2,805 results match your criteria covid-19 discussed

A recommended paradigm for vaccination of rheumatic disease patients with the SARS-CoV-2 vaccine.

J Autoimmun 2021 May 1;121:102649. Epub 2021 May 1.

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens and Academy of Athens, Athens, Greece. Electronic address:

Autoimmune and autoinflammatory rheumatic disorders (ARD) are treated with antimetabolites, calcineurin inhibitors and biologic agents either neutralizing cytokines [Tumor Necrosis Factor (TNF), Interleukin (IL)-1, IL-6, IL-17, B-cell activating factor] or being directed against B-cells (anti-CD-20), costimulatory molecules or JAK kinases. Similarly for the influenza or pneumococcal vaccines, there is limited data on the effectiveness of vaccination against SARS-CoV-2 infection and COVID-19 prevention for this susceptible patient population. Moreover, preliminary data from vaccinated organ transplanted, inflammatory bowel and connective tissue disease patients suggests only limited immunogenicity after the first vaccine dose, particularly in patients on immunosuppressive regimens. Read More

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How Academic Medical Centers Can Navigate the Pandemic and its Aftermath: Solutions for Three Major Issues.

Acad Med 2021 May 11. Epub 2021 May 11.

B.F. Godley is Adjunct Professor, Ophthalmology and Visual Sciences, University of Texas, Medical Branch. T.J. Lawley is William P. Timmie Professor of Dermatology and Former Dean at Emory School of Medicine. A. Rubenstein is Professor in the Department of Medicine and the Division of Endocrinology and Former Dean and Executive Vice President at the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania. P.A. Pizzo is the David and Susan Heckerman Professor of Pediatrics and of Microbiology and Immunology at Stanford and Former Dean, School of Medicine and Founding Director of the Stanford Distinguished Careers Institute, Stanford University; ORCID: https://orcid.org/0000-0002-1000-6516.

The COVID-19 crisis has seriously affected academic medical centers (AMCs) on multiple levels. Combined with many trends that were already under way pre-pandemic, the current situation has generated significant disruption and underscored the need for change within and across AMCs. In this article, the authors explore some of the major issues and propose actionable solutions in 3 areas of concentration. Read More

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Urology practice during the COVID-19 vaccination campaign.

Urologia 2021 May 13:3915603211016321. Epub 2021 May 13.

Department of Urology, Federico II University of Naples, Naples, Italy.

Introduction: The current scenario of the COVID-19 pandemic is significantly different from that of the first, emergency phase. Several countries in the world are experiencing a second, or even a third, wave of contagion, while awaiting the effects of mass vaccination campaigns. The aim of this report was to provide an update of previously released recommendations on prioritization and restructuring of urological activities. Read More

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Implicit theories of health, consideration of future consequences, and engagement in health protective behaviors during the COVID-19 pandemic in China.

Ning Zhang Yun Kou

J Health Psychol 2021 May 13:13591053211017191. Epub 2021 May 13.

School of Public Health and the Second Affiliated Hospital of Zhejiang University School of Medicine, China.

This research investigated how implicit theories of health and consideration of future consequences influence people's engagement in health-protective behaviors during the COVID-19 pandemic in China. Three hundred and ninety Chinese completed the study during the peak period of COVID-19 pandemic in China. Gender, education level, implicit theories of health, and consideration of future consequences were significant predictors of people's engagement in health-protective behaviors. Read More

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To vaccinate or not to vaccinate; that is the question! (New insights on COVID-19 Vaccination).

Sarah El-Nakeep

Curr Mol Med 2021 May 11. Epub 2021 May 11.

Ain Shams University Internal Medicine, Egypt.

Aim: This is a mini-review of the literature; to discuss the obstacles and benefits of vaccination in the era of current pandemic, either the COVID-19 vaccines, which are on their way to be released or the influenza vaccines. There is much debate concerning their effectiveness on ameliorating the severity of the COVID-19 pandemic.

Methodology: Searching the literature till November 2020 in the PubMed database. Read More

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Problems associated with antiviral drugs and vaccines development for COVID-19: approach to intervention using expression vectors via GPI anchor.

Khue Vu Nguyen

Nucleosides Nucleotides Nucleic Acids 2021 May 13:1-32. Epub 2021 May 13.

Department of Medicine, Biochemical Genetics and Metabolism, The Mitochondrial and Metabolic Disease Center, School of Medicine, University of California, San Diego, San Diego, CA, USA.

