1,014 results match your criteria covid-19 emphasis


Student-senior isolation prevention partnership: a Canada-wide programme to mitigate social exclusion during the COVID-19 pandemic.

Health Promot Int 2021 Oct 20. Epub 2021 Oct 20.

Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto M5T 3M7, Canada.

Amidst the pandemic, Canada has taken critical steps to curb the transmission of the 2019 novel coronavirus disease (COVID-19). A key intervention has been physical distancing. Although physical distancing may protect older adults and other at-risk groups from COVID-19, research suggests quarantine and isolation may worsen mental health. Read More

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October 2021

Product review on MAbs (alemtuzumab and ocrelizumab) for the treatment of multiple sclerosis.

Hum Vaccin Immunother 2021 Oct 20:1-18. Epub 2021 Oct 20.

Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia.

Traditionally, the management of active relapsing remitting MS was based on the, so-called, maintenance therapy, which is characterized by continuous treatment with particular disease modifying therapy (DMT), and a return of disease activity when the drug is discontinued. Another approach is characterized by a short treatment course of a DMT, which is hypothesized to act as an immune reconstitution therapy (IRT), with the potential to protect against relapses for years after a short course of treatment. Introduction of monoclonal antibodies in the treatment of MS has revolutionized MS treatment in the last decade. Read More

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October 2021

Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.

PLoS One 2021 19;16(10):e0258858. Epub 2021 Oct 19.

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.

Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC communities in infectious disease research is a critical component in efforts to increase vaccine confidence, acceptability, and uptake of future approved products. Recent data highlight the relative absence of BIPOC communities in vaccine clinical trials. Read More

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October 2021

Identification of most important features based on a fuzzy ensemble technique: Evaluation on joint space narrowing progression in knee osteoarthritis patients.

Int J Med Inform 2021 Oct 11;156:104614. Epub 2021 Oct 11.

Institute for Bio-Economy and Agri-Technology, Center for Research and Technology Hellas, 38333, Greece. Electronic address:

Objective: Feature selection (FS) is a crucial and at the same time challenging processing step that aims to reduce the dimensionality of complex classification or regression problems. Various techniques have been proposed in the literature to address this challenge with emphasis to medical applications. However, each one of the existing FS algorithms come with its own advantages and disadvantages introducing a certain level of bias. Read More

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October 2021

Evaluation of global evolutionary variations in the early stage of SARS-CoV-2 pandemic.

Heliyon 2021 Oct 13:e08170. Epub 2021 Oct 13.

Pathogen Resource TF, Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju-si, Republic of Korea.

To understand the origin of variants and their evolutionary history in the early stage of the COVID-19 pandemic, time-scaled phylogenetic and gene variation analyses were performed. The mutation patterns and evolution characteristics were examined using the Bayesian Evolutionary Analysis Sampling Trees (BEAST) with 349 whole-genome sequences available by March 2020. The results revealed five phylogenetic clusters (Groups A-E), with 408 nucleotide variants. Read More

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October 2021

Hand Sanitizer Intoxication in the Emergency Department.

Cureus 2021 Sep 12;13(9):e17906. Epub 2021 Sep 12.

Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington DC, USA.

Hand hygiene has always been an area of emphasis within the hospital setting, never more so than during the coronavirus disease 2019 (COVID-19) pandemic. The consumption of alcohol-containing hand sanitizer products, whether intentional or accidental, often garners attention, particularly since these products may contain methanol. This report describes a case of surreptitious theft and intentional ingestion of the emergency department's (ED) ethanol-based hand sanitizer by a patient who presented to the ED clinically intoxicated with a high ethanol level. Read More

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September 2021

Don't Call It Smart: Working From Home During the Pandemic Crisis.

Front Psychol 2021 30;12:741585. Epub 2021 Sep 30.

Department of Pedagogy, Psychology and Philosophy, University of Cagliari, Cagliari, Italy.

The recent COVID-19 pandemic and related social distancing measures have significantly changed worldwide employment conditions. In developed economies, institutions and organizations, both public and private, are called upon to reflect on new organizational models of work and human resource management, which - in fact - should offer workers sufficient flexibility in adapting their work schedules remotely to their personal (and family) needs. This study aims to explore, within a Job Demands-Resources framework, whether and to what extent job demands (workload and social isolation), organizational job resources (perceived organizational support), and personal resources (self-efficacy, vision about the future and commitment to organizational change) have affected workers' quality of life during the pandemic, taking into account the potential mediating role of job satisfaction and perceived stress. Read More

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September 2021

The healthy behaviours and COVID-19 mortality among Iranian women: a case-control study.

