1,093 results match your criteria covid-19 survivors

COVID-19 and atrial fibrillation in older patients. Does oral anticoagulant therapy provide a survival benefit? An insight from the GeroCovid Registry.

Thromb Haemost 2021 May 7. Epub 2021 May 7.

Department of Medicine, Campus Bio-Medico University, Roma, Italy.

Introduction: Atrial fibrillation (AF), the most frequent arrhythmia of older patients, associates with serious thrombo-embolic complications and high mortality. COVID-19 severely affects aged subjects, determining an important prothrombotic status. Aim of this study was to evaluate mortality-related factors in older AF patients with COVID-19. Read More

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Clinical Features and Outcomes of ICU Patients with COVID-19 Infection in Tehran, Iran: a Single-Centered Retrospective Cohort Study.

Tanaffos 2020 Dec;19(4):300-311

Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The clinical characteristics of the novel coronavirus disease (COVID-19) were diverse and unspecific. Here, we identified the associated factors with surviving of COVID-19 ICU patients based on the clinical characteristics of patients admitted to one of the Corona Centre Hospitals of Iran.

Materials And Methods: This cohort study was performed retrospectively from February to June 2020 on 133 COVID-19 patients admitted to 4 intensive care units of Masih Daneshvari Hospital in Tehran, Iran. Read More

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December 2020

Risk Factors Associated with Mortality in Intensive Care COVID-19 Patients: the importance of chest CT score and intubation timing as risk factors.

Turk J Med Sci 2021 May 7. Epub 2021 May 7.

Background/aim: Coronavirus disease 2019 (COVID-19) is a disease with a high rate of progression to critical illness. However, the predictors of mortality in critically ill patients admitted to the intensive care unit (ICU) are not yet well understood. In this study, we aimed to investigate the risk factors associated with ICU mortality in our hospital. Read More

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[The "Fourth Wave"? COVID-19 and consecutive cognitive impairment].

Dtsch Med Wochenschr 2021 May 6;146(10):671-676. Epub 2021 May 6.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität München.

The COVID-19 pandemic poses new challenges for the healthcare systems world-wide which will go beyond prevention, acute and intensive care treatment of patients with severe illness. A large proportion of "COVID-survivors" - and not only elderly patients - suffers from "post-COVID-syndrome". Risk factors are preexisting somatic multimorbidity, cognitive and cerebral changes together with pneumonia and hypoxemia, intensive care treatment and confusional states during the acute phase of illness. Read More

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ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors.

Clin Chim Acta 2021 May 3. Epub 2021 May 3.

Czech Technical University, Faculty of Biomedical Engineering, Sítná 3105, Kladno, Czech Republic; Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague, Czech Republic.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread from China in 2019/2020 to all continents. Significant geographical and ethnic differences were described, and host genetic background seems to be important for the resistance to and mortality of COVID-19. Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4646994) is one of the candidates with the potential to affect infection symptoms and mortality. Read More

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Delayed production of neutralizing antibodies correlates with fatal COVID-19.

Nat Med 2021 May 5. Epub 2021 May 5.

Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.

Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody responses that govern COVID-19 disease outcomes remain unclear. In this study, we analyzed humoral immune responses in 229 patients with asymptomatic, mild, moderate and severe COVID-19 over time to probe the nature of antibody responses in disease severity and mortality. Read More

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Effect of intensive care unit-specific virtual reality (ICU-VR) to improve psychological well-being and quality of life in COVID-19 ICU survivors: a study protocol for a multicentre, randomized controlled trial.

Trials 2021 May 5;22(1):328. Epub 2021 May 5.

Department of Intensive Care, Erasmus MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.

Background: The SARS-CoV-2 outbreak has resulted in a tremendous increase in hospital and intensive care unit (ICU) admissions all over the world. Patients with severe coronavirus disease 2019 (COVID-19) warranting ICU treatment usually have prolonged mechanical ventilation and are expected to be prone to develop psychological impairments, such as post-traumatic stress disorder (PTSD), anxiety and depression, which negatively impact quality of life. To date, no effective treatment strategy is available. Read More

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Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study.

Carly Welch

Age Ageing 2021 05;50(3):617-630

Introduction: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear.

Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. Read More

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Off-label tocilizumab and adjuvant iron chelator effectiveness in a group of severe COVID-19 pneumonia patients: A single center experience.

