301 results match your criteria cpi measured

The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults.

Int J Environ Res Public Health 2021 03 23;18(6). Epub 2021 Mar 23.

School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.

The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density (BMD) were collected for the diagnostic criteria of osteopenia and osteoporosis. Read More

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Mechanism of α1-Adrenergic Receptor-Induced Increased Contraction of Rat Mesenteric Artery in Aging Hypertension Rats.

Gerontology 2021 22;67(3):323-337. Epub 2021 Mar 22.

Key Lab of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China,

Introduction: Vasoconstriction is triggered by an increase in intracellular-free calcium concentration. Growing evidence indicates that contraction is also regulated by calcium-independent mechanisms involving RhoA-Rho kinase (ROCK), protein kinase C (PKC), and so on. In this study, we studied the changes of vascular reactivity as well as the underlying signaling pathways in aging spontaneously hypertensive rats (SHRs). Read More

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The effects of histone crotonylation and bromodomain protein 4 on prostate cancer cell lines.

Transl Androl Urol 2021 Feb;10(2):900-914

Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: The aims of this study were to detect the level of histone crotonylation in prostate cancer (PCa) tissues, analyze the correlations between its level and clinical stage and grade, and explore the effects of bromodomain-containing protein 4 (BRD4) inhibitors and sodium crotonate on the histone crotonylation in PCa cell lines and on the functions of PCa cells.

Methods: PCa tissues from 72 patients and adjacent tissues from 7 patients were collected, and immunohistochemistry was used to measure the level of histone crotonylation. Three human PCa cell lines, PC-3, LNCaP, and C42B, were selected and treated with IC50 value of I-BET762, I-BET726, and CPI-203, respectively. Read More

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February 2021

A novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure-volume loops.

Eur Heart J Cardiovasc Imaging 2021 Feb 28. Epub 2021 Feb 28.

Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Klinikstrasse 32, Giessen 35392, Germany.

Aims: We sought to assess the feasibility of constructing right ventricular (RV) pressure-volume (PV) loops solely by echocardiography.

Methods And Results: We performed RV conductance and pressure wire (PW) catheterization with simultaneous echocardiography in 35 patients with pulmonary hypertension. To generate echocardiographic PV loops, a reference RV pressure curve was constructed using pooled PW data from the first 20 patients (initial cohort). Read More

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February 2021

The impact of psychological attachment on the relationship between periodontal health and dental fear in patients with versus without psoriasis: a questionnaire-based, cross-sectional study.

BMC Oral Health 2021 03 4;21(1):95. Epub 2021 Mar 4.

Department of Psychology, University of Cologne, Cologne, Germany.

Background: While there is increasing evidence for the relevance of psychosocial variables such as dental fear or psychological attachment in dentistry, much less is known about the mechanisms that determine the strength of those associations. One potential moderator is the occurrence of a comorbid chronic disease such as psoriasis, which is linked to relevant disease parameters such as periodontal inflammation. The aim of the study was to test a moderation model of the relationship between dental fear, psychological attachment and psoriasis on periodontal health. Read More

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The effect of improved dietary control on cognitive and psychiatric functioning in adults with phenylketonuria: the ReDAPT study.

Orphanet J Rare Dis 2021 01 18;16(1):35. Epub 2021 Jan 18.

Neuropsychiatry Unit, Royal Melbourne Hospital, Level 2, John Cade Building, Melbourne,, 3050, Australia.

Background: Phenylketonuria (PKU) is an autosomal recessive inherited disorder characterised by a deficiency in phenylalanine hydroxylase. Untreated, PKU is associated with a wide range of cognitive and psychiatric sequelae. Contemporary management guidelines recommend lifetime dietary control of phenylalanine (Phe) levels, however many individuals who discontinue dietary control subsequently suffer symptoms of anxiety, depression and disturbances to cognition. Read More

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January 2021

Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts.

