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Analyzing Digital Evidence From a Telemental Health Platform to Assess Complex Psychological Responses to the COVID-19 Pandemic: Content Analysis of Text Messages.

JMIR Form Res 2021 Feb 9;5(2):e26190. Epub 2021 Feb 9.

Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

Background: The novel COVID-19 disease has negatively impacted mortality, economic conditions, and mental health. These impacts are likely to continue after the COVID-19 pandemic ends. There are no methods for characterizing the mental health burden of the COVID-19 pandemic, and differentiating this burden from that of the prepandemic era. Read More

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February 2021

Germline mutations in MDS/AML predisposition disorders.

Lucy A Godley

Curr Opin Hematol 2021 03;28(2):86-93

Section of Hematology/Oncology, Departments of Medicine and Human Genetics and the University of Chicago Comprehensive Cancer Center, Chicago, IL, USA.

Purpose Of Review: Recognition of hereditary hematopoietic malignancies impacts patient management as well as health surveillance strategies for the patient and relatives who share the causative DNA variant. In this review, barriers to the diagnosis and management of patients are outlined.

Recent Findings: Increasingly, individuals are being recognized as having germline predisposition to hematopoietic malignancies. Read More

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Are Consanguineous Marriages to Blame for Usher Syndrome Type 1, a Rare Disease in Pakistan?

Cureus 2020 Oct 23;12(10):e11117. Epub 2020 Oct 23.

Internal Medicine, King Edward Medical University, Mayo Hospital, Lahore, PAK.

Usher syndrome type I is a rare genetic autosomal recessive disease caused by mutations in specific genes that provide instructions for making proteins involved in normal hearing, vision, and balance. It is characterized by hearing impairment due to the inability of auditory nerves to send sensory input to the brain leading to hearing loss along with retinitis pigmentosa (RP), which is a progressive, bilateral, symmetrical retinal degeneration involving photoreceptor cells. We report a 32-year-old male patient who presented to us with complaints of night blindness and progressive vision loss for the past 20 years. Read More

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October 2020

Sentinel lymph node biopsy in vulvar cancer: status, level of knowledge, and counseling in outpatient setting.

Arch Gynecol Obstet 2020 10 18;302(4):1001-1007. Epub 2020 Jul 18.

Department of Obstetrics and Gynecology, Hanover Medical School, Carl-Neuberg-Street 1, 30625, Hannover, Germany.

Purpose: Evaluating the counseling of patients with vulvar cancer in outpatient setting regarding the application of sentinel lymph node dissection (SLND), the selection of hospitals for further treatment, and level of knowledge.

Methods: A questionnaire containing 29 questions about SLND in vulvar cancer was sent to gynecologists in Lower Saxony. The questionnaire contained multiple choice questions and open questions. Read More

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October 2020

An Attitude Survey and Assessment of the Feasibility, Acceptability, and Usability of a Traumatic Brain Injury Decision Support Tool in Uganda.

World Neurosurg 2020 07 4;139:495-504. Epub 2020 May 4.

Duke Global Health Institute, Durham, North Carolina, USA; Division of Global Neurosurgery and Neurology, Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA; Duke University School of Medicine, Durham, North Carolina, USA. Electronic address:

Background: Traumatic brain injury (TBI) prognostic models are potential solutions to severe human and technical shortages. Although numerous TBI prognostic models have been developed, none are widely used in clinical practice, largely because of a lack of feasibility research to inform implementation. We previously developed a prognostic model and Web-based application for in-hospital TBI care in low-resource settings. Read More

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Two-Way Short Message Service (SMS) Communication May Increase Pre-Exposure Prophylaxis Continuation and Adherence Among Pregnant and Postpartum Women in Kenya.

Glob Health Sci Pract 2020 03 31;8(1):55-67. Epub 2020 Mar 31.

Department of Global Health, University of Washington, Seattle, Washington, USA.

Introduction: We evaluated a 2-way short message service (SMS) communication platform to improve continuation of pre-exposure prophylaxis (PrEP) for HIV prevention among Kenyan women who initiated PrEP within routine maternal child health (MCH) and family planning clinics.

Methods: We adapted an existing SMS platform (Mobile WACh [mWACh]) to send PrEP-tailored, theory-based SMS and allow clients to communicate with a remote nurse. Women who did not have HIV and who were initiating PrEP at 2 MCH/family planning clinics in Kisumu County, Kenya, from February to October 2018, were offered enrollment into the mWACh-PrEP program; SMS communication was free. Read More

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Rapid prenatal diagnosis of skeletal dysplasia using medical trio exome sequencing: Benefit for prenatal counseling and pregnancy management.

Prenat Diagn 2020 04 10;40(5):577-584. Epub 2020 Feb 10.

Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, China.

Objective: The aim of this study is to explore the utility of rapid medical trio exome sequencing (ES) for prenatal diagnosis using the skeletal dysplasia as an exemplar.