BMC Womens Health 2021 Oct 17;21(1):366. Epub 2021 Oct 17.

Social Determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: Women are among the susceptible groups to Coronavirus disease-19 (COVID-19) in Ardabil, north-west of Iran, despite the current global status. The underlying causes of high incidence and fatality rate of women in Ardabil are not fully understood. Hence, this study aimed to investigate the healthy behaviours in women of Ardabil and its relationship with COVID-19 mortality. Read More

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October 2021

Impact of COVID -19 Pandemic on Plastic Surgery Practices in a Tertiary Care Set Up in Southern India.

Niger J Clin Pract 2021 Oct;24(10):1558-1564

Department of Plastic Surgery, Sri Ramachandra Institute of Higher Education and Research, Sri Ramachandra Nagar, Porur, Chennai, Tamil Nadu, India.

Background: The COVID-19 pandemic has modified the way, plastic surgeons treat their patients. This article depicts how we as a plastic surgery department in a tertiary care setup handled the pandemic with an emphasis on infection control policy.

Methods: Data was collected from hospital records and quality assurance cell from March 21, 2020 to June 19, 2020 in terms of patient triaging, consultations, perioperative protocols, duty rosters, and academic activities. Read More

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October 2021

Iraq experience in handling the COVID-19 pandemic: implications of public health challenges and lessons learned for future epidemic preparedness planning.

J Public Health (Oxf) 2021 Oct 14. Epub 2021 Oct 14.

Directorate of Public Health, Ministry of Health, Baghdad 10047, Iraq.

Background: Iraq has been exceptionally challenged by the COVID-19 pandemic due to the already exhausted healthcare system.

Objectives: To describe the epidemiological situation of COVID-19 in Iraq, the government's response to the pandemic, and provide recommendations for further action.

Methods: A desk review of secondary data using the available reports on the epidemiological situation in Iraq as well as official governmental sources was conducted. Read More

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October 2021

Recovery Home Environment Characteristics Associated with Recovery Capital.

J Drug Issues 2020 Apr 11;51(2):253-267. Epub 2020 Dec 11.

Alcohol Research Group, Public Health Institute, Emeryville, California.

Background: Recovery capital refers to internal and external resources that facilitate recovery from alcohol and drug disorders. Examples include support from friends and family, access to health and other services, stable housing and finances, and internal assets, such as self-esteem and motivation. Recovery capital is receiving increased emphasis as an integral component of addiction services. Read More

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Protective Immunity after Natural Infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) - Kentucky, USA, 2020.

Int J Infect Dis 2021 Oct 11. Epub 2021 Oct 11.

Kentucky Department for Public Health, USA; Career Epidemiology Field Officer Program, Center for Preparedness and Response, CDC, USA.

Background: As vaccine supply and access remain limited in many parts of the world, understanding the duration of protection from reinfection after natural infection is important.

Methods: Distinct individuals testing positive and negative for SARS-CoV-2 between March 6, 2020, and August 31, 2020, in Kentucky, USA, were identified using the Kentucky National Electronic Disease Surveillance System. Individuals were followed for occurrence of a positive test for SARS-CoV-2 from 91 days after their initial test result through December 31, 2020. Read More

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October 2021

Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91-112 & 231-290 regions.

Microb Pathog 2021 Oct 11:105236. Epub 2021 Oct 11.

School of Basic Sciences, Indian Institute of Technology Mandi, VPO Kamand, Himachal Pradesh, 175005, India. Electronic address:

The NSP6 protein of SARS-CoV-2 is a transmembrane protein, with some regions lying outside the membrane. Besides a brief role of NSP6 in autophagosome formation, this is not studied significantly. Also, there is no structural information available to date. Read More

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October 2021

COVID-19-Associated Parosmia and Dysgeusia: A Case Series.

Cureus 2021 Aug 30;13(8):e17584. Epub 2021 Aug 30.

Primary Care, Pueblo Seco Rural Health Clinic, San Ignacio, CHL.

Impairment of the chemical senses - smell, taste, and chemesthesis - has been pinpointed as one of the main clinical presentations of coronavirus disease 2019 (COVID-19). Chemosensory dysfunction can be quantitative, involving reduction or loss of perception (e.g. Read More

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[COVID-19 as a syndemic: a theoretical model and foundations for a comprehensive approach in health].

Cad Saude Publica 2021 8;37(10):e00119021. Epub 2021 Oct 8.

Centro de Ciências da Saúde, Universidade Federal do Recôncavo da Bahia, Santo Antônio de Jesus, Brasil.