The outbreak of a novel coronavirus responsible for the severe acquired respiratory syndrome: SARS-CoV-2, also known as coronavirus disease 2019: COVID-19, represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for diagnostic, development of antibodies, entry inhibitors, and vaccines. COVID-19 also recognizes angiotensin-converting enzyme 2 (ACE2) as its host receptor binding to viral S protein. Read More

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The management of upper airway diseases: an ongoing challenge for the clinician.

J Biol Regul Homeost Agents 2021 Jan-Feb;35(1 Suppl. 2):1-2

International Federation ORL Societies (IFOS) Executive Board members, Rome, Italy.

Upper airway diseases are widespread in clinical practice. However, some aspects are still debated. The current supplement presents and discusses the most common disorders encountered in daily medical activity. Read More

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COVID-19 cases with delayed absorption of lung lesion.

Open Med (Wars) 2021 27;16(1):692-695. Epub 2021 Apr 27.

The Affiliated Yangming Hospital of Ningbo University, Yuyao People's Hospital of Zhejiang Province, Yuyao, China.

Objective: Over 90% of the COVID-19 patients with computed tomographic (CT) manifestations showed radiological improvement on dissipating stage. Cases with refractory pulmonary infiltration were discussed in this study.

Methods: During hospitalization, chest CT scan and reverse transcriptase polymerase chain reaction (RT-PCR) test were repeatedly performed. Read More

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Deemed consent for organ donation: a comparison of the English and Scottish approaches.

Jordan A Parsons

J Law Biosci 2021 Jan-Jun;8(1):lsab003. Epub 2021 Mar 4.

Bristol Medical School, University of Bristol, UK.

Deemed consent for organ donation has long been discussed as a potential solution to the shortage of organs for transplantation, with several countries having implemented it. In Great Britain, Wales was the first nation to introduce such a system, having done so in 2015. Now, the other two nations are following suit. Read More

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Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients.

Front Endocrinol (Lausanne) 2021 26;12:587518. Epub 2021 Apr 26.

Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tuebingen, Tuebingen, Germany.

Thyroxine and triiodothyronine (T3) are classical thyroid hormones and with relatively well-understood actions. In contrast, the physiological role of thyroid hormone metabolites, also circulating in the blood, is less well characterized. These molecules, namely, reverse triiodothyronine, 3,5-diiodothyronine, 3-iodothyronamine, tetraiodoacetic acid and triiodoacetic acid, mediate both agonistic (thyromimetic) and antagonistic actions additional to the effects of the classical thyroid hormones. Read More

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Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis.

Clin Microbiol Rev 2021 06 12;34(3). Epub 2021 May 12.

Public Health Research Institute (PHRI) at New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million COVID-19-positive cases and a mortality rate of about 2.2%, as of 10 December 2020. About 20% of COVID-19 patients exhibit moderate to severe symptoms. Read More

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Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection.

Clin Microbiol Rev 2021 06 12;34(3). Epub 2021 May 12.

Department of Chemical and Materials Engineering, Gina Cody School of Engineering, Concordia University, Montréal, Québec, Canada

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory disease coronavirus 2 (SARS-CoV-2), has led to millions of confirmed cases and deaths worldwide. Efficient diagnostic tools are in high demand, as rapid and large-scale testing plays a pivotal role in patient management and decelerating disease spread. This paper reviews current technologies used to detect SARS-CoV-2 in clinical laboratories as well as advances made for molecular, antigen-based, and immunological point-of-care testing, including recent developments in sensor and biosensor devices. Read More

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Collective Emotion During Collective Trauma: A Metaphor Analysis of the COVID-19 Pandemic.

Qual Health Res 2021 May 13:10497323211011589. Epub 2021 May 13.

Fordham University, New York City, New York, USA.

This study provides insight into lived experiences of the COVID-19 pandemic in the United States. Participant metaphors of the pandemic were collected by conducting in-depth semi-structured interviews ( = 44). Participants were asked to compare the pandemic with an animal and with a color, and to provide contextual sensemaking about their metaphors. Read More

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Aptamer-based lateral flow assay on-site biosensors.

Biosens Bioelectron 2021 Apr 24;186:113279. Epub 2021 Apr 24.

