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Serum zinc concentration and risk of adverse outcomes to in vitro fertilization and embryo transfer: A prospective cohort study in northern China.

Sci Total Environ 2021 Jun 10;792:148405. Epub 2021 Jun 10.

Center of Reproductive Medicine, Peking University People's Hospital, Beijing 100044, PR China. Electronic address:

Zinc (Zn) plays an important role in female reproductive health. Few studies have currently assessed the effects of female Zn level on the outcome of in vitro fertilization-embryo transfer (IVF-ET). This study investigated the association between serum Zn concentration and IVF-ET outcomes, and the potential effects of some lifestyles on this association. Read More

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Mental Health of High-Risk Urban Youth: The Housing Subsidies Paradox.

Race Soc Probl 2021 Mar 9;13(1):22-33. Epub 2021 Mar 9.

Global Psychiatric Epidemiology Group, Division of Child and Adolescent Psychiatry, Department of Psychiatry, Columbia University-New York State Psychiatric Institute, room 5217, 1051 Riverside Drive, New York, 10032, USA.

Housing subsidies, including public housing and Section 8 vouchers, are key components of the social safety net, intended to promote family and child welfare. Studies evaluating the impact of housing subsidies on child and adolescent mental health, however, are generally inconclusive. This may reflect variation in the influence by type of subsidies to income, improved physical environment, increased access to resources, and improved perception of neighborhood safety. Read More

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Complete genome and description of sp. nov.: a new bacterium within the genus.

New Microbes New Infect 2021 Jul 5;42:100893. Epub 2021 May 5.

Aix Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

In 2020, as part of the diagnosis in IHU-Méditerranée Infection Institute in Marseille (France) we isolated the new bacterial strain Marseille-3630 from a 7-year-old girl blood specimen (= CSUR: Q3630). Matrix-assisted desorption ionisation time-of-flight mass spectrometry failed to identify this isolate. Analysis of the 16S rRNA gene and genome-to-genome comparison suggested that this taxon belongs to a novel bacterial species within the family in the phylum . Read More

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Predicting the chemical reactivity of organic materials using a machine-learning approach.

Chem Sci 2020 Jul 3;11(30):7813-7822. Epub 2020 Jul 3.

Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University 1 Gwanak-ro, Gwanak-gu Seoul 151-742 Republic of Korea

Stability and compatibility between chemical components are essential parameters that need to be considered in the selection of functional materials in configuring a system. In configuring devices such as batteries or solar cells, not only the functionality of individual constituting materials such as electrodes or electrolyte but also an appropriate combination of materials which do not undergo unwanted side reactions is critical in ensuring their reliable performance in long-term operation. While the universal theory that can predict the general chemical reactivity between materials is long awaited and has been the subject of studies with a rich history, traditional ways proposed to date have been mostly based on simple electronic properties of materials such as electronegativity, ionization energy, electron affinity and hardness/softness, and could be applied to only a small group of materials. Read More

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Revision Surgery and Progression to Total Hip Arthroplasty After Surgical Correction of Femoroacetabular Impingement: A Systematic Review.

Am J Sports Med 2021 Jun 3:3635465211011744. Epub 2021 Jun 3.

Department of Orthopaedics and Trauma Surgery, University Medical Centre Mannheim of the University Heidelberg, Mannheim, Germany.

Background: Femoroacetabular impingement (FAI) is a major cause of hip pain in young adults and athletes. Surgical treatment of FAI is recommended in cases of failed nonoperative treatment that have the typical clinical and radiographic findings. At present, the role of risk factors for revision surgery and progression to total hip arthroplasty (THA) in patients with FAI is still unclear. Read More

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An investigation of the effectiveness of oral cyclosporine on perioperative myocardial injury (PMI) in patients who undergo the surgical procedure of coronary artery bypass graft (CABG): A Randomized Controlled Clinical Trial.

J Family Med Prim Care 2021 Feb 27;10(2):675-680. Epub 2021 Feb 27.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Routine clinical strategies for the prevention of myocardial infarction (MI) during the surgical procedure of CABG include cross-clamp fibrillation and cardioplegia have failed to decrease the risk of perioperative myocardial injury (PMI). Cyclosporine-A (CsA) might be able to prevent mitochondrial dysfunction and PMI.

