134,073 results match your criteria cox model

Prognostic Value of Positive Lymph Nodes in Patients with Renal Cell Carcinoma and Tumor Thrombus Undergoing Nephrectomy and Thrombectomy.

Urol Int 2021 Apr 21:1-9. Epub 2021 Apr 21.

Department of Urology, Peking University Third Hospital, Beijing, China.

Introductions: The objective of this study was to determine the prognostic value of positive lymph nodes (LNs) in patients with renal cell carcinoma (RCC) and tumor thrombus (TT) and to explore risk factors predicting LNs metastasis.

Methods: We retrospectively analyzed 216 patients with RCC and TT treated at a single institution from January 2015 to December 2019. Overall survival (OS) and progression-free survival (PFS) was estimated using the Kaplan-Meier curves divided by pathological LN status. Read More

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Hypomagnesemia Is a Risk Factor for Cardiovascular Disease- and Noncardiovascular Disease-Related Mortality in Peritoneal Dialysis Patients.

Blood Purif 2021 Apr 21:1-8. Epub 2021 Apr 21.

Department of Nephrology, Jiujiang No. 1 People's Hospital, Jiujiang, China.

Purpose: Recent research has shown that hypomagnesemia is associated with increased all-cause mortality in hemodialysis patients. However, the relationship between the long-term prognosis of peritoneal dialysis (PD) and the study is not yet clear. This study will analyze the effects of hypomagnesemia on all-cause, cardiovascular diseases (CVD), and non-CVD mortality in PD patients. Read More

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Association of bezafibrate with transplant-free survival in patients with primary biliary cholangitis.

J Hepatol 2021 Apr 18. Epub 2021 Apr 18.

Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis (MIVB-H), Saint-Antoine Hospital, European Reference (ERN) Network Rare-Liver, Saint-Antoine Research Center (CRSA), Assistance Publique - Hôpitaux de Paris (APHP), Sorbonne University, Paris, France. Electronic address:

Background & Aims: Beneficial effect of bezafibrate (BZF) on symptoms and biochemical features of primary biliary cholangitis (PBC) with incomplete response to ursodeoxycholic acid (UDCA) has been reported but long-term efficacy on survival remains unknown. In Japan, BZF has been used as a de facto second-line therapy for PBC since 2000. Herein, we compared the survival rates between patients treated with and those without BZF in a large nationwide Japanese PBC cohort. Read More

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A Study on Survival Scenario of COVID-19 patients in India: An Application of Survival Analysis on patient demographics.

JMIR Form Res 2021 Apr 13. Epub 2021 Apr 13.

International Institute for Population Sciences, Govandi Station Road, Deonar, Mumbai, IN.

Background: The study of transmission dynamics of COVID-19, have depicted the rate, patterns and predictions of the pandemic cases. In order to combat the disease transmission in India, the Government had declared lockdown on the 25th of March. Even after a strict lockdown nationwide, the cases are increasing and have crossed 4. Read More

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Feature screening with large scale and high dimensional survival data.

Biometrics 2021 Apr 21. Epub 2021 Apr 21.

Department of Statistics, Texas A&M University, 3143 TAMU, College Station, TX, 77843-3143.

Data with a huge size present great challenges in modeling, inferences and computation. In handling big data, much attention has been directed to settings with "large p small n", and relatively less work has been done to address problems with p and n being both large, though data with such a feature have now become more accessible than before, where p represent the number of variables and n stands for the sample size. The big volume of data does not automatically ensure good quality of inferences because a large number of unimportant variables may be collected in the process of gathering informative variables. Read More

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Arrabidaea chica Verlot fractions reduce MIA-induced osteoarthritis progression in rat knees.

Inflammopharmacology 2021 Apr 21. Epub 2021 Apr 21.

Biological and Health Sciences Center, Federal University of Maranhão, Av. dos Portugueses 1966, São Luís, MA, 65085-580, Brazil.

This study aims to investigate the activity of n-hexane, ethyl acetate and butanol fractions obtained from Arrabidaea chica Verlot against MIA-induced osteoarthritis (OA). The antinociceptive potentials of each fraction were evaluated through a cyclooxygenase (COX) 1 and 2 inhibition test and an in vivo OA-model. In addition, toxicity assessments in the liver, spleen and kidney, as well as radiographic and histopathological knee analyses, were performed. Read More

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Assessment of morphological CT imaging features for the prediction of risk stratification, mutations, and prognosis of gastrointestinal stromal tumors.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

Objectives: To investigate the correlation between CT imaging features and risk stratification of gastrointestinal stromal tumors (GISTs), prediction of mutation status, and prognosis.

