16,276 results match your criteria craniofacial surgery

Characteristics of craniofacial morphology and factors affecting them in patients with isolated cleft palate.

PeerJ 2021 20;9:e11297. Epub 2021 Apr 20.

Section of Orthodontics and Dentofacial Orthopedics, Faculty of Dental Science, Kyushu University, Fukuoka, Fukuoka, Japan.

Background: Myriad maxillo-mandibular occlusal relationships are observed in patients with isolated cleft palate (ICP), unlike in patients with other cleft types, such as cleft lip and palate.

Objectives: This study aimed to categorise the characteristics of craniofacial morphology in patients with ICP, and investigate the clinical factors affecting these categorised morphological characteristics.

Methods: Thirty-six girls with ICP (age (mean ± SD): 5. Read More

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Augmented reality navigation method for recontouring surgery of craniofacial fibrous dysplasia.

Sci Rep 2021 May 11;11(1):10043. Epub 2021 May 11.

Department of Oral and Craniomaxillofacial Surgery, Shanghai 9Th People's Hospital, Shanghai Jiaotong University College of Medicine, Shanghai, China.

The objective of this study is to introduce the application of augmented reality (AR) navigation system developed by the authors in recontouring surgery of craniofacial fibrous dysplasia. Five consecutive patients with craniofacial fibrous dysplasia were enrolled. Through three-dimensional (3D) simulation, a virtual plan was designed to reconstruct the normal anatomical contour of the deformed region. Read More

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Empty Sella Syndrome Associated with Growth Hormone Deficiency: the First Case Report of Weiss-Kruszka Syndrome.

J Korean Med Sci 2021 May 10;36(18):e133. Epub 2021 May 10.

Department of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.

Weiss-Kruszka syndrome (WSKA), caused by heterozygous loss-of-function variants in gene, is a recently described and extremely rare genetic disorder. The main phenotypes include characteristic craniofacial features, ptosis, dysgenesis of the corpus callosum, and neurodevelopmental impairment. We report the first Korean boy with molecularly confirmed WSKA presenting with an atypical manifestation. Read More

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Tomographic similarity scan with a computed modified absolute mandibular midsagittal plane for precise and objective localization of mandibular asymmetry.

Comput Biol Med 2021 May 4;134:104465. Epub 2021 May 4.

Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, 03722, Republic of Korea. Electronic address:

The application of 3D imaging is at its cusp in craniofacial diagnosis and treatment planning. However, most applications are limited to simple subjective superimposition-based analysis. As the diagnostic accuracy dictates the precision in operability, we propose a novel method that enables objective clinical decision making for patients with mandibular asymmetry. Read More

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Rethinking Farkas: Updating Cephalic Index Norms in a Large, Diverse Population.

Plast Reconstr Surg 2021 May 10. Epub 2021 May 10.

From the Division of Plastic Surgery, Department of Surgery, and the Department of Quantitative Health Sciences, Division of Biostatistics, University of Massachusetts Medical School.

Background: Cephalic index, the ratio of head width to length, is frequently used in decision-making in craniofacial surgery. Insurers derive criteria for helmet authorization for plagiocephaly based on deviations from norms, with one indicator being cephalic index. Current cephalic index norms were established by the Farkas and Munro data set, a small sample of Caucasian children published in 1987. Read More

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Audiologic and Otologic Clinical Manifestations of Loeys-Dietz Syndrome: A Heritable Connective Tissue Disorder.

Otolaryngol Head Neck Surg 2021 May 11:1945998211008899. Epub 2021 May 11.

Office of the Clinical Director, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA.

Objective: Loeys-Dietz syndrome (LDS) is a rare genetic connective tissue disorder resulting from TGF-ß signaling pathway defects and characterized by a wide spectrum of aortic aneurysm, arterial tortuosity, and various extravascular abnormalities. This study describes the audiologic, otologic, and craniofacial manifestations of LDS.

Study Design: Consecutive cross-sectional study. Read More

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Log odds of positive lymph nodes as an independent predictor of overall survival in oral squamous cell carcinoma.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):576. Epub 2021 Jan 9.

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Mangalore, A Constituent Unit of Manipal Academy of Higher Education, Manipal, Karnataka, India.

Context: Log odds of positive lymph nodes (LODDS) have been recently demonstrated as a very promising staging model and have outperformed AJCC pN, lymph node ratio (LNR) category in major cancers. Literature is scarce concerning the prognostic ability of LODDS in oral squamous cell carcinoma (OSCC) patients.

Aims: The present study was aimed to evaluate the importance of LODDS in predicting locoregional recurrence and overall survival (OS) in patients with OSCC compared to LNR. Read More

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January 2021

Regenerative potential of perichondrium - a tissue engineering perspective.