Method: Pregnant women who were referred for genetic testing because of ultrasound detection of fetal abnormalities suggestive of a skeletal dysplasia were identified prospectively. Fetal samples (amniocytes or cord blood), along with parental blood, were send for rapid copy number variations testing and medical trio ES in parallel. Read More

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An Exploratory Study of Sexting Behaviors Among Heterosexual and Sexual Minority Early Adolescents.

J Adolesc Health 2019 11 28;65(5):621-626. Epub 2019 Aug 28.

Department of Communication Studies, IMEC-MICT-Ghent University, Ghent, Belgium.

Purpose: Although research on adolescent sexting-the sending of self-made sexually explicit pictures through digital media-has increased in recent years, prior studies have primarily focused on older youth and the act of sending of such images. Little is known about the experiences of early adolescent sexual minority youth, who might be particularly vulnerable to abusive forms of sexting. To address this gap in the literature, we aim to investigate differences in the prevalence of a wide range of sexting behaviors among a convenience sample of heterosexual and sexual minority early adolescents. Read More

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November 2019

Exploration of genetic health professional - laboratory specialist interactions in diagnostic genomic sequencing.

Eur J Med Genet 2020 Mar 28;63(3):103749. Epub 2019 Aug 28.

Center for Biomedical Ethics and Law, Department of Public Health and Primary Care, KU Leuven, Belgium; Leuven Institute for Human Genetics and Society, Leuven, Belgium.

Like any new technology, rapid integration of genomic sequencing (GS) into the clinical setting can pose challenges for genetic health professionals (GHPs) using it to diagnose patients. We conducted semi-structured interviews with 31 clinical geneticists and genetic counsellors across Europe, Australia and Canada to gain a better understanding of the issues they were experiencing when requesting GS and receiving reports from laboratories. There was a spectrum of interactions between genetic health professionals and laboratories. Read More

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The viral load monitoring cascade in a resource-limited setting: A prospective multicentre cohort study after introduction of routine viral load monitoring in rural Lesotho.

PLoS One 2019 28;14(8):e0220337. Epub 2019 Aug 28.

Swiss Tropical & Public Health Institute, Basel, Switzerland.

Introduction: For HIV-positive individuals on antiretroviral therapy (ART), the World Health Organization (WHO) recommends routine viral load (VL) monitoring. We report on the cascade of care in individuals with unsuppressed VL after introduction of routine VL monitoring in a district in Lesotho.

Materials And Methods: In Butha-Buthe district 12 clinics (11 rural, 1 hospital) send samples for VL testing to the district laboratory. Read More

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A Questionnaire to Assess the Challenges Faced by Women Who Quit Working as Full-Time Neurosurgeons.

World Neurosurg 2020 Jan 19;133:331-342. Epub 2019 Aug 19.

Department of Neurosurgery, Fujita Health University BANTANE Hospital, Nakagawa-ward, Nagoya, Aichi, Japan.

Objective: To analyze why women quit full-time employment as neurosurgeons and to discuss the conditions required for their reinstatement.

Methods: We asked 94 core hospitals providing training programs in the board certification system adopted by the Japan Neurosurgical Society to indicate the total number and present status of women in their department and to send our anonymous questionnaire to women who had formerly worked as full-time neurosurgeons. The questionnaire consisted of closed and open questions on their reasons for quitting as full-time neurosurgeons. Read More

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January 2020

Acceptability and Feasibility of Self-Collecting Biological Specimens for HIV, Sexually Transmitted Infection, and Adherence Testing Among High-Risk Populations (Project Caboodle!): Protocol for an Exploratory Mixed-Methods Study.

JMIR Res Protoc 2019 May 2;8(5):e13647. Epub 2019 May 2.

Division of HIV, Infectious Disease, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.

Background: Men who have sex with men (MSM) in the United States experience a disproportionate burden of HIV and bacterial sexually transmitted infections (STIs), such as gonorrhea and chlamydia. Screening levels among MSM remain inadequate owing to barriers to testing such as stigma, privacy and confidentiality concerns, transportation issues, insufficient clinic time, and limited access to health care. Self-collection of specimens at home and their return by mail for HIV and bacterial STI testing, as well as pre-exposure prophylaxis (PrEP) adherence monitoring, could be a resource-efficient option that might mitigate some of these barriers. Read More

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Patient and health-care worker experiences of an HIV viral load intervention using SMS: A qualitative study.

PLoS One 2019 11;14(4):e0215236. Epub 2019 Apr 11.

Médecins Sans Frontières, Southern Africa Medical Unit (SAMU), Cape Town, South Africa.

Background: Mobile Health or mHealth interventions, including Short Message Service (SMS), can help increase access to care, enhance the efficiency of health service delivery and improve diagnosis and treatment for HIV. Text messaging, or SMS, allows for the low cost transmission of information, and has been used to send appointment reminders, information about HIV counselling and treatment, messages to encourage adherence and information on nutrition and side-effects. HIV Viral Load (VL) monitoring is recommended by the WHO and has been progressively adopted in many settings. Read More

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January 2020

Is Sexting Associated with Sexual Behaviors During Adolescence? A Systematic Literature Review and Meta-Analysis.

J Midwifery Womens Health 2019 Jan 6;64(1):88-97. Epub 2018 Dec 6.

