91,298 results match your criteria cox regression

Postsurgical status of articular cartilage after arthroscopic posterior cruciate ligament reconstruction in patients with or without concomitant meniscal pathology.

Clin Imaging 2021 Sep 8;80:406-412. Epub 2021 Sep 8.

Department of Physical & Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: Several factors present at the time of posterior cruciate ligament reconstruction (PCLR) may cause the subsequent progression of articular cartilage lesions. This study aimed to evaluate postsurgical articular cartilage lesions which can be seen on MRI in patients who underwent arthroscopic PCLR with or without concomitant meniscal pathology.

Material And Methods: A total of sixty-five patients (mean age 35. Read More

View Article and Full-Text PDF
September 2021

Identification of a novel immune-related prognostic signature associated with tumor microenvironment for breast cancer.

Int Immunopharmacol 2021 Sep 15;100:108122. Epub 2021 Sep 15.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: In the view that immune-related genes play a crucial role in breast cancer progression and long-term patient outcomes, we aimed to identify a novel gene signature based on immune-related genes to improve the prognostic prediction of breast cancer.

Methods: RNA sequencing data and clinical information were obtained from The Cancer Genome Atlas (TCGA). Univariate and multivariate Cox regression analyses were conducted to establish the immune-related prognostic signature (IRPS). Read More

View Article and Full-Text PDF
September 2021

Self-Reported Physical Activity and Asthma Risk in Children.

J Allergy Clin Immunol Pract 2021 Sep 15. Epub 2021 Sep 15.

Background: Increased physical activity (PA) may protect against asthma but PA can trigger asthma symptoms.

Objective: To investigate relationships between moderate to vigorous PA (MVPA) assessed during routine care visits and incident asthma.

Methods: Retrospective cohort of 542,486 children, 2-17 years from 2010-2017 with MVPA assessed (exercise vital sign) during routine care visits. Read More

View Article and Full-Text PDF
September 2021

Multiple-type HPV infection predicting condyloma acuminatum recurrence after aminolevulinic acid photodynamic therapy.

Photodiagnosis Photodyn Ther 2021 Sep 15:102538. Epub 2021 Sep 15.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Background: Aminolevulinic acid photodynamic therapy (ALA-PDT) has been widely used in the treatment of condyloma acuminatum (CA), but there is a lack of reports on clinical factors related to CA relapse after photodynamic therapy.

Methods: The clinical data of patients with CA treated with ALA-PDT from April 2018 to December 2019 were retrospectively analyzed, including HPV type, follow-up time and recurrence within 6 months after treatment. The patients were classified into single-type HPV infection and multiple-type HPV infection groups. Read More

View Article and Full-Text PDF
September 2021

Multi-ethnic genome-wide and HLA association study of total serum IgE.

J Allergy Clin Immunol 2021 Sep 15. Epub 2021 Sep 15.

Department of Human Genetics, University of Chicago, Chicago, IL.

Background: Total serum IgE (tIgE) is an important intermediate phenotype of allergic disease. Whole genome genetic association studies across ancestries may identify important determinants of IgE.

Objective: By leveraging data from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) and the Atopic Dermatitis Research Network (ADRN), we aim to increase understanding of genetic variants affecting tIgE production across the ancestry and allergic disease spectrum (N=21,901). Read More

View Article and Full-Text PDF
September 2021

Low-dose aspirin use and mortality risk in patients with head and neck cancer - a nationwide cohort study of 10,770 patients.

Int J Cancer 2021 Sep 18. Epub 2021 Sep 18.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Several recent observational studies have linked low-dose aspirin use to improved survival in patients with head and neck cancer. However, studies of patterns of aspirin use and risk of cancer-specific mortality are lacking. This nationwide cohort study included all patients in the Danish Cancer Registry with a primary diagnosis of head and neck squamous cell cancer (HNSCC) during 2000-2016, aged 30-84 years, without prior cancer (except non-melanoma skin cancer), and alive 1 year after diagnosis. Read More

View Article and Full-Text PDF
September 2021

Hypothyroidism is a Predictive Factor of Superior Anti-tumor Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma.