Tissue Eng Part B Rev 2021 May 8. Epub 2021 May 8.

Ruprecht Karls Universitat Heidelberg, 9144, Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty Mannheim, Mannheim, Germany;

The clinical relevance of perichondrium was recognized more than a century ago. In children and adolescents, perichondrium is essential for the formation and growth of the cartilaginous part of craniofacial features and must be considered during reconstructive surgery in the head and neck area. Also in adults, perichondrium must be preserved during surgical intervention for adequate postoperative healing and cartilage maintenance. Read More

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Lefort II distraction with zygomatic repositioning versus Lefort III distraction: A comparison of surgical outcomes and complications.

J Craniomaxillofac Surg 2021 Apr 28. Epub 2021 Apr 28.

Craniofacial Center, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA. Electronic address:

The aim of the study was to determine if the additional surgical complexity of Lefort II distraction with zygomatic repositioning (LF2ZR) results in increased complications compared to Lefort III distraction (LF3). A retrospective review was performed of all LF3 and LF2ZR advancements performed by the senior author over 15 years. Demographic, operative, postoperative, and cephalometric data were collected from initial procedure through greater than 1 year postoperatively. Read More

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The clinical significance and correlative signaling pathways of paired box gene 9 in development and carcinogenesis.

Biochim Biophys Acta Rev Cancer 2021 May 6:188561. Epub 2021 May 6.

Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Sundergarh, Odisha, India. Electronic address:

Paired box 9 (PAX9) gene belongs to the PAX family, which encodes a family of metazoan transcription factors documented by a conserved DNA binding paired domain 128-amino-acids, critically essential for physiology and development. It is primarily expressed in embryonic tissues, such as the pharyngeal pouch endoderm, somites, neural crest-derived mesenchyme, and distal limb buds. PAX9 plays a vital role in craniofacial development by maintaining the odontogenic potential, mutations, and polymorphisms associated with the risk of tooth agenesis, hypodontia, and crown size in dentition. Read More

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A novel mouse model for SNP in Steroid Receptor Co-activator-1 reveals role in bone density and breast cancer metastasis.

Endocrinology 2021 May 8. Epub 2021 May 8.

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh PA.

The steroid receptor coactivator-1 (SRC-1) is a nuclear receptor co-activator, known to play key roles in both estrogen response in bone and in breast cancer metastases. We previously demonstrated that the P1272S SNP (P1272S; rs1804645) in SRC-1 decreases the activity of estrogen receptor in the presence of selective estrogen receptor modulators (SERM) and that it is associated with a decrease in bone mineral density (BMD) after tamoxifen therapy, thus suggesting it may disrupt the agonist action of tamoxifen. Given such dual roles of SRC-1 in the bone microenvironment and in tumor cell-intrinsic phenotypes, we hypothesized that SRC-1 and a naturally occurring genetic variant, P1272S may promote breast cancer bone metastases. Read More

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Evaluation of the optimal cooling temperature for the face measured by the tissue perfusion during hilotherapy using laser Doppler spectrophotometry.

Sci Rep 2021 May 7;11(1):9805. Epub 2021 May 7.

Department of Oral, Maxillofacial and Facial Plastic Surgery, School of Medicine, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.

After craniofacial trauma, symptoms like swelling and pain occur. Cooling reduces these symptoms but the optimal cooling temperature for a maximum benefit without adverse effects is unclear. 30 participants were cooled at 10 °C, 15 °C, 20 °C, 25 °C and 30 °C for 30 min. Read More

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Simultaneous Midface Advancement and Orthognathic Surgery: A Powerful Technique for Managing Midface Hypoplasia and Malocclusion.

Plast Reconstr Surg 2021 May 6. Epub 2021 May 6.

Department of Plastic and Reconstructive Surgery and Craniofacial Research Center Chang Gung Memorial Hospital Chang Gung University Taoyuan, Taiwan.

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Reply: Effect of Cyclic Compressive Forces on New Bone Formation during the Distraction Period in Mandibular Distraction Osteogenesis Using a Microactuator-Generated Distractor.

Plast Reconstr Surg 2021 May 6. Epub 2021 May 6.

Division of Anatomy and Developmental Biology Department of Oral Biology Human Identification Research Institute BK21 PLUS Project Yonsei University College of Dentistry eoul, Republic of Korea.

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Objective measurements for upper airway obstruction in infants with Robin sequence: what are we measuring? A systematic review.

J Clin Sleep Med 2021 May 7. Epub 2021 May 7.

Department of Plastic and Reconstructive Surgery, Amsterdam University Medical Centre, location AMC & VU, Emma Children's Hospital, Amsterdam, The Netherlands.