School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China. Electronic address:

The lateral flow assay (LFA) is a widely used paper-based on-site biosensor that can detect target analytes and obtain test results in several minutes. Generally, antibodies are utilized as the biorecognition molecules in the LFA. However, antibodies selected using an in vivo process not only may risk killing the animal hosts and causing errors between different batches but also their range is restricted by the refrigerated conditions used to store them. Read More

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Nanobased Platforms for Diagnosis and Treatment of COVID-19: From Benchtop to Bedside.

ACS Biomater Sci Eng 2021 May 12. Epub 2021 May 12.

Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera 56025, Pisa, Italy.

Human respiratory viral infections are the leading cause of morbidity and mortality around the world. Among the various respiratory viruses, coronaviruses (e.g. Read More

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[Pneumomediastinum in patients with a novel coronavirus infection (COVID-19)].

Khirurgiia (Mosk) 2021 (5):20-24

Volgograd State Medical University, Volgograd, Russia.

Objective: To determine the optimal management of pneumomediastinum in patients with a novel coronavirus infection (COVID-19).

Material And Methods: There were 14 patients with pneumomediastinum and COVID-19 infection without mechanical ventilation. We discussed the world data on pneumomediastinum in patients with coronavirus infection. Read More

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SARS-CoV-2 in patients with cancer: possible role of mimicry of human molecules by viral proteins and the resulting anti-cancer immunity.

Cell Stress Chaperones 2021 May 11. Epub 2021 May 11.

Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), Institute of Human Anatomy and Histology, University of Palermo, 90141, Palermo, Italy.

A few reports suggest that molecular mimicry can have a role in determining the more severe and deadly forms of COVID-19, inducing endothelial damage, disseminated intravascular coagulation, and multiorgan failure. Heat shock proteins/molecular chaperones can be involved in these molecular mimicry phenomena. However, tumor cells can display on their surface heat shock proteins/molecular chaperones that are mimicked by SARS-CoV-2 molecules (including the Spike protein), similarly to what happens in other bacterial or viral infections. Read More

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Bilateral Traumatic Maculopathy after Closed-Globe Injury in Context of National Lockdown: A Case Report.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):159-163. Epub 2021 Apr 12.

Department of Ophthalmology 2, Quinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT, University Paris Descartes, Paris, France.

The aim of this study is to report a case of bilateral traumatic maculopathy in a 19-year-old male following blunt trauma during 2020 coronavirus disease-2019 national lockdown. Descriptive case report based on data from clinical records, patient observation, and analysis of diagnostic tests. A previously healthy, 19-year-old male presented for a visit in our department at 15-20 National Ophthalmology Institute with complaints of bilateral decreased visual acuity. Read More

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Overview of sleep management during COVID-19.

Philip M Becker

Sleep Med 2021 Apr 24. Epub 2021 Apr 24.

Sleep Medicine Associates of Texas, Department of Psychiatry, University of Texas Medical Center at Dallas, 12327 Brittany Circle, Dallas, TX 75230 USA. Electronic address:

The sleep of millions has suffered during the global COVID-19 pandemic. Prevalence rates of 20-45% are reported globally for insomnia symptoms during the pandemic. Affected populations include the public and health care workers. Read More

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A case of a pregnant patient with COVID-19 infection treated with emergency c-section and extracorporeal membrane oxygenation.

J Card Surg 2021 May 11. Epub 2021 May 11.

Department of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Coronavirus disease 2019 (COVID-19) causes the development of severe acute respiratory distress syndrome. Pregnant women may be at increased risk for the development of severe disease. We present the case of a pregnant patient who developed respiratory failure due to COVID-19 and rapidly decompensated requiring intubation. Read More

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Answering the Challenge of COVID-19 Pandemic Through Innovation and Ingenuity.

Adv Exp Med Biol 2021 ;1318:859-873

Department of Surgery, University Campus, St. Luke's University Health Network, Bethlehem, PA, USA.

The novel coronavirus disease 2019 (COVID-19) pandemic has created a maelstrom of challenges affecting virtually every aspect of global healthcare system. Critical hospital capacity issues, depleted ventilator and personal protective equipment stockpiles, severely strained supply chains, profound economic slowdown, and the tremendous human cost all culminated in what is questionably one of the most profound challenges that humanity faced in decades, if not centuries. Effective global response to the current pandemic will require innovation and ingenuity. Read More

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Reopening Schools After a Novel Coronavirus Surge.

Adv Exp Med Biol 2021 ;1318:785-813

Yale School of Public Health, New Haven, CT, USA.

