4,048 results match your criteria coxiella burnetii


Detection and distribution of zoonotic pathogens in wild Norway rats () from Tehran, Iran.

New Microbes New Infect 2021 Jul 24;42:100908. Epub 2021 Jun 24.

Pediatric Infection Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This is the first study on the prevalence of vector-borne zoonotic pathogens found in () in urban areas of Tehran, Iran. Serological tests were used to detect IgG antibodies against () and spp. using a commercial qualitative rat ELISA kit. Read More

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APRANK: Computational Prioritization of Antigenic Proteins and Peptides From Complete Pathogen Proteomes.

Front Immunol 2021 15;12:702552. Epub 2021 Jul 15.

Instituto de Investigaciones Biotecnológicas "Rodolfo Ugalde" (IIB), Universidad de San Martín (UNSAM) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Availability of highly parallelized immunoassays has renewed interest in the discovery of serology biomarkers for infectious diseases. Protein and peptide microarrays now provide a rapid, high-throughput platform for immunological testing and validation of potential antigens and B-cell epitopes. However, there is still a need for tools to prioritize and select relevant probes when designing these arrays. Read More

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Ticks on wild boar in the metropolitan area of Barcelona (Spain) are infected with spotted fever group rickettsiae.

Transbound Emerg Dis 2021 Jul 31. Epub 2021 Jul 31.

Wildlife Ecology & Health group and Servei d'Ecopatologia de Fauna Salvatge, Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Travessera dels Turons s/n, Bellaterra, Barcelona, 08193, Spain.

Tick-borne pathogens (TBPs) constitute an emerging public health concern favoured by multidimensional global changes. Amongst these, increase and spread of wild boar (Sus scrofa) populations are of special concern, since this species can act as reservoir of zoonotic pathogens and promote tick abundance. Thus, we aimed to make a first assessment of the risk by TBPs resulting from wild boar and ticks in the vicinity of a highly populated area. Read More

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Q Fever presenting with hepatic and splenic lesions in a kidney transplant recipient.

Transpl Infect Dis 2021 Jul 29. Epub 2021 Jul 29.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

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Shifting proteomes: limitations in using the BioID proximity labeling system to study SNARE protein trafficking during infection with intracellular pathogens.

Pathog Dis 2021 Jul 29. Epub 2021 Jul 29.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

We hypothesize that intracellular trafficking pathways are altered in chlamydial infected cells to maximize the ability of Chlamydia to scavenge nutrients while not overtly stressing the host cell. Previous data demonstrated the importance of two eukaryotic SNARE proteins, VAMP4 and syntaxin 10 (St × 10), in chlamydial growth and development. Although, the mechanism for these effects is still unknown. Read More

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Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state.

Trans R Soc Trop Med Hyg 2021 Jul 26. Epub 2021 Jul 26.

Faculty of Pharmacy, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, Minas Gerais, Brazil.

Background: Q fever is among the top 13 global priority zoonoses, however, it is still neglected and under-reported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state.

Methods: Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Read More

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Identification of Bacillus anthracis, Brucella spp., and Coxiella burnetii DNA signatures from bushmeat.

Sci Rep 2021 Jul 21;11(1):14876. Epub 2021 Jul 21.

Applied Biological and Biosecurity Research Laboratory, Pennsylvania State University, University Park, PA, USA.

Meat from wildlife species (bushmeat) represents a major source of dietary protein in low- and middle-income countries where humans and wildlife live in close proximity. Despite the occurrence of zoonotic pathogens in wildlife, their prevalence in bushmeat remains unknown. To assess the risk of exposure to major pathogens in bushmeat, a total of 3784 samples, both fresh and processed, were collected from three major regions in Tanzania during both rainy and dry seasons, and were screened by real-time PCR for the presence of DNA signatures of Bacillus anthracis (B. Read More

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The diagnostic challenge of acute Q fever endocarditis.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Internal Medicine Department, Hospital de Santa Marta - Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal.

A 79-year-old man was admitted to our ward with symptomatic heart failure 2 months after aortic valve replacement due to severe aortic stenosis. On the third day following admission, he became febrile (>38°C) while manifesting an increase in inflammatory markers. Endocarditis was suspected despite negative blood cultures. Read More

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The epidemic of Q fever in 2018 to 2019 in Zhuhai city of China determined by metagenomic next-generation sequencing.

