139,633 results match your criteria coverage

Immune amnesia induced by measles and its effects on concurrent epidemics.

J R Soc Interface 2021 Jun 16;18(179):20210153. Epub 2021 Jun 16.

Departamento de Electromagnetismo y Física de la Materia, e Instituto Carlos I de Física Teórica y Computacional, Universidad de Granada, E-18071 Granada, Spain.

It has been recently discovered that the measles virus can damage pre-existing immunological memory, destroying B lymphocytes and reducing the diversity of non-specific B cells of the infected host. In particular, this implies that previously acquired immunization from vaccination or direct exposition to other pathogens could be partially erased in a phenomenon named 'immune amnesia', whose effects can become particularly worrisome given the actual rise of anti-vaccination movements. Here, we present the first attempt to incorporate immune amnesia into standard models of epidemic spreading by proposing a simple model for the spreading of two concurrent pathogens causing measles and another generic disease. Read More

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Evaluation of liver tissue extraction protocol for untargeted metabolomics analysis by ultra-high performance liquid chromatography/tandem mass spectrometry.

J Sep Sci 2021 Jun 15. Epub 2021 Jun 15.

National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, P. R. China.

The aim of untargeted metabolomics study is to obtain a global metabolome coverage from biological samples. Therefore, a comprehensive and systematic protocol for tissue metabolite extraction is highly desirable. In this study, we evaluated a comprehensive liver pretreatment strategy based on ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to obtain more metabolites using four different protocols. Read More

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Going Beyond the State Law: Investigating High School Sport-Related Concussion Protocols.

J Athl Train 2020 Jun 18. Epub 2020 Jun 18.

A.T. Still University, Athletic Training Programs, School of Osteopathic Medicine in Arizona, 5850 E Still Circle, Mesa, Arizona 85206, United States,

Context: State laws provide general guidelines for sport-related concussion (SRC) management, but do not comprehensively address the multiple layers of management for this complex injury. While high schools are encouraged to develop a SRC protocol that includes both state law tenets and additional management practices, the execution of this warrants examination.

Objective: To investigate state law compliance and practice components included in high school SRC protocols, and determine whether the degree of sports medicine coverage influenced protocol quality. Read More

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Positioning the National Health Insurance for financial sustainability and Universal Health Coverage in Ghana: A qualitative study among key stakeholders.

PLoS One 2021 15;16(6):e0253109. Epub 2021 Jun 15.

Department of Health Policy Planning and Management, School of Public Health, University of Ghana, Legon, Accra.

Introduction: The National Health Insurance Scheme (NHIS) was introduced in 2003 to reduce "out-of-pocket" payments for health care in Ghana. Over a decade of its implementation, issues about the financial sustainability of this pro-poor policy remains a crippling fact despite its critical role to go towards Universal Health Coverage. We therefore conducted this study to elicit stakeholders' views on ways to improve the financial sustainability of the operations of NHIS. Read More

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Forest Coverage and Socioeconomic Factors Associated with Dengue in El Salvador, 2011-2013.

Vector Borne Zoonotic Dis 2021 Jun 14. Epub 2021 Jun 14.

Department of Public Health, School of Social Sciences Humanities and Arts, University of California Merced, Merced, California, USA.

Dengue virus serotypes 1, 2, 3, and 4 are transmitted by and mosquitoes, which cause illness in an estimated 100 million annually. Although dengue viruses are endemic throughout El Salvador, very little is known about their ecology and epidemiology. The principal methods to prevent and reduce dengue cases are through vector control and by adoption of a vaccine. Read More

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Perceptions That Influence Acupuncture Use in Hospice Settings: Results of a State-Wide Survey Study.

J Altern Complement Med 2021 Jun 15. Epub 2021 Jun 15.

OHSU Division of General Internal Medicine and Geriatrics, Portland, OR, USA.

Acupuncture is an effective and low-risk therapy for a wide spectrum of medical conditions. In the hospice setting, where comfort is the top priority, acupuncture could play a vital role in reducing symptom burden at the end of life. This state-wide survey study explored perceived barriers to acupuncture use in the hospice setting from acupuncturist and hospice staff perspectives. Read More

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Effect of Tractor Speed and Spray Application Volume on Severity of Scab at Different Heights in the Canopy of Tall Pecan Trees.

Plant Dis 2021 Jun 15. Epub 2021 Jun 15.

Byron, United States;

Scab (caused by Venturia effusa) is the most important yield-limiting disease of pecan in the southeastern USA. On susceptible cultivars, the disease is managed using fungicides, but spray coverage is an issue in tall trees. In four experiments we used an air-blast sprayer to compare scab severity on fruit at 5. Read More

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First report of infecting white clover () in Finland.

