1,037 results match your criteria counterparts accompanied

Inequality and the Chinese elite: Between international convergence and national divergence.

Paul Segal

Br J Sociol 2021 May 10. Epub 2021 May 10.

Department of International Development, King's College London, London, UK.

This paper considers the position of the Chinese elite in both national and international contexts. I show that the Chinese elite has converged with the global elite in terms of their incomes, and that many senior Chinese executives are at least as well paid as their counterparts in rich countries. Their insertion into the global elite is further demonstrated by their increasing participation in the World Economic Forum. Read More

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Simvastatin is effective in killing the radioresistant breast carcinoma cells.

Radiol Oncol 2021 May 4. Epub 2021 May 4.

Medical University of Innsbruck, Therapeutic Radiology and Oncology, Innsbruck, Austria.

Background: Statins, small molecular 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are widely used to lower cholesterol levels in lipid-metabolism disorders. Recent preclinical and clinical studies have shown that statins exert beneficial effects in the management of breast cancer by increasing recurrence free survival. Unfortunately, the underlying mechanisms remain elusive. Read More

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Nano-Confinement Effects on Structural Development and Organic Solvent-Induced Swelling of Ultrathin Carbon Molecular Sieve Films.

ACS Appl Mater Interfaces 2021 Apr 28. Epub 2021 Apr 28.

Functional Polymer Membranes Group, Advanced Membranes and Porous Materials Center, Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Saudi Arabia.

Successful implementation of carbon molecular sieve (CMS) membranes in large scale chemical processes inevitably relies on fabrication of high performance integrally skinned asymmetric or thin-film composite membranes. In principle, to maximize separation efficiency the selective CMS layer should be as thin as possible which requires its lateral confinement to a supporting structure. In this work, we studied pyrolysis-induced structural development as well as ethanol vapor-induced swelling of ultrathin CMS films made from a highly aromatic polyimide of an intrinsic microporosity (PIM-PI) precursor. Read More

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Cotton pan-genome retrieves the lost sequences and genes during domestication and selection.

Genome Biol 2021 Apr 23;22(1):119. Epub 2021 Apr 23.

National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.

Background: Millennia of directional human selection has reshaped the genomic architecture of cultivated cotton relative to wild counterparts, but we have limited understanding of the selective retention and fractionation of genomic components.

Results: We construct a comprehensive genomic variome based on 1961 cottons and identify 456 Mb and 357 Mb of sequence with domestication and improvement selection signals and 162 loci, 84 of which are novel, including 47 loci associated with 16 agronomic traits. Using pan-genome analyses, we identify 32,569 and 8851 non-reference genes lost from Gossypium hirsutum and Gossypium barbadense reference genomes respectively, of which 38. Read More

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Primer malignant giant cell tumour of kidney: a case report.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Sitki Kocman University, Mugla, Turkey.

Osteoclast-like giant cell tumours of the kidney are extremely rare and usually accompanied by a conventional urothelial neoplasm such as papillary, transitional renal cell, or sarcomatoid carcinoma. Although they have morphological features similar to those of the giant cell tumours in the skeletal system, their counterparts in the urinary system show highly malignant features. Our case is the third primer malignant giant cell tumour of the kidney in the literature. Read More

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Pulse Electrodeposited Ni-26 at. %Mo-A Crossover from Nanocrystalline to Amorphous.

Nanomaterials (Basel) 2021 Mar 9;11(3). Epub 2021 Mar 9.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.

A Ni-26 at. %Mo alloy with a composite structure of nanocrystalline and amorphous was synthesized by pulse electrodeposition. The composite structure was composed of mixed regions of amorphous and nanograins divided by a nanocrystalline interface network, which significantly suppressed grain coarsening and shear banding that would otherwise deteriorate mechanical properties of extremely fine nanograined metal. Read More

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Hunger for Home Delivery: Cross-Sectional Analysis of the Nutritional Quality of Complete Menus on an Online Food Delivery Platform in Australia.

Nutrients 2021 Mar 11;13(3). Epub 2021 Mar 11.

Westmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2145, Australia.

Online food delivery (OFD) platforms have changed how consumers purchase food prepared outside of home by capitalising on convenience and smartphone technology. Independent food outlets encompass a substantial proportion of partnering outlets, but their offerings' nutritional quality is understudied. Little is also known as to how OFD platforms influence consumer choice. Read More

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Living donor liver transplantation in septuagenarians: Better late than never.

