183,404 results match your criteria covid


The path to resilience and recovery: understanding the epidemiology, neuropathology and treatment of neurologic injury due to the SARS-CoV-2 virus in children.

Curr Opin Pediatr 2021 Oct 13. Epub 2021 Oct 13.

Division of Pediatric Neurology, University of Washington School of Medicine, Seattle, Washington, USA.

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October 2021

Worldwide epidemiology of neuro-coronavirus disease in children: lessons for the next pandemic.

Curr Opin Pediatr 2021 Oct 13. Epub 2021 Oct 13.

Division of Critical Care Medicine at The Children's Hospital of Philadelphia Department of Pediatrics Department of Anesthesiology and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania Division of Neurology at The Children's Hospital of Philadelphia Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA Pediatric Intensive Care Unit, Birmingham Women's and Children's NHS Foundation Trust Birmingham Acute Care Research Group, University of Birmingham, Birmingham, UK Division of Critical Care, Department of Pediatrics, Universidad Nacional de Colombia and Fundación Universitaria de Ciencias de la Salud, Hospital de la Misericordia, LARed Network, Bogotá, Colombia Division of Pediatric Critical Care Medicine, UPMC Children's Hospital of Pittsburgh Safar Center for Resuscitation Research, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Purpose Of Review: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has overwhelmed the global community, negatively impacting patient health and research efforts; associated neurological manifestations are a significant cause of morbidity. This review outlines the worldwide epidemiology of neurologic manifestations of different SARS-CoV-2 clinical pediatric phenotypes, including acute coronavirus disease 2019 (COVID-19), multisystem inflammatory syndrome in children (MIS-C) and postacute sequelae of COVID-19 (PASC). We discuss strategies to develop adaptive global research platforms for future investigation into emerging pediatric neurologic conditions. Read More

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October 2021

A Cross-Sectional Study of Psychosocial Factors and Sickness Presenteeism in Japanese Workers During the COVID-19 Pandemic.

J Occup Environ Med 2021 Oct 14. Epub 2021 Oct 14.

Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan (Masuda, Ishimaru, Fujino), Department of Mental Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan (Hino), Department of Work Systems and Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan (Ando), Department of Occupational Medicine, School of Medicine, University of Occupational and Environmental Health, Japan (Tateishi), Department of Occupational Health Practice and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan (Nagata), Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Japan (Tsuji), Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Japan (Matsuda).

Background: We examined the association between socioeconomic and health status, and lifestyle and sickness presenteeism among Japanese workers during the COVID-19 epidemic.

Methods: A cross-sectional study using an Internet-monitor survey was conducted in December, 2020 in Japan. Of 33,302 survey participants, we analyzed 27,036 participants (13,814 men and 13,222 women) who reported experience with sickness presenteeism. Read More

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October 2021

Home-based Telework and Presenteeism: New Lessons Learned from the Covid-19 Pandemic.

Authors:
Joachim Gerich

J Occup Environ Med 2021 Oct 14. Epub 2021 Oct 14.

Department of Sociology, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040 Linz, Austria.

Objective: Previous research found increased sickness presenteeism (working despite sickness) associated with home-based telework. The Covid-19 pandemic offers new insights into mechanisms, as a large proportion of the workforce was forced to work from home, irrespective of organizational and individual predispositions.

Methods: A path analysis based on survey data from a sample of teleworkers collected during the Covid-crisis was performed. Read More

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October 2021

Telehealth Availability and Usage Among Medicare Beneficiaries During the COVID-19 Pandemic, October and November 2020.

J Public Health Manag Pract 2021 Oct 12. Epub 2021 Oct 12.

National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (Ms Chang and Dr Truman), and Office of Genomics and Precision Public Health (Dr Moonesinghe), Centers for Disease Control and Prevention, Atlanta, Georgia.

Context: During the COVID-19 pandemic, demand for telehealth services increased to reduce disease exposure for patients and providers and to meet preexisting demand for physician services in health resource shortage areas.

Objective: To estimate self-reported telehealth availability, equipment for accessing telehealth, and telehealth usage among Medicare beneficiaries during the COVID-19 pandemic.

Design: We used data from the 2020 Medicare Current Beneficiary Survey (MCBS) COVID-19 Fall Supplement Public Use File to estimate the weighted percentages of beneficiaries who had (a) access to telehealth before or during COVID-19; (b) equipment for accessing telehealth; and (c) telehealth visits during COVID-19. Read More

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October 2021

Impact of COVID-19 on presentation, staging, and treatment of head and neck mucosal squamous cell carcinoma.