Methods: This retrospective dual-institution study included patients with pathologically proven GISTs meeting the following criteria: (i) preoperative contrast-enhanced CT performed between 2008 and 2019; (ii) no treatments before imaging; (iii) available pathological analysis. Tumor risk stratification was determined according to the National Institutes of Health (NIH) 2008 criteria. Read More

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A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST).

Eur Heart J 2021 Apr 21. Epub 2021 Apr 21.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8056, USA.

Aims: Coronary artery disease is frequently diagnosed following evaluation of stable chest pain with anatomical or functional testing. A more granular understanding of patient phenotypes that benefit from either strategy may enable personalized testing.

Methods And Results: Using participant-level data from 9572 patients undergoing anatomical (n = 4734) vs. Read More

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Family Genetic Risk Scores and the Genetic Architecture of Major Affective and Psychotic Disorders in a Swedish National Sample.

JAMA Psychiatry 2021 Apr 21. Epub 2021 Apr 21.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Importance: Family and genetic approaches have traditionally been used to evaluate our diagnostic concepts. Using a novel method, the family genetic risk score (FGRS), can we validate the genetic architecture of major affective and psychotic disorders in a national Swedish sample?

Objective: To determine whether FGRSs, calculated for the entire Swedish population, can elucidate the genetic relationship between major affective and psychotic disorders and clarify the association of genetic risk with important clinical features of disease.

Design, Setting, And Participants: This cohort study included the native Swedish population born from January 1, 1950, through December 31, 1995, and followed up through December 31, 2017. Read More

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Association of frailty and pre-frailty with increased risk of mortality among older Canadians.

Health Rep 2021 Apr;32(4):15-26

Health Analysis Division, Statistics Canada, Ottawa, Ontario.

Background: Frailty is a complex syndrome that is associated with aging but not synonymous with the normal aging process. It has been associated with all-cause mortality, but less is known about frailty and mortality from specific causes.

Data And Methods: Data from the 2013 and 2014 Canadian Community Health Survey (CCHS) linked to the Canadian Vital Statistics - Death Database were used to estimate the prevalence of frailty among Canadians aged 65 or older. Read More

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Identification of prognostic marker genes in head and neck squamous cell carcinoma: a study based on TCGA database and experimental validation.

J Oral Pathol Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Ear-Nose-Throat, Maoming People's Hospital, Maoming, 525000, P.R. China.

Background: Early detection and prognostic prediction are crucial in improving the survival of patients with head and neck squamous cell carcinoma (HNSCC). Therefore, we provided potential molecular markers in this study for early diagnosis and prognosis of this cancer based on the The Cancer Genome Atlas (TCGA) database analysis and experimental validations.

Methods: Differentially expressed genes (DEGs) between HNSCC tumor and normal samples were identified by TCGA database-based analyses. Read More

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Semiparametric recurrent event vs time-to-first-event analyses in randomized trials: Estimands and model misspecification.

Stat Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada.

Insights regarding the merits of recurrent event and time-to-first-event analyses are needed to provide guidance on strategies for analyzing intervention effects in randomized trials involving recurrent event responses. Using established asymptotic results we introduce a framework for studying the large sample properties of estimators arising from semiparametric proportional rate function models and Cox regression under model misspecification. The asymptotic biases and power implications are investigated for different data generating models, and we study the impact of dependent censoring on these findings. Read More

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Protective Factors Using the Life Course Perspective in Maternal and Child Health.

Engage 2020 18;1(3):69-86. Epub 2020 Dec 18.

Northern Arizona University.

The life course perspective (LCP), a valuable theoretical framework for investigating racial disparities in birth outcomes, examines the cumulative exposure of risk and protective factors throughout the life span. Although risk and protective exposures are equally vital to health, most studies have focused solely on the risk factor exposures faced by vulnerable populations. In clear contrast to the traditional public health approach, which emphasizes a deficit model, strengths-based approaches focus on protective factors and fostering resilience. Read More

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December 2020

Anti-Inflammatory and Antimicrobial Activities of Compounds Isolated from .

Biomed Res Int 2021 6;2021:6624347. Epub 2021 Apr 6.

Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

is a native black ginger that grows in Vietnam. In point of fact, there is limitation of available information in the literature making mention of the chemical constituents and bioactive properties of this plant. This study is aimed at isolating -coumaric acid (), -cinnamic acid (), and borneol () from the rhizomes of Q. Read More

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The Prognostic Significance of Sarcopenia and the Neutrophil-to-Lymphocyte Ratio in Elderly Patients with Esophageal Squamous Cell Carcinoma.

Cancer Manag Res 2021 13;13:3209-3218. Epub 2021 Apr 13.

Department of Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.

Objective: To evaluate the correlation between systemic inflammation markers and sarcopenia in elderly patients with esophageal squamous cell carcinoma (ESCC) and their prognostic value.

