4,034 results match your criteria covid-19 treatment


COVID-19: Considerations about immune suppression and biologicals at the time of SARS-CoV-2 pandemic.

World J Clin Cases 2021 Jul;9(20):5352-5357

Department of Medical Sciences and Public Health, University of Cagliari, Monserrato 09042, Cagliari, Italy.

The extent of the profound immunological and nonimmunological responses linked to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is currently being investigated worldwide due to the large burden associated with death due to SARS-CoV-2 and the short-term consequences of coronavirus disease 2019 (COVID-19). It has been hypothesized that patients on immunosuppressive treatments, including biologics, may have an augmented risk of being infected by SARS-CoV-2; however, there are currently no definitive data about biological drugs and COVID-19 in immune-mediated inflammatory diseases. Current epidemiological models developed to understand how long the COVID-19 epidemic may last are not conclusive and range from sustained epidemics to complete elimination. Read More

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Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia.

Cardiol Res Pract 2021 8;2021:5537275. Epub 2021 Jul 8.

Medical Team from West China Hospital of Sichuan University in Hubei General Hospital (East Branch), Wuhan, China.

In this study, we investigated the association between the plasma NT-proBNP level at admission and the severity of COVID-19 pneumonia. For this retrospective, single-centre cohort study, we enrolled consecutive patients from February 9 to March 4, 2020, in a COVID-19 ward of Hubei General Hospital (East Branch) in Wuhan, which is a government-assigned centre for COVID-19 treatment. Diagnosis was confirmed by microbiological and radiographic findings following the interim guidance of the World Health Organization (WHO). Read More

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An observational cohort study to assess N-acetylglucosamine for COVID-19 treatment in the inpatient setting.

Authors:
Ameer E Hassan

Ann Med Surg (Lond) 2021 Aug 16;68:102574. Epub 2021 Jul 16.

Valley Baptist Medical Center, 2101 Pease St, Harlingen, TX, 78550, USA.

Background: Coronavirus disease 2019 (COVID-19) has affected millions globally, with a continued need for effective treatments. N-acetylglucosamine has anti-inflammatory activities and modulates immune response. This study evaluated whether N-acetylglucosamine administered orally improves clinical outcomes for patients admitted to the hospital due to COVID-19. Read More

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Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude.

EPMA J 2021 Jul 16:1-18. Epub 2021 Jul 16.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078 Hunan People's Republic of China.

Aims: Coronavirus disease 2019 (COVID-19) is rapidly spreading worldwide. Drug therapy is one of the major treatments, but contradictory results of clinical trials have been reported among different individuals. Furthermore, comprehensive analysis of personalized pharmacotherapy is still lacking. Read More

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Trust in the Health System and COVID-19 Treatment.

Front Psychol 2021 9;12:643758. Epub 2021 Jul 9.

School of Economics and Management, University "Carlo Cattaneo" - LIUC, Castellanza, Italy.

COVID-19 continues to spread across the globe at an exponential speed, infecting millions and overwhelming even the most prepared healthcare systems. Concerns are looming that the healthcare systems in low- and middle-income countries (LMICs) are mostly unprepared to combat the virus because of limited resources. The problems in LMICs are exacerbated by the fact that citizens in these countries generally exhibit low trust in the healthcare system because of its low quality, which could trigger a number of uncooperative behaviors. Read More

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Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19.

Front Pharmacol 2021 9;12:707205. Epub 2021 Jul 9.

Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

The total number of cumulative cases and deaths from the COVID-19 pandemic caused by SARS-CoV-2 is still increasing worldwide. Although many countries have actively implemented vaccination strategies to curb the epidemic, there is no specific efficient therapeutic drug for this virus to effectively reduce deaths. Therefore, the underappreciated macromolecular compounds have become the spotlight of research. Read More

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Previously published ethno-pharmacological reports reveal the potentiality of plants and plant-derived products used as traditional home remedies by Bangladeshi COVID-19 patients to combat SARS-CoV-2.

Saudi J Biol Sci 2021 Jul 17. Epub 2021 Jul 17.

Department of Botany, University of Rajshahi, Rajshahi-6205, Bangladesh.

Several plants have traditionally been used since antiquity to treat various gastroenteritis and respiratory symptoms similar to COVID-19 outcomes. The common symptoms of COVID-19 include fever or chills, cold, cough, flu, headache, diarrhoea, tiredness/fatigue, sore throat, loss of taste or smell, asthma, shortness of breath, or difficulty breathing, etc. This study aims to find out the plants and plant-derived products which are being used by the COVID-19 infected patients in Bangladesh and how those plants are being used for the management of COVID-19 symptoms. Read More

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Antigenic sites in SARS-CoV-2 spike RBD show molecular similarity with pathogenic antigenic determinants and harbors peptides for vaccine development.