Study Objectives: Identifying optimal treatment for infants with Robin sequence (RS) is challenging due to substantial variability in the presentation of upper airway obstruction (UAO) in this population. Objective assessments of UAO and treatments are not standardized. A systematic review of objective measures of UAO was conducted as step towards evidence based clinical decision making for RS. Read More

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Readability of Online Patient Information Relating to Cleft Palate Surgery.

Cleft Palate Craniofac J 2021 May 7:10556656211013177. Epub 2021 May 7.

Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Objective: It is important for health care education materials to be easily understood by caretakers of children requiring craniofacial surgery. This study aimed to analyze the readability of Google search results as they pertain to "Cleft Palate Surgery" and "Palatoplasty." Additionally, the study included a search from several locations globally to identify possible geographic differences. Read More

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Recent update on craniofacial tissue engineering.

J Tissue Eng 2021 Jan-Dec;12:20417314211003735. Epub 2021 Apr 20.

Division of Craniofacial and Surgical Care, University of North Carolina (UNC) School of Dentistry, Chapel Hill, NC, USA.

The craniofacial region consists of several different tissue types. These tissues are quite commonly affected by traumatic/pathologic tissue loss which has so far been traditionally treated by grafting procedures. With the complications and drawbacks of grafting procedures, the emerging field of regenerative medicine has proved potential. Read More

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Ectopia Cordis Sternal Cleft Repair With Mandibular Distractors: A Follow-Up Case Report.

World J Pediatr Congenit Heart Surg 2021 May 6:2150135120978951. Epub 2021 May 6.

Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

A neonate with thoracic ectopia cordis presented following an uncomplicated delivery. A mandibular distractor was placed to bridge the sternal cleft and retracted (reverse distractor activation) over 24 days to facilitate sternal closure. Follow-up at five years postoperatively demonstrated a well-healed sternum. Read More

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Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model.

Bioconjug Chem 2021 May 6. Epub 2021 May 6.

Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States.

We describe the design and synthesis of OFS-1, an Osteoadsorptive Fluorogenic Sentinel imaging probe that is adsorbed by hydroxyapatite (HAp) and bone mineral surfaces, where it generates an external fluorescent signal in response to osteoclast-secreted cathepsin K (Ctsk). The probe consists of a bone-anchoring bisphosphonate moiety connected to a Förster resonance energy transfer (FRET) internally quenched fluorescent (IQF) dye pair, linked by a Ctsk peptide substrate, GHPGGPQG. Key structural features contributing to the effectiveness of OFS-1 were defined by structure-activity relationship (SAR) and modeling studies comparing OFS-1 with two cognates, OFS-2 and OFS-3. Read More

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Septum submucosal glands exhibit aberrant morphology and reduced mucin production in chronic rhinosinusitis.

Int Forum Allergy Rhinol 2021 May 6. Epub 2021 May 6.

Program in Craniofacial Biology, University of California, San Francisco, San Francisco, California, USA.

Background: Chronic rhinosinusitis (CRS) is characterized by significant accumulation and thickening of mucus in the sinonasal cavities. One contributor of aberrant mucus production and impaired mucociliary clearance (MCC) is altered function of the sinonasal submucosal glands (SMGs), yet contributions of SMGs to upper airway disease initiation and progression remain unknown. The objective of this study was to characterize the morphology and secretory cell identities of the nasal septum SMGs in both healthy and CRS adults. Read More

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Does the Timing of 1-Stage Palatoplasty With Radical Muscle Dissection Effect Long-Term Midface Growth? A Single-Center Retrospective Analysis.

Cleft Palate Craniofac J 2021 May 6:10556656211013174. Epub 2021 May 6.

Chairman, Klinik Professor Sailer, Zurich, Switzerland.

Objective: To evaluate the long-term effect of timing of 1-stage palatoplasty on midfacial growth in patients with cleft lip and palate (CLP).

Design: Retrospective observational cohort study.

Study Setting: Institutional hospital. Read More

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Camouflage Treatment for Skeletal Maxillary Protrusion and Lateral Deviation with Classic-Type Ehlers-Danlos Syndrome.

Acta Med Okayama 2021 Apr;75(2):205-212

Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar "cigarette-paper" scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. Read More

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Mesenchymal stem cells and platelet-rich plasma-impregnated polycaprolactone-β tricalcium phosphate bio-scaffold enhanced bone regeneration around dental implants.

Int J Implant Dent 2021 May 5;7(1):35. Epub 2021 May 5.

Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Korea.