Am J Otolaryngol 2021 Oct 8;43(1):103263. Epub 2021 Oct 8.

Department of Otolaryngology Head and Neck Surgery, Vanderbilt University Medical Center, 7th floor 1215 21st Ave S, Nashville, TN 37232, USA.

Objectives: During the COVID-19 pandemic, maintenance of safe and timely oncologic care has been challenging. The goal of this study is to compare presenting symptoms, staging, and treatment of head and neck mucosal squamous cell carcinoma during the pandemic with an analogous timeframe one year prior.

Materials And Methods: Retrospective cohort study at a single tertiary academic center of new adult patients evaluated in a head and neck surgical oncology clinic from March -July 2019 (pre-pandemic control) and March - July 2020 (COVID-19 pandemic). Read More

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October 2021

COVID-19 in Multiple Sclerosis: Clinically reported outcomes from the UK Multiple Sclerosis Register.

Mult Scler Relat Disord 2021 Oct 8;56:103317. Epub 2021 Oct 8.

Imperial College London, London, United Kingdom.

Background: In March 2020, the United Kingdom Multiple Sclerosis Register (UKMSR) established an electronic case return form, designed collaboratively by MS neurologists, to record data about COVID-19 infections in people with MS (pwMS).

Objectives: Examine how hospital admission and mortality are affected by disability, age and disease modifying treatments (DMTs) in people with Multiple Sclerosis with COVID-19.

Methods: Anonymised data were submitted by clinical teams. Read More

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October 2021

Chinese Color Nest Project : An accelerated longitudinal brain-mind cohort.

Dev Cogn Neurosci 2021 Oct 11;52:101020. Epub 2021 Oct 11.

Research Center for Lifespan Development of Mind and Brain, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Science, Beijing 100049, China; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; Developmental Population Neuroiscience Research Center, International Data Group/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China. Electronic address:

The ongoing Chinese Color Nest Project (CCNP) was established to create normative charts for brain structure and function across the human lifespan, and link age-related changes in brain imaging measures to psychological assessments of behavior, cognition, and emotion using an accelerated longitudinal design. In the initial stage, CCNP aims to recruit 1520 healthy individuals (6-90 years), which comprises three phases: developing (devCCNP: 6-18 years, N = 480), maturing (matCCNP: 20-60 years, N = 560) and aging (ageCCNP: 60-84 years, N = 480). In this paper, we present an overview of the devCCNP, including study design, participants, data collection and preliminary findings. Read More

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October 2021

Dispositional characteristics in firearm ownership and purchasing behavior during the 2020 purchasing surge.

Soc Sci Med 2021 Oct 5;289:114408. Epub 2021 Oct 5.

New Jersey Gun Violence Research Center, Rutgers, the State University of New Jersey, USA; Department of Psychology, School of Arts & Sciences, Rutgers, the State University of New Jersey, USA.

Rationale: In 2020 the U.S. saw a firearm purchasing surge that was synchronous with the onset of the SARS-CoV-2 (COVID-19) pandemic and notable community unrest. Read More

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October 2021

MRI-negative myeloradiculoneuropathy following Covid-19 infection: An index case.

Diabetes Metab Syndr 2021 Oct 6;15(6):102305. Epub 2021 Oct 6.

Department of Neurology, Institute of Post Graduate Medical Education and Research, Bangur Institute of Neurosciences Kolkata, India. Electronic address:

Covid-19 associated several neurological manifestation in the form of Post-infectious transverse myelitis(TM) and para-infectious TM has been reported. A 54 years old female patient presented to us with acute retention of urine and upper motor neuron type of bilateral lower limb weakness in shock stage, after 12 days of covid-19 infection. MRI (3T) brain and spine showed no abnormality and Nerve conduction study showed acquired motor axonal polyradiculoneuropathy in bilateral lower limbs. Read More

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October 2021

A new standard scoring for interstitial pneumonia based on quantitative analysis of ultrasonographic data: A study on COVID-19 patients.

Respir Med 2021 Oct 7;189:106644. Epub 2021 Oct 7.

National Research Council - Institute of Clinical Physiology, Lecce, Italy.