Introduction: A growing body of research has addressed adolescent use of mobile devices to exchange sexually explicit images and messages (sexting). Although there are legal consequences in some states for sexting among adolescents, research findings have also demonstrated associations between sexting and sexual activity. The purpose of this systematic review was to synthesize research examining the association between adolescent sexting and sexual activity. Read More

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January 2019

A burden from birth? Non-invasive prenatal testing and the stigmatization of people with disabilities.

Bioethics 2019 01 21;33(1):91-97. Epub 2018 Nov 21.

Ulm University, Institute of History, Philosophy and Ethics of Medicine, Ulm, Germany.

The notion of being a burden to others is mostly discussed in the context of care-intensive diseases or end-of-life decisions. But the notion is also crucial in decision-making at the beginning of life, namely regarding prenatal testing. Ever more sophisticated testing methods, especially non-invasive prenatal testing (NIPT), allow the detection of genetic traits in the unborn child that may cause disabilities. Read More

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January 2019

Multidisciplinary Care and the Standards of Care for Transgender and Gender Nonconforming Individuals.

Clin Plast Surg 2018 Jul;45(3):295-299

Private Practice, Counseling Psychology, 204 Clement Street, San Francisco, CA 94118, USA.

In providing care to transgender patients, surgeons interact with health care providers of other disciplines, including medical and mental health providers. Mental health or medical providers often see a patient first, when hormones are initiated. The Standards of Care recommend that mental health professionals assess patients for surgery according to set criteria and send surgeons their evaluations prior to surgery. Read More

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Unsolicited information letters to increase awareness of Lynch syndrome and familial colorectal cancer: reactions and attitudes.

Fam Cancer 2019 01;18(1):43-51

The Danish HNPCC Register, Clinical Research Center, Copenhagen University Hospital, Hvidovre, Kettegård allé 32, 2650, Hvidovre, Denmark.

Dissemination of information on a genetically increased risk should according to guidelines primarily be family-mediated. Incomplete and incorrect information spread has, however, been documented and implies missed possibilities for prevention. In Denmark, the national HNPCC register has been granted an exception to send unsolicited letters with information on hereditary colorectal cancer and an invitation to genetic counseling to members of families with familial and hereditary colorectal cancer. Read More

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January 2019

Parents' Knowledge and Attitude Regarding Their Child's Cancer and Effectiveness of Initial Disease Counseling in Pediatric Oncology Patients.

Indian J Palliat Care 2017 Oct-Dec;23(4):393-398

Regional Cancer Centre, Division of Pediatric Oncology, Trivandrum, Kerala, India.

Objective: To examine parent's knowledge, attitude and psychosocial response regarding their child's cancer and treatment after initial disease counseling by doctor.

Materials And Methods: Structured questionnaire based study of 43 mothers of newly diagnosed pediatric cancer patients undergoing treatment in pediatric oncology division. Mothers received initial counseling regarding their child's cancer and treatment from the doctor. Read More

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November 2017

Assessment of Current Genetic Counselor Practices in Post-Visit Written Communications to Patients.

J Genet Couns 2018 06 12;27(3):681-688. Epub 2017 Oct 12.

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 540 E. Canfield St., 2375 Scott Hall, Detroit, MI, 48201, USA.

Providing patients with post-visit written communication (PVWC) is a long-standing component of genetic counseling. However the depiction of this practice in today's clinical landscape is limited. To better describe this practice, we surveyed practicing clinical genetic counselors to ask if they send post-visit communications to patients and if so, what are the types, the average length, and the average time spent writing. Read More

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Vasectomy Practice Patterns Among Family Medicine Physicians and Compliance With the American Urological Association 2012 Vasectomy Guidelines.

Urology 2017 Nov 12;109:115-120. Epub 2017 Aug 12.

Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Objective: To survey urologists and family medicine physicians (FMPs) within a single institution to determine current vasectomy practice patterns and determine compliance with 2012 American Urological Association (AUA) vasectomy guidelines.

Methods: In 2016, a single-institution survey was conducted to understand the vasectomy practice patterns among urologists and nonurologists. The survey questions and 3 clinical scenarios were designed based on the 2012 AUA vasectomy guidelines. Read More

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November 2017

The Experiences of Newly Diagnosed Men Who Have Sex with Men Entering the HIV Care Cascade in Lima, Peru, 2015-2016: A Qualitative Analysis of Counselor-Participant Text Message Exchanges.

Cyberpsychol Behav Soc Netw 2017 Jun;20(6):389-396

2 Asociación Civil Vía Libre , Lima, Peru .

Mobile phone technology (mHealth) is a promising tool that has been used to improve HIV care in high-risk populations worldwide. Understanding patient perspectives of newly diagnosed men who have sex with men (MSM) in Lima, Peru during linkage and engagement in the HIV care continuum can help close the gaps in care following initial HIV diagnosis and ensure retention in continuous care. From June 2015 to March 2016, as part of a randomized controlled trial, 40 MSM participants were linked to care with an mHealth intervention within 3 months of HIV diagnosis at Via Libre clinic. Read More

