3,978 results match your criteria coxiella infection


Ticks on wild boar in the metropolitan area of Barcelona (Spain) are infected with spotted fever group rickettsiae.

Transbound Emerg Dis 2021 Jul 31. Epub 2021 Jul 31.

Wildlife Ecology & Health group and Servei d'Ecopatologia de Fauna Salvatge, Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Travessera dels Turons s/n, Bellaterra, Barcelona, 08193, Spain.

Tick-borne pathogens (TBPs) constitute an emerging public health concern favoured by multidimensional global changes. Amongst these, increase and spread of wild boar (Sus scrofa) populations are of special concern, since this species can act as reservoir of zoonotic pathogens and promote tick abundance. Thus, we aimed to make a first assessment of the risk by TBPs resulting from wild boar and ticks in the vicinity of a highly populated area. Read More

View Article and Full-Text PDF

Shifting proteomes: limitations in using the BioID proximity labeling system to study SNARE protein trafficking during infection with intracellular pathogens.

Pathog Dis 2021 Jul 29. Epub 2021 Jul 29.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

We hypothesize that intracellular trafficking pathways are altered in chlamydial infected cells to maximize the ability of Chlamydia to scavenge nutrients while not overtly stressing the host cell. Previous data demonstrated the importance of two eukaryotic SNARE proteins, VAMP4 and syntaxin 10 (St × 10), in chlamydial growth and development. Although, the mechanism for these effects is still unknown. Read More

View Article and Full-Text PDF

Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state.

Trans R Soc Trop Med Hyg 2021 Jul 26. Epub 2021 Jul 26.

Faculty of Pharmacy, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, Minas Gerais, Brazil.

Background: Q fever is among the top 13 global priority zoonoses, however, it is still neglected and under-reported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state.

Methods: Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Read More

View Article and Full-Text PDF

Bacterial Infection and Non-Hodgkin B-Cell Lymphoma: Interactions between Pathogen, Host and the Tumor Environment.

Int J Mol Sci 2021 Jul 9;22(14). Epub 2021 Jul 9.

Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, 50-367 Wroclaw, Poland.

Non-Hodgkin B-cell lymphomas (NHL) are a heterogeneous group of lymphoid neoplasms with complex etiopathology, rich symptomatology, and a variety of clinical courses, therefore requiring different therapeutic approaches. The hypothesis that an infectious agent may initiate chronic inflammation and facilitate B lymphocyte transformation and lymphogenesis has been raised in recent years. Viruses, like EBV, HTLV-1, HIV, HCV and parasites, like have been linked to the development of lymphomas. Read More

View Article and Full-Text PDF

The diagnostic challenge of acute Q fever endocarditis.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Internal Medicine Department, Hospital de Santa Marta - Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal.

A 79-year-old man was admitted to our ward with symptomatic heart failure 2 months after aortic valve replacement due to severe aortic stenosis. On the third day following admission, he became febrile (>38°C) while manifesting an increase in inflammatory markers. Endocarditis was suspected despite negative blood cultures. Read More

View Article and Full-Text PDF

Screening for Q Fever in Patients Undergoing Transcatheter Aortic Valve Implantation, Israel, June 2018-May 2020.

Emerg Infect Dis 2021 08;27(8):2205-2207

Q fever infective endocarditis frequently mimics degenerative valvular disease. We tested for Coxiella burnettii antibodies in 155 patients in Israel who underwent transcatheter aortic valve implantation. Q fever infective endocarditis was diagnosed and treated in 4 (2. Read More

View Article and Full-Text PDF

Seroprevalence of brucellosis and Q fever infections amongst pastoralists and their cattle herds in Sokoto State, Nigeria.

PLoS One 2021 20;16(7):e0254530. Epub 2021 Jul 20.

Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Ibadan, Nigeria.

Brucellosis and Q fever are neglected zoonoses of global health importance, with unknown true prevalence in occupationally vulnerable settings, partly due to misdiagnosis for other febrile conditions and poor access to primary health care. We examined the seroprevalence of these diseases and associated factors amongst pastoralists and their cattle in Sokoto State, a hub of cattle and pastoral populations in Nigeria. Serum samples randomly collected from 137 pastoralists and 366 cattle from 27 herds in three selected Local Government Areas (LGAs) in the state were analysed for antibodies to Brucella abortus using Rose Bengal Plate Test (RBT) and competitive Enzyme-Linked Immunosorbent Assay (cELISA) as well as antibodies to Coxiella burnetti using indirect ELISA. Read More

View Article and Full-Text PDF

The epidemic of Q fever in 2018 to 2019 in Zhuhai city of China determined by metagenomic next-generation sequencing.

PLoS Negl Trop Dis 2021 Jul 15;15(7):e0009520. Epub 2021 Jul 15.

