are commonly used by the south Indian peoples. Read More

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First-principles correction scheme for linear-response time-dependent density functional theory calculations of core electronic states.

J Chem Phys 2021 Jul;155(3):034108

Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

Linear-response time-dependent density functional theory (LR-TDDFT) for core level spectroscopy using standard local functionals suffers from self-interaction error and a lack of orbital relaxation upon creation of the core hole. As a result, LR-TDDFT calculated x-ray absorption near edge structure spectra needed to be shifted along the energy axis to match experimental data. We propose a correction scheme based on many-body perturbation theory to calculate the shift from first-principles. Read More

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Recent advances in the application of isoindigo derivatives in materials chemistry.

Beilstein J Org Chem 2021 6;17:1533-1564. Epub 2021 Jul 6.

A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov St., Kazan 420088, Russian Federation.

In this review, the data on the application of isoindigo derivatives in the chemistry of functional materials are analyzed and summarized. These bisheterocycles can be used in the creation of organic solar cells, sensors, lithium ion batteries as well as in OFET and OLED technologies. The potentials of the use of polymer structures based on isoindigo as photoactive component in the photoelectrochemical reduction of water, as matrix for MALDI spectrometry and in photothermal cancer therapy are also shown. Read More

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Function Follows Form: Using the Aesthetic Association Principle to Enhance Haptic Interface Design.

Front Psychol 2021 5;12:646986. Epub 2021 Jul 5.

Bamberg Graduate School of Affective and Cognitive Sciences (BaGrACS), Bamberg, Germany.

Novel tangible user interface technologies facilitate current trends toward seamless user interfaces. They enable the design of yet unseen interfaces and thus the creation of a new kind of haptic language. In order to use the benefits of a touch-and-feel design for a positive user experience, carefully designed haptic feedback plays an important role by providing aesthetically pleasing and sustainable product features. Read More

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Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide.

Food Chem 2021 Jul 9;366:130563. Epub 2021 Jul 9.

Department of Ecosystem Science and Management and Materials Research Institute, 204 Energy and the Environment Laboratory, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address:

Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide. The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent. During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide. Read More

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Controlling the Structure and Function of Protein Thin Films through Amyloid-like Aggregation.

Acc Chem Res 2021 Jul 20. Epub 2021 Jul 20.

Key of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China.

ConspectusProtein thin films (PTFs) with tunable structure and function can offer multiple opportunities in various fields such as surface modification, biomaterials, packaging, optics, electronics, separation, energy, and environmental science. Although nature may offer a variety of examples of high-level control of structure and function, e.g. Read More

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Embryo Microinjection and Knockout Mutant Identification of CRISPR/Cas9 Genome-Edited Helicoverpa Armigera (Hübner).

J Vis Exp 2021 Jul 1(173). Epub 2021 Jul 1.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences; Guangdong Laboratory of Lingnan Modern Agriculture, Shenzhen; Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences;

The cotton bollworm, Helicoverpa armigera, is one of the most destructive pests in the world. A combination of molecular genetics, physiology, functional genomics, and behavioral studies has made H. armigera a model species in Lepidoptera Noctuidae. Read More

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Ag(I) Pyridine-Amidoxime Complex as the Catalysis Activity Domain for the Rapid Hydrolysis of Organothiophosphate-Based Nerve Agents: Mechanistic Evaluation and Application.

ACS Appl Mater Interfaces 2021 Jul 19;13(29):34428-34437. Epub 2021 Jul 19.

Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry and Frontier Science Center for the Creation of New Organic Substances, Nankai University, Tianjin 300071, China.

Two novel Ag(I) complexes containing synergistic pyridine and amidoxime ligands (Ag-DPAAO and Ag-PAAO) were first designed as complex monomers. Taking advantage of the molecular imprinting technique and solvothermal method, molecular imprinted porous cross-linked polymers (MIPCPs) were developed as a robust platform for the first time to incorporate Ag-PAAO into a polymer material as a recyclable catalyst. Advantageously, the observed pseudo first-order rate constant () of MIPCP-Ag-PAAO-20% for ethyl-parathion () hydrolysis is about 1. Read More

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Irrationality and economic morality of SMEs' behavior during the Covid-19 pandemic: lesson from Indonesia.

Heliyon 2021 Jul 25;7(7):e07400. Epub 2021 Jun 25.

Faculty of Economics, Universitas Negeri Malang, Indonesia.