Immunobiology 2021 Jul 13;226(5):152091. Epub 2021 Jul 13.

Genome & Computational Biology Lab, Department of Biotechnology, Mohanlal Sukhadia University, Udaipur 313001, Rajasthan, India. Electronic address:

The spike protein of coronavirus is key target for drug development and other pharmacological interventions. In current study, we performed an integrative approach to predict antigenic sites in SARS-CoV-2 spike receptor binding domain and found nine potential antigenic sites. The predicted antigenic sites were then assessed for possible molecular similarity with other known antigens in different organisms. Read More

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Stress and Associated Factors among Frontline Healthcare Workers in the COVID-19 Epicenter of Da Nang City, Vietnam.

Int J Environ Res Public Health 2021 Jul 10;18(14). Epub 2021 Jul 10.

Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue 530000, Vietnam.

Frontline healthcare workers (HCWs) involved in the COVID-19 response have a higher risk of experiencing psychosocial distress amidst the pandemic. Between July and September 2020, a second wave of the COVID-19 pandemic appeared in Vietnam with Da Nang city being the epicenter. During the outbreak, HCWs were quarantined within the health facilities in a bid to limit the spread of COVID-19 to their respective communities. Read More

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Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells.

DNA Repair (Amst) 2021 Jul 16;106:103180. Epub 2021 Jul 16.

Department of Population & Public Health Sciences, USC Keck School of Medicine, University of Southern California, M/C 9603, Los Angeles, CA, 90033, USA.

Since the early stages of the pandemic, hydroxychloroquine (HCQ), a widely used drug with good safety profile in clinic, has come to the forefront of research on drug repurposing for COVID-19 treatment/prevention. Despite the decades-long use of HCQ in the treatment of diseases, such as malaria and autoimmune disorders, the exact mechanisms of action of this drug are only beginning to be understood. To date, no data are available on the genotoxic potential of HCQ in vitro or in vivo. Read More

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Is Mucormycosis an inevitable complication of Covid-19 in India?

Braz J Infect Dis 2021 Jul 5;25(3):101597. Epub 2021 Jul 5.

Department of Pharmacology, Siddha Central Research Institute, Central Council for Research in Siddha, Anna Govt. Hospital Campus, Arumbakkam, Chennai-600 106, Tamil Nadu, India.

Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pandemic, the prevalence of this infection is found to be high in the Indian population. Read More

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Short-term changes in ganglion cell complex in patients with COVID-19 treated with hydroxychloroquine.

Arq Bras Oftalmol 2021 Jul-Aug;84(4):408-409

Department of Ophthalmology, Kırşehir Ahi Evran Training and Research Hospital, Kırşehir, Turkey.

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Letter to editor on the paper entitled "Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19".

Authors:
O Nugraha Putra

Eur Rev Med Pharmacol Sci 2021 07;25(13):4446-4447

Department of Clinical Pharmacy, Hang Tuah University, Surabaya, Indonesia.

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Reply Letter - Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19.

Eur Rev Med Pharmacol Sci 2021 07;25(13):4445

Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

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Analysis of Available Nutrition Recommendations to Combat COVID-19: A Scoping Review.

Malays J Med Sci 2021 Jun 30;28(3):18-45. Epub 2021 Jun 30.

Institute for Public Health, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia.

The current COVID-19 pandemic remains severe. There is no doubt that the COVID-19 pandemic is affecting every aspect of our lives. Currently, the spread of inaccurate information or fake news on the internet to the public is causing the community to panic. Read More

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The Role of Micronutrient and Immunomodulation effect in the vaccine era of COVID-19.

J Chin Med Assoc 2021 Jul 16. Epub 2021 Jul 16.

Department of Obstetrics and Gynecology, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC School of Agricultural and Environmental Sciences, Global Disease Biology, UC Davis, Davis, CA, USA; Department of Medical Research, Taipei Veterans General Hospital, National Yang Ming Chao Tung University, Taipei, Taiwan, ROC.

Different dietary nutrients have distinct effects, including enhancing immune response activity and supporting mucous membrane integrity. These effects are critical in fighting against pathogenic agents, which cover COVID-19, the coronavirus disease that shuts down globally. Recent researches have shown that micronutrient deficiency is commonly associated with compromised immune responses, respiratory tract infections, or even susceptibility to COVID-19. Read More

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Assessment of potential risk factors for coronavirus disease-19 (COVID-19) among health care workers.