Department of Infectious Diseases, the Fifth Affiliated Hospital of Sun Yat-Sen University (SYSU), Zhuhai, China.

Q fever is a worldwide zoonosis caused by Coxiella burnetii (Cb). From January 2018 to November 2019, plasma samples from 2,382 patients with acute fever of unknown cause at a hospital in Zhuhai city of China were tested using metagenomic next-generation sequencing (mNGS). Of those tested, 138 patients (5. Read More

View Article and Full-Text PDF

Incidence of chronic Q fever and chronic fatigue syndrome: A 6 year follow-up of a large Q fever outbreak.

Transbound Emerg Dis 2021 Jul 9. Epub 2021 Jul 9.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.

Acute Q fever is a generally self-limiting infection caused by the intracellular gram-negative bacterium Coxiella burnetii. For yet unknown reasons, a subset of patients develops chronic infection. Furthermore, chronic fatigue syndrome (CFS) as post-acute Q fever sequelae has been described. Read More

View Article and Full-Text PDF

Analysis of environmental dust in goat and sheep farms to assess Coxiella burnetii infection in a Q fever endemic area: Geographical distribution, relationship with human cases and genotypes.

Zoonoses Public Health 2021 Jul 8. Epub 2021 Jul 8.

Department of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain.

Real-time PCR analysis of environmental samples (dust and aerosols) is an easy tool to investigate the presence of Coxiella burnetii in the farm environment. The aim of this study was to assess the distribution of C. burnetii DNA in dust collected inside animal premises from 272 small ruminant farms in Bizkaia (northern Spain), a region with recent reports of human Q fever cases and outbreaks. Read More

View Article and Full-Text PDF

Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells.

mSphere 2021 Jul 7:e0044221. Epub 2021 Jul 7.

Department of Microbiology and Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.

Coxiella burnetii is a highly infectious, intracellular, Gram-negative bacterial pathogen that causes human Q fever, an acute flu-like illness that can progress to chronic endocarditis. C. burnetii is transmitted to humans via aerosols and has long been considered a potential biological warfare agent. Read More

View Article and Full-Text PDF

Molecular Detection of Zoonotic Pathogens in the Blood and Tissues of Camels () in Central Desert of Iran.

Yale J Biol Med 2021 Jun 30;94(2):249-258. Epub 2021 Jun 30.

Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.

Dromedary camels () play a major economic role in many countries in Africa and Asia. Although they are resistant to harsh environmental conditions, they are susceptible to a wide range of zoonotic agents. This study aimed to provide an overview on the prevalence of selected zoonotic pathogens in blood and tissues of camels in central Iran. Read More

View Article and Full-Text PDF

Ticks and Tick-Borne Pathogens Associated with Dromedary Camels () in Northern Kenya.

Microorganisms 2021 Jun 30;9(7). Epub 2021 Jun 30.

International Centre of Insect Physiology and Ecology (icipe), Nairobi P.O. Box 30772-00100, Kenya.

Ticks and tick-borne pathogens (TBPs) are major constraints to camel health and production, yet epidemiological data on their diversity and impact on dromedary camels remain limited. We surveyed the diversity of ticks and TBPs associated with camels and co-grazing sheep at 12 sites in Marsabit County, northern Kenya. We screened blood and ticks (858 pools) from 296 camels and 77 sheep for bacterial and protozoan TBPs by high-resolution melting analysis and sequencing of PCR products. Read More

View Article and Full-Text PDF

Flock Management Risk Factors Associated with Q Fever Infection in Sheep in Saudi Arabia.

Animals (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Al Ahsa Veterinary Diagnostic Lab, Ministry of Environment, Water and Agriculture, Al-Ahsa 31982, Saudi Arabia.

Q fever is a zoonotic disease caused by (), an intracellular, Gram-negative bacterium that infects humans and domestic ruminants. Information on flock management factors associated with Q fever seropositivity in Saudi Arabia is very scarce. Therefore, the objective of this study was to identify the animal and flock management factors associated with Q fever seropositivity. Read More

View Article and Full-Text PDF

Wild Small Mammals and Ticks in Zoos-Reservoir of Agents with Zoonotic Potential?

Pathogens 2021 Jun 21;10(6). Epub 2021 Jun 21.

Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Palackého tř. 1946/1, 61242 Brno, Czech Republic.

Wild small mammals and ticks play an important role in maintaining and spreading zoonoses in nature, as well as in captive animals. The aim of this study was to monitor selected agents with zoonotic potential in their reservoirs and vectors in a zoo, and to draw attention to the risk of possible contact with these pathogens. In total, 117 wild small mammals (rodents) and 166 ticks were collected in the area of Brno Zoo. Read More

View Article and Full-Text PDF

Acute Q Fever in an Ankylosing Spondyloarthritis Patient Treated with Etanercept.