Objective: To assess the effectiveness of 3 novel lung ultrasound (LUS)-based parameters: Pneumonia Score and Lung Staging for pneumonia staging and COVID Index, indicating the probability of SARS-CoV-2 infection.

Methods: Adult patients admitted to the emergency department with symptoms potentially related to pneumonia, healthy volunteers and clinical cases from online accessible databases were evaluated. The patients underwent a clinical-epidemiological questionnaire and a LUS acquisition, following a 14-zone protocol. Read More

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October 2021

Characterization of the non-covalent interaction between the PF-07321332 inhibitor and the SARS-CoV-2 main protease.

J Mol Graph Model 2021 Oct 5;110:108042. Epub 2021 Oct 5.

Dipartimento di Chimica "Ugo Schiff", Università degli Studi di Firenze, Via della Lastruccia 3, Sesto Fiorentino I-50019, Italy. Electronic address:

We have studied the non-covalent interaction between PF-07321332 and SARS-CoV-2 main protease at the atomic level using a computational approach based on extensive molecular dynamics simulations with explicit solvent. PF-07321332, whose chemical structure has been recently disclosed, is a promising oral antiviral clinical candidate with well-established anti-SARS-CoV-2 activity in vitro. The drug, currently in phase III clinical trials in combination with ritonavir, relies on the electrophilic attack of a nitrile warhead to the catalytic cysteine of the protease. Read More

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October 2021

Melatonin mitigates Chloroquine-induced defects in porcine immature Sertoli cells.

Theriogenology 2021 Oct 8;177:1-10. Epub 2021 Oct 8.

College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, Heilongjiang, China; College of Animal Science, Yangtze University, Jingzhou, 434025, Hubei, China. Electronic address:

Chloroquine (CQ) could function as a lysosomotropic agent to inhibit the endolysosomal trafficking in the autophagy pathway, and is widely used on malarial, tumor and recently COVID-19. However, the effect of CQ treatment on porcine immature Sertoli cells (iSCs) remains unclear. Here we showed that CQ could reduce iSC viability in a dose-dependent manner. Read More

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October 2021

Prevalence of mental health problems and sleep disturbances in nursing students during the COVID-19 pandemic: A systematic review and meta-analysis.

Nurse Educ Pract 2021 Oct 7;57:103228. Epub 2021 Oct 7.

College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Aim: To identify the prevalence of mental health problems and sleep disturbances among nursing students during the COVID-19 pandemic.

Background: As a future professional workforce, nursing students are expected to play a role in controlling the COVID-19 pandemic; however, physical and mental health problems may hinder their willingness to stay in the nursing profession. Evidence of the prevalence of the health problems among nursing students related to COVID-19 may allow educators to manage their students' health problems and make them feel more positive about their future careers. Read More

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October 2021

A case of Graves' disease and type 1 diabetes mellitus following SARS-CoV-2 vaccination.

J Autoimmun 2021 Oct 12;125:102738. Epub 2021 Oct 12.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. Electronic address:

Autoimmune diseases, including autoimmune endocrine diseases (AIED), are thought to develop following environmental exposure in patients with genetic predisposition. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccines against it could represent new environmental triggers for AIED. We report a patient, with history of vitiligo vulgaris and 8 years of type 2 diabetes, who came to our institution because of fever, weight loss, asthenia and thyrotoxicosis occurred 4 weeks later the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Read More

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October 2021

Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system.

Biomed Pharmacother 2021 Oct 12;144:112291. Epub 2021 Oct 12.

Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan; Open Innovation Laboratory for Food and Medicinal Resource Engineering, National Institute of Advanced Industrial Science and Technology (AIST) and University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan; Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan; Tsukuba Life Science Innovation Program (T-LSI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577 Ibaraki, Japan. Electronic address:

Background: Oxytocin (OXT), a neuropeptide involved in mammal reproductive and prosocial behaviors, has been reported to interact with various stressor-provoked neurobiological changes, including neuroendocrine, neurotransmitter, and inflammatory processes. In view of disturbances in psychosocial relationships due to social isolation and physical distancing measures amid the COVID-19 pandemic, being one of the triggering factors for the recent rise in depression and anxiety, OXT is a potential candidate for a new antidepressant.