BMJ Open Respir Res 2021 Jan;8(1)

Department for Pulmonary Medicine, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland

Background: Non-invasive biomarkers for the assessment of disease severity in idiopathic pulmonary fibrosis (IPF) are urgently needed. Calprotectin belongs to the S-100 proteins produced by neutrophils, which likely contribute to IPF pathogenesis. Calprotectin is a well-established biomarker in inflammatory bowel diseases. Read More

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January 2021

Serum markers of pulmonary epithelial damage in systemic sclerosis-associated interstitial lung disease and disease progression.

Respirology 2021 May 17;26(5):461-468. Epub 2020 Dec 17.

Interstitial Lung Disease Unit, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London, UK.

Background And Objective: The course of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is highly variable, and accurate prognostic markers are needed. KL-6 is a mucin-like glycoprotein (MUC1) expressed by type II pneumocytes, while CYFRA 21-1 is expressed by alveolar and bronchiolar epithelial cells. Both are released into the blood from cell injury. Read More

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Quantification of MRI T2 Interstitial Lung Disease Signal-Intensity Volume in Idiopathic Pulmonary Fibrosis: A Pilot Study.

J Magn Reson Imaging 2021 05 25;53(5):1500-1507. Epub 2020 Nov 25.

Centre de Recherche Cardio-Thoracique de Bordeaux, Univ. Bordeaux, INSERM U1045, CIC 1401, Bordeaux, France.

Background: Imaging has played a pivotal role in the diagnosis of idiopathic pulmonary fibrosis (IPF). Recent reports suggest that T -weighted MRI could be sensitive to monitor signal-intensity modifications of the lung parenchyma, which may relate to the disease activity in IPF. However, there is a lack of automated tools to reproducibly quantify the extent of the disease, especially using MRI. Read More

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Evidences of brain and lung invasion of a local water Cryptosporidium parvum isolate in comparison to Iowa strain: serological and immunohistochemical cytokine evaluation.

Ann Parasitol 2020 ;66(3):311-318

Department of Parasitology, Faculty of Medicine, Assiut University, Major General Ahmed Kamel Street, Al-Qasr Road, Assiut 71515, Egypt.

Cryptosporidium spp. is an obligate intracellular parasite that has become a community threat. The pathological consequences of cryptosporidiosis vary not only in different Cryptosporidium species but even among different isolates of the same species. Read More

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November 2020

Optimization of IMU Sensor Placement for the Measurement of Lower Limb Joint Kinematics.

Sensors (Basel) 2020 Oct 22;20(21). Epub 2020 Oct 22.

Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.

There is an increased interest in using wearable inertial measurement units (IMUs) in clinical contexts for the diagnosis and rehabilitation of gait pathologies. Despite this interest, there is a lack of research regarding optimal sensor placement when measuring joint kinematics and few studies which examine functionally relevant motions other than straight level walking. The goal of this clinical measurement research study was to investigate how the location of IMU sensors on the lower body impact the accuracy of IMU-based hip, knee, and ankle angular kinematics. Read More

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October 2020

Hemodynamic Profiles of Cardiogenic Shock Depending on Their Etiology.

J Clin Med 2020 Oct 22;9(11). Epub 2020 Oct 22.

Cardiology Department, APHM, Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), Centre for CardioVascular and Nutrition Research (C2VN), Aix-Marseille Univ, INSERM 1263, INRA 1260, Hopital Nord, 13015 Marseille, France.

The pathophysiology of cardiogenic shock (CS) varies depending on its etiology, which may lead to different hemodynamic profiles (HP) and may help tailor therapy. We aimed to assess the HP of CS patients according to their etiologies of acute myocardial infarction (AMI) and acute decompensated chronic heart failure (ADCHF). We included patients admitted for CS secondary to ADCHF and AMI. Read More

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October 2020

Association of baseline systemic corticosteroid use with overall survival and time to next treatment in patients receiving immune checkpoint inhibitor therapy in real-world US oncology practice for advanced non-small cell lung cancer, melanoma, or urothelial carcinoma.