PLoS Negl Trop Dis 2021 Jul 15;15(7):e0009520. Epub 2021 Jul 15.

Department of Infectious Diseases, the Fifth Affiliated Hospital of Sun Yat-Sen University (SYSU), Zhuhai, China.

Q fever is a worldwide zoonosis caused by Coxiella burnetii (Cb). From January 2018 to November 2019, plasma samples from 2,382 patients with acute fever of unknown cause at a hospital in Zhuhai city of China were tested using metagenomic next-generation sequencing (mNGS). Of those tested, 138 patients (5. Read More

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Conditional impairment of Coxiella burnetii by glucose-6P dehydrogenase activity.

Pathog Dis 2021 Jul;79(6)

Paul G. Allen School for Global Health, Washington State University, Pullman, WA 99164, USA.

Coxiella burnetii is a bacterial obligate intracellular parasite and the etiological agent of query (Q) fever. While the C. burnetii genome has been reduced to ∼2 Mb as a likely consequence of genome streamlining in response to parasitism, enzymes for a nearly complete central metabolic machinery are encoded by the genome. Read More

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Micropathogen community identification in ticks (Acari: Ixodidae) using third-generation sequencing.

Int J Parasitol Parasites Wildl 2021 Aug 25;15:238-248. Epub 2021 Jun 25.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Xujiaping 1, Lanzhou, Gansu, 730046, PR China.

Ticks are important vectors that facilitate the transmission of a broad range of micropathogens to vertebrates, including humans. Because of their role in disease transmission, it has become increasingly important to identify and characterize the micropathogen profiles of tick populations. The objective of the present study was to survey the micropathogens of ticks by third-generation metagenomic sequencing using the PacBio Sequel platform. Read More

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Seroepidemiological study on Coxiella burnetii and associated risk factors in ruminants at Kurdistan Province, west of Iran.

Comp Immunol Microbiol Infect Dis 2021 Jul 7;78:101691. Epub 2021 Jul 7.

Department of Pathobiology, Sanandaj Branch Islamic Azad University, Sanandaj, Iran.

Q fever is zoonotic disease caused by Coxiella burnetii. Ruminants are the main reservoir of this pathogen, which is often asymptomatic but lead to abortion. This study aims to survey the seroprevalence and risk factors of this zoonose among ruminants in Kurdistan province, the west of Iran. Read More

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Incidence of chronic Q fever and chronic fatigue syndrome: A 6 year follow-up of a large Q fever outbreak.

Transbound Emerg Dis 2021 Jul 9. Epub 2021 Jul 9.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.

Acute Q fever is a generally self-limiting infection caused by the intracellular gram-negative bacterium Coxiella burnetii. For yet unknown reasons, a subset of patients develops chronic infection. Furthermore, chronic fatigue syndrome (CFS) as post-acute Q fever sequelae has been described. Read More

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Analysis of environmental dust in goat and sheep farms to assess Coxiella burnetii infection in a Q fever endemic area: Geographical distribution, relationship with human cases and genotypes.

Zoonoses Public Health 2021 Jul 8. Epub 2021 Jul 8.

Department of Animal Health, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain.

Real-time PCR analysis of environmental samples (dust and aerosols) is an easy tool to investigate the presence of Coxiella burnetii in the farm environment. The aim of this study was to assess the distribution of C. burnetii DNA in dust collected inside animal premises from 272 small ruminant farms in Bizkaia (northern Spain), a region with recent reports of human Q fever cases and outbreaks. Read More

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Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells.

mSphere 2021 Jul 7:e0044221. Epub 2021 Jul 7.

Department of Microbiology and Immunology, University of Arkansas for Medical Sciencesgrid.241054.6, Little Rock, Arkansas, USA.

Coxiella burnetii is a highly infectious, intracellular, Gram-negative bacterial pathogen that causes human Q fever, an acute flu-like illness that can progress to chronic endocarditis. C. burnetii is transmitted to humans via aerosols and has long been considered a potential biological warfare agent. Read More

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Molecular Detection of Zoonotic Pathogens in the Blood and Tissues of Camels () in Central Desert of Iran.

Yale J Biol Med 2021 Jun 30;94(2):249-258. Epub 2021 Jun 30.

Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.