Plant Dis 2021 Jun 15. Epub 2021 Jun 15.

Finnish Food Authority, Laboratory and Research, Mustialankatu 3, Helsinki, Finland, 00790;

Soybean dwarf virus (SbDV, genus ) is a single-stranded positive-sense RNA virus able to infect several legume species. SbDV was first reported in Japan where it was associated with significant yield losses in soybean (Tamada, 1969). Since then the virus has been detected worldwide. Read More

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Inferring Population Histories for Ancient Genomes Using Genome-Wide Genealogies.

Mol Biol Evol 2021 Jun 15. Epub 2021 Jun 15.

Department of Statistics, University of Oxford, Oxford, UK.

Ancient genomes anchor genealogies in directly observed historical genetic variation and contextualise ancestral lineages with archaeological insights into their geography and cultural associations. However, the majority of ancient genomes are of lower coverage and cannot be directly built into genealogies. Here, we present a fast and scalable method, Colate, the first approach for inferring ancestral relationships through time between low-coverage genomes without requiring phasing or imputation. Read More

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Cancer Registration in the Caribbean.

J Registry Manag 2020 ;47(3):161-169

The Caribbean region faces a growing burden due to cancer. Urgent action needs to be taken to monitor this disease and inform measures required for prevention and control. Cancer surveillance, supported by the implementation of population-based cancer registries (PBCRs), is an important component of cancer prevention and control strategies. Read More

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Interobserver agreement and clinical disparity between the Graf method and femoral head coverage measurement in developmental dysplasia of the hip screening: A prospective observational study of 198 newborns.

Medicine (Baltimore) 2021 Jun;100(24):e26291

Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital.

Abstract: Ultrasonography is the ideal tool for assessing hip morphology in infants younger than 6-month-old. This study assessed the interobserver agreement and clinical disparities of the 2 most widely used ultrasound (US) methods, the Graf method, and femoral head coverage (FHC) measurement.A prospective observational study (STROBE compliant) of 2024 newborns was conducted between January 2017 and December 2018. Read More

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Potential Strategies to Increase Gynecologic Oncologist Treatment for Ovarian Cancer.

J Womens Health (Larchmt) 2021 Jun;30(6):769-781

ICF, Atlanta, Georgia, USA.

Evidence shows that treatment by gynecologic oncologists (GOs) increases overall survival among women with ovarian cancer. However, specific strategies for institutions and community-based public health programs to promote treatment by GOs are lacking. To address this, we conducted a literature review to identify evidence-based and promising system- and environmental-change strategies for increasing treatment by GOs, in effort to ensure that all women with ovarian cancer receive the standard of care. Read More

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Two-Dimensional Magnets beyond the Monolayer Limit.

ACS Nano 2021 Jun 15. Epub 2021 Jun 15.

National Research Center "Kurchatov Institute", Kurchatov Sq. 1, Moscow 123182, Russia.

Intrinsic two-dimensional (2D) magnetism has been demonstrated in various materials scaled down to a single monolayer. However, the question is whether 2D magnetism extends beyond the monolayer limit, to chemical species formed by sparse but regular 2D arrays of magnetic atoms. Here we show that sub-monolayer superstructures of Eu atoms self-assembled on the silicon surface exhibit strong magnetic signals. Read More

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Integrative Medicine: Acupuncture.

FP Essent 2021 Jun;505:18-22

99th MDG, Nellis Air Force Base, 4700 Las Vegas Blvd North, Las Vegas, NV 89191.

Acupuncture is used to manage pain and a variety of medical and psychological conditions. It modulates nociceptive areas of the brain, affects neuropeptide and purinergic signaling, and stimulates production of opioid neuropeptides. There are many types of acupuncture, including traditional, dry needling, laser, auricular, scalp, Japanese, and Korean. Read More

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Consumer perspectives of accelerated access to medicines: a qualitative study.

J Health Organ Manag 2021 Jun;ahead-of-print(ahead-of-print)

University of Sydney, Sydney, Australia.

Purpose: In this study, the authors aimed to explore consumer perspectives on accelerated access to medicines. The authors were particularly interested in how they balance competing considerations of safety, efficacy, equity and access; whether and how their views change when there are different levels of uncertainty surrounding the safety and efficacy of new medicines; and the procedures that they think should be used to make decisions about accelerated access to new medicines.

Design/methodology/approach: This was an exploratory qualitative study. Read More

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The effect of coverage of smoking-cessation aids on tobacco use: Evidence from Canada.