Methods: In the present clinical trial, patients were divided into two groups (Case receive 2. Read More

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February 2021

The High-Spin Heme Mutant Exposes Dominant Reaction Leading to the Formation of the Semiquinone Spin-Coupled to the [2Fe-2S] Cluster at the Q Site of Cytochrome .

Front Chem 2021 7;9:658877. Epub 2021 May 7.

Department of Molecular Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.

Cytochrome (mitochondrial complex III) catalyzes electron transfer from quinols to cytochrome and couples this reaction with proton translocation across lipid membrane; thus, it contributes to the generation of protonmotive force used for the synthesis of ATP. The energetic efficiency of the enzyme relies on a bifurcation reaction taking place at the Q site which upon oxidation of ubiquinol directs one electron to the Rieske 2Fe2S cluster and the other to heme . The molecular mechanism of this reaction remains unclear. Read More

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Dysregulated circ_0004913, circ_0008160, circ_0000517, and their potential as biomarkers for disease monitoring and prognosis in hepatocellular carcinoma.

J Clin Lab Anal 2021 Jun 21;35(6):e23785. Epub 2021 May 21.

Department of Digestive Medical, Affiliated Nanhua Hospital, University of South China, Hengyang, China.

Objective: Circular RNA_0004913 (circ_0004913), circular RNA_0008160 (circ_0008160), and circular RNA_0000517 (circ_0000517) are shown to be dysregulated in HCC tissues and cell lines, and also show potential in regulating hepatocellular carcinoma (HCC) pathogenesis. This current study attempted to find possible associations of circ_0004913, circ_0008160, and circ_0000517 with clinical features and prognosis of HCC patients.

Methods: A hundred and fifty HCC patients who received hepatectomy were retrospectively reviewed, and their resected specimens including tumor tissues and paired adjacent tissues were obtained, in which the circ_0004913, circ_0008160, and circ_0000517 expressions were detected. Read More

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Efficacy and risk of sexual orientation change efforts: a retrospective analysis of 125 exposed men.

F1000Res 2021 18;10:222. Epub 2021 Mar 18.

Southern California Seminary, El Cajon, CA, 92019, USA.

Background: Voluntary therapeutic interventions to reduce unwanted same-sex sexuality are collectively known as sexual orientation change efforts (SOCE).  To date almost all evidence addressing the contested question whether SOCE is effective or safe has consisted of anecdotes or very small sample qualitative studies of persons who currently identify as sexual minority and thus by definition failed to change.  We conducted this study to examine the efficacy and risk outcomes for a group of SOCE participants unbiased by current sexual orientation. Read More

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Predictive Factors of Conception and the Cumulative Pregnancy Rate in Subfertile Couples Undergoing Timed Intercourse With Ultrasound.

Front Endocrinol (Lausanne) 2021 15;12:650883. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

The aim of this study was to determine predictive factors for pregnancy and assess the cumulative pregnancy rate (CPR) and live birth rate (CLBR) in subfertile couples undergoing timed intercourse (TI) using ultrasound. This retrospective cohort study included 285 women (854 cycles) who started TI with ultrasound between January 2017 and October 2019. The overall clinical pregnancy rate was 28. Read More

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Single-center thorough evaluation and targeted treatment of globozoospermic men.

J Assist Reprod Genet 2021 Apr 20. Epub 2021 Apr 20.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, Y720, New York, NY, 10021, USA.

Purpose: To characterize, by specific biomarkers and nucleic acid sequencing, the structural and genomic sperm characteristics of partial (PG) and complete globozoospermic (CG) men in order to identify the best reproductive treatment.

Methods: We assessed spermatozoa from 14 consenting men ultrastructurally, as well as for histone content, sperm chromatin integrity, and sperm aneuploidy. Additional genomic, transcriptomic, and proteomic evaluations were carried out to further characterize the CG cohort. Read More

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Successful intrathecal neurolytic block for the management of cancer pain in a 10-year-old child: a case report.

JA Clin Rep 2021 Apr 12;7(1):33. Epub 2021 Apr 12.

Department of Anesthesiology and Pain Medicine, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Background: Cancer pain management in children is challenging owing to their unique patient characteristics. We present the case of a 10-year-old girl whose cancer pain was successfully managed using an intrathecal neurolytic block.