Dromedary camels () play a major economic role in many countries in Africa and Asia. Although they are resistant to harsh environmental conditions, they are susceptible to a wide range of zoonotic agents. This study aimed to provide an overview on the prevalence of selected zoonotic pathogens in blood and tissues of camels in central Iran. Read More

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Ticks and Tick-Borne Pathogens Associated with Dromedary Camels () in Northern Kenya.

Microorganisms 2021 Jun 30;9(7). Epub 2021 Jun 30.

International Centre of Insect Physiology and Ecology (icipe), Nairobi P.O. Box 30772-00100, Kenya.

Ticks and tick-borne pathogens (TBPs) are major constraints to camel health and production, yet epidemiological data on their diversity and impact on dromedary camels remain limited. We surveyed the diversity of ticks and TBPs associated with camels and co-grazing sheep at 12 sites in Marsabit County, northern Kenya. We screened blood and ticks (858 pools) from 296 camels and 77 sheep for bacterial and protozoan TBPs by high-resolution melting analysis and sequencing of PCR products. Read More

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Causes of Abortions in South American Camelids in Switzerland-Cases and Questionnaire.

Animals (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Clinic for Ruminants, Department of Clinical Veterinary Science, Vetsuisse-Faculty, University of Bern, 3012 Bern, Switzerland.

Over the last decade, South American camelids (SAC) have gained increasing popularity in Switzerland. They are used for several purposes such as fiber and meat production, as companion or guard animals and for trekking activities. The purpose of this study was to investigate the frequency and reasons for pregnancy loss and perinatal death in SAC herds. Read More

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Flock Management Risk Factors Associated with Q Fever Infection in Sheep in Saudi Arabia.

Animals (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Al Ahsa Veterinary Diagnostic Lab, Ministry of Environment, Water and Agriculture, Al-Ahsa 31982, Saudi Arabia.

Q fever is a zoonotic disease caused by (), an intracellular, Gram-negative bacterium that infects humans and domestic ruminants. Information on flock management factors associated with Q fever seropositivity in Saudi Arabia is very scarce. Therefore, the objective of this study was to identify the animal and flock management factors associated with Q fever seropositivity. Read More

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Wild Small Mammals and Ticks in Zoos-Reservoir of Agents with Zoonotic Potential?

Pathogens 2021 Jun 21;10(6). Epub 2021 Jun 21.

Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Palackého tř. 1946/1, 61242 Brno, Czech Republic.

Wild small mammals and ticks play an important role in maintaining and spreading zoonoses in nature, as well as in captive animals. The aim of this study was to monitor selected agents with zoonotic potential in their reservoirs and vectors in a zoo, and to draw attention to the risk of possible contact with these pathogens. In total, 117 wild small mammals (rodents) and 166 ticks were collected in the area of Brno Zoo. Read More

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High Prevalence and New Genotype of in Ticks Infesting Camels in Somalia.

Pathogens 2021 Jun 12;10(6). Epub 2021 Jun 12.

College of Veterinary Medicine, Sudan University of Science and Technology, P.O. Box 204 Hilat Kuku, Khartoum North 13321, Sudan.

is the causative agent of Q fever. It can infect animals, humans, and birds, as well as ticks, and it has a worldwide geographical distribution. To better understand the epidemiology of in Somalia, ticks infesting camels were collected from five different regions, including Bari, Nugaal, Mudug, Sool, and Sanaag, between January and March 2018. Read More

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Seroprevalence and risk factors of antibodies against among dog owners in southwestern Québec, Canada.

Epidemiol Infect 2021 Jun 28:1-45. Epub 2021 Jun 28.

Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Québec, Canada.

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Acute Q Fever in an Ankylosing Spondyloarthritis Patient Treated with Etanercept.

Case Rep Rheumatol 2021 1;2021:9944387. Epub 2021 Jun 1.

Department of Internal Medicine, Farhat Hached Hospital, Sousse, Tunisia.

Q fever is a rare zoonotic infection caused by . Tumor necrosis factor-alpha (TNF-) has an important role in the early control of this infection. However, TNF- blockers increase the risk of infectious diseases. Read More

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Polymicrobial Infections Among Patients with Vascular Q Fever, France, 2004-2020.