Int J Cancer 2021 Sep 18. Epub 2021 Sep 18.

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Programmed death 1(PD-1) inhibitors are widely used for treatment of hepatocellular carcinoma (HCC). Hypothyroidism is commonly associated with this therapy, although the mechanism underlying this complication and effects on patient prognosis remain unclear. We retrospectively analysed the data of patients with HCC who received anti-PD-1 therapy at Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology between January 2018 and May 2020. Read More

View Article and Full-Text PDF
September 2021

An Echocardiography-derived Calcium Score as a Predictor of Major Adverse Cardiovascular Events in Peritoneal Dialysis Patients - A Prospective Cohort Study.

Nephrology (Carlton) 2021 Sep 18. Epub 2021 Sep 18.

Kwong Wah Hospital, Hong Kong.

Background: An echocardiography-derived calcium score (ECS) has been shown to predict CV mortality in the general population but has not been utilized in the dialysis population.

Methods: We conducted a prospective cohort study including 125 prevalent PD patients. Two blinded and independent echocardiographers determined the ECS for each subject at baseline. Read More

View Article and Full-Text PDF
September 2021

Demographic and clinical characteristics of a population-based paediatric cohort of type 1 and type 2 diabetes in Western Australia (1999-2019).

Pediatr Diabetes 2021 Sep 18. Epub 2021 Sep 18.

Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia.

Objectives: To determine demographic and clinical characteristics of youth diagnosed with type 1 (T1D) or type 2 (T2D) diabetes aged ≤15 years from 1999-2019 in Western Australia, and examine time to first diagnosis of diabetes complications.

Methods: A retrospective cohort study was conducted of patients identified from the population-based, prospective Western Australian Children's Diabetes Database and longitudinal data extracted for available demographic and clinical variables. Patients were followed from diagnosis to transition to adult services, death or 31 December 2019. Read More

View Article and Full-Text PDF
September 2021

A comprehensive prognostic analysis of osimertinib treatment in advanced non-small cell lung cancer patients with acquired EGFR-T790M mutation: a real-world study.

J Cancer Res Clin Oncol 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Purpose: Osimertinib is the standard treatment for advanced non-small cell lung cancer (NSCLC) patients with T790M mutation after the failure of first-/second-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). We comprehensively analyzed factors that affect the therapeutic efficacy of the osimertinib treatment in NSCLC patients.

Methods: 351 NSCLC patients with T790M mutation receiving osimertinib treatment were included. Read More

View Article and Full-Text PDF
September 2021

Surgical management of splenic flexure colon cancer: a retrospective propensity-matched study comparing open and minimally invasive approaches using the national cancer database.

Int J Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Department of Colon and Rectal Surgery, George Washington University Hospital, Washington, DC, USA.

Purpose: Minimally invasive resection of colon cancer at the splenic flexure can be technically challenging with concerns for a suboptimal oncologic outcome. We aimed to compare open and minimally invasive approaches following curative resection.

Methods: The National Cancer Database was queried for patients with non-metastatic colon adenocarcinoma at the splenic flexure who underwent resection from 2010 to 2016. Read More

View Article and Full-Text PDF
September 2021

Immune signatures of bone marrow cells can independently predict prognosis in patients with myelodysplastic syndrome.

Br J Haematol 2021 Sep 18. Epub 2021 Sep 18.

Division of Haematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Increasing evidence supports the role of the immune microenvironment and associated signalling in the pathogenesis of myelodysplastic syndromes (MDS). Nevertheless, the clinical relevancy of immune signals in patients with MDS remains elusive. To address this, we used single-sample gene-set enrichment analysis to score immune signatures of bone marrow (BM) samples from 176 patients with primary MDS. Read More

View Article and Full-Text PDF
September 2021

Sleep Disturbance in Individuals at Clinical High Risk for Psychosis.

Schizophr Bull 2021 Sep 18. Epub 2021 Sep 18.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.