Medicine (Baltimore) 2021 May;100(18):e25832

Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu, Academic Emergency Hospital Sibiu - Internal Medicine Clinic, Sibiu, Romania.

Abstract: Tocilizumab (TCZ), a monoclonal recombinant antibody against IL-6 receptor, is currently used in managing the cytokine release syndrome (CRS) that occurred in coronavirus disease 2019 (COVID-19) selected cases. The primary objective of our study was to establish the effectiveness of TCZ in patients with severe or critical severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pneumonia.We retrospectively analyzed 25 consecutive patients, admitted in the Academic Emergency Hospital Sibiu, Romania from April 1, 2020 until May 25, 2020, all with confirmed SARS-CoV-2 infection and severe pneumonia. Read More

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Care, crisis and coalition: imagining antiprophylactic citizenship through AIDS hospice activism.

Ally Day

Cult Health Sex 2021 May 5:1-13. Epub 2021 May 5.

Disability Studies, The University of Toledo, Toledo, OH, USA.

Using crip theory, specifically Barounis' formulation of antiprophylactic citizenship, Piepzna-Samarasinha's conceptualisation of care work, and Shotwell's calls against purity, this paper analyses the making of the film during the COVID-19 crisis. HIV in the Rust Belt (directed by Holly Hey) documents some of the experiences of local HIV survivors. During the course of filming, however, a story emerged about the importance of an AIDS facility, David's House Compassion, which had served as a hospice and a resource centre between 1988 to 2003. Read More

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Renal impairment and its impact on clinical outcomes in patients who are critically ill with COVID-19: a multicentre observational study.

Anaesthesia 2021 03 16;76(3):320-326. Epub 2020 Oct 16.

Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK.

Renal impairment is common in patients who are critically ill with coronavirus disease-19 (COVID-19). We examined the association between acute and chronic kidney disease with clinical outcomes in 372 patients with coronavirus disease-19 admitted to four regional intensive care units between 10 March 2020 and 31 July 2020. A total of 216 (58%) patients presented with COVID-19 and renal impairment. Read More

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Characteristics, outcomes and risk factors for mortality of 522 167 patients hospitalised with COVID-19 in Brazil: a retrospective cohort study.

BMJ Open 2021 05 4;11(5):e049089. Epub 2021 May 4.

Secretariat of Health Surveillance, Brazilian Ministry of Health, Brasilia, Brazil.

Objective: To provide a comprehensive description of demographic, clinical and radiographic characteristics; treatment and case outcomes; and risk factors associated with in-hospital death of patients hospitalised with COVID-19 in Brazil.

Design: Retrospective cohort study of hospitalised patients diagnosed with COVID-19.

Setting: Data from all hospitals across Brazil. Read More

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Dynamic modelling to identify mitigation strategies for the COVID-19 pandemic.

Swiss Med Wkly 2021 04 4;151:w20487. Epub 2021 May 4.

Department of Mechanical and Process Engineering, Swiss Federal Institute of Technology, IFD, Zurich, Switzerland.

Relevant pandemic-spread scenario simulations can provide guiding principles for containment and mitigation policies. We devised a compartmental model to predict the effectiveness of different mitigation strategies with a main focus on mass testing. The model consists of a set of simple differential equations considering the population size, reported and unreported infections, reported and unreported recoveries, and the number of COVID-19-inflicted deaths. Read More

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Post-acute sequelae of SARS-CoV-2 infection: Caring for the 'long-haulers'.

Cleve Clin J Med 2021 05 3;88(5):267-272. Epub 2021 May 3.

Department of Critical Care Medicine; Department of Pulmonary Medicine; Cleveland Clinic, Cleveland, OH.

An estimated 10% of COVID-19 survivors continue to experience symptoms several weeks to months after the appearance of initial symptoms, a condition termed post-acute sequelae of SARS-CoV-2 infection (PASC). These patients, also called "long-haulers," most commonly report protracted symptoms of fatigue, cough, dyspnea, chest tightness, difficulty concentrating, arthralgia, olfactory dysfunction, and headache. While age, comorbid medical conditions, and COVID-19 severity are risk factors, young and previously healthy individuals with mild COVID-19 are also at risk. Read More

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Severe COVID-19 in the intensive care unit: a case series.

J Med Case Rep 2021 May 3;15(1):259. Epub 2021 May 3.

Faculty of Medicine, Department of Anesthesiology and Intensive Care, Universitas Pelita Harapan, Jl. M. H. Thamrin Boulevard 1100, Lippo Village Tangerang, Tangerang, Banten, 15811, Indonesia.