The coronavirus disease 2019 (COVID-19) pandemic shook the world in ways not seen since the pandemic influenza of 1918-1919. As of late August 2020, over 25 million persons had been infected, and we will see the global death toll exceed one million by the end of 2020. Both are minimum estimates. Read More

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Potential Mechanisms of COVID-19-Related Psychological Problems and Mental Disorders.

Alfred Shaw

Adv Exp Med Biol 2021 ;1318:727-735

Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Beijing, China.

As the coronavirus disease 2019 (COVID-19) pandemic has spread, so has the psychological impact of the disease been felt worldwide. Despite this, the mechanisms of COVID-19-related psychological problems and mental disorders remain unclear. As such, effective therapeutic schemes or intervention strategies cannot be developed. Read More

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The Main Sources and Potential Effects of COVID-19-Related Discrimination.

Adv Exp Med Biol 2021 ;1318:705-725

Chair of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland.

The outbreak of a new coronavirus disease (COVID-19), which appeared in late 2019 and eventually resulted in the announcement of a pandemic by the World Health Organization, led to global fear and panic as well as the spread of false information and fake news from different sources. As a result, a sharp increase in prejudice, discrimination, and xenophobia against different groups of people was observed in different geographical locations. This chapter presents the psychological and social sources of stereotypes and prejudices that take forms in the COVID-19 pandemic. Read More

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Prevention of COVID-19: Preventive Strategies for General Population, Healthcare Setting, and Various Professions.

Adv Exp Med Biol 2021 ;1318:575-604

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

The disease 2019 (COVID-19) made a public health emergency in early 2020. Despite attempts for the development of therapeutic modalities, there is no effective treatment yet. Therefore, preventive measures in various settings could help reduce the burden of disease. Read More

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Immune-Based Therapy for COVID-19.

Adv Exp Med Biol 2021 ;1318:449-468

School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel zoonotic virus identified as the cause of coronavirus disease 2019 (COVID-19) that has crossed species and infected humans. In order to develop new insights on the immune-based treatments against this disease, it is vital to understand the immunopathology of the COVID-19, implications of the immune response to SARS-CoV-2, and immune dysfunction in response to SARS-CoV-2. There is no approved drug for the treatment of COVID-19. Read More

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Autoimmune Processes Involved in Organ System Failure Following Infection with SARS-CoV-2.

Adv Exp Med Biol 2021 ;1318:355-368

Biological Safety and Security, Frederick, MD, USA.

During the COVID-19 pandemic associated with high incidence, transmissibility, and mortality, this chapter focuses on three phases of the disease: initial exposure, initiation of the immune response to the agent, and finally, an inflammatory/autoimmune-like presentation with pulmonary, neurological, and renal failure and disseminated intravascular coagulation which occurs in a small proportion of the patients. The elegant demonstration of the site of interaction between the spike (S) protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of COVID-19, and the ACE (angiotensin-converting enzyme) 2 receptor of cells distributed throughout the body has enabled research efforts to develop pharmacological and immune countermeasures to the viral phase of the disease. This chapter rapidly reviews the molecular and structural organization of SARS-CoV-2 and its interaction with ACE2. Read More

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COVID-19 in Patients with Cancer.

Adv Exp Med Biol 2021 ;1318:315-331

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

With more than 5 million cases and 333,212 deaths, COVID-19 (or SARS-CoV-2) continues to spread. General symptoms of this disease are similar to that of many other viral respiratory diseases, including fever, cough, dyspnea, and fatigue, with a chance of progression to more severe complications. However, the virus does not affect all people equally, and cases with comorbidities such as malignancies, cardiovascular diseases, respiratory diseases, and kidney diseases are at higher risk of developing severe events, including requiring intensive ventilation, intensive care unit (ICU) admission, and death. Read More

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Coronavirus: Pure Infectious Disease or Genetic Predisposition.

Adv Exp Med Biol 2021 ;1318:91-107

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes novel coronavirus disease (COVID-19), is the seventh pathogenic coronavirus recently discovered in December 2019 in Wuhan, China. To date, our knowledge about its effect on the human host remains limited. It is well known that host genetic factors account for the individual differences in the susceptibility to infectious diseases. Read More

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Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment.

J Transl Med 2021 05 10;19(1):198. Epub 2021 May 10.

Institute of Microcirculation, Hebei North University, 11 Diamond South-road, Keji Building, Room 213, Zhangjiakou, 075000, Hebei, China.

The mortality rate of critically ill patients with acute respiratory distress syndrome (ARDS) is 30.9% to 46.1%. Read More

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