Introduction: Disturbed sleep is a common feature of psychotic disorders that is also present in the clinical high risk (CHR) state. Evidence suggests a potential role of sleep disturbance in symptom progression, yet the interrelationship between sleep and CHR symptoms remains to be determined. To address this knowledge gap, we examined the association between disturbed sleep and CHR symptoms over time. Read More

View Article and Full-Text PDF
September 2021

Diamond-Forrester classification using echocardiography haemodynamic assessment in cardiac intensive care unit patients.

ESC Heart Fail 2021 Sep 18. Epub 2021 Sep 18.

Department of Cardiovascular Medicine, Echocardiography Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Aims: We sought to determine whether the Diamond-Forrester classification using non-invasive haemodynamic measurements by 2-D and Doppler echocardiography would predict hospital mortality in cardiac intensive care unit (CICU) patients.

Methods And Results: We retrospectively analysed unique patients admitted to the CICU at Mayo Clinic Rochester from 2007 to 2018. Doppler-derived cardiac index (CI) and ratio of mitral valve E velocity to medial mitral annulus e' velocity (E/e' ratio) were used to classify patients into four profiles: Profile I (warm/dry), Profile II (warm/wet), Profile III (cold/dry), and Profile IV (cold/wet). Read More

View Article and Full-Text PDF
September 2021

Tumor microenvironment is associated with clinical and genetic properties of diffuse gliomas and predicts overall survival.

Cancer Immunol Immunother 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Tumor microenvironment (TME) is a complex and dynamic evolving environment which facilitates tumor proliferation and progression. We aimed at investigating the characteristics of tumor microenvironment and its prognostic value in gliomas. Transcriptome data of 702 glioma samples from The Cancer Genome Atlas were included as training dataset, while 325 samples from Chinese Glioma Genome Atlas database and 268 samples from GSE16011 database were used to validate. Read More

View Article and Full-Text PDF
September 2021

A Biomarker-Based Score for Risk of Hospitalization for Heart Failure in Patients With Diabetes.

Diabetes Care 2021 Sep 17. Epub 2021 Sep 17.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Objective: Heart failure (HF) is an impactful complication of type 2 diabetes mellitus (T2DM). We aimed to develop and validate a risk score for hospitalization for HF (HHF) incorporating biomarkers and clinical factor(s) in patients with T2DM.

Research Design And Methods: We derived a risk score for HHF using clinical data, high-sensitivity troponin T (hsTnT), and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) from 6,106 placebo-treated patients with T2DM in SAVOR-TIMI 53 (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction 53). Read More

View Article and Full-Text PDF
September 2021

Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: Report of an international multicenter cohort study with propensity score matching.

Surgery 2021 Sep 14. Epub 2021 Sep 14.

Department of Hepatobiliary and Liver Transplantation Surgery, AP-HP, Hôpital Pitié Salpêtrière, CRSA, Sorbonne Université, Paris, France. Electronic address:

Background: Intrahepatic cholangiocarcinoma is a rare disease with a poor prognosis. In patients where surgical resection is possible, outcome is influenced by perioperative morbidity and lymph node status. Laparoscopic liver resection is associated with improved clinical and oncological outcomes in primary and metastatic liver cancer compared with open liver resection, but evidence on intrahepatic cholangiocarcinoma is still insufficient. Read More

View Article and Full-Text PDF
September 2021

Does weight change modify the association between the consumption of sugar-sweetened beverages and 100% fruit juice and the risk of metabolic syndrome?

Clin Nutr 2021 Aug 28;40(10):5261-5268. Epub 2021 Aug 28.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background & Aims: This study aimed to determine the prospective relationship between the consumption of sugar-sweetened beverages (SSBs) and 100% fruit juice and metabolic syndrome (MetS) and to investigate whether weight change can modify this association in a representative sample of the population of Tehran, Iran.

Methods: In this 8.9-year follow-up study, the consumption of SSBs and 100% fruit juice by 1915 individuals, who participated in Tehran Lipid and Glucose Study (TLGS), was examined using a validated food frequency questionnaire. Read More

View Article and Full-Text PDF

Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease.