Background: Coronavirus disease 2019 (COVID-19) was first identified in Indonesia in March 2020, and the number of infections has grown exponentially. The situation is at its worst, overwhelming intensive care unit (ICU) resources and capacity.

Case Presentation: This is a single-center observational case study of 21 confirmed COVID-19 patients admitted to the ICU from March 20, 2020, to April 31, 2020. Read More

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Airway pressure release ventilation in mechanically ventilated patients with COVID-19: a multicenter observational study.

Acute Crit Care 2021 May 4. Epub 2021 May 4.

Intensive Care Department, Sir Charles Gairdner Hospital, Perth, Australia.

Background: There is high prevalence of severe hypoxia, use of invasive mechanical ventilation, and high mortality in patients with severe coronavirus disease 2019 (COVID-19) pneumonitis. Evidence prior to the COVID-19 pandemic suggested that, compared with conventional ventilation strategies, airway pressure release ventilation (APRV) can improve oxygenation and reduce mortality in patients with acute respiratory distress syndrome. We aimed to assess the association between APRV use and clinical outcomes among adult patients receiving mechanical ventilation for COVID-19 and hypothesized that APRV use would be associated with improved survival compared with conventional ventilation. Read More

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High Mobility Group Box 1 and Interleukin 6 at Intensive Care Unit Admission as Biomarkers in Critically Ill COVID-19 Patients.

Am J Trop Med Hyg 2021 May 3. Epub 2021 May 3.

10School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand.

Exuberant inflammation manifesting as a "cytokine storm" has been suggested as a central feature in the pathogenesis of severe coronavirus disease 2019 (COVID-19). This study investigated two prognostic biomarkers, the high mobility group box 1 (HMGB1) and interleukin-6 (IL-6), in patients with severe COVID-19 at the time of admission in the intensive care unit (ICU). Of 60 ICU patients with COVID-19 enrolled and analyzed in this prospective cohort study, 48 patients (80%) were alive at ICU discharge. Read More

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Analysis of laboratory blood parameter results for patients diagnosed with COVID-19, from all ethnic group populations: A single centre study.

Int J Lab Hematol 2021 May 3. Epub 2021 May 3.

Department of Haematology, Sandwell and West Birmingham Hospitals, NHS Trust, West Bromwich, UK.

Introduction: Although factors such as age, sex, diabetes, obesity and changes in certain laboratory investigations are important prognostic factors in COVID-19 infection, these may not apply to all ethnic/racial groups. We hypothesized differences in routine biochemistry and haematology indices in Caucasian and a combined group of Black, Asian and Minority Ethnic (BAME) patients who tested positive for COVID-19 who died, compared to survivors.

Methods: We tested our hypothesis in 445 patients (229 Caucasian, 216 BAME) admitted to secondary care with proven COVID-19 infection, in whom standard routine laboratory indices were collected on admission. Read More

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Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome.

Front Cell Infect Microbiol 2021 15;11:646688. Epub 2021 Apr 15.

Centre for Primary Immunodeficiencies, Clinic of Pneumology and Phthisiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia.

The velocity of the COVID-19 pandemic spread and the variable severity of the disease course has forced scientists to search for potential predictors of the disease outcome. We examined various immune parameters including the markers of immune cells exhaustion and activation in 21 patients with COVID-19 disease hospitalised in our hospital during the first wave of the COVID-19 pandemic in Slovakia. The results showed significant progressive lymphopenia and depletion of lymphocyte subsets (CD3, CD4, CD8 and CD19) in correlation to the disease severity. Read More

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Nutritional risk at hospital admission is associated with prolonged length of hospital stay in old patients with COVID-19.

Clin Nutr 2021 Mar 23. Epub 2021 Mar 23.

Clinical Nutrition, University Hospitals of Geneva and University of Geneva, Chemin du Pont-Bochet 3, Geneva, Switzerland. Electronic address:

Background & Aims: To investigate the association of nutritional risk at admission with the length of hospital stay (LOS) and mortality in older patients with COVID-19.

Methods: Retrospective monocentric study in an acute geriatric hospital. Data were collected after an extensive review of medical records and the nutritional risk was assessed according to the Nutritional Risk Screening (NRS). Read More

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Patient perspectives on chemotherapy de-escalation in breast cancer.

Cancer Med 2021 May 1. Epub 2021 May 1.