Case Rep Rheumatol 2021 1;2021:9944387. Epub 2021 Jun 1.

Department of Internal Medicine, Farhat Hached Hospital, Sousse, Tunisia.

Q fever is a rare zoonotic infection caused by . Tumor necrosis factor-alpha (TNF-) has an important role in the early control of this infection. However, TNF- blockers increase the risk of infectious diseases. Read More

View Article and Full-Text PDF

Polymicrobial Infections Among Patients with Vascular Q Fever, France, 2004-2020.

Emerg Infect Dis 2021 ;27(7):1961-1963

We report 5 cases of vascular Q fever complicated by polymicrobial superinfection in patients who had no risk factors for acute Q fever. Q fever was diagnosed by serologic and molecular assays for Coxiella burnetii. We confirmed additional infections using conventional graft cultures. Read More

View Article and Full-Text PDF

Francisella FlmX broadly affects lipopolysaccharide modification and virulence.

Cell Rep 2021 Jun;35(11):109247

Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA; Research Service, Atlanta VA Medical Center, Decatur, GA 30033, USA. Electronic address:

The outer membrane protects Gram-negative bacteria from the host environment. Lipopolysaccharide (LPS), a major outer membrane constituent, has distinct components (lipid A, core, O-antigen) generated by specialized pathways. In this study, we describe the surprising convergence of these pathways through FlmX, an uncharacterized protein in the intracellular pathogen Francisella. Read More

View Article and Full-Text PDF

SEROLOGICAL EVIDENCE OF INFECTION IN THE WHITE RHINOCEROS () IN SOUTH AFRICA.

J Zoo Wildl Med 2021 Jun;52(2):573-579

White Oak Conservation, Yulee, FL 32097, USA.

Coxiellosis, or Query (Q) fever, a disease caused by the intracellular bacteria , was recently described in a managed breeding herd of white rhinoceros () in the southeastern United States. Clinical disease often results in abortion and could represent a conservation challenge for this species. In addition to the reproductive and herd management consequences, coxiellosis is also a zoonotic disease. Read More

View Article and Full-Text PDF

Serological survey of Coxiella burnetii infections in dairy cattle, sheep, goats and zoo animals in Hungary - Short communication.

Acta Vet Hung 2021 Jun 8. Epub 2021 Jun 8.

3Institute for Veterinary Medical Research, Centre for Agricultural Research, Budapest, Hungary.

Q fever is a disease of high zoonotic potential, but interest in its causative agent is rather low although it causes some public health problems in Hungary. The prevalence of Q fever is highly variable by country. The main reservoirs of the disease are the same domestic ruminant species everywhere, but the epidemiological profile depends on the features of the specific reservoir. Read More

View Article and Full-Text PDF

A multipronged next-generation sequencing metabarcoding approach unearths hyperdiverse and abundant dog pathogen communities in Cambodia.

Transbound Emerg Dis 2021 Jun 7. Epub 2021 Jun 7.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Victoria, Australia.

Recent surveys in Southeast Asia, including Cambodia, have identified canine vector-borne pathogens (VBPs), including those with zoonotic potential, as highly prevalent. The lack of veterinary care alongside the close association semidomesticated dogs have with humans in the region exacerbates these zoonotic risks. Nonetheless, the number of studies investigating such pathogens and the threats they pose to dog and human health is limited. Read More

View Article and Full-Text PDF

Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions.

Curr Trop Med Rep 2021 Jun 1:1-10. Epub 2021 Jun 1.

Departamento de Tuberculosis, Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.

Purpose Of Review: In this review, we report on the state of knowledge about human Q fever in Brazil and on the Guiana Shield, an Amazonian region located in northeastern South America. There is a contrast between French Guiana, where the incidence of this disease is the highest in the world, and other countries where this disease is practically non-existent.

Recent Findings: Recent findings are essentially in French Guiana where a unique strain MST17 has been identified; it is probably more virulent than those usually found with a particularly marked pulmonary tropism, a mysterious animal reservoir, a geographical distribution that raises questions. Read More

View Article and Full-Text PDF

Animal board invited review: Risks of zoonotic disease emergence at the interface of wildlife and livestock systems.

Animal 2021 Jun 3;15(6):100241. Epub 2021 Jun 3.

College of Veterinary Medicine, Comparative Medicine Research Institute, Yangzhou University, 225009 Yangzhou, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, 225009 Yangzhou, China.