Case Presentation: The patient experienced severe cancer pain due to recurrent right ilium osteosarcoma. Read More

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"The Back-up Vasectomy Reversal." Simultaneous Sperm Retrieval and Vasectomy Reversal in the Couple With Advanced Maternal Age: A Cost-Effectiveness Analysis.

Urology 2021 Apr 2. Epub 2021 Apr 2.

Division of Urology, University of Utah, Salt Lake City, UT, Reproductive Medicine Associates of New Jersey.

Objective: To determine the cost-effectiveness of different fertility options in men who have undergone vasectomy in couples with a female of advanced maternal age (AMA). The options include vasectomy reversal (VR), sperm retrieval (SR) with in vitro fertilization (IVF), and the combination of VR and SR with IVF, which is a treatment pathway that has been understudied.

Materials And Methods: Using TreeAge software, a model-based cost-utility analysis was performed estimating the cost per quality-adjusted life years (QALY) in couples with infertility due to vasectomy and advanced female age over a period of one year. Read More

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Predictors of testicular sperm retrieval in patients with non-obstructive azoospermia: a review.

J Int Med Res 2021 Apr;49(4):3000605211002703

Department of Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Azoospermia is divided into two categories of obstructive azoospermia and non-obstructive azoospermia. Before 1995, couples with a male partner diagnosed with non-obstructive azoospermia had to choose sperm donation or adoption to have a child. Currently, testicular sperm aspiration or micro-dissection testicular sperm extraction combined with intracytoplasmic sperm injection allows patients with non-obstructive azoospermia to have biological offspring. Read More

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Observed dyadic collaboration among couples coping with type 1 diabetes.

J Fam Psychol 2021 Apr 1. Epub 2021 Apr 1.

Department of Psychology.

Previous research linking collaboration to relationship and health outcomes has relied almost exclusively on individual self-report and failed to take into consideration the dyadic nature of collaboration. We enrolled couples ( = 193) in which one person had Type 1 diabetes (52% female; 91% non-Hispanic white) into the study and asked them to discuss a diabetes-related issue of high concern for 8 min. These videotaped interactions were coded for dyadic collaboration. Read More

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Modeling Postnatal Hearing Case Finding Within the Italian National Health System.

Front Pediatr 2021 12;9:564662. Epub 2021 Mar 12.

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Despite the successful implementation of newborn hearing screening (NHS), a debate is emerging as to what should be the best means of enabling timely diagnosis and intervention for preschoolers with educationally significant sensorineural or conductive hearing impairment (HI) missed at the time of NHS or occurred after birth. Our study aims to document the proportion and characteristics of HIs diagnosed in children in need of audiologic assessment, in order to outline the optimization areas of an operational framework for auditory surveillance during preschool age. The referral routes and outcomes of 730 audiological assessments performed in 3 years within the framework of the early hearing identification program in Trieste (Italy) were retrospectively analyzed. Read More

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Ride-Share Use and Child Passenger Safety Behaviors: An Online Survey of Parents.

Acad Pediatr 2021 Mar 26. Epub 2021 Mar 26.

Northwestern University Feinberg School of Medicine (MF Savage, ML Macy), Chicago, Ill; Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Division of Emergency Medicine (ML Macy), Chicago, Ill. Electronic address:

Objective: Ride-share services are increasingly used for transportation, but little is known about ride-share use and passenger safety behaviors among parents of children for whom child restraint systems (CRS) are recommended. Our objectives were to characterize ride-share use with children and examine passenger restraint use in ride-share.

Methods: A cross-sectional survey, distributed to the TurkPrime Parent Panel using Amazon Mechanical Turk (MTurk), was designed to assess ride-share and passenger safety behaviors. Read More

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Clinical characteristics and sociodemographic features of psychotic major depression.

Ann Gen Psychiatry 2021 Mar 26;20(1):24. Epub 2021 Mar 26.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No 11, Bei San Huan East Road, Chaoyang District, Beijing, 100029, China.

Background: Psychotic major depression (PMD) is a subtype of depression with a poor prognosis. Previous studies have failed to find many differences between patients with PMD and those with non-psychotic major depression (NMD) or schizophrenia (SZ). We compared sociodemographic factors (including season of conception) and clinical characteristics between patients with PMD, NMD, and schizophrenia. Read More

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Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation.