The Covid-19 pandemic provides severe consequences of economic behavior as an increase of unemployment rates, and providing a new business creation can continue the economic activities. This study explores a functional relationship between irrational behavior, which proxied by loss aversion, the endowment effect, and herd behavior toward the morality of economic among small and medium enterprises (SMEs), as well as the mediating role of altruism in the perspectives of behavioral economics. The research involved a quantitative survey and cross-sectional data with a sample of 288 SMEs in East Java of Indonesia. Read More

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Two Techniques for Treating Medium-Sized Supraspinatus Tears: The Medially Based Single-Row Technique and the Suture Bridge Technique.

Kotaro Yamakado

JBJS Essent Surg Tech 2021 Apr-Jun;11(2). Epub 2021 Jun 8.

Department of Orthopaedics, Fukui General Hospital, Fukui, Japan.

Background: Arthroscopic rotator cuff repair emerged in the early 1990s, and the single-row repair technique (i.e., suture anchor[s] set at the center or laterally on the greater tuberosity) has shown promising outcomes; however, the healing rate of the repaired cuff is suboptimal. Read More

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Outcome After Pollicization for Congenital Thumb Deficiency: A Cohort Study of Cases in a Single Unit, 1987 to 2016.

J Hand Surg Am 2021 Jul 15. Epub 2021 Jul 15.

Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.

Purpose: To investigate the functional and aesthetic outcomes in a cohort with pollicizations performed due to congenital anomalies in our hospital.

Methods: From 1987 to 2016, we performed pollicizations in 32 hands of children aged 1 to 8 years (median, 2 years). We followed-up on 31 of the hands from 1 to 31 years (median, 10 years) after the procedure. Read More

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Indications, functional and quality of life outcomes of new pouch creation during re-do ileal pouch anal anastomosis: A comparative study with existing pouch salvage.

Surgery 2021 Jul 13. Epub 2021 Jul 13.

Inflammatory Bowel Disease Center, NYU Langone Health, NYU Grossman School of Medicine, New York, NY. Electronic address:

Background: Salvage of the existing ileal pouch is favored during re-do ileal pouch anal anastomosis if the pouch is not damaged after pelvic dissection and there are no other mechanical reasons that may necessitate construction of a new pouch. Excision of the existing pouch may be associated with some concerns for short-bowel syndrome and poor functional outcomes. This study aimed to report indications and compare functional and quality of life outcomes of new pouch creation versus salvage of the existing pouch during re-do ileal pouch anal anastomosis. Read More

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Utility and health-related quality of life measures in adult Colombian patients with solid tumours.

Ecancermedicalscience 2021 3;15:1240. Epub 2021 Jun 3.

Proyéctame Group, Transversal 60#124-20 Oficina 210, Colombia.

According to a 2020 report, the World Health Organization explained how, in 20 years, the prevalence of cancer cases will increase by 60% worldwide. In lower-middle-income countries, this figure will be 74.07%. Read More

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The Taxus genome provides insights into paclitaxel biosynthesis.

Nat Plants 2021 Jul 15. Epub 2021 Jul 15.

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Shenzhen Key Laboratory of Agricultural Synthetic Biology, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.

The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of Taxus chinensis var. mairei with a total length of 10. Read More

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Long term relationship between farming damselfish, predators, competitors and benthic habitat on coral reefs of Moorea Island.

Sci Rep 2021 Jul 15;11(1):14548. Epub 2021 Jul 15.

PSL Research University: EPHE-UPVD-CNRS, USR 3278 CRIOBE BP 1013, 98729, Papetoai, Moorea, French Polynesia.

Understanding the processes that shape biodiversity is essential for effective environmental management. Across the world's coral reefs, algal farming damselfish (Stegastes sp.) modify the surrounding benthic community through their creation of algae "farms". Read More

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[AgPd(PPh)Cl]: A new family of synthesizable bi-icosahedral superatomic molecules.

J Chem Phys 2021 Jul;155(2):024302

Research Institute for Science and Technology, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

Icosahedral noble-metal 13-atom nanoclusters (NCs) can form connected structures, which can be regarded as superatomic molecules, by vertex sharing. However, there have been very few reports on the superatomic molecules formed using silver (Ag) as the base element. In this study, we synthesized [AgPd(PPh)Cl] (Pd = palladium, PPh = triphenylphosphine, Cl = chloride), in which two icosahedral 13-atom NCs are connected, and elucidated its geometric and electronic structures to clarify what type of superatomic molecules can be synthesized. Read More

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