Oncoimmunology 2020 10 5;9(1):1824645. Epub 2020 Oct 5.

Clinic for Dermatology, Allergology und Venerology, Hannover Medical School, Hannover, Germany.

Immune checkpoint inhibitors (CPIs) have expanded treatment options for patients with solid tumors. Systemic corticosteroids (CSs) have an indispensable role in cancer care, but CS-related immunosuppression may counteract the CPI-driven antitumor immune response. This retrospective study investigated the association between baseline CS use (bCS; ≤14 days before, ≤30 days after CPI initiation) and clinical outcomes in patients with advanced non-small cell lung cancer (aNSCLC), melanoma (aMel), or urothelial carcinoma (aUC). Read More

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October 2020

Developing a new index for evaluating physiological safety in high temperature weather based on entropy-TOPSIS model - A case of sanitation worker.

Environ Res 2020 12 30;191:110091. Epub 2020 Aug 30.

North China Electric Power University, Baoding, China.

Objectives: Sanitation workers are at high-risk of suffering from heat-related illnesses in high temperature weather. However, some well-known heat stress indexes have limitations in practical application. This paper aims to establish a new index-comprehensive physiological index (CPI) for evaluating physiological safety. Read More

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December 2020

Insulin Sensitivity and Pancreatic β-Cell Function in Ecuadorian Women With Turner Syndrome.

Front Endocrinol (Lausanne) 2020 7;11:482. Epub 2020 Aug 7.

Faculty of Biological Sciences, Biological Sciences School, Central University of Ecuador, Quito, Ecuador.

To assess insulin sensitivity and pancreatic β-cell function in an adult population of Ecuadorian individuals with Turner syndrome (TS). This was a cross-sectional correlational study conducted in TS subjects (>20 years old; = 38). A standard 2-h oral glucose tolerance test was performed in both women with TS and the reference group. Read More

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A comparative assessment of clinical parameters, sialic acid, and glycosaminoglycans levels in periodontitis patients with and without dental fluorosis: A clinical and biochemical study.

J Indian Soc Periodontol 2020 May-Jun;24(3):237-243. Epub 2020 May 4.

Department of Periodontics, College of Dental Sciences, Davangere, Karnataka, India.

Aim: This study was aimed to evaluate and compare the clinical parameters and the gingival crevicular fluid (GCF) levels of sialic acid (SA) and chondroitin sulfate (CS) in dental fluorosed and nonfluorosed (NF) gingivitis and periodontitis patients.

Materials And Methods: A total of 100 patients were divided into two control (healthy) and four test (diseased) groups of gingivitis and periodontitis patients with and without dental fluorosis. The GCF-SA and chondrotin sulphate levels were measured using the conventional method and enzyme-linked immuno sorbent assay, respectively. Read More

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Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study.

Nucleic Acid Ther 2020 12 20;30(6):335-345. Epub 2020 Jul 20.

Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt, Germany.

MicroRNA (miRNA) inhibition is a promising therapeutic strategy in several disease indications. MRG-110 is a locked nucleic acid-based antisense oligonucleotide that targets miR-92a-3p and experimentally was shown to have documented therapeutic effects on cardiovascular disease and wound healing. To gain first insights into the activity of anti-miR-92a in humans, we investigated miR-92a-3p expression in several blood compartments and assessed the effect of MRG-110 on target derepression. Read More

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December 2020

Assessment of Periodontal Status Based on Carotid Artery Intima Media Thickness.

Oral Health Prev Dent 2020;18(1):511-519

Purpose: Atherosclerosis is a devastating disease worldwide since it is the most frequent cause of myocardial infarction, stroke, renal failure, peripheral vascular disease and perhaps dementia. There is a well-documented evidence supporting the association between clinical/subclinical atherosclerosis and periodontitis. Carotid intima media wall thickness (CIMT) is a histopathologically validated marker of atherosclerosis. Read More

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Predictors of mortality in fibrosing pulmonary sarcoidosis.