Materials And Methods: The clinical data of 121 elderly patients with ESCC were collected. The skeletal muscle area at the level of the third lumbar vertebrae (L3) was measured by computed tomography (CT), and then the skeletal muscle index (SMI) was calculated. Read More

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Construction of the Prediction Model for Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy Based on Pretreatment Tumor-Infiltrating Macrophage-Associated Biomarkers.

Onco Targets Ther 2021 13;14:2599-2610. Epub 2021 Apr 13.

Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.

Purpose: To assess the value of macrophage-related biomarkers (CD163, CD68, MCSF, and CCL2) for predicting the response to neo-chemoradiotherapy (NCRT) and the prognosis of locally advanced rectal cancer (LARC).

Methods: We enrolled 191 patients who underwent neoadjuvant chemoradiotherapy and radical resection between 2011 and 2015. Tumor tissues were collected before NCRT with a colonoscope and post-surgery and were subjected to immunohistochemical analysis. Read More

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A Novel Transcription Factor-Based Prognostic Signature in Endometrial Cancer: Establishment and Validation.

Onco Targets Ther 2021 13;14:2579-2598. Epub 2021 Apr 13.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, People's Republic of China.

Background: Endometrial cancer (EC) is a common malignancy of the female reproductive system worldwide. Increasing evidence has suggested that many transcription factors are aberrantly expressed in various cancers. This study aimed to develop a transcription factor-based prognostic signature for EC. Read More

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[Semiquantitative parameters of F-FDG PET/CT, gene mutation states of epidermal growth factor receptor and anaplastic lymphoma kinase in prognosis evaluation of patients with lung adenocarcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Oct;53(2):246-254

Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.

Objective: To explore the valuable predictors for evaluating progression-free survival (PFS) in patients with lung adenocarcinoma, we analyzed the potential roles of standardized uptake value (SUV)-derived parameters from F-FDG PET/CT, combining with the gene mutation states of epidermal growth factor receptor () and anaplastic lymphoma kinase (), and other clinical characteristics.

Methods: Data of 84 lung adenocarcinoma patients pre-treated, who underwent F-FDG PET/CT scans, gene mutations test, rearrangement assay and other relative tests, were retrospectively collected. Then a series of clinical parameters including / mutation status and SUV-derived features [maximum standardized uptake value (SUVmax), average of standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] were evaluated. Read More

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October 2020

In silico screening using bulk and single-cell RNA-seq data identifies RIMS2 as a prognostic marker in basal-like breast cancer: A retrospective study.

Medicine (Baltimore) 2021 Apr;100(16):e25414

Department of Thyroid Surgery.

Abstract: Single-cell RNA-seq has become a powerful tool to understand tumor cell heterogenicity. This study tried to screen prognosis-related genes in basal-like breast tumors and evaluate their correlations with cellular states at the single-cell level.Bulk RNA-seq data of basal-like tumor cases from The Cancer Genome Atlas-Breast Cancer (TCGA-BRCA) and single-cell RNA-seq from GSE75688 were retrospectively reviewed. Read More

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Body mass index linked to short-term and long-term all-cause mortality in patients with acute myocardial infarction.

Postgrad Med J 2021 Apr 20. Epub 2021 Apr 20.

Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

Purposes Of Study: This study aimed to elucidate the relationship between obesity and short-term and long-term mortality in patients with acute myocardial infarction (AMI) by analysing the body mass index (BMI).

Study Design: A retrospective cohort study was performed on adult intensive care unit (ICU) patients with AMI in the Medical Information Mart for Intensive Care III database. The WHO BMI classification was used in the study. Read More

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Down-regulation of miR-219-5p increase the risk of cancer-related mortality in patients with prostate cancer.

Postgrad Med J 2021 Apr 20. Epub 2021 Apr 20.

Department of Oncology, Suining Central Hospital, Suining, China

Introduction: Prostate cancer is a common malignancy in men that is difficult to treat and carries a high risk of death. miR-219-5p is expressed in reduced amounts in many malignancies. However, the prognostic value of miR-219-5p for patients with prostate cancer remains unclear. Read More

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Underweight rather than adiposity is an important predictor of death in rural Chinese adults: a cohort study.

J Epidemiol Community Health 2021 Apr 20. Epub 2021 Apr 20.

School of Public Health,NHC Key Laboratory of Health Technology Assessment, Key Laboratory of Public Health Safety, Fudan University, Shanghai, China

Background: To assess the associations of body mass index (BMI) with all-cause and cause-specific mortalities among rural Chinese.

Methods: A prospective study of 28 895 individuals was conducted from 2006 to 2014 in rural Deqing, China. Height and weight were measured. Read More

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Independent and joint effects of testosterone replacement therapy and statins use on the risk of prostate cancer among White, Black and Hispanic men.