Clin Nutr 2021 Aug 25;40(10):5252-5260. Epub 2021 Aug 25.

Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, 16995, Republic of Korea. Electronic address:

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is closely related to metabolic dysfunction, including insulin resistance, obesity, and metabolic syndrome. Dairy protein, rich in casein and whey protein, could help to reduce metabolic diseases. Therefore, we investigated the relationship between dairy protein intake and incident NAFLD. Read More

View Article and Full-Text PDF

Post-operative Renal Failure, Shunt Type and Mortality after Norwood Palliation.

Ann Thorac Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatrics, Duke University Medical Center, 2301 Erwin Road, Durham, North Carolina 27710; Duke Clinical Research Institute, Duke University Medical Center, 2301 Erwin Road, Durham, North Carolina 27710.

Background: The Single Ventricle Reconstruction (SVR) trial demonstrated increased risk of death or heart transplant one year post-Norwood in subjects randomized to Blalock-Taussig shunts (mBTS) compared to right ventricle-to-pulmonary artery (RV-PA) shunts. We used the SVR public use database to evaluate incidence and risk factors for post-operative renal failure and relationships between renal failure, shunt type and outcomes post-Norwood.

Methods: Post-operative renal failure was defined a-priori as a 3-fold rise in creatinine from baseline, or dialysis use, within 7 days of Norwood. Read More

View Article and Full-Text PDF
September 2021

Risk of nontyphoidal Salmonella infection in patients with cholecystectomy: Results from a nationwide matched cohort study in Taiwan.

Int J Clin Pract 2021 Sep 17:e14787. Epub 2021 Sep 17.

Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Background: The current study was designed to investigate the association between cholecystectomy and the risk of nontyphoidal Salmonella (NTS) infection.

Methods: We obtained claims-based data from the Taiwan National Health Insurance Research Database (NHIRD) to perform a nationwide cohort study. A propensity score (PS)-matching analysis was performed with a ratio of 1:2 in the cholecystectomy cohort and cholecystectomy-free group to reduce selection bias. Read More

View Article and Full-Text PDF
September 2021

Effects of biologics on reducing the risks of total knee replacement and total hip replacement in rheumatoid arthritis.

Rheumatology (Oxford) 2021 Sep 17. Epub 2021 Sep 17.

Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Objectives: RA damages the joints and increases the risks of total knee replacement (TKR) and total hip replacement (THR). However, the benefits of biologics in preventing TKR or THR remain unclear.

Methods: This retrospective nationwide study used the 2000-2013 claims-based National Health Insurance dataset. Read More

View Article and Full-Text PDF
September 2021

Nucleotide variants in hepatitis B virus preS region predict the recurrence of hepatocellular carcinoma.

Aging (Albany NY) 2021 Sep 17;13(undefined). Epub 2021 Sep 17.

Department of Epidemiology, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China.

Background: Hepatitis B virus (HBV) variants in the preS region have been associated with hepatocellular carcinoma (HCC). However, the effect of the preS variants on HCC prognosis remains largely unknown. We aimed to identify the preS variants that reliably predict postoperative prognosis in HCC. Read More

View Article and Full-Text PDF
September 2021

Day-to-day variation in sleep duration is associated with increased all-cause mortality.

J Clin Sleep Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, NYC Health + Hospitals/Jacobi, Albert Einstein College of Medicine.

Study Objectives: There is paucity of data on association between day-to-day variation in sleep pattern and all-cause mortality. We aim to investigate if day-to-day variation in sleep duration and onset of sleep are associated with cardiovascular and all-cause mortality.

Methods: Data belonging to 388 unique subjects from the Midlife in the United States (MIDUS) 2 Biomarker study (2004-09) was used in our study. Read More

View Article and Full-Text PDF
September 2021

Noninvasive ventilation at home reduces mortality in COPD with CRF.

Am J Manag Care 2021 Sep 1;27(9):e308-e315. Epub 2021 Sep 1.

