2,921 results match your criteria cox subunit


Abdominal dioctophymosis in a domestic cat from the Peruvian rainforest confirmed morphologically and molecularly.

Parasitol Int 2021 Apr 17:102359. Epub 2021 Apr 17.

Laboratorio de Epidemiologia y Economía Veterinaria, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Av. Circunvalación 2800, San Borja. Lima, Peru.

A case of abdominal dioctophymosis in a domestic cat was found in San Juan Bautista district, the Peruvian rainforest, in the Loreto department of Peru. The pet went to a veterinary clinic for a routine ovariohysterectomy during which a large nematode was found in the abdominal cavity. The nematode was morphologically identified as an adult female of Dioctophyme sp. Read More

View Article and Full-Text PDF

Recombinase polymerase amplification with lateral flow strip for detecting Babesia microti infections.

Parasitol Int 2021 Apr 16:102351. Epub 2021 Apr 16.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China; Key Laboratory of Animal Epidemical Disease and Infectious Zoonoses, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, Hubei 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan, Hubei 430070, China. Electronic address:

Babesia microti is one of the most important pathogens causing humans and rodents babesiosis-an emerging tick-borne disease that occurs worldwide. At present, the gold standard for the detection of Babesia is the microscopic examination of blood smears, but this diagnostic test has several limitations. The recombinase polymerase amplification with lateral flow (LF-RPA) assay targeting the mitochondrial cytochrome oxidase subunit I (cox I) gene of B. Read More

View Article and Full-Text PDF

Ptosis, ophthalmoplegia and corneal endothelial disease - ocular manifestations of mitochondrial disease.

Am J Ophthalmol Case Rep 2021 Jun 17;22:101073. Epub 2021 Mar 17.

Department of Orbit, Plastic and Lacrimal Surgery, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria, Australia.

Purpose: To describe two patients with bilateral ptosis, ophthalmoplegia, cataracts and corneal endothelial disease requiring corneal transplantation.

Observations: Histopathological analysis of muscle biopsy samples from both patients identified features consistent with a mitochondrial cytopathy. A single multigenic mitochondrial deoxyribonucleic acid (DNA) deletion was detected in the first patient. Read More

View Article and Full-Text PDF

A novel nonsense variant in MT-CO3 causes MELAS syndrome.

Neuromuscul Disord 2021 Mar 3. Epub 2021 Mar 3.

Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 West Wenhua Road Jinan, Jinan, Shandong 250012 China; Department of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong 266035 China; Mitochondrial Medicine Laboratory, Qilu Hospital (Qingdao), Shandong University, Qingdao, Shandong 266035 China; Brain Science Research Institute, Shandong University, Jinan, Shandong 250000, China. Electronic address:

Both mitochondrial and nuclear gene mutations can cause cytochrome c oxidase (COX, complex Ⅳ) dysfunction, leading to mitochondrial diseases. Although numerous diseases caused by defects of the COX subunits or COX assembly factors have been documented, clinical cases directly related to mitochondrial cytochrome c oxidase subunit 3 gene (MT-CO3) mutations are relatively rare. Here, we report a 47-year-old female patient presented with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. Read More

View Article and Full-Text PDF

A metabolism-related gene signature for predicting the prognosis and therapeutic responses in patients with hepatocellular carcinoma.

Ann Transl Med 2021 Mar;9(6):500

Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.

Background: Hepatocellular carcinoma (HCC) often has an insidious onset and rapid progression. Often, when the disease is first diagnosed, the opportune time for surgical intervention has already lapsed. In addition, the effects of systemic treatment is relatively unsatisfactory. Read More

View Article and Full-Text PDF

Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes.

Circ Res 2021 Apr 14. Epub 2021 Apr 14.

Cardiovascular Sciences, University of Manchester, UNITED KINGDOM.

Athletes present with atrioventricular node (AV node) dysfunction manifesting as AV block. This can necessitate electronic pacemaker implantation, known to be more frequent in athletes with a long training history. AV block in athletes is attributed to high vagal tone. Read More

View Article and Full-Text PDF

Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice.