Respir Med 2020 08 12;169:105997. Epub 2020 May 12.

INSERM UMR 1272, Université Sorbonne Paris Nord, Bobigny, France; AP-HP, service de pneumologie, hôpital Avicenne, Bobigny, France.

Introduction: Pulmonary fibrosing sarcoidosis is associated with increased mortality. This study was aimed to explore the prognosis value of a panel of parameters for predicting mortality.

Methods: This retrospective study included 216 patients with confirmed stage 4 pulmonary sarcoidosis. Read More

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CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling.

J Exp Clin Cancer Res 2020 Apr 28;39(1):73. Epub 2020 Apr 28.

Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.

Background: Pancreatic cancer remains one of the most rapidly progressive and deadly malignancies worldwide. Current treatment regimens only result in small improvements in overall survival for patients with this cancer type. CPI-613 (Devimistat), a novel lipoate analog inhibiting mitochondrial metabolism, shows the new hope for pancreatic cancer treatment as an efficient and well-tolerated therapeutic option treated alone or in combination with chemotherapy. Read More

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Behaviour of traffic emitted semi-volatile and intermediate volatility organic compounds within the urban atmosphere.

Sci Total Environ 2020 Jun 20;720:137470. Epub 2020 Feb 20.

Division of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. Electronic address:

Particulate matter originated from traffic has attracted major interest over the last few years. The semi-volatile organic component of the particles may evaporate with dispersion away from the emission source, creating vapour which may oxidise to form secondary organic aerosol. Air samples were collected from a street canyon, the adjacent park and an urban background site during the winter-spring period in central London, UK. Read More

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Novel Liquid Biomarker Panels for A Very Early Response Capturing of NSCLC Therapies in Advanced Stages.

Cancers (Basel) 2020 Apr 12;12(4). Epub 2020 Apr 12.

Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), INF 156, 69120 Heidelberg, Germany.

Computed tomography (CT) scans are the gold standard to measure treatment success of non-small cell lung cancer (NSCLC) therapies. Here, we investigated the very early tumor response of patients receiving chemotherapy or targeted therapies using a panel of already established and explorative liquid biomarkers. Blood samples from 50 patients were taken at baseline and at three early time points after therapy initiation. Read More

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Decreased masticatory performance is related to increased intima-media thickness in a general urban Japanese population: The Suita study.

J Prosthodont Res 2020 Jul 19;64(3):346-353. Epub 2020 Mar 19.

Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.

Purpose: The association between periodontal disease and carotid atherosclerosis has been widely discussed, but to our knowledge, no population-based studies have been conducted on the association between masticatory ability and carotid atherosclerosis. We aimed to clarify the hypothesis that objectively accessed masticatory performance is related to increased intima-media thickness (IMT) in a general urban population.

Methods: We studied 1,484 Japanese (mean age: 66. Read More

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Does Resting Cardiac Power Index Affect Survival Post Transcatheter Aortic Valve Replacement?

J Invasive Cardiol 2020 Apr 20;32(4):129-137. Epub 2020 Mar 20.

Mayo Clinic Arizona, 5777 E. Mayo Blvd, Phoenix, AZ 85054. USA.

Objective: Cardiac power index (CPI) is an integrative hemodynamic measure of cardiac pumping capability and is the product of the simultaneously measured mean arterial pressure and the cardiac output. We assessed the association between baseline resting CPI and survival post transcatheter aortic valve replacement (TAVR).

Methods And Results: We retrospectively abstracted data of patients who underwent TAVR at the Mayo Clinic Foundation with follow-up data available at 1 year. Read More

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Immunotherapy Potentiates the Effect of Chemotherapy in Metastatic Melanoma-A Retrospective Study.