Methods: In this present study, we have aimed to investigate the effects of oral administration of Rosmarinus officinalis extract (RE), extracted from distillation residue of rosemary essential oil, on central OXT level in the context of other stress biomarkers and neurotransmitter levels in mice models. Read More

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October 2021

Food insecurity associated with higher COVID-19 infection in households with older adults.

Authors:
S L Choi F Men

Public Health 2021 Sep 11;200:7-14. Epub 2021 Sep 11.

The University of Alabama, 316 Adams Hall, Box 870158, Tuscaloosa, AL 35487, United States.

Objectives: As a well-documented social determinant of health, food insecurity may be associated with COVID-19 infection in households with older adults. We examined whether older adults were vulnerable to COVID-19 infection during the early pandemic if they were food insecure versus food secure.

Study Design: A cross-sectional study using a nationally representative population-based survey of US older adults. Read More

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September 2021

Investigating the relationship between reopening the economy and implementing control measures during the COVID-19 pandemic.

Public Health 2021 Sep 11;200:15-21. Epub 2021 Sep 11.

Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Obstetrics, Gynaecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Objectives: The COVID-19 pandemic has resulted in an enormous burden on population health and the economy around the world. Although most cities in the United States have reopened their economies from previous lockdowns, it was not clear how the magnitude of different control measures-such as face mask use and social distancing-may affect the timing of reopening the economy for a local region. This study aimed to investigate the relationship between reopening dates and control measures and identify the conditions under which a city can be reopened safely. Read More

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September 2021

In vitro induction of interleukin-8 by SARS-CoV-2 Spike protein is inhibited in bronchial epithelial IB3-1 cells by a miR-93-5p agomiR.

Int Immunopharmacol 2021 Sep 28;101(Pt B):108201. Epub 2021 Sep 28.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Research Center for Innovative Therapies of Cystic Fibrosis, University of Ferrara, Italy; Italian Consortium for Biotechnologies (C.I.B.), Italy. Electronic address:

One of the major clinical features of COVID-19 is a hyperinflammatory state, which is characterized by high expression of cytokines (such as IL-6 and TNF-α), chemokines (such as IL-8) and growth factors and is associated with severe forms of COVID-19. For this reason, the control of the "cytokine storm" represents a key issue in the management of COVID-19 patients. In this study we report evidence that the release of key proteins of the COVID-19 "cytokine storm" can be inhibited by mimicking the biological activity of microRNAs. Read More

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September 2021

Risk of symptomatic venous thromboembolism in mild and moderate COVID-19: A comparison of two prospective European cohorts.

Thromb Res 2021 Oct 8;208:4-10. Epub 2021 Oct 8.

Emergency Department, Angers University Hospital, Angers, France; UNIV Angers, UMR MitoVasc CNRS 6015 - INSERM 1083, Angers, France; FCRIN, INNOVTE, Saint Etienne, France.

Background: Severely ill patients with SARS-CoV-2 have an increased risk of venous thromboembolism (VTE) i.e., deep vein thrombosis and pulmonary embolism. Read More

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October 2021

Exploiting the orthogonal CRISPR-Cas12a/Cas13a trans-cleavage for dual-gene virus detection using a handheld device.

Biosens Bioelectron 2021 Oct 10;196:113701. Epub 2021 Oct 10.

School of Life Sciences, South China Normal University, Guangzhou, 510631, China. Electronic address:

Although CRISPR-Cas12a and CRISPR-Cas13a systems work individually effective on gene detection, their multiplex detection capability is limited due to the lack of specific probe cleavage mechanism. Herein we present a high-efficient dual-gene diagnostic technique based on the orthogonal DNA/RNA collateral cleavage mechanism of Cas12a/Cas13a system. In this design, dual-gene amplified products from the multiplex recombinase polymerase amplification (RPA) were simultaneously detected by Cas12a and Cas13a assay in a single tube. Read More

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October 2021

High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells.

Ocul Surf 2021 Oct 12. Epub 2021 Oct 12.

Department of Medicine, VA Boston Healthcare System, Boston, MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston, MA, United States; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address:

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October 2021

The combined regimens of antiviral therapy might not be useful for the viral clearance of severe COVID-19 cases.

J Infect Public Health 2021 Oct 1;14(11):1693-1700. Epub 2021 Oct 1.

