1,500 results match your criteria covid-19-associated


COVID-19-associated cavitating pneumonia.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Microbiology and Infectious Diseases, The Royal London Hospital, London, UK.

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Anticoagulation in the obese patient with COVID-19-associated venous thromboembolism.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Internal Medicine, Midland Regional Hospital Portlaoise, Portlaoise, Ireland.

A 61-year-old obese man who had recently tested positive for COVID-19 presented to the emergency department following an unwitnessed collapse, with a brief period of unresponsiveness. CT pulmonary angiography confirmed the presence of extensive bilateral pulmonary embolism despite the patient reporting full compliance with long-term dabigatran. The patient was initially anticoagulated with low-molecular-weight heparin and was treated with non-invasive ventilation and dexamethasone for COVID-19 pneumonia. Read More

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Thrombolysis for COVID-19-associated bioprosthetic mitral valve thrombosis with shock.

Eur Heart J 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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Kawasaki-like Multisystem Inflammatory Syndrome Associated with Coronavirus disease 2019 in an Adult: A case report.

Br J Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Command Hospital Air Force Bangalore, Bengaluru, India.

As Coronavirus disease 2019 (COVID -19) pandemic continues to surge, varied spectrum of clinical presentations keeps growing. Centers for Disease Control and Prevention (CDC) has recently described COVID-19 associated multisystem inflammatory syndrome in adults (MIS-A) that presents as amalgam of Kawasaki disease (KD) and toxic shock syndrome (TSS). We report a 22-year-old Indian male, with five days of fever, headache, myalgia, skin rash and one day history of lower extremity and upper abdominal pain, and vomiting. Read More

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Case series of four secondary mucormycosis infections in COVID-19 patients, the Netherlands, December 2020 to May 2021.

Euro Surveill 2021 Jun;26(23)

Center for Infectious Disease Research, Diagnostics and Laboratory Surveillance National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

We describe four secondary fungal infections caused by Mucorales species in COVID-19 patients. Three COVID-19 associated mucormycosis (CAM) occurred in ICU, one outside ICU. All were men aged > 50 years, three died. Read More

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Immunothrombosis: a COVID-19 concerto.

Br J Haematol 2021 Jun 10. Epub 2021 Jun 10.

Section of Hematology, Yale School of Medicine, New Haven, Connecticut, USA.

The paradigm of immunothrombosis observed in COVID-19 intertwines hyperinflammation and hypercoagulability in a hematologic crescendo that parallels the spectrum of disease severity observed in patients afflicted with COVID-19. In an unparalleled global effort, the cellular and non-cellular mechanisms at play continue to be elucidated daily, in addition to the initial and subsequent descriptions of COVID-19 associated coagulopathy. Read More

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COVID-19 and Immunothrombosis: emerging understanding and clinical management.

Br J Haematol 2021 Jun 10. Epub 2021 Jun 10.

Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK.

The COVID-19 pandemic has been the most significant health crisis in recent global history. Early studies from Wuhan highlighted COVID-19-associated coagulopathy and a significant association with mortality was soon recognised. As research continues across the world, more evidence is emerging of the cross-talk between the innate immune system, coagulation activation and inflammation. Read More

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A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome.

Pharmacol Rep 2021 Jun 10. Epub 2021 Jun 10.

Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Shahid Fahmideh Ave, 6517838678, Hamadan, Iran.

Background: We designed this single-centre clinical trial to assess the potential benefits of N-Acetylcysteine (NAC) in patients with COVID19-associated acute respiratory distress syndrome (ARDS).

Methods: Ninety-two patients with mild-to-moderate COVID19-associated ARDS were allocated to the placebo (45-cases) or NAC groups (47-cases). Besides standard-of-care treatment, the patients received either intravenous NAC at a dose of 40 mg/kg/day or the placebo for three consecutive days. Read More

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Acute submassive pulmonary embolism after SARS-CoV-2 infection: a case report of reinfection or prolonged hypercoagulable state.

Eur Heart J Case Rep 2021 Mar 24;5(3):ytab103. Epub 2021 Mar 24.

Department of Cardiology, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60153, USA.