Emerg Infect Dis 2021 ;27(7):1961-1963

We report 5 cases of vascular Q fever complicated by polymicrobial superinfection in patients who had no risk factors for acute Q fever. Q fever was diagnosed by serologic and molecular assays for Coxiella burnetii. We confirmed additional infections using conventional graft cultures. Read More

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SEROLOGICAL EVIDENCE OF INFECTION IN THE WHITE RHINOCEROS () IN SOUTH AFRICA.

J Zoo Wildl Med 2021 Jun;52(2):573-579

White Oak Conservation, Yulee, FL 32097, USA.

Coxiellosis, or Query (Q) fever, a disease caused by the intracellular bacteria , was recently described in a managed breeding herd of white rhinoceros () in the southeastern United States. Clinical disease often results in abortion and could represent a conservation challenge for this species. In addition to the reproductive and herd management consequences, coxiellosis is also a zoonotic disease. Read More

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The epidemiology of bacterial zoonoses in pastoral and dairy cattle in Cameroon, Central Africa.

Zoonoses Public Health 2021 Jun 15. Epub 2021 Jun 15.

Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK.

Previous work identified that bacterial zoonoses (Brucella species, Coxiella burnetii and Leptospira hardjo) were present in Cameroonian pastoral cattle. To assess the characteristics of this zoonotic risk, we analyse seroprevalence of each pathogen and the associated management, herd and environmental factors in Cameroonian pastoral and dairy cattle. Cross-sectional samples included pastoralist herds in the Northwest Region (NWR n = 750) and Vina Division (VD n = 748) and small holder dairy herds in the NWR (n = 60). Read More

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Serological survey of Coxiella burnetii infections in dairy cattle, sheep, goats and zoo animals in Hungary - Short communication.

Acta Vet Hung 2021 Jun 8. Epub 2021 Jun 8.

3Institute for Veterinary Medical Research, Centre for Agricultural Research, Budapest, Hungary.

Q fever is a disease of high zoonotic potential, but interest in its causative agent is rather low although it causes some public health problems in Hungary. The prevalence of Q fever is highly variable by country. The main reservoirs of the disease are the same domestic ruminant species everywhere, but the epidemiological profile depends on the features of the specific reservoir. Read More

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Human Q Fever on the Guiana Shield and Brazil: Recent Findings and Remaining Questions.

Curr Trop Med Rep 2021 Jun 1:1-10. Epub 2021 Jun 1.

Departamento de Tuberculosis, Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.

Purpose Of Review: In this review, we report on the state of knowledge about human Q fever in Brazil and on the Guiana Shield, an Amazonian region located in northeastern South America. There is a contrast between French Guiana, where the incidence of this disease is the highest in the world, and other countries where this disease is practically non-existent.

Recent Findings: Recent findings are essentially in French Guiana where a unique strain MST17 has been identified; it is probably more virulent than those usually found with a particularly marked pulmonary tropism, a mysterious animal reservoir, a geographical distribution that raises questions. Read More

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Animal board invited review: Risks of zoonotic disease emergence at the interface of wildlife and livestock systems.

Animal 2021 Jun 3;15(6):100241. Epub 2021 Jun 3.

College of Veterinary Medicine, Comparative Medicine Research Institute, Yangzhou University, 225009 Yangzhou, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, 225009 Yangzhou, China.

The ongoing coronavirus disease 19s pandemic has yet again demonstrated the importance of the human-animal interface in the emergence of zoonotic diseases, and in particular the role of wildlife and livestock species as potential hosts and virus reservoirs. As most diseases emerge out of the human-animal interface, a better understanding of the specific drivers and mechanisms involved is crucial to prepare for future disease outbreaks. Interactions between wildlife and livestock systems contribute to the emergence of zoonotic diseases, especially in the face of globalization, habitat fragmentation and destruction and climate change. Read More

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Proteome-wide analysis of Coxiella burnetii for conserved T-cell epitopes with presentation across multiple host species.

BMC Bioinformatics 2021 Jun 2;22(1):296. Epub 2021 Jun 2.

USDA-ARS Animal Disease Research Unit, Pullman, WA, 99164, USA.

Background: Coxiella burnetii is the Gram-negative bacterium responsible for Q fever in humans and coxiellosis in domesticated agricultural animals. Previous vaccination efforts with whole cell inactivated bacteria or surface isolated proteins confer protection but can produce a reactogenic immune responses. Thereby a protective vaccine that does not cause aberrant immune reactions is required. Read More

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