This essay aims to present and discuss the theoretical framework for the COVID-19 syndemic. The first part presents the foundations and principles of syndemic theory. For the purposes of this essay, syndemic was defined as a process of synergic interaction between two or more diseases, in which the effects are mutually enhanced. Read More

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October 2021

Quality of life of COVID-19 recovered patients in Bangladesh.

PLoS One 2021 13;16(10):e0257421. Epub 2021 Oct 13.

Institute of Statistical Research and Training (ISRT), University of Dhaka, Dhaka, Bangladesh.

Coronavirus Disease-2019 (COVID-19) quickly surged the whole world and affected people's physical, mental, and social health thereby upsetting their quality of life. Therefore, we aimed to investigate the quality of life (QoL) of COVID-19 positive patients after recovery in Bangladesh. This was a study of adult (aged ≥18 years) COVID-19 individuals from eight divisions of Bangladesh diagnosed and confirmed by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) from June 2020 to November 2020. Read More

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October 2021

COVID-19-associated venous thromboembolism portends worse survival.

Semin Vasc Surg 2021 Sep 9;34(3):117-124. Epub 2021 Aug 9.

Emory University, 1364 E Clifton Road NE, Atlanta, GA 30322; Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, GA 30033.

Patients with coronavirus disease 2019 (COVID-19) seem to be at high risk for venous thromboembolism (VTE) development, but there is a paucity of data exploring both the natural history of COVID-19-associated VTE and the risk for poor outcomes after VTE development. This investigation aims to explore the relationship between COVID-19-associated VTE development and mortality. A prospectively maintained registry of patients older than 18 years admitted for COVID-19-related illnesses within an academic health care network between March and September 2020 was reviewed. Read More

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September 2021

O-JMeSH: creating a bilingual English-Japanese controlled vocabulary of MeSH UIDs through machine translation and mutual information.

Genomics Inform 2021 Sep 30;19(3):e26. Epub 2021 Sep 30.

Graduate School of Integrative Science and Engineering, Tokyo City University, Tokyo 158-8557, Japan.

Previous approaches to create a controlled vocabulary for Japanese have resorted to existing bilingual dictionary and transformation rules to allow such mappings. However, given the possible new terms introduced due to coronavirus disease 2019 (COVID-19) and the emphasis on respiratory and infection-related terms, coverage might not be guaranteed. We propose creating a Japanese bilingual controlled vocabulary based on MeSH terms assigned to COVID-19 related publications in this work. Read More

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September 2021

Treatment of overdose in the synthetic opioid era.

Authors:
Phil Skolnick

Pharmacol Ther 2021 Oct 9:108019. Epub 2021 Oct 9.

Opiant Pharmaceuticals, 233 Wilshire Blvd., Suite 280, Santa Monica, CA 90401, United States of America. Electronic address:

Overdose deaths are often viewed as the leading edge of the opioid epidemic which has gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is perhaps unsurprising because opioid overdose is both the number-one cause of death for individuals between 25 and 64 years old (Dezfulian et al., 2021) and a significant contributor to the decline in average lifespan (Dowell et al. Read More

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October 2021

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2.

Curr Drug Targets 2021 Oct 5. Epub 2021 Oct 5.

Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur. India.

Coronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. Read More

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October 2021

SARS-CoV-2 subunit vaccine adjuvants and their signaling pathways.

Expert Rev Vaccines 2021 Oct 11. Epub 2021 Oct 11.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001 China.

Introduction: Vaccines are the agreed upon weapon against the COVID-19 pandemic. Adjuvanted subunit vaccines are well controlled, safe and effective. This review discusses about COVID-19 subunit vaccines and their signaling pathways which could provide a glimpse into the selection of appropriate adjuvants for prospective vaccine development studies. Read More

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October 2021

Coronaviruses: An overview with special emphasis on COVID-19 outbreak with musculoskeletal manifestations.

World J Orthop 2021 Sep 18;12(9):620-628. Epub 2021 Sep 18.

Department of Paediatric Orthopaedics, King George's Medical University, Lucknow 226003, Uttar Pradesh, India.

An acute respiratory illness caused by a novel coronavirus, namely, severe acute respiratory syndrome coronavirus 2, the virus that causes coronavirus disease 2019 (COVID-19), began spreading across China in late December 2019. The disease gained global attention as it spread worldwide. Since the COVID-19 pandemic began, many studies have focused on the impact of the disease on conditions such as diabetes, cardiovascular disease, pulmonary disorders, and renal malfunction. Read More

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September 2021

Liver disease in the era of COVID-19: Is the worst yet to come?