Background: Finding a material that supports bone regeneration is the concern for many investigators. We supposed that a composite scaffold of poly(ε) caprolactone and β-tricalcium phosphate (PCL-TCP) would entail desirable characteristics of biocompatibility, bioresorbability, rigidity, and osteoconductivity for a proper guided bone regeneration. Furthermore, the incorporation of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) would boost the bone regeneration. Read More

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One-splint versus two-splint technique in orthognathic surgery for class III asymmetry: comparison of patient-centred outcomes.

Clin Oral Investig 2021 May 5. Epub 2021 May 5.

Craniofacial Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Objectives: Two-jaw orthognathic surgery (OGS) is done using either the one-splint technique with free-hand positioning of the maxillomandibular complex or the two-splint technique with intermediate splints to position the maxilla. It is uncertain which technique achieves better outcomes. This study compares frontal soft tissue symmetry and subjective patient QoL between one-splint and two-splint techniques in skeletal Class III asymmetry patients undergoing OGS with three-dimensional surgical planning. Read More

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Application of cryopreservation to tooth germ transplantation for root development and tooth eruption.

Sci Rep 2021 May 4;11(1):9522. Epub 2021 May 4.

Division of Craniofacial Development and Tissue Biology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

We cryopreserved mouse tooth germs with widely open cervical margins of the enamel organ to overcome difficulties in cryoprotectant permeation and tested their efficacy by transplanting them into recipient mice. The upper right first molar germs of 8-day-old donor mice were extracted and categorized into the following four groups according to cryopreservation time: no cryopreservation, 1 week, 1 month, and 3 months. The donor tooth germs were transplanted into the upper right first molar germ sockets of the 8-day-old recipient mice. Read More

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Speech Characteristics and Oromyofunctional Outcomes in Two Bimaxillary Face Transplantation Patients in Helsinki.

Laryngoscope 2021 May 4. Epub 2021 May 4.

Department of Plastic Surgery, Töölö Hospital, Helsinki University Hospital (HUS), University of Helsinki, Helsinki, Finland.

Objectives/hypothesis: Facial functional restoration is one of the main goals in face transplantation. We report the oromyofacial function outcomes of two bimaxillary face transplantation (FT) patients in Helsinki.

Study Design: Outcome Study. Read More

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Goldenhar Syndrome With Ankylosis of the Temporomandibular Joint: A Case Report.

Lauren M Partyka

A A Pract 2021 May 4;15(5):e01461. Epub 2021 May 4.

From the Department of Anesthesiology, The University of Iowa, Iowa City, Iowa.

Goldenhar syndrome, or oculoauriculovertebral dysplasia, represents approximately 10% of craniofacial microsomia anomalies. These patients have a variety of clinical features that are relevant to anesthesia providers, including a high-arched palate, mandibular hypoplasia, micrognathia, and temporomandibular joint (TMJ) malformation. The oral manifestations of Goldenhar syndrome range from malocclusion to complex TMJ involvement. Read More

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Revisiting the unrepaired unilateral cleft lip and nasal deformity using 3D surface image analysis: A data-driven model and its implications.

J Plast Reconstr Aesthet Surg 2021 Mar 30. Epub 2021 Mar 30.

Division of Craniofacial and Plastic Surgery, Department of Surgery, Seattle Children's Hospital, Seattle, WA, USA.

Background: Current descriptions of the unilateral cleft lip and nasal deformity (uCLND) are based upon limited sample sets and subjective observations. While those descriptions are inconsistent and contradictory, theoretical models, including Hogan's "tilted tripod" and Fisher's "nasal arch forms", have never been tested. Given that favorable outcomes of treatment remain elusive, detailed study of the deformity is critical in devising better treatments. Read More

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The influences of distraction osteogenesis therapy on airway morphology in patients with craniofacial microsomia.

J Craniomaxillofac Surg 2021 Apr 20. Epub 2021 Apr 20.

Department of Maxillofacial Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Science, Peking Union Medical College, China. Electronic address:

The aim of this study was to explore how mandibular distraction osteogenesis influences morphological changes in the oropharynx and laryngopharynx. This was a retrospective study of airway parameter measurements in CFM patients undergoing mandibular distraction osteogenesis treatment. The indication for surgical treatment was the obvious facial asymmetry. Read More

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SH3BP2-related fibro-osseous disorders of the maxilla and mandible: A systematic review.

Int J Oral Maxillofac Surg 2021 Apr 30. Epub 2021 Apr 30.

Division of Plastic and Reconstructive Surgery, Mass General Brigham, Harvard Medical School, Boston, MA, USA; Shriners Hospital for Children, Boston, MA, USA. Electronic address:

Cherubism is a disorder of bony overgrowth of the jaws that manifests in childhood. SH3BP2 gene variants have been associated with cherubism; this gene plays a major role in bone homeostasis. Due to its rare occurrence, there is as yet no comprehensive understanding of the natural history and clinical course of the disease. Read More

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