Background: Coronavirus disease 19 (COVID-19) reinfection has been a topic of discussion with data still emerging. Viral antibodies are known to develop upon initial infection; however, it is unclear the amount of protection this confers against reinfection. Additionally, COVID-19-associated coagulopathy (CAC) is a well-documented phenomenon; however, there are no high-quality studies to support the treatment of outpatients beyond standard indications of venous thromboembolism (VTE) prophylaxis. Read More

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COVID-19 Associated Spontaneous Pneumothorax and Pneumopericardium: A Case Report.

Cureus 2021 May 5;13(5):e14861. Epub 2021 May 5.

Critical Care, United General Hospital, Houston, USA.

Novel coronavirus 2019 (COVID-19) has been one of the largest and most devastating global pandemics of our time. There have been several complications of this disease that have also proven to be debilitating and deadly. While primarily affecting the respiratory system, some cases presented with uncommon complications such as pneumopericardium and spontaneous pneumothorax. Read More

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COVID-19-Associated Pneumonia: Radiobiological Insights.

Front Pharmacol 2021 25;12:640040. Epub 2021 May 25.

Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Brétigny-sur-Orge, France.

The evolution of SARS-CoV-2 pneumonia to acute respiratory distress syndrome is linked to a virus-induced "cytokine storm", associated with systemic inflammation, coagulopathies, endothelial damage, thrombo-inflammation, immune system deregulation and disruption of angiotensin converting enzyme signaling pathways. To date, the most promising therapeutic approaches in COVID-19 pandemic are linked to the development of vaccines. However, the fight against COVID-19 pandemic in the short and mid-term cannot only rely on vaccines strategies, in particular given the growing proportion of more contagious and more lethal variants among exposed population (the English, South African and Brazilian variants). Read More

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The Effect of Neutropenia and Filgrastim (G-CSF) in Cancer Patients With COVID-19 Infection.

Clin Infect Dis 2021 Jun 10. Epub 2021 Jun 10.

Infectious Disease, Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, NY, USA.

Background: Neutropenia is commonly encountered in cancer patients. Recombinant human granulocyte colony-stimulating factor (G-CSF, filgrastim), a cytokine that initiates proliferation and differentiation of mature granulocytes, is widely given to oncology patients to counteract neutropenia, reducing susceptibility to infection. However, the clinical impact of neutropenia and G-CSF use in cancer patients with COVID-19 remains unknown. Read More

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Hospitalization of Adolescents Aged 12-17 Years with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 1, 2020-April 24, 2021.

MMWR Morb Mortal Wkly Rep 2021 Jun 11;70(23):851-857. Epub 2021 Jun 11.

Most COVID-19-associated hospitalizations occur in older adults, but severe disease that requires hospitalization occurs in all age groups, including adolescents aged 12-17 years (1). On May 10, 2021, the Food and Drug Administration expanded the Emergency Use Authorization for Pfizer-BioNTech COVID-19 vaccine to include persons aged 12-15 years, and CDC's Advisory Committee on Immunization Practices recommended it for this age group on May 12, 2021.* Before that time, COVID-19 vaccines had been available only to persons aged ≥16 years. Read More

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COVID-19 associated Mucormycosis: An epidemic within a pandemic.

QJM 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

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Differences in Cardiac Magnetic Resonance Imaging Markers Between Patients With COVID-19-associated Myocardial Injury and Patients With Clinically Suspected Myocarditis.

J Thorac Imaging 2021 Jun 9. Epub 2021 Jun 9.

Departments of Radiology Medicine I COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Germany.

Purpose: Coronavirus 2019 disease (COVID-19) has been shown to affect the myocardium, resulting in a worse clinical outcome. In this registry study, we aimed to identify differences in cardiac magnetic resonance imaging (CMRI) between COVID-19 and all-cause myocarditis.

Materials And Methods: We examined CMRI of patients with COVID-19 and elevated high-sensitivity serum troponin levels performed between March 31st and May 5th and compared them to CMRI of patients without SARS-CoV-2 infection with suspected myocarditis in the same time period. Read More

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Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment.