Cancer Prev Res (Phila) 2021 Apr 20. Epub 2021 Apr 20.

University of Texas McGovern Medical School.

The associations of testosterone therapy (TTh) and statins use with prostate cancer (PCa) remain conflicted. However, the joint effects of TTh and statins use on the incidence of PCa, stage and grade at diagnosis, and PCa-specific mortality (PCSM) have not been studied. We identified White (N=74181), Black (N=9157) and Hispanic (N=3313) men diagnosed with PCa in SEER-Medicare 2007-2016. Read More

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Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study.

Open Heart 2021 Apr;8(1)

NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), The University of Manchester, Manchester, UK.

Objective: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD) and evaluated the association between severity and adverse outcomes.

Methods: Primary and secondary care data for 213 088 people with CHD in 398 practices in England between 2007 and 2017 were used. Read More

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Clinical and pathological risk factors for worse stage and mortality of eyelid and periocular squamous cell carcinoma.

Br J Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

Background: The clinical and pathological risk factors for worse T stage and prognosis in eyelid and periocular squamous cell carcinomas (SCCs) remain unclear. P63 was reported to predict a worse prognosis in other SCCs; however, this correlation was not validated in eyelid and periocular SCCs.

Methods: We reported on a retrospective case series of 85 consecutive patients with eyelid and periocular SCCs from 1995 to 2019. Read More

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Circulating levels of testosterone, sex hormone binding globulin and colorectal cancer risk: observational and Mendelian randomization analyses.

Cancer Epidemiol Biomarkers Prev 2021 Apr 20. Epub 2021 Apr 20.

Section of Nutrition and Metabolism, International Agency For Research On Cancer.

Background Epidemiological studies evaluating associations between sex steroid hormones and colorectal cancer risk have yielded inconsistent results. To elucidate the role of circulating levels of testosterone, and sex hormone-binding globulin (SHBG) in colorectal cancer risk we conducted observational and Mendelian randomization (MR) analyses. Methods The observational analyses included 333,530 participants enrolled in the UK Biobank with testosterone and SHBG measured. Read More

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Acquired Idiopathic Stiffness After Contemporary Total Knee Arthroplasty: Incidence, Risk Factors, and Results Over 25 Years.

J Arthroplasty 2021 Apr 1. Epub 2021 Apr 1.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.

Background: Acquired idiopathic stiffness (AIS) remains a common failure mode of contemporary total knee arthroplasties (TKAs). The present study investigated the incidence of AIS and manipulation under anesthesia (MUA) at a single institution over time, determined outcomes of MUAs, and identified risk factors associated with AIS and MUA.

Methods: We identified 9771 patients (12,735 knees) who underwent primary TKAs with cemented, modular metal-backed, posterior-stabilized implants from 2000 to 2016 using our institutional total joint registry. Read More

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Comorbidity of depression and anxiety leads to a poor prognosis following angina pectoris patients: a prospective study.

BMC Psychiatry 2021 Apr 20;21(1):202. Epub 2021 Apr 20.

Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, No.106 Zhongshan Er Road, Yuexiu District, Guangzhou, 510080, People's Republic of China.

Background: Depression and anxiety are two common mood problems among patients with cardiovascular disease (CVD) and are associated with poor cardiac prognoses. The comorbidity of depression and anxiety is considered to be a more severe psychological status than non-comorbid mood disorders. However, little is known about the relationship between depression or anxiety and noncardiac readmission. Read More

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Active behavior of triple-negative breast cancer with adipose tissue invasion: a single center and retrospective review.

BMC Cancer 2021 Apr 20;21(1):434. Epub 2021 Apr 20.

Department of Urology (Chair of the Board of Directors), Seisyukai Social Medical Corporation, Fukuoka, Japan.

Background: Interactions between adipocyte and breast cancer (BC) cells have yet to be fully elucidated. Here we investigated the prognostic impact of marginal adipose tissue invasion in both luminal breast cancer (HR+/HER2-) and triple-negative breast cancer (TNBC) (HR-/HER2-).

Methods: A total of 735 patients with early-stage invasive BC (1999-2014) were retrospectively registered. Read More

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RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer.

BMC Cancer 2021 Apr 20;21(1):432. Epub 2021 Apr 20.

Medical Oncology Department, Plataforma de Oncologia, Hospital Quironsalud Torrevieja, Pda. La Loma s/n, 03184, Torrevieja (Alicante), Spain.

Background: Muscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53 somatic alterations in a variable percentage of tumors throughout all molecular subtypes. MIBCs with neuroendocrine features have a high response rate to immunity checkpoint inhibitors (ICIs). Whether the presence of somatic co-alterations in these 2 genes in MIBCs is relevant to their responsiveness to ICIs is not known. Read More

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