FASEB J 2021 Apr;35(4):e21336

Centre for Early Life, Warwick Medical School, University of Warwick, Coventry, UK.

Decidualizing endometrial stromal cells (EnSC) critically determine the maternal response to an implanting conceptus, triggering either menstruation-like disposal of low-fitness embryos or creating an environment that promotes further development. However, the mechanism that couples maternal recognition of low-quality embryos to tissue breakdown remains poorly understood. Recently, we demonstrated that successful transition of the cycling endometrium to a pregnancy state requires selective elimination of pro-inflammatory senescent decidual cells by activated uterine natural killer (uNK) cells. Read More

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Improved economic and clinical outcomes with oritavancin versus a comparator group for treatment of acute bacterial skin and skin structure infections in a community hospital.

PLoS One 2021 18;16(3):e0248129. Epub 2021 Mar 18.

Texas A&M College of Medicine affiliated DeTar Family Medicine Residency, Victoria, Texas, United States of America.

Background: Oritavancin is a lipoglycopeptide antibiotic with in vitro bactericidal activity against gram-positive pathogens indicated for use in adults with acute bacterial skin and skin structure infections (ABSSSI). Its concentration-dependent activity and prolonged half-life provide a convenient single-dose alternative to multi-dose daily therapies for ABSSSI. This retrospective cohort study was conducted to quantify the clinical and economic advantages of using oritavancin compared to other antibiotic agents that have been historically effective for ABSSSI. Read More

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Prevalence and predictors of the usage of complementary alternative medicine among infertile patients.

J Gynecol Obstet Hum Reprod 2021 Jun 13;50(6):102112. Epub 2021 Mar 13.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, S.B.U. Gülhane Training and Research Hospital, Ankara, Turkey.

Purpose: The primary objective of this study was to evaluate the prevalence, characteristics and the most frequently used complementary and alternative medicine (CAM) methods among infertile couples. A secondary aim was to assess predictors and patients' attitude to disclose the usage of CAM.

Methods: This study was designed as a cross-sectional survey and conducted on patients admitted to infertility clinics of two hospitals. Read More

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Individual-, household- and community-level determinants of infant mortality in Ethiopia.

PLoS One 2021 12;16(3):e0248501. Epub 2021 Mar 12.

Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.

Introduction: People living in the same area share similar determinants of infant mortality, such as access to healthcare. The community's prevailing norms and attitudes about health behaviours could also influence the health care decisions made by individuals. In diversified communities like Ethiopia, differences in child health outcomes might not be due to variation in individual and family characteristics alone, but also due to differences in the socioeconomic characteristics of the community where the child lives. Read More

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Levels of seminal tRNA-derived fragments from normozoospermic men correlate with the success rate of ART.

Mol Hum Reprod 2021 Mar;27(4)

Institute of Clinical and Experimental Immunology of Rosario (IDICER CONICET-UNR), Rosario, Argentina.

Decreased fertility is becoming an important social and medical problem and the male factor is involved in at least half of infertility cases. Since conventional semen analysis provides limited prediction of male fertility; in this work, we evaluated the potential use of seminal small RNAs (sRNA) as markers of semen quality in ART. Our bioinformatic analyses of available sRNA-seq databases showed that the most abundant sRNA species in seminal plasma of normozoospermic men are tRNA-derived fragments (tRFs), a novel class of regulatory sRNAs. Read More

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Successful Targeted Testicular Sperm Extraction Using Microsurgical Technique (microTESE) Following Fine Needle Aspiration (FNA) Mapping in a Non-Obstructive Azoospermia (NOA) Patient: A Case Report.

J Reprod Infertil 2021 Jan-Mar;22(1):65-69

Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia.

Background: Management for male infertility can be difficult for some cases. Surgical intervention has long been thought as the last resort to help married couples to conceive. The current guideline recommends testicular sperm extraction with micro-surgery technique (microTESE) in severe cases of male infertility. Read More

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Draft genome and description of strain Marseille-Q2068T sp. nov., a new bacterium isolated from human healthy skin.

New Microbes New Infect 2021 Mar 15;40:100839. Epub 2021 Jan 15.