Front Oncol 2020 14;10:70. Epub 2020 Feb 14.

Sharett Institute of Oncology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Melanoma survival increased with targeted- and immunotherapy agents, yet most patients ultimately progress and require salvage therapy. In our experience, some progressive disease patients on immune-checkpoint inhibitors (ICIs) demonstrate deep and sustained responses to chemotherapy. We hypothesized that ICIs improve the response to subsequent chemotherapy in metastatic melanoma. Read More

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February 2020

Health-related quality of life and symptoms in patients with IPF treated with nintedanib: analyses of patient-reported outcomes from the INPULSIS® trials.

Respir Res 2020 Jan 30;21(1):36. Epub 2020 Jan 30.

University of Colorado, Denver, CO, USA.

Background: In the Phase III INPULSIS® trials, treatment of patients with idiopathic pulmonary fibrosis (IPF) with nintedanib significantly reduced the annual rate of decline in forced vital capacity (FVC) versus placebo, consistent with slowing disease progression. However, nintedanib was not associated with a benefit in health-related quality of life (HRQoL) assessed using the St George's respiratory questionnaire (SGRQ). We aimed to further examine the impact of IPF progression on HRQoL and symptoms, and to explore the effect of nintedanib on HRQoL in patients from the INPULSIS® trials stratified by clinical factors associated with disease progression. Read More

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January 2020

A Multiple-Trait Bayesian Lasso for Genome-Enabled Analysis and Prediction of Complex Traits.

Genetics 2020 02 26;214(2):305-331. Epub 2019 Dec 26.

Department of Animal Science, Iowa State University, Ames, Iowa 50011.

A multiple-trait Bayesian LASSO (MBL) for genome-based analysis and prediction of quantitative traits is presented and applied to two real data sets. The data-generating model is a multivariate linear Bayesian regression on possibly a huge number of molecular markers, and with a Gaussian residual distribution posed. Each (one per marker) of the [Formula: see text] vectors of regression coefficients (: number of traits) is assigned the same -variate Laplace prior distribution, with a null mean vector and unknown scale matrix Σ. Read More

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February 2020

Obesity and its association with chronic periodontitis: A cross-sectional study.

J Educ Health Promot 2019 29;8:222. Epub 2019 Nov 29.

Department of Periodontics, Yenepoya Dental College and Hospital, Mangalore, Karnataka, India.

Background: Relationship among periodontitis, obesity, and chronic diseases may be multidirectional. Inflammatory diseases such as periodontitis induce the production of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6. It has been suggested that the secretion of TNF-α by adipose tissue triggered by lipopolysaccharides from periodontal Gram-negative bacteria promotes hepatic dyslipidemia and decreases insulin sensitivity. Read More

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November 2019

OGTT 2-hour serum C-peptide index as a predictor of post-transplant diabetes mellitus in kidney transplant recipients.

Ann Transl Med 2019 Oct;7(20):538

Organ Transplant Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.

Background: The high incidence of post-transplant diabetes mellitus (PTDM) necessitates the identification of new factors to explain its pathogenesis. This study aimed to clarify the association between the C-peptide index (CPI) and PTDM.

Methods: A total of 290 non-diabetic kidney transplant patients were analyzed. Read More

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October 2019

CPI-17 Overexpression and Its Correlation With the NF2 Mutation Spectrum in Sporadic Vestibular Schwannomas.

Otol Neurotol 2020 01;41(1):e94-e102

ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University.

Hypothesis: We hypothesized that CPI-17 expression and NF2 mutations are correlated with merlin phosphorylation in the etiology of sporadic vestibular schwannoma (VS).

Background: NF2 gene mutations have been identified in the majority of sporadic and NF2-associated schwannomas and NF2 gene mutations have been shown to result in merlin protein phosphorylation. CPI-17 can drive Ras activity and promote tumorigenic transformation by inhibiting the tumor suppressor merlin. Read More

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January 2020