J Cancer Prev 2021 Mar;26(1):41-53

Laboratory of Immunology, Division of Biotechnology Review and Research-III, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

Colon tumors develop more frequently in male than in female. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays differential roles in the stage of tumorigenesis. The purpose of this study was to investigate the role of Nrf2 on colitis-associated tumorigenesis using Nrf2 knockout (KO) female mice. Read More

View Article and Full-Text PDF

Overexpression of GINS4 Is Associated With Tumor Progression and Poor Survival in Hepatocellular Carcinoma.

Front Oncol 2021 25;11:654185. Epub 2021 Mar 25.

Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.

Purpose: Our research was aimed to identify the expression, clinical value and biological significance of GINS complex subunit 4 (GINS4) in hepatocellular carcinoma (HCC).

Materials And Methods: GINS4 was initially screened through weighted gene co-expression network analysis (WGCNA). The TCGA, GEO, and TIMER databases were applied for analyzing the GINS4 mRNA expression in HCC. Read More

View Article and Full-Text PDF

COPB2: A Novel Prognostic Biomarker That Affects Progression of HCC.

Biomed Res Int 2021 20;2021:6648078. Epub 2021 Mar 20.

Department of Hepatobiliary Surgery and Center of Organ Transplantation, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China.

Purpose: This study is aimed at investigating the expression, underlying biological function, and clinical significance of coatomer protein complex subunit beta 2 (COPB2) in hepatocellular carcinoma (HCC).

Methods: HCC-related data were extracted from The Cancer Genome Atlas (TCGA) database, International Cancer Genome Consortium (ICGC) database, and Gene Expression Omnibus (GEO) database. A logistic regression module was applied to analyze the relationship between the expression of COPB2 and clinicopathologic characteristics. Read More

View Article and Full-Text PDF

Development and Validation of a Hypoxia-Associated Prognostic Signature Related to Osteosarcoma Metastasis and Immune Infiltration.

Front Cell Dev Biol 2021 18;9:633607. Epub 2021 Mar 18.

Department of Orthopedics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Increasing evidence has shown that hypoxia microenvironment relates to tumor initiation and progression. However, no studies focus on the application of hypoxia-associated genes in predicting osteosarcoma patients' prognosis. This research aims to identify the hypoxia-associated genes related to osteosarcoma metastasis and construct a gene signature to predict osteosarcoma prognosis. Read More

View Article and Full-Text PDF

Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer's Disease.

Aging Dis 2021 Apr 1;12(2):441-465. Epub 2021 Apr 1.

1Division of Neurodegenerative Disorders, St. Boniface Hospital Research, Winnipeg, MB, Canada.

Current treatments targeting amyloid beta in Alzheimer's disease (AD) have minimal efficacy, which results in a huge unmet medical need worldwide. Accumulating data suggest that brain mitochondrial dysfunction play a critical role in AD pathogenesis. Targeting cellular mechanisms associated with mitochondrial dysfunction in AD create a novel approach for drug development. Read More

View Article and Full-Text PDF

NF-κB activation in retinal microglia is involved in the inflammatory and neovascularization signaling in laser-induced choroidal neovascularization in mice.

Exp Cell Res 2021 Mar 31;403(1):112581. Epub 2021 Mar 31.

Department of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

Purpose: To evaluate Nuclear Factor NF-κB (NF-κB) signaling on microglia activation, migration, and angiogenesis in laser-induced choroidal neovascularization (CNV).

Methods: Nine-week-old C57BL/6 male mice were randomly assigned to IMD-0354 treated or untreated groups (5 mice, 10 eyes per group). CNV was induced with a 532-nm laser. Read More

View Article and Full-Text PDF

Isorhapontigenin alleviates lipopolysaccharide-induced acute lung injury via modulating Nrf2 signaling.

Respir Physiol Neurobiol 2021 Mar 30;289:103667. Epub 2021 Mar 30.