Health Econ 2021 Jun 15. Epub 2021 Jun 15.

Faculty of Political Science and Economics, Waseda University, Tokyo, Japan.

In clinical trials, smoking-cessation aids (SCAs) have proven to be effective at improving the odds of smoking cessation. Because of the effectiveness of SCAs in these settings, many countries have adopted the coverage of SCAs to reduce tobacco use. However, the effect of such coverage on tobacco use is ambiguous. Read More

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E-cigarette manufacturers' compliance with clinical trial reporting expectations: a case series of registered trials by Juul Labs.

Tob Control 2021 Jun 14. Epub 2021 Jun 14.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Electronic cigarettes (e-cigarettes) are a frequently debated topic in public health. It is essential that clinical trials examining e-cigarettes are fully and accurately reported, especially given long-standing concerns about tobacco industry research. We assess the reporting of clinical trials sponsored by Juul Labs, the largest e-cigarette company in the USA, against accepted reporting standards. Read More

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Differences in U.S. Rural-Urban Trends in Diabetes ABCS, 1999-2018.

Diabetes Care 2021 Jun 14. Epub 2021 Jun 14.

Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.

Objective: To examine changes in and the relationships between diabetes management and rural and urban residence.

Research Design And Methods: Using National Health and Nutrition Examination Survey (1999-2018) data from 6,372 adults aged ≥18 years with self-reported diagnosed diabetes, we examined poor ABCS: A1C >9% (>75 mmol/mol), Blood pressure (BP) ≥140/90 mmHg, Cholesterol (non-HDL) ≥160 mg/dL (≥4.1 mmol/L), and current Smoking. Read More

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Semin Cell Dev Biol 2021 Jun 11. Epub 2021 Jun 11.

Chromosome Instability & Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Cell Division Group, Experimental Biology Unit, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. Electronic address:

The establishment of a metaphase plate in which all chromosomes are attached to mitotic spindle microtubules and aligned at the cell equator is required for faithful chromosome segregation in metazoans. The achievement of this configuration relies on the precise coordination between several concurrent mechanisms that start upon nuclear envelope breakdown, mediate chromosome capture at their kinetochores during mitotic spindle assembly and culminate with the congression of all chromosomes to the spindle equator. This period is called 'prometaphase'. Read More

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Post-vaccination HPV seroprevalence among female sexual health clinic attenders in England.

Vaccine 2021 Jun 11. Epub 2021 Jun 11.

Blood Safety, Hepatitis, Sexually Transmitted Infections (STI) and HIV Service, Public Health England, London, UK.

Background: The National HPV Immunisation Programme was introduced in England in September 2008 using the HPV16/18 bivalent vaccine. We conducted serological surveillance to explore vaccination coverage levels. We also conducted a case-control study to investigate a hypothesised cross-protective effect of the HPV16/18 vaccine against genital warts. Read More

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Key issues affecting the current status of infectious diseases in Chinese cattle farms and their control through vaccination.

Vaccine 2021 Jun 11. Epub 2021 Jun 11.

The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei Province, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei Province 430070, China; Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Huazhong Agricultural University, Wuhan, Hubei Province 430070, China. Electronic address:

Infectious diseases can have a major impact on the profitability of the cattle industry. To determine the occurrence of bovine infectious diseases in China and the adoption of vaccination to control them, a national-wide questionnaire and focus group meeting were performed. The questionnaire was administered to 189 farmers including 93 dairy farmers, 80 beef cattle farmers and 16 yak farmers. Read More

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Homogeneity density scores of quarter milk in automatic milking systems.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, PO Box 7054, SE-50 07 Uppsala, Sweden.

Milk quality and clinical mastitis in dairy cows are monitored by detecting visually abnormal milk. A standardized method to evaluate clots in milk and studies of the incidence and dynamics of clots in milk at the quarter level are lacking. We validated a method to score clot density in quarter milk samples and describe the prevalence and dynamics of the density scores between consecutive samplings and periods in 4 farms with automatic milking systems. Read More

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The role of community participation in primary health care: practices of South African health committees.

Prim Health Care Res Dev 2021 Jun 15;22:e31. Epub 2021 Jun 15.

School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Background: Community participation is an essential component in a primary health care (PHC) and a human rights approach to health. In South Africa, community participation in PHC is organised through health committees linked to all clinics.

Aims: This paper analyses health committees' roles, their degree of influence in decision-making and factors impacting their participation. Read More

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Quantifying Psychopathology in Rapid Readmissions.

CNS Spectr 2021 Apr;26(2):165-166

The Loretto Hospital, Chicago, IL, USA.