Department of Liver Diseases, Shenzhen Third People's Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China. Electronic address:

Background: Severe COVID-19 caused by SARS-CoV-2 should closely be cared because of the relatively high mortality rate. If SARS-CoV-2 could be cleared as soon as possible, the mortality rate might lower. In the present study, we analyzed factors which might be related to the clearance of SARS-CoV-2. Read More

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October 2021

The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients.

Int J Infect Dis 2021 Oct 12. Epub 2021 Oct 12.

MBChB., F.I.C.M.S.(clinical hematology), Clinical hematologist, Ibn-Sina Teaching Hospital, Mosul, Iraq. Electronic address:

The purpose of this study is to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19).

Methods: This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 at Al-Shifaa hospital in Mosul, Iraq. There were 158 patients with severe COVID-19 included in the study, 82 in the melatonin group (who received 10 mg melatonin in addition to standard therapeutic care), and 76 in the control group (given standard therapeutic care only). Read More

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October 2021

The role of COVID-19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after sinovac vaccine administration on clinical year medical student in Indonesia.

Int J Infect Dis 2021 Oct 12. Epub 2021 Oct 12.

Department of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Indonesia 15811.

Background: Sinovac was the first vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) used in Indonesia. However, data regarding the effects of certain variables such as clinical demographic on antibody levels in individuals vaccinated with Sinovac are scarce. We aimed to investigate the impact of gender and previous SARS-CoV-2 infection status on neutralizing antibody titers 1, 2, and 3 months after the administration of Sinovac vaccine. Read More

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October 2021

Practice of COVID-19 preventive measures and risk of acute respiratory infections: a longitudinal study in students from 95 countries.

Int J Infect Dis 2021 Oct 12. Epub 2021 Oct 12.

Department of Public Health, Hacettepe University School of Medicine, Ankara, Turkey.

Objectives: We aimed to investigate whether the implementation of personal protective measures against coronavirus disease 2019 reduced the transmission of influenza-like illnesses.

Methods: We followed 758 international students from 95 countries located in five continents from October 2020 to March 2021. Their frequency of wearing masks, social distancing, washing hands, and avoiding crowded places as well as their reported cases of influenza-like illnesses were examined. Read More

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October 2021

Public attitudes to the use of remote data collection in clinical research.

Contemp Clin Trials 2021 Oct 12:106595. Epub 2021 Oct 12.

University of Bristol, Faculty of Health Sciences, Bristol Medical School, Population Health Sciences, Bristol, UK; Royal United Hospitals Bath NHS Foundation Trust, Older Peoples Unit, Bath, UK.

Background/aims: Coronavirus Disease 2019 (COVID-19) has presented an unprecedented challenge for delivering clinical research. The use of technology-assisted data collection for clinical research is desirable for many practitioners, but the acceptability of use in the general population has not been assessed. The aim of the study was to assess attitudes towards using technology-assisted remote methods in the delivery of clinical research in the UK and to understand the barriers to taking part in research with respect to both remote assessments and traditional research methods across different age ranges. Read More

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October 2021

Japanese project for telepsychiatry evaluation during COVID-19: Treatment comparison trial (J-PROTECT): Rationale, design, and methodology.

Contemp Clin Trials 2021 Oct 12:106596. Epub 2021 Oct 12.

Takamiya Hospital, 1931 Omachikou, Yoshimura, Miyazaki, Miyazaki 880-0841, Japan.

Introduction: The COVID-19 pandemic has had a profound impact on the mental health of people around the world. Anxiety related to infection, stress and stigma caused by the forced changes in daily life have reportedly increased the incidence and symptoms of depression, anxiety disorder and obsessive-compulsive disorder. Under such circumstances, telepsychiatry is gaining importance and attracting a great deal of attention. Read More

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October 2021

The impact of confinement on orthopaedic and trauma surgical activity.

Orthop Traumatol Surg Res 2021 Oct 12:103113. Epub 2021 Oct 12.

Institut de Chirurgie Réparatrice Locomoteur et du Sport (ICR); Groupe KANTYS; 7 avenue durante, 06000 Nice, France.

Introduction: On the 16th of March 2020, in the face of a health emergency declared in France, the government imposed containment measures whose impact on orthopaedic and trauma surgery remains to be demonstrated. The hypothesis of this study was that confinement reduced orthopaedic and trauma surgical activity. The main objective was to assess orthopaedic and trauma surgical activity during confinement and to compare it to the activity outside confinement. Read More

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October 2021