Alzheimers Res Ther 2021 06 9;13(1):110. Epub 2021 Jun 9.

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Background: Dementia-like cognitive impairment is an increasingly reported complication of SARS-CoV-2 infection. However, the underlying mechanisms responsible for this complication remain unclear. A better understanding of causative processes by which COVID-19 may lead to cognitive impairment is essential for developing preventive and therapeutic interventions. Read More

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Lung ultrasound score as a tool to monitor disease progression and detect ventilator-associated pneumonia during COVID-19-associated ARDS.

Heart Lung 2021 May 31;50(5):700-705. Epub 2021 May 31.

Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Médecine Intensive-Réanimation, F-69437, Lyon, France; Université de Lyon, Université Claude Bernard Lyon 1, Faculté de médecine Lyon-Est, F-69373, Lyon, France.

Background: Lung ultrasound can accurately detect pandemic coronavirus disease (COVID-19) pulmonary lesions. A lung ultrasound score (LUS) was developed to improve reproducibility of the technique.

Objectives: To evaluate the clinical value of LUS monitoring to guide COVID-19-associated acute respiratory distress syndrome (ARDS) management. Read More

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Sarilumab (IL-6R antagonist) in critically ill patients with cytokine release syndrome by SARS-CoV2.

Medicine (Baltimore) 2021 May;100(19):e25923

Unitat de Malalties Infeccioses.

Abstract: Blocking IL-6 pathways with sarilumab, a fully human anti-IL-6R antagonist may potentially curb the inflammatory storm of SARS-CoV2. In the present emergency scenario, we used "off-label" sarilumab in 5 elderly patients in life-threatening condition not candidates to further active measures. We suggest that sarilumab can modulate severe COVID-19-associated Cytokine Release Syndrome. Read More

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Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus.

Microbiol Spectr 2021 Jun 9:e0001021. Epub 2021 Jun 9.

Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.

The ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), first described in Wuhan, China. A subset of COVID-19 patients has been reported to have acquired secondary infections by microbial pathogens, such as opportunistic fungal pathogens from the genus Aspergillus. To gain insight into COVID-19-associated pulmonary aspergillosis (CAPA), we analyzed the genomes and characterized the phenotypic profiles of four CAPA isolates of Aspergillus fumigatus obtained from patients treated in the area of North Rhine-Westphalia, Germany. Read More

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Spontaneous right coronary artery dissection in a patient with COVID-19 infection: A case report and review of the literature.

Turk Kardiyol Dern Ars 2021 06;49(4):334-338

Department of Cardiology, Katip Çelebi University School of Medicine, İzmir, Turkey.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global coronavirus disease 2019 (COVID-19) pandemic. Although the virus predominantly causes respiratory system infection, recent reports have shown that it is also associated with many cardiovascular complications. It has been reported that COVID-19 may cause myocarditis, type 1 and 2 acute myocardial infarction, and thrombotic complications. Read More

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COVID-19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta-analysis of the relationship to CSF SARS-CoV-2.

J Neuroimaging 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, NYU Langone Medical Center, New York, New York, USA.

Background And Purpose: We reviewed the literature to evaluate cerebrospinal fluid (CSF) results from patients with coronavirus disease 2019 (COVID-19) who had neurological symptoms and had an MRI that showed (1) central nervous system (CNS) hyperintense lesions not attributed to ischemia and/or (2) leptomeningeal enhancement. We sought to determine if these findings were associated with a positive CSF severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR).

Methods: We performed a systematic review of Medline and Embase from December 1, 2019 to November 18, 2020. Read More

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High frequency of endoluminal thrombus in patients with ischaemic stroke following SARS-CoV-2 infection.

Neurologia 2021 May 11. Epub 2021 May 11.

Servicio de Neurología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España. Electronic address:

Background: Ischaemic stroke may be a major complication of SARS-CoV-2 infection. Studying and characterising the different aetiological subtypes, clinical characteristics, and functional outcomes may be valuable in guiding patient selection for optimal management and treatment.