Psychiatric readmissions contribute to a significant cost and healthcare burden to physicians, hospitals, and the healthcare system as an entity. Furthermore, as part of the Affordable Care Act, the Centers for Medicare and Medicaid Services (CMS) began to reduce financial coverage to hospitals with overwhelming rehospitalization rates. The purpose of this study was to do a systematic analysis on inpatient psychiatric readmission data and identify co-morbidities and risk factors that lead to high readmission rates. Read More

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Landscape and selection of vaccine epitopes in SARS-CoV-2.

Genome Med 2021 06 14;13(1):101. Epub 2021 Jun 14.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB# 7295, Chapel Hill, NC, 27599-7295, USA.

Background: Early in the pandemic, we designed a SARS-CoV-2 peptide vaccine containing epitope regions optimized for concurrent B cell, CD4 T cell, and CD8 T cell stimulation. The rationale for this design was to drive both humoral and cellular immunity with high specificity while avoiding undesired effects such as antibody-dependent enhancement (ADE).

Methods: We explored the set of computationally predicted SARS-CoV-2 HLA-I and HLA-II ligands, examining protein source, concurrent human/murine coverage, and population coverage. Read More

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Discordant structural chromosomal aberrations in chorionic villi and amniotic fluid leading to a formation of an isochromosome 21: a case report.

Mol Cytogenet 2021 Jun 14;14(1):30. Epub 2021 Jun 14.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Background: Fetoplacental discrepancies occur in approximately 1-2% of analyzed prenatal cases. They are typically due to confined placental mosaicism, where an aberration is observed in the placental cells but not found in the fetal cells. Confined placental mosaicism usually involves aneuploidies and more sparsely structural chromosomal aberrations. Read More

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A novel external beam radiotherapy method for cervical cancer patients using virtual straight or bending boost areas; an in-silico feasibility study.

Radiat Oncol 2021 Jun 14;16(1):110. Epub 2021 Jun 14.

Varian Medical Systems, Palo Alto, USA.

Aim: To investigate the potential role of a novel spatially fractionated radiation therapy (SFRT) method where heterogeneous dose patterns are created in target areas with virtual rods, straight or curving, of variable position, diameter, separation and alignment personalised to a patient's anatomy. The images chosen for this study were CT scans acquired for the external beam part of radiotherapy.

Methods: Ten patients with locally advanced cervical cancer were retrospectively investigated with SFRT. Read More

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Influenza co-infection associated with severity and mortality in COVID-19 patients.

Virol J 2021 06 14;18(1):127. Epub 2021 Jun 14.

Pediatric Pulmonology Department, King Fahad Medical City, Riyadh, Saudi Arabia.

Background: In COVID-19 patients, undetected co-infections may have severe clinical implications associated with increased hospitalization, varied treatment approaches and mortality. Therefore, we investigated the implications of viral and bacterial co-infection in COVID-19 clinical outcomes.

Methods: Nasopharyngeal samples were obtained from 48 COVID-19 patients (29% ICU and 71% non-ICU) and screened for the presence of 24 respiratory pathogens using six multiplex PCR panels. Read More

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Shark-Related Injuries in the United States: A National Trauma Data Bank Analysis.

Am Surg 2021 Jun 14:31348211024171. Epub 2021 Jun 14.

Cottage Health Research Institute, Santa Barbara Cottage Hospital, Santa Barbara, CA, USA.

Background: Shark-related injuries (SRIs) are a dreaded, but rare, source of injury that have not been well described. The present study aims to examine the incidence, injuries, and outcomes of SRIs presenting to US trauma centers.

Study Design: The National Trauma Data Bank was queried from 2015 to 2018 to identify SRIs using ICD-10 e-codes W56. Read More

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Spontaneous S-Si bonding of alkanethiols to Si(111)-H: towards Si-molecule-Si circuits.

Chem Sci 2020 Apr 27;11(20):5246-5256. Epub 2020 Apr 27.

School of Molecular and Life Sciences, Curtin Institute of Functional Molecules and Interfaces, Curtin University Bentley WA 6102 Australia

We report the synthesis of covalently linked self-assembled monolayers (SAMs) on silicon surfaces, using mild conditions, in a way that is compatible with silicon-electronics fabrication technologies. In molecular electronics, SAMs of functional molecules tethered to gold sulfur linkages dominate, but these devices are not robust in design and not amenable to scalable manufacture. Whereas covalent bonding to silicon has long been recognized as an attractive alternative, only formation processes involving high temperature and/or pressure, strong chemicals, or irradiation are known. Read More

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