PRECISIONheor, 11100 Santa Monica Blvd, Ste 500, Los Angeles, CA 90034. Email:

Objectives: Patients with chronic respiratory failure resulting from chronic obstructive pulmonary disease (COPD-CRF) have limited treatment options and poor health outcomes. We examined the effect of noninvasive ventilation at home (NIVH) treatment on all-cause mortality, hospitalizations, and emergency department (ED) visits.

Study Design: Retrospective cohort study. Read More

View Article and Full-Text PDF
September 2021

Time on treatment with abiraterone and enzalutamide in the Patient-overview Prostate Cancer in The National Prostate Cancer Register of Sweden.

Acta Oncol 2021 Sep 17:1-8. Epub 2021 Sep 17.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Background: There are little and inconsistent data from clinical practice on time on treatment with the androgen receptor-targeted drugs (ART) abiraterone and enzalutamide in men with metastatic castration-resistant prostate cancer (mCRPC). We assessed time on treatment with ART and investigated predictors of time on treatment.

Material And Methods: Time on treatment with ART in men with mCRPC in the patient-overview prostate cancer (PPC), a subregister of the National Prostate Cancer Register (NPCR) of Sweden, was assessed by use of Kaplan-Meier plots and Cox regression. Read More

View Article and Full-Text PDF
September 2021

Prognostic significance of surgery-induced sarcopenia in the survival of gastric cancer patients: a sex-specific analysis.

J Cachexia Sarcopenia Muscle 2021 Sep 17. Epub 2021 Sep 17.

Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.

Background: Preoperative sarcopenia is associated with a poor long-term prognosis in patients with gastric cancer (GC). Most GC patients rapidly lose muscle mass after gastrectomy. This retrospective cohort study analysed the effect of postoperative muscle loss and surgery-induced sarcopenia on the long-term outcomes of patients with GC. Read More

View Article and Full-Text PDF
September 2021

Stratification Tools for Disease-Modifying Trials in Prodromal Synucleinopathy.

Mov Disord 2021 Sep 17. Epub 2021 Sep 17.

Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.

Background: Dopamine transporter single photon-emission computed tomography (DAT-SPECT) is the strongest risk factor for phenoconversion in patients with idiopathic rapid eye movement (REM)-sleep behavior disorder (iRBD). However, it might be used as a second-line stratification tool in clinical trials, because it is expensive and mini-invasive.

Objective: Aim of the study is to investigate whether other cost-effective and non-invasive biomarkers may be proposed as first-line stratification tools. Read More

View Article and Full-Text PDF
September 2021

Influence of changes in body fat on clinical outcomes in a general population: a 12-year follow-up report on the Ansan-Ansung cohort in the Korean Genome Environment Study.

Ann Med 2021 Dec;53(1):1646-1658

Division of Cardiology, Department of Internal Medicine, Hanyang University Medical Center, Seoul, South Korea.

Background: The impact of the changes in the obesity status on mortality has not been established; thus, we investigated the long-term influence of body fat (BF) changes on all-cause deaths and cardiovascular outcomes in a general population.

Methods: A total of 8374 participants were observed for 12 years. BF was measured at least two times using a bioimpedance method. Read More

View Article and Full-Text PDF
December 2021

Optimal Lymph Node Staging System in Evaluating Prognosis of Gallbladder Carcinoma: A Multi-institutional Study.

Ann Surg Oncol 2021 Sep 16. Epub 2021 Sep 16.

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Lymph node (LN) involvement is a critical prognostic factor in patients with gallbladder carcinoma (GBC). Controversy exists regarding optimal categorization of nodal metastasis status, including anatomical location of positive nodes (AJCC 7th N staging), number of metastatic lymph nodes (NMLN), log odds of metastatic LNs (LODDS), and lymph node ratio (LNR).

Methods: Patients who underwent curative-intent resection for GBC from six Chinese tertiary hospitals between 2008 and 2013 were analyzed retrospectively. Read More

View Article and Full-Text PDF
September 2021