Clin Transplant 2021 Mar 30:e14301. Epub 2021 Mar 30.

Organ Transplant Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background: The coupling of increased life expectancy and improvements in both quality and access to chronic liver disease care, is culminating in an expanding population of septuagenarians (≥70 years) in need of liver transplantation (LT). The objective of this study is to partially alleviate this knowledge deficit and to add clarity to the current status and role of LDLT in this recipient population.

Methods: Of 295 adult patients underwent LDLT between January 1, 2011 and December 31, 2016. Read More

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Inhibition of Allogeneic and Autologous T Cell Proliferation by Adipose-Derived Mesenchymal Stem Cells of Ankylosing Spondylitis Patients.

Stem Cells Int 2021 12;2021:6637328. Epub 2021 Mar 12.

Department of Pathophysiology and Immunology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw 02-637, Poland.

Background: In ankylosing spondylitis (AS), accompanied by chronic inflammation, T cell expansion plays a pathogenic role; the immunoregulatory properties of bone marrow-derived mesenchymal stem cells (BM-MSCs) are impaired, while functional characteristics of their adipose tissue-derived counterparts are (ASCs) unknown.

Methods: We evaluated the antiproliferative activity of AS/ASCs, obtained from 20 patients, towards allogeneic and autologous T lymphocytes, using ASCs from healthy donors (HD/ASCs) as the reference cell lines. The PHA-activated peripheral blood mononuclear cells (PBMCs) were cocultured in cell-cell contact and transwell conditions with untreated or TNF + IFN (TI-) licensed ASCs, then analyzed by flow cytometry to identify proliferating and nonproliferating CD4 and CD8 T cells. Read More

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Effect of diurnal temperature change on cardiovascular risks differed under opposite temperature trends.

Environ Sci Pollut Res Int 2021 Mar 25. Epub 2021 Mar 25.

Chinese PLA General Hospital, Beijing, 100000, China.

Temperature change between neighboring days (TCN) is an important trigger for cardiovascular diseases, but the modulated effects by seasonal temperature trends have been barely taken into account. A quantified comparison between impacts of positive TCNs (temperature rise) and negative situations (temperature drop) is also needed. We evaluated the associations of TCNs with emergency room (ER) visits for coronary heart disease (CHD) and cerebral infarction (CI) in Beijing, China, from 2008 to 2012. Read More

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Ontogenic shifts in cellular fate are linked to proteotype changes in lineage-biased hematopoietic progenitor cells.

Cell Rep 2021 Mar;34(12):108894

Lund Stem Cell Center, Division of Molecular Hematology, Lund University, 221 84 Lund, Sweden. Electronic address:

The process of hematopoiesis is subject to substantial ontogenic remodeling that is accompanied by alterations in cellular fate during both development and disease. We combine state-of-the-art mass spectrometry with extensive functional assays to gain insight into ontogeny-specific proteomic mechanisms regulating hematopoiesis. Through deep coverage of the cellular proteome of fetal and adult lympho-myeloid multipotent progenitors (LMPPs), common lymphoid progenitors (CLPs), and granulocyte-monocyte progenitors (GMPs), we establish that features traditionally attributed to adult hematopoiesis are conserved across lymphoid and myeloid lineages, whereas generic fetal features are suppressed in GMPs. Read More

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Proteomic and phospholipidomic characterization of extracellular vesicles inducing tumor microenvironment in Epstein-Barr virus-associated lymphomas.

FASEB J 2021 Apr;35(4):e21505

Department of Hematological Malignancy, Tokai University, Isehara, Japan.

Epstein-Barr virus (EBV) causes malignant carcinomas including B cell lymphomas accompanied by the systemic inflammation. Previously, we observed that phosphatidylserine (PS)-exposing subset of extracellular vesicles (EVs) secreted from an EBV strain Akata-transformed lymphoma (Akata EVs) convert surrounding phagocytes into tumor-associated macrophages (TAMs) via induction of inflammatory response, which is in part mediated by EBV-derived micro RNAs. However, it is still unclear about EV-carried other potential inflammatory factors associated with TAM formation in EBV lymphomas. Read More

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Phospholipid-Gold Nanorods Induce Energy Crisis in MCF-7 Cells: Cytotoxicity Evaluation Using LC-MS-Based Metabolomics Approach.

Biomolecules 2021 Feb 27;11(3). Epub 2021 Feb 27.

Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman 11942, Jordan.

Phospholipid-modified gold nanorods (phospholipid-GNRs) have demonstrated drastic cytotoxicity towards MCF-7 breast cancer cells compared to polyethylene glycol-coated GNRs (PEG-GNRs). In this study, the mechanism of cytotoxicity of phospholipid-GNRs towards MCF-7 cells was investigated using mass spectrometry-based global metabolic profiling and compared to PEGylated counterparts. The results showed that when compared to PEG-GNRs, phospholipid-GNRs induced significant and more pronounced impact on the metabolic profile of MCF-7 cells. Read More

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February 2021

Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity.

Toxins (Basel) 2021 02 12;13(2). Epub 2021 Feb 12.

Institute of Hygiene, University of Münster, D-48149 Münster, Germany.

Human kidney epithelial cells are supposed to be directly involved in the pathogenesis of the hemolytic-uremic syndrome (HUS) caused by Shiga toxin (Stx)-producing enterohemorrhagic (EHEC). The characterization of the major and minor Stx-binding glycosphingolipids (GSLs) globotriaosylceramide (Gb3Cer) and globotetraosylceramide (Gb4Cer), respectively, of primary human renal cortical epithelial cells (pHRCEpiCs) revealed GSLs with Cer (d18:1, C16:0), Cer (d18:1, C22:0), and Cer (d18:1, C24:1/C24:0) as the dominant lipoforms. Using detergent-resistant membranes (DRMs) and non-DRMs, Gb3Cer and Gb4Cer prevailed in the DRM fractions, suggesting their association with microdomains in the liquid-ordered membrane phase. Read More

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February 2021

Scrutinizing Mechanisms of the 'Obesity Paradox in Sepsis': Obesity Is Accompanied by Diminished Formation of Neutrophil Extracellular Traps (NETs) Due to Restricted Neutrophil-Platelet Interactions.

Cells 2021 Feb 12;10(2). Epub 2021 Feb 12.

Department of Experimental Hematology, Institute of Zoology and Biomedical Research, Jagiellonian University, 30-387 Krakow, Poland.

Systemic inflammation is a detrimental condition associated with high mortality. However, obese individuals seem to have higher chances of surviving sepsis. To elucidate what immunological differences exist between obese and lean individuals we studied the course of endotoxemia in mice fed high-fat diet (HFD) and ob/ob animals. Read More

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February 2021

Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses.

J Neuroinflammation 2021 Feb 20;18(1):52. Epub 2021 Feb 20.

UNICAEN, INSERM, GIP Cyceron, Institut Blood and Brain @Caen-Normandie (BB@C), UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Normandie Univ, Caen, France.

Background: Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme also contributes to pathological processes in the CNS such as neuroinflammation by activating microglia and increasing blood-brain barrier permeability. Read More

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February 2021

Effect of Grafting on Viral Resistance of Non-transgenic Plum Scion Combined With Transgenic PPV-Resistant Rootstock.

Front Plant Sci 2021 1;12:621954. Epub 2021 Feb 1.

Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Pushchino, Russia.

In stone fruit trees, resistance to (PPV) can be achieved through the specific degradation of viral RNA by the mechanism of RNA interference (RNAi). Transgenic virus-resistant plants, however, raise serious biosafety concerns due to the insertion and expression of hairpin constructs that usually contain various selective foreign genes. Since a mature stone tree represents a combination of scion and rootstock, grafting commercial varieties onto transgenic virus-tolerant rootstocks is a possible approach to mitigate biosafety problems. Read More

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February 2021

Effect of sex/gender on obesity traits in Canadian first year university students: The GENEiUS study.

PLoS One 2021 16;16(2):e0247113. Epub 2021 Feb 16.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.

Background: While weight gain during first year of university has been well documented in North America, literature on sex-specific effects is scarce and inconsistent. The objective of this investigation was to explore sex-specific changes in obesity traits during first year of university at McMaster University (Ontario, Canada).

Methods: 245 first-year students (80. Read More

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February 2021

The combined disulfide cross-linking and tyrosine-modification of very low molecular weight linear PEI synergistically enhances transfection efficacies and improves biocompatibility.

Eur J Pharm Biopharm 2021 Apr 11;161:56-65. Epub 2021 Feb 11.

Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Leipzig University, Faculty of Medicine, Leipzig, Germany. Electronic address:

Efficient and non-toxic DNA delivery is still a major limiting factor for non-viral gene therapy. Among the large diversity of non-viral vectors, the cationic polymer polyethylenimine (PEI) plays a prominent role in nucleic acid delivery. Since higher molecular weight of PEI is beneficial for transfection efficacy, but also leads to higher cytotoxicity, the biodegradable cross-linking of low-molecular PEIs, e. Read More

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Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein.

J Alzheimers Dis 2021 ;80(2):813-829

Maptimmune BV, The Hague, The Netherlands.

Background: Alzheimer's disease (AD) and other tauopathies are neurodegenerative disorders characterized by cellular accumulation of aggregated tau protein. Tau pathology within these disorders is accompanied by chronic neuroinflammation, such as activation of the classical complement pathway by complement initiation factor C1q. Additionally, about half of the AD cases present with inclusions composed of aggregated alpha-synuclein called Lewy bodies. Read More

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January 2021

Altered mRNA and Protein Expression of Monocarboxylate Transporter MCT1 in the Cerebral Cortex and Cerebellum of Prion Protein Knockout Mice.

Int J Mol Sci 2021 Feb 4;22(4). Epub 2021 Feb 4.

Département de Physiologie, Université de Lausanne, 1005 Lausanne, Switzerland.

The effect of a cellular prion protein (PrP) deficiency on neuroenergetics was primarily analyzed via surveying the expression of genes specifically involved in lactate/pyruvate metabolism, such as monocarboxylate transporters (, , ). The aim of the present study was to elucidate a potential involvement of PrP in the regulation of energy metabolism in different brain regions. By using quantitative real-time polymerase chain reaction (qRT-PCR), we observed a marked reduction in MCT1 mRNA expression in the cortex of symptomatic Zürich I mice, as compared to their wild-type (WT) counterparts. Read More

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February 2021

Spectral phase transitions in optical parametric oscillators.

Nat Commun 2021 Feb 5;12(1):835. Epub 2021 Feb 5.

Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

Driven nonlinear resonators provide a fertile ground for phenomena related to phase transitions far from equilibrium, which can open opportunities unattainable in their linear counterparts. Here, we show that optical parametric oscillators (OPOs) can undergo second-order phase transitions in the spectral domain between degenerate and non-degenerate regimes. This abrupt change in the spectral response follows a square-root dependence around the critical point, exhibiting high sensitivity to parameter variation akin to systems around an exceptional point. Read More

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February 2021

Twisted One-Dimensional Charge Transfer and Related Y-Shaped Chromophores with a 4-Pyranylidene Donor: Synthesis and Optical Properties.

J Org Chem 2021 Feb 2;86(4):3152-3163. Epub 2021 Feb 2.

Instituto de Nanociencia y Materiales de Aragón (INMA)-Departamento de Química Orgánica, CSIC-Universidad de Zaragoza, Zaragoza 50009, Spain.

Three series of push-pull derivatives bearing 4-pyranylidene as electron donor group and a variety of acceptors were designed. On one hand, one-dimensional chromophores with a thiophene ring (series ) or 5-dimethylaminothiophene moiety (series ) as an auxiliary donor, non-coplanar with the π-conjugated system, were synthesized. On the other hand, related two-dimensional (2D) Y-shaped chromophores (series ) were also prepared to compare how the diverse architectures affect the electrochemical, linear, and second-order nonlinear optical (NLO) properties. Read More

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February 2021

Macrophage autophagy protects mice from cerium oxide nanoparticle-induced lung fibrosis.

Part Fibre Toxicol 2021 02 1;18(1). Epub 2021 Feb 1.

Univ Paris Est Creteil, INSERM, IMRB, F-94010, Creteil, France.

Background: Cerium (Ce) is a rare earth element, rapidly oxidizing to form CeO, and currently used in numerous commercial applications, especially as nanoparticles (NP). The potential health effects of Ce remain uncertain, but literature indicates the development of rare earth pneumoconiosis accompanied with granuloma formation, interstitial fibrosis and inflammation. The exact underlying mechanisms are not yet completely understood, and we propose that autophagy could be an interesting target to study, particularly in macrophages. Read More

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February 2021

Mammary Tumors Growing in the Absence of Growth Hormone Are More Sensitive to Doxorubicin Than Wild-Type Tumors.

Endocrinology 2021 Apr;162(4)

School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI, USA.