Wake Forest School of Medicine, Winston-Salem, NC, USA.

Background: Given excellent survival outcomes in breast cancer, there is interest in de-escalating the amount of chemotherapy delivered to patients. This approach may be of even greater importance in the setting of the COVID-19 pandemic.

Methods: This concurrent mixed methods study included (1) interviews with patients and patient advocates and (2) a cross-sectional survey of women with breast cancer served by a charitable nonprofit organization. Read More

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Changes in the respiratory function of COVID-19 survivors during follow-up: a novel respiratory disorder on the rise?

Int J Clin Pract 2021 May 1:e14301. Epub 2021 May 1.

Department of Respiratory Medicine, G. Papanikolaou Hospital, Thessaloniki, Greece.

Background: The Human Coronavirus Disease 2019 (COVID-19) is a highly contagious respiratory disorder that it may result in acute respiratory distress syndrome. The aim of this review was to investigate the incidence and type of respiratory function abnormalities during follow-up of patients who recovered from COVID-19.

Methods: A systematic search of MEDLINE was conducted, utilizing various term combinations. Read More

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Overwhelmed by the news: A longitudinal study of prior trauma, posttraumatic stress disorder trajectories, and news watching during the COVID-19 pandemic.

Soc Sci Med 2021 Apr 23;278:113956. Epub 2021 Apr 23.

School of Psychology, Interdisciplinary Center (IDC), Herzliya, Israel.

Rationale: It has been recognized that exposure to mass trauma tends to increase the time spent watching television (TV) news. Yet, research on the effects of this tendency on individuals' well-being yielded inconclusive findings.

Objective: The aim of this longitudinal study is to examine the effects of prior trauma and posttraumatic stress disorder (PTSD) on changes in the amount of TV news watching and its effect on subsequent PTSD. Read More

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Epidemiology, outcomes, and utilization of intensive care unit resources for critically ill COVID-19 patients in Libya: A prospective multi-center cohort study.

PLoS One 2021 30;16(4):e0251085. Epub 2021 Apr 30.

Faculty of Medicine University of Tripoli, Tripoli, Libya.

Background: The coronavirus disease (COVID-19) pandemic has severely affected African countries, specifically the countries, such as Libya, that are in constant conflict. Clinical and laboratory information, including mortality and associated risk factors in relation to hospital settings and available resources, about critically ill patients with COVID-19 in Africa is not available. This study aimed to determine the mortality and morbidity of COVID-19 patients in intensive care units (ICU) following 60 days after ICU admission, and explore the factors that influence in-ICU mortality rate. Read More

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Functional Decline in Hospitalized Patients with COVID-19 in the Early Months of the Pandemic.

PM R 2021 Apr 30. Epub 2021 Apr 30.

Department of Physical Medicine and Rehabilitation, University of Michigan Health System.

Introduction: COVID-19 survivors are at risk of functional decline. To address the current gap in knowledge about post-acute needs of those infected by COVID-19, we examined discharge function data to better prepare patients, providers, and health systems to return patients to optimal levels of functioning.

Objective: This study examines the prevalence of functional decline and related rehabilitation needs at hospital discharge. Read More

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Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients with COVID-19 in Germany: An Observational Cohort Study.

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Department of Intensive and Intermediate Care, University Hospital RWTH Aachen, 52074 Aachen, Germany.

The coronavirus disease 2019 (COVID-19) pandemic has placed a significant burden on hospitals worldwide. Objective biomarkers for early risk stratification and clinical management are still lacking. The aim of this work was to determine whether bioactive adrenomedullin can assist in the risk stratification and clinical management of critically ill COVID-19 patients. Read More

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Skeletal Muscle Damage in COVID-19: A Call for Action.

Medicina (Kaunas) 2021 Apr 12;57(4). Epub 2021 Apr 12.

Department of Psychiatry, School of Medicine, Teikyo University, Tokyo 173-8605, Japan.

Both laboratory investigations and body composition quantification measures (e.g., computed tomography, CT) portray muscle loss in symptomatic Coronavirus disease 2019 (COVID-19) patients. Read More

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Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms.

Viruses 2021 04 18;13(4). Epub 2021 Apr 18.

Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Bio-technology (IIOAB), Nonakuri, Purba Medinipur, West Bengal 721172, India.

The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-term care of COVID-19 survivors. It is thus imperative to study post-COVID (i.e. Read More

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