Aix-Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

In 2019, by culturing a skin swab from the forehead of a 70-year-old healthy woman via the culturomics method, we isolated the new bacterial strain Marseille-Q2068T (= CSUR-Q2068). Matrix-assisted desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) failed to identify this isolate. Analysis of the 16S ribosomal RNA gene and genome-to-genome comparison suggested that this taxon belongs to a novel bacterial species within the family in the phylum Proteobacteria. Read More

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β-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability.

Front Pharmacol 2021 15;12:593953. Epub 2021 Feb 15.

College of Animal Sciences and Technology, Qingdao Agricultural University, Qingdao, China.

β-carotene, precursor of vitamin A, is an excellent antioxidant with many beneficial properties. It is a lipid-soluble antioxidant and a very effective quencher of reactive oxygen species (ROS) to reduce the oxidative stress. In contrast to vitamin A, β-carotene is not toxic even consumed in higher amount when it is delivered from natural plant products. Read More

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February 2021

Do donor spermatozoa improve reproductive outcomes after oocyte donation failure? A retrospective analysis of cumulative live birth rates per donor oocyte consumed.

Reprod Biomed Online 2021 Apr 16;42(4):779-788. Epub 2021 Jan 16.

IVIRMA, IVI Foundation, Avenida Fernando Abril Martorell, 106 - Torre A, Planta 1(a), 46026, Valencia, Spain; Instituto de Investigación Sanitaria La Fe, Valencia, Spain.

Research Question: Do donor spermatozoa improve IVF outcomes after first oocyte donation failure?

Design: Retrospective, multicentre study including couples undergoing oocyte donation cycles using autologous or donor spermatozoa after a failed first attempt. Male partners were further characterized as normozoospermic or oligoasthenoteratospermic, i.e. Read More

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Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice.

Am J Hum Genet 2021 03 23;108(3):469-481. Epub 2021 Feb 23.

Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410078, China; Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha 410078, China; Clinical Research Center for Reproduction and Genetics in Hunan Province, Changsha 410078, China; Laboratory of Reproductive and Stem Cell Engineering, National Health and Family Planning Commission, Changsha 410078, China. Electronic address:

Total fertilization failure (TFF) can occur during in vitro fertilization (IVF) treatments, even following intracytoplasmic sperm injection (ICSI). Various male or female factors could contribute to TFF. Increasing evidence suggested that genetic variations in PLCZ1, which encodes 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCζ), is involved in oocyte activation and is a key male factor in TFF. Read More

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Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers.

Hum Reprod 2021 03;36(4):929-940

GeneraLife IVF, Clinica Valle Giulia, 00197 Rome, Italy.

Study Question: Is there an association between patients' reproductive history and the mean euploidy rates per biopsied blastocysts (m-ER) or the live birth rates (LBRs) per first single vitrified-warmed euploid blastocyst transfers?

Summary Answer: Patients' reproductive history (as annotated during counselling) showed no association with the m-ER, but a lower LBR was reported after euploid blastocyst transfer in women with a history of repeated implantation failure (RIF).

What Is Known Already: Several studies have investigated the association between the m-ER and (i) patients' basal characteristics, (ii) ovarian stimulation strategy and dosage, (iii) culture media and conditions, and (iv) embryo morphology and day of full blastocyst development. Conversely, the expected m-ER due to women's reproductive history (previous live births (LBs), miscarriages, failed IVF cycles and transfers, and lack of euploid blastocysts among prior cohorts of biopsied embryos) still needs investigations. Read More

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Draft genome and description of strain Marseille-Q2057 sp.nov., a new bacterium isolated from human healthy skin.

New Microbes New Infect 2021 Mar 15;40:100840. Epub 2021 Jan 15.

Aix Marseille Université, IRD, AP-HM, MEPHI, Marseille, France.

In 2019, by culturing a skin swab from the hand of a 30-year-old healthy woman using the culturomic method, we isolated the new bacterial strain Marseille-Q2057 (= CSUR-Q2057). Matrix-assisted desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) failed to identify this isolate. Analysis of the 16S rRNA gene and Genome-to-Genome comparison suggested that this taxon belongs to a novel bacterial species within the family , phylum We describe here its main phenotypic characteristics, genome sequence and annotation of strain Marseille-Q2057, a new member of the genus, that we propose as type strain. Read More

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