Methods: Data were collected retrospectively on consecutive patients with SARS-CoV-2 infection who developed acute focal brain ischaemia (between 1 March and 19 April 2020) at a tertiary university hospital in Madrid (Spain). Read More

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Effectiveness of SARS-CoV-2 vaccination in fully-vaccinated solid organ transplant recipients.

Am J Transplant 2021 Jun 8. Epub 2021 Jun 8.

Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.

The COVID-19 pandemic has disproportionately impacted immunosuppressed patients, including solid organ transplant recipients (SOTR). COVID-19-associated mortality among SOTR was estimated at 20.5% in the early phase of the pandemic(1). Read More

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MRI negative myelopathy post mild SARS-CoV-2 infection: vasculopathy or inflammatory myelitis?

J Neurovirol 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, Icahn School of Medicine At Mount Sinai, 1468 Madison Avenue, New York, NY, 10029, USA.

Since the onset of the COVID-19 pandemic, there have been rare reports of spinal cord pathology diagnosed as inflammatory myelopathy and suspected spinal cord ischemia after SARS-CoV-2 infection. Herein, we report five cases of clinical myelopathy and myeloradiculopathy in the setting of post-COVID-19 disease, which were all radiographically negative. Unlike prior reports which typically characterized hospitalized patients with severe COVID-19 disease and critical illness, these patients typically had asymptomatic or mild-moderate COVID-19 disease and lacked radiologic evidence of structural spinal cord abnormality. Read More

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Self-identified Race and COVID-19-Associated Acute Kidney Injury and Inflammation: a Retrospective Cohort Study of Hospitalized Inner-City COVID-19 Patients.

J Gen Intern Med 2021 Jun 7. Epub 2021 Jun 7.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: Black individuals have been disproportionately affected by the coronavirus disease 2019 (COVID-19). However, it remains unclear whether there are any biological factors that predispose Black patients to COVID-19-related morbidity and mortality.

Objective: To compare in-hospital morbidity, mortality, and inflammatory marker levels between Black and White hospitalized COVID-19 patients. Read More

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The "Black Fungus" in India: The Emerging Syndemic of COVID-19-Associated Mucormycosis.

Ann Intern Med 2021 Jun 8. Epub 2021 Jun 8.

University of Massachusetts Medical School, Worcester, Massachusetts (S.R., S.M.L.).

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Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicenter study from Iran.

Mycoses 2021 Jun 7. Epub 2021 Jun 7.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: The aim of the study was to report clinical features, contributing factors and outcome of patients with coronavirus disease 2019 (COVID-19) associated mucormycosis (CAM).

Methods: A cross-sectional descriptive multicenter study was conducted on patients with biopsy-proven mucormycosis with RT-PCR confirmed COVID-19 from April to September 2020. Demographics, the time interval between COVID-19 and mucormycosis, underlying systemic diseases, clinical features, course of disease and outcomes were collected and analyzed. Read More

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Assessment of patient recognition of coronavirus disease 2019 (COVID-19)-associated olfactory loss and recovery: a longitudinal study.

Int Forum Allergy Rhinol 2021 Jun 6. Epub 2021 Jun 6.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego, San Diego, California, USA.

Background: The clinical course of coronavirus disease 2019 (COVID-19) olfactory dysfunction remains poorly characterized, often limited by self-reported measures. Given the logistical challenges of psychophysical testing, understanding the longitudinal relationship between self-reported and quantitative measures can help accurately identify patients with persistent olfactory dysfunction. This study aimed to longitudinally correlate measured and subjective olfactory function in COVID-19 subjects. Read More

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Laboratory trends, hyperinflammation, and clinical outcomes for patients with a systemic rheumatic disease admitted to hospital for COVID-19: a retrospective, comparative cohort study.

Lancet Rheumatol 2021 May 28. Epub 2021 May 28.

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA.

Background: COVID-19 can induce a hyperinflammatory state, which might lead to poor clinical outcomes. We aimed to assess whether patients with a systemic rheumatic disease might be at increased risk for hyperinflammation and respiratory failure from COVID-19.

Methods: We did a retrospective, comparative cohort study of patients aged 18 years or older admitted to hospital with PCR-confirmed COVID-19 at Mass General Brigham (Boston, USA). Read More

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