The ongoing coronavirus disease 19s pandemic has yet again demonstrated the importance of the human-animal interface in the emergence of zoonotic diseases, and in particular the role of wildlife and livestock species as potential hosts and virus reservoirs. As most diseases emerge out of the human-animal interface, a better understanding of the specific drivers and mechanisms involved is crucial to prepare for future disease outbreaks. Interactions between wildlife and livestock systems contribute to the emergence of zoonotic diseases, especially in the face of globalization, habitat fragmentation and destruction and climate change. Read More

View Article and Full-Text PDF

Geographical Variation in Seroprevalence in Dairy Farms Located in South-Western Ethiopia: Understanding the Broader Community Risk.

Pathogens 2021 May 23;10(6). Epub 2021 May 23.

UQ Spatial Epidemiology Laboratory, School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia.

Q fever is a zoonotic disease that is caused by and leads to abortion and infertility in ruminants and debilitating disease in humans. Jimma zone, including Jimma town, located in the Oromia region of Ethiopia, was affected by an outbreak of abortions in ruminants related to Q fever infection between 2013 and 2015. This study aimed to investigate the geo-clustering of seroprevalence in dairy farms of Jimma town and identify the environmental risk factors associated with seroprevalence distribution. Read More

View Article and Full-Text PDF

From Infection to Pregnancy Complications: Key Role of the Immune Response of Placental Cells.

Pathogens 2021 May 19;10(5). Epub 2021 May 19.

Aix-Marseille University, MEPHI, IRD, APHM, 13005 Marseille, France.

The infection of pregnant animals and women by , an intracellular bacterium, compromises both maternal health and foetal development. The placenta is targeted by as demonstrated by bacteriological and histological evidence. It now appears that placental strains of   are highly virulent compared to reference strains and that placental injury involves different types of placental cells. Read More

View Article and Full-Text PDF

One Health Approach: An Overview of Q Fever in Livestock, Wildlife and Humans in Asturias (Northwestern Spain).

Animals (Basel) 2021 May 13;11(5). Epub 2021 May 13.

Department of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.

This study aimed to investigate the seroprevalence of in domestic ruminants, wild ungulates, as well as the current situation of Q fever in humans in a small region in northwestern Spain where a close contact at the wildlife-livestock-human interface exists, and information on infection is scarce. Seroprevalence of was 8.4% in sheep, 18. Read More

View Article and Full-Text PDF

Utility of positron emission tomography imaging in the diagnosis of chronic Q fever: A Systematic Review.

J Med Imaging Radiat Oncol 2021 May 30. Epub 2021 May 30.

Pathology Queensland, Townsville University Hospital, Douglas, Queensland, Australia.

Chronic Q fever is a diagnostic challenge. Diagnosis relies on serology and/or the detection of DNA from blood or tissue samples. PET-CT identifies tissues with increased glucose metabolism, thus identifying foci of inflammation. Read More

View Article and Full-Text PDF

White thrombus as a possible feature of atypical stroke etiology: as the primary cause of acute ischemic stroke.

Interv Neuroradiol 2021 May 29:15910199211021716. Epub 2021 May 29.

Diagnostic and Interventional Neuroradiology, Foch Hospital, Suresnes, France.

Acute ischemic stroke (AIS) is the most common neurologic complication of infective endocarditis. We describe a singular case report of a 62- year-old male with AIS related to the occlusion of the left middle cerebral artery. Thrombus-aspiration allowed retrieving a 6 millimeters white thrombus. Read More

View Article and Full-Text PDF

A one-year descriptive epidemiology of zoonotic abortifacient pathogen bacteria in farm animals in Turkey.

Comp Immunol Microbiol Infect Dis 2021 Aug 15;77:101665. Epub 2021 May 15.

Selcuk University, Department of Microbiology, Faculty of Veterinary Medicine, Konya, Turkey. Electronic address:

This study aimed to investigate the epidemiology of 10 suspicious pathogenic bacteria in 250 stomach contents of aborted calf, lamb, and goat foetuses in 2019. The 155 positive samples obtained from PCR consisted of 53 (58.88 %) bacteria from 90 lamb samples, 10 (43. Read More

View Article and Full-Text PDF

Identification of tick-borne pathogens by metagenomic next-generation sequencing in Dermacentor nuttalli and Ixodes persulcatus in Inner Mongolia, China.

Parasit Vectors 2021 May 27;14(1):287. Epub 2021 May 27.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, PR China.

Background: Hard ticks act as arthropod vectors in the transmission of human and animal pathogens and are widely distributed in northern China. The aim of this study is to screen the important tick-borne pathogens (TBPs) carried by hard ticks in Inner Mongolia using metagenomic next-generation sequencing (mNGS) and to estimate the risk of human infection imposed by tick bites.

Methods: The adult Dermacentor nuttalli (n = 203) and Ixodes persulcatus (n = 36) ticks feeding on cattle were collected. Read More

View Article and Full-Text PDF