Taiwan J Obstet Gynecol 2021 Jan;60(1):152-156
Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Objective: We present prenatal diagnosis and molecular cytogenetic characterization of a small supernumerary marker chromosome (sSMC) derived from chromosome 15 in a pregnancy associated with recurrent Down syndrome.
Case Report: A 33-year-old, gravida 4, para 2, woman underwent amniocentesis at 16 weeks of gestation because of a previous child with Down syndrome and a karyotype of 46,XY,der(14;21)(q10; q10),+21. In this pregnancy, amniocentesis revealed a karyotype of 47,XX,+21/48,XX,+21,+mar. Read More