Previously, we reported that N-methyl-N-nitrosourea (MNU)-induced mammary tumors could be established in mutant spontaneous dwarf rats (SDRs), which lack endogenous growth hormone (GH) by supplementing with exogenous GH, and almost all such tumors regressed upon GH withdrawal. When the highly inbred SDR line was outcrossed to wild-type (WT) Sprague-Dawley rats, MNU-induced mammary tumors could still be established in resulting outbred SDRs by supplementing with exogenous GH. However, unlike tumors in inbred SDRs, 65% of mammary tumors established in outbred SDRs continued growth after GH withdrawal. Read More

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Management of tumor growth and angiogenesis in triple-negative breast cancer by using redox nanoparticles.

Biomaterials 2021 Feb 6;269:120645. Epub 2021 Jan 6.

Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan; Master's School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan; Center for Research in Isotopes and Environmental Dynamics (CRiED), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8573, Japan. Electronic address:

In cancer, angiogenesis is a critical phenomenon of nascent blood vessel development to facilitate the oxygen and nutrient supply prerequisite for tumor progression. Therefore, targeting tumors at the angiogenesis step may be significant to prevent their advanced progression and metastasis. Although angiogenesis inhibitors can limit the further growth of tumors, complete eradication of tumors may not be possible by monotherapy alone. Read More

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February 2021

THz, Raman, IR and DFT studies of noncentrosymmetric metal dicyanamide frameworks comprising benzyltrimethylammonium cations.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 5;251:119416. Epub 2021 Jan 5.

Institute of Optoelectronics, Military University of Technology, S. Kaliskiego 2, 00-908 Warsaw, Poland.

We report density functional theory (DFT) studies of vibrational modes for benzyltrimethylammonium cations (BeTriMe) as well as THz, IR and Raman studies of [BeTriMe][M(dca)(HO)] (dca = N(CN), dicyanamide; M = Mn, Co, Ni) and their anhydrous analogues. These studies show that the anhydrous BeTriMeMn and BeTriMeNi have the same or very similar structures and loss of water molecules leads to significant changes in the metal-dicyanamide frameworks. In particular, the number of dca modes decreases, suggesting increase of crystal symmetry, probablly related with decrease in the number of non-equivalent dca bridges from two to one. Read More

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Development and evaluation of a quality control system based on transdermal electrical resistance for skin barrier function in vitro.

Skin Res Technol 2021 Jan 6. Epub 2021 Jan 6.

Department of Drug Delivery, PharmBioTec GmbH, Saarbrücken, Germany.

Background: In vitro skin permeation experiments are highly relevant for pharmaceutical, cosmetic, agricultural developments, and regulatory evaluation. A key requirement is the skin barrier integrity, that is accompanied by an intact stratum corneum (SC) which implements high skin quality. A variety of integrity tests are currently available, for example, measurement of transepidermal water loss, monitoring the permeation of tritiated water and the measurement of transdermal electrical resistance (TER). Read More

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January 2021

ATM Kinase Inhibition Preferentially Sensitises PTEN-Deficient Prostate Tumour Cells to Ionising Radiation.

Cancers (Basel) 2020 Dec 30;13(1). Epub 2020 Dec 30.

Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast BT9 7AE, UK.

Radical radiotherapy, often in combination with hormone ablation, is a safe and effective treatment option for localised or locally-advanced prostate cancer. However, up to 30% of patients with locally advanced PCa will go on to develop biochemical failure, within 5 years, following initial radiotherapy. Improving radiotherapy response is clinically important since patients exhibiting biochemical failure develop castrate-resistant metastatic disease for which there is no curative therapy and median survival is 8-18 months. Read More

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December 2020

Color Fixation Strategies on Sustainable Poly-Butylene Succinate Using Biobased Itaconic Acid.

Polymers (Basel) 2020 Dec 28;13(1). Epub 2020 Dec 28.

Fundación Aitiip, Polígono Industrial Empresarium C/Romero Nº, 12, 50720 Zaragoza, Spain.

Biopo-lybutylene succinate (bioPBS) is gaining attention in the biodegradable polymer market due to its promising properties, such as high biodegradability and processing versatility, representing a potential sustainable replacement for fossil-based commodities. However, there is still a need to enhance its properties for certain applications, with aesthetical and mechanical properties being a challenge. The aim of the present work is to improve these properties by adding selected additives that will confer bioPBS with comparable properties to that of current counterparts such as polypropylene (PP) for specific applications in the automotive and household appliances sectors. Read More

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December 2020