J Infect Public Health 2021 Jul 8. Epub 2021 Jul 8.

Endemic and Infectious Diseases Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.

Background: Understanding COVID-19 infection among health workers and the risk factors for adverse outcomes is important not only for characterizing virus transmission patterns and risk factors for infection, but also for preventing the future infection of health workers and other patients and reducing secondary COVID-19 transmission within health care settings. Our aim was to identify risk factors for infection among health care workers to limit adverse events in health care facilities.

Subjects And Methods: A total of 336 HCWs from COVID-19 treatment hospitals took part in the study with varying COVID-19 exposure risk depending on job function and working site. Read More

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Conventional and Unconventional Approaches for Innovative Drug Treatments in COVID-19: Looking Outside of Plato's Cave.

Int J Mol Sci 2021 Jul 5;22(13). Epub 2021 Jul 5.

Postgraduate Research Institute of Science, Technology, Environment and Medicine, 3 Ammochostou Street, Limassol 3021, Cyprus.

Thousands of drugs and nutraceuticals along with their combinations can be used to select candidate therapeutics for targeting the transmission, proliferation and the fatal or severe symptoms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in order to reduce the unacceptably high mortality rate observed in the coronavirus disease 2019 (COVID-19) pandemic and its associated negative effects on daily life worldwide [... Read More

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Assessment of Referrals and Hospitalizations in the Hospital Transformed into COVID-19 Facility in Poland during the "Spring Wave" of the Epidemic in 2020-A Cross-Sectional Study.

Int J Environ Res Public Health 2021 07 3;18(13). Epub 2021 Jul 3.

Department of Geriatrics, Hospital of the Ministry of Interior in Bialystok, 15-471 Bialystok, Poland.

The study aimed to evaluate hospitalizations in a COVID-dedicated facility during the "spring wave" of the epidemic in 2020 in Poland and analyze changes in access to hospital treatment in the country in the early phase of the pandemic. We investigated all referrals and admissions to the Ministry of Interior and Administration hospital in Białystok from 14 April to 14 August 2020. A total of 238 patients were referred to the hospital (with a median age of 64. Read More

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Assessment of SARS-CoV-2 Infection among Healthcare Workers of a German COVID-19 Treatment Center.

Int J Environ Res Public Health 2021 07 1;18(13). Epub 2021 Jul 1.

Institute of Laboratory Medicine, SLK Clinics Heilbronn GmbH, 74078 Heilbronn, Germany.

To date, more than 160 million people have been infected with COVID-19 worldwide. In the present study, we investigated the history of SARS-CoV-2 infection among 3067 healthcare workers (HCW) in a German COVID-19 treatment center during the early phase of the pandemic (July 2020) based on the seroprevalence of SARS-CoV-2 antibodies and self-reported previous PCR results. The results demonstrate a low prevalence of SARS-CoV-2 infection ( = 107 [3. Read More

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Exploring peptide studies related to SARS-CoV to accelerate the development of novel therapeutic and prophylactic solutions against COVID-19.

J Infect Public Health 2021 Jul 3;14(8):1106-1119. Epub 2021 Jul 3.

Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. Electronic address:

Recent advances in peptide research revolutionized therapeutic discoveries for various infectious diseases. In view of the ongoing threat of the COVID-19 pandemic, there is an urgent need to develop potential therapeutic options. Intense and accomplishing research is being carried out to develop broad-spectrum vaccines and treatment options for corona viruses, due to the risk of recurrent infection by the existing strains or pandemic outbreaks by new mutant strains. Read More

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Relationship between the period from symptom onset to confirmation and the prevalence: results from 159 COVID-19 patients using public information through the data crawling.

J Med Internet Res 2021 Jun 9. Epub 2021 Jun 9.

Wonju College of Medicine, 20 Ilsan-ro, Wonju, KR.

Background: In general, early intervention based on early diagnosis of the disease is considered to be very important for improving the health outcome. However, there is still not enough evidence of how medical care that is based on the early diagnosis of confirmed cases can affect the COVID-19 treatment outcomes.

Objective: Accordingly, we aimed to investigate the effects of the duration from the onset of clinical symptoms to confirmation on the duration to the resolution of COVID-19 (release from quarantine). Read More

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Associastion of In-hospital Use of Statins, Aspirin, and Renin-Angiotensin-Aldosterone Inhibitors with Mortality and ICU Admission Due to COVID-19.