World J Gastroenterol 2021 Sep;27(36):6039-6052

Department of Gastroenterology, Clinical Hospital Center Rijeka, Rijeka 51000, Croatia.

The global social, economic and political crises related to coronavirus disease 2019 (COVID-19) presumably had more indirect than direct negative impacts on health systems. Drastic lifestyle changes, social isolation and distancing, and individual and global financial crises resulted in robust populations forfeiting healthy habits and seeking comfort in alcoholic beverages, drugs and unhealthy diets. The inevitable consequences are increases in the incidence of nonalcoholic fatty liver disease, viral hepatitis, acute alcoholic hepatitis, liver cirrhosis decompensation and ultimately liver-related mortality. Read More

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September 2021

Nordic responses to Covid-19: Governance and policy measures in the early phases of the pandemic.

Health Policy 2021 Sep 5. Epub 2021 Sep 5.

European Observatory on Health Systems and Policies, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, UK. Electronic address:

This paper explores and compares health system responses to the COVID-19 pandemic in Denmark, Finland, Iceland, Norway and Sweden, in the context of existing governance features. Content compiled in the Covid-19 Health System Response Monitor combined with other publicly available country information serve as the foundation for this analysis. The analysis mainly covers early response until August 2020, but includes some key policy and epidemiological developments up until December 2020. Read More

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September 2021

Screening S protein - ACE2 blockers from natural products: Strategies and advances in the discovery of potential inhibitors of COVID-19.

Eur J Med Chem 2021 Oct 4;226:113857. Epub 2021 Oct 4.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China. Electronic address:

The Coronavirus disease, 2019 (COVID-19) is caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), which poses a major threat to human life and health. Given its continued development, limiting the spread of COVID-19 in the population remains a challenging task. Currently, multiple therapies are being tried around the world to deal with SARS-CoV-2 infection, and a variety of studies have shown that natural products have a significant effect on COVID-19 patients. Read More

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October 2021

Identifying opportunities to engage communities with social mobilisation activities to tackle NCDs in El Salvador in the context of the global COVID-19 pandemic.

Int J Equity Health 2021 10 9;20(1):222. Epub 2021 Oct 9.

Research Unit on Health in Situations of Fragility, Institute for Global Health & Development, Queen Margaret University, Edinburgh, UK.

Background: Social mobilisation is potentially a key tool in the prevention of non-communicable diseases (NCDs) in fragile settings. This formative study addressed existing and potential social mobilisation mechanisms seeking behaviour to tackle NCDs in El Salvador, with an emphasis on the implications in the context of the current COVID-19 pandemic.

Methods: We conducted 19 semi-structured interviews with health workers, government officials, NGO leaders, and community members. Read More

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October 2021

Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative.

Biomed Pharmacother 2021 Oct 2;144:112282. Epub 2021 Oct 2.

Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. Electronic address:

Six months after the publication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequence, a record number of vaccine candidates were listed, and quite a number of them have since been approved for emergency use against the novel coronavirus disease 2019 (COVID-19). This unprecedented pharmaceutical feat did not only show commitment, creativity and collaboration of the scientific community, but also provided a swift solution that prevented global healthcare system breakdown. Notwithstanding, the available data show that most of the approved COVID-19 vaccines protect only a proportion of recipients against severe disease but do not prevent clinical manifestation of COVID-19. Read More

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October 2021

Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models.

J Clin Invest 2021 Oct 7. Epub 2021 Oct 7.

Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.

Nucleoside-modified mRNA vaccines have gained global attention because of COVID-19. We evaluated a similar vaccine approach for preventing a chronic latent genital infection rather than an acute respiratory infection. We used animal models to compare an HSV-2 trivalent nucleoside-modified mRNA vaccine with the same antigens prepared as proteins with an emphasis on antigen-specific memory B cell responses and immune correlates of protection. Read More

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October 2021

Olympic anti-doping laboratory: the analytical technological road from 2016 Rio De Janeiro to 2021 Tokyo.

Bioanalysis 2021 Oct 7;13(19):1511-1527. Epub 2021 Oct 7.

Anti-Doping Lab Qatar (ADLQ), Doha, 27775, Qatar.

The summer Olympic Games is the major mega sports event since the first modern era Olympiad, held in Athens, Greece in 1896. International Olympic Committee (IOC) has the responsibility of the organization of the summer and winter Games ensuring the broadcast in all corners of earth. The World Anti-Doping Agency (WADA) is the responsible organization of the fight against doping in sports. Read More

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October 2021