Department of Respiratory and Critical Care, Tianjin Medical University General Hospital, Tianjin, 300052, China. Electronic address:

Nuclear factor erythroid-2 related factor 2 (Nrf2) is involved in mitigating various oxidative stress- and inflammation-induced diseases, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Isorhapontigenin (ISO), from the Chinese herb Gnetum cleistostachyum, exhibits antioxidant and anti-inflammatory properties. In this study, we explored the protective effects of ISO in ALI and its underlying molecular mechanisms. Read More

View Article and Full-Text PDF

Downregulation of ITGA6 confers to the invasion of multiple myeloma and promotes progression to plasma cell leukaemia.

Br J Cancer 2021 Mar 30. Epub 2021 Mar 30.

Department of Cell Biology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, China.

Background: Secondary plasma cell leukaemia (sPCL) is an aggressive form of multiple myeloma (MM), but the mechanism underlying MM progresses into PCL remains unknown.

Methods: Gene expression profiling of MM patients and PCL patients was analysed to identify the molecular differences between the two diseases. Cox survival regression and Kaplan-Meier analysis were performed to illustrate the impact of integrin subunit alpha 6 (ITGA6) on prognosis of MM. Read More

View Article and Full-Text PDF

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211004944

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Background And Objective: Gastric cancer (GC) is a common tumor malignancy with high incidence and poor prognosis. Laminin is an indispensable component of basement membrane and extracellular matrix, which is responsible for bridging the internal and external environment of cells and transmitting signals. This study mainly explored the association of the LAMB1 expression with clinicopathological characteristics and prognosis in gastric cancer. Read More

View Article and Full-Text PDF

Patient-Reported Outcomes in Patients With -Mutated Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer From SOLAR-1.

J Clin Oncol 2021 Mar 29:JCO2001139. Epub 2021 Mar 29.

Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.

Purpose: In the phase III SOLAR-1 trial (NCT02437318), the PI3Kα-selective inhibitor and degrader alpelisib significantly improved median progression-free survival when added to fulvestrant in patients with phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ()-mutated, hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer. We assessed health-related quality of life using patient-reported outcome measures in these patients.

Materials And Methods: In the -mutant cohort, 341 patients were randomly assigned 1:1 to receive alpelisib 300 mg daily or placebo plus fulvestrant 500 mg on days 1 and 15 of cycle 1 and on day 1 of subsequent 28-day cycles. Read More

View Article and Full-Text PDF

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.

Autophagy 2021 Mar 28:1-18. Epub 2021 Mar 28.

Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Macroautophagy/autophagy and necroptosis represent two opposing cellular s tress responses. Whereas autophagy primarily fulfills a cyto-protective function, necroptosis is a form of regulated cell death induced via death receptors. Here, we aimed at investigating the molecular crosstalk between these two pathways. Read More

View Article and Full-Text PDF

miR-708 Negatively Regulates TNF/IL-1 Signaling by Suppressing NF-B and Arachidonic Acid Pathways.

Mediators Inflamm 2021 10;2021:5595520. Epub 2021 Mar 10.

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers School of Graduate Studies-RBHS, Newark, NJ 07005, USA.

Two pathways commonly dysregulated in autoimmune diseases and cancer are tumor necrosis factor alpha (TNF) and interleukin 1 beta (IL-1) signaling. Researchers have also shown that both signaling cascades positively regulate arachidonic acid (AA) signaling. More specifically, TNF/IL-1 promotes expression of the prostaglandin E2- (PGE-) producing enzymes, cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1). Read More

View Article and Full-Text PDF

Construction of a prognostic value model in papillary renal cell carcinoma by immune-related genes.

Medicine (Baltimore) 2021 Mar;100(12):e24903

Department of Pharmacy, Traditional Chinese Medical Hospital of Huangdao District, Qingdao, P.R. China.

Abstract: Papillary renal cell carcinoma (PRCC) is the second most common type of renal carcinoma following clear cell renal cell carcinoma, and the role of immune-related genes (IRGs) in tumorigenesis and metastasis is evident; its prognostic value in PRCC remains unclear. In this study, we downloaded the gene expression profiles and clinical data of patients with PRCC from The Cancer Genome Atlas (TCGA) database and obtained IRGs from the ImmPort database. A total of 371 differentially expressed IRGs (DEIRGs) were discovered between PRCC and normal kidney tissues. Read More

View Article and Full-Text PDF

Zerumin A attenuates the inflammatory responses in LPS-stimulated H9c2 cardiomyoblasts.

J Biochem Mol Toxicol 2021 Mar 23:e22777. Epub 2021 Mar 23.

Biochemistry and Molecular Mechanism Laboratory, Agro-Processing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, Kerala, India.

Zerumin A (ZA) is one of the potential components of Curcuma amada rhizomes, and it has been shown to possess a variety of pharmacological activities. This study deals with the beneficial activity of ZA in lipopolysaccharide (LPS)-stimulated inflammation in H9c2 cardiomyoblasts. Herein, H9c2 cells were preincubated with ZA for 1 h and stimulated with LPS for 24 h. Read More

View Article and Full-Text PDF

In search for biomarkers and potential drug targets for uterine serous endometrial cancer.

J Cancer Res Clin Oncol 2021 Mar 23. Epub 2021 Mar 23.

Department of Life Sciences and Public Health, Section of Gynaecology and Obstetrics, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: Serous endometrial cancer (USC) is a challenging malignancy associated with metastasis, recurrence and poor outcome. To identify clinically relevant prognostic biomarkers, we focused on a panel of proteins selected after a comprehensive literature review, for tumour profiling of a homogeneous cohort of USC patients.

Methods: Protein levels and localization were assessed by immunohistochemistry analysis in 36 hysterectomy samples. Read More

View Article and Full-Text PDF

Diagnostic significance of serum PP4R1 and its predictive value for the development of chronic complications in patients with type 2 diabetes mellitus.

Diabetol Metab Syndr 2021 Mar 9;13(1):27. Epub 2021 Mar 9.

Nephrology and Urology Centre, University-Town Hospital of Chongqing Medical University, No. 55, University-Town Middle Road, Chongqing, 401551, China.

Background: Protein phosphatase 4 regulatory subunit 1 (PP4R1) is one of the regulatory subunits of PP4. It has been determined to be involved in the regulation of TNF-α-induced hepatic insulin resistance and gluconeogenesis. Considering the important role of PP4R1 in hepatic insulin resistance, the current study explored the expression and diagnostic value of PP4R1 in type 2 diabetes mellitus (T2DM) patients and further investigated its predictive value for the development of chronic complications. Read More

View Article and Full-Text PDF

Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.

Oxid Med Cell Longev 2021 26;2021:6675264. Epub 2021 Feb 26.

Department of Emergency Medicine, Northern Jiangsu People's Hospital, Yangzhou University College of Clinical Medicine, Yangzhou 225001, China.

Acute lung injury (ALI) is a serious respiratory syndrome characterized with uncontrolled inflammatory response. Oxyberberine has strong potential for clinical usage since it showed strong anti-inflammatory, antifungal, and antiarrhythmic effects in various diseases. In the present study, we evaluated whether oxyberberine can inhibit lipopolysaccharide- (LPS-) induced ALI and further evaluated the possible involvement of mitophagy by using A549 cells, a human lung epithelial cell line. Read More

View Article and Full-Text PDF
February 2021

PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma.

Front Oncol 2021 26;11:607021. Epub 2021 Feb 26.

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Proteasome 26S subunit ATPase 2 (PSMC2) plays a pathogenic role in various cancers. However, its function and molecular mechanism in hepatocellular carcinoma (HCC) remain unknown. In this study, tissue microarray (TMA) analysis showed that PSMC2 is highly expressed in HCC tumors and correlates with poor overall and disease-free survival in HCC patients. Read More

View Article and Full-Text PDF
February 2021

Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.

Mol Metab 2021 Mar 9;49:101207. Epub 2021 Mar 9.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark. Electronic address:

Objectives: Obesity is a complex disease associated with a high risk of comorbidities. Gastric bypass surgery, an invasive procedure with low patient eligibility, is currently the most effective intervention that achieves sustained weight loss. This beneficial effect is attributed to alterations in gut hormone signaling. Read More

View Article and Full-Text PDF

Molecular and Functional Effects of Loss of Cytochrome c Oxidase Subunit 8A.

Biochemistry (Mosc) 2021 Jan;86(1):33-43

Institute of Experimental Epileptology and Cognition Research, Life & Brain Center, University of Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.

In this work we studied molecular and functional effects of the loss of the smallest nuclear encoded subunit of cytochrome c oxidase COX8A in fibroblasts from a patient with a homozygous splice site mutation and in CRISPR/Cas9 genome-edited HEK293T cells. In both cellular model systems, between 20 to 30% of the residual enzymatic activity of cytochrome c oxidase (COX) was detectable. In immunoblots of BN-PAGE separated mitochondria from both cellular models almost no monomers and dimers of the fully assembled COX could be visualized. Read More

View Article and Full-Text PDF
January 2021

Description of a new species of Moniliformis (Acanthocephala: Moniliformidae) from Peromyscus hylocetes (Rodentia: Cricetidae) in Mexico.

Parasitol Int 2021 Mar 4;83:102315. Epub 2021 Mar 4.

Departamento de Zoología, Instituto de Biología, Universidad Nacional Autónoma de México, Apartado Postal 70-153, CP 04510 Ciudad de México, Mexico. Electronic address:

Moniliformis ibunami n. sp., is described from the intestine of the transvolcanic deermouse Peromyscus hylocetes Merriam 1898 (Cricetidae) from Parque Nacional Nevado de Colima "El Floripondio", Jalisco, Mexico. Read More

View Article and Full-Text PDF

Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency.

Cells 2021 Feb 20;10(2). Epub 2021 Feb 20.

Department of Genetics, Hadassah Medical Center, Jerusalem 9112001, Israel.

Cytochrome--oxidase (COX) subunit 4 (COX4) plays important roles in the function, assembly and regulation of COX (mitochondrial respiratory complex 4), the terminal electron acceptor of the oxidative phosphorylation (OXPHOS) system. The principal COX4 isoform, COX4-1, is expressed in all tissues, whereas COX4-2 is mainly expressed in the lungs, or under hypoxia and other stress conditions. We have previously described a patient with a COX4-1 defect with a relatively mild presentation compared to other primary COX deficiencies, and hypothesized that this could be the result of a compensatory upregulation of COX4-2. Read More

View Article and Full-Text PDF
February 2021

Identification of NDRG Family Member 4 (NDRG4) and CDC28 Protein Kinase Regulatory Subunit 2 (CKS2) as Key Prognostic Genes in Adrenocortical Carcinoma by Transcriptomic Analysis.

Med Sci Monit 2021 Mar 5;27:e928523. Epub 2021 Mar 5.

Department of Urology, Shanghai Yangsi Hospital, Shanghai, China (mainland).

BACKGROUND Adrenocortical carcinoma (ACC) is an aggressive cancer with heterogeneous outcomes. In this study, we aimed to investigate genomic and prognostic features of ACC. MATERIAL AND METHODS Clinical, pathologic, and transcriptomic data from 2 independent datasets derived from ACC samples (TCGA-ACC dataset, GEO-GSE76021 dataset) were collected. Read More

View Article and Full-Text PDF

Ultramorphology and Molecular Studies of Larvae (Nematoda: Anisakidae) Collected in Five Cyprinid Fish Species from Sulaimani Province, Kurdistan Region-Iraq.

Helminthologia 2021 Mar 10;58(1):41-58. Epub 2021 Feb 10.

Biology Dept., College of Science, University of Sulaimani, Erbil, Iraq.

A total of 1134 freshwater fishes belonging to Cyprinidae ( (n=20), (n=7), (n=62), (n=123), (n=7), (n=222), (n=161), (n=5), (n=89), (n=54), (n=52), (n=10) and (n=322)) were collected in different water bodies in Sulaimani Province, Kurdistan Region-Iraq for the presence of larval nematode of the genus . This investigation revealed that 17 fishes belonged to five species (, , , and ) were infected with larvae with prevalence of 35 %, 0.81 %, 0. Read More

View Article and Full-Text PDF