Adv Exp Med Biol 2021 ;1327:205-214

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

The exaggerated host response to Sars-CoV-2 plays an important role in COVID-19 pathology but provides a therapeutic opportunity until definitive virus targeted therapies and vaccines become available. Given a central role of endothelial dysfunction and systemic inflammation, repurposing ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), statins, and aspirin has been of interest. In this retrospective, single-center study, we evaluated the primary outcomes of mortality and ICU admission in 587 hospitalized patients with documented COVID-19 with or without ACEIs, ARBs, statins, and aspirin. Read More

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Perspectives from the frontline: A pharmacy department's response to the COVID-19 pandemic.

Am J Health Syst Pharm 2020 08;77(17):1409-1416

Department of Pharmacy Services, St. Joseph Mercy Health System, Ann Arbor, MI.

Purpose: The global coronavirus disease 2019 (COVID-19) pandemic has created unprecedented strains on healthcare systems around the world. Challenges surrounding an overwhelming influx of patients with COVID-19 and changes in care dynamics prompt the need for care models and processes that optimize care in this medically complex patient population. The purpose of this report is to describe our institution's strategy to deploy pharmacy resources and standardize pharmacy processes to optimize the management of patients with COVID-19. Read More

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Performance Analysis of the National Early Warning Score and Modified Early Warning Score in the Adaptive COVID-19 Treatment Trial Cohort.

Crit Care Explor 2021 Jul 13;3(7):e0474. Epub 2021 Jul 13.

Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD.

We sought to validate prognostic scores in coronavirus disease 2019 including National Early Warning Score, Modified Early Warning Score, and age-based modifications, and define their performance characteristics.

Design: We analyzed prospectively collected data from the Adaptive COVID-19 Treatment Trial. National Early Warning Score was collected daily during the trial, Modified Early Warning Score was calculated, and age applied to both scores. Read More

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Indian Ethnomedicinal Phytochemicals as Promising Inhibitors of RNA-Binding Domain of SARS-CoV-2 Nucleocapsid Phosphoprotein: An Study.

Front Mol Biosci 2021 2;8:637329. Epub 2021 Jul 2.

Department of Biotechnology, Alagappa University, Karaikudi, India.

SARS-CoV-2, an etiological agent of COVID-19, has been the reason for the unexpected global pandemic, causing severe mortality and imposing devastative effects on public health. Despite extensive research work put forward by scientist around globe, so far, no suitable drug or vaccine (safe, affordable, and efficacious) has been identified to treat SARS-CoV-2. As an alternative way of improvising the COVID-19 treatment strategy, that is, strengthening of host immune system, a great deal of attention has been given to phytocompounds from medicinal herbs worldwide. Read More

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Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis.

Lancet Psychiatry 2021 Jul 15. Epub 2021 Jul 15.

University Psychiatric Hospital Campus Duffel, Duffel, Belgium; Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp, Belgium. Electronic address:

Background: Mental disorders might be a risk factor for severe COVID-19. We aimed to assess the specific risks of COVID-19-related mortality, hospitalisation, and intensive care unit (ICU) admission associated with any pre-existing mental disorder, and specific diagnostic categories of mental disorders, and exposure to psychopharmacological drug classes.

Methods: In this systematic review and meta-analysis, we searched Web of Science, Cochrane, PubMed, and PsycINFO databases between Jan 1, 2020, and March 5, 2021, for original studies reporting data on COVID-19 outcomes in patients with psychiatric disorders compared with controls. Read More

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Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.

J Genet Eng Biotechnol 2021 Jul 16;19(1):104. Epub 2021 Jul 16.

Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, España Blvd., 1015, Manila, Philippines.

Background: Accessing COVID-19 vaccines is a challenge despite successful clinical trials. This burdens the COVID-19 treatment gap, thereby requiring accelerated discovery of anti-SARS-CoV-2 agents. This study explored the potential of anti-HIV reverse transcriptase (RT) phytochemicals as inhibitors of SARS-CoV-2 non-structural proteins (nsps) by targeting in silico key sites in the structures of SARS-CoV-2 nsps. Read More

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In vitro efficacy of artemisinin-based treatments against SARS-CoV-2.

Sci Rep 2021 07 16;11(1):14571. Epub 2021 Jul 16.

Max Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany.

Effective and affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are needed. We report in vitro efficacy of Artemisia annua extracts as well as artemisinin, artesunate, and artemether against SARS-CoV-2. The latter two are approved active pharmaceutical ingredients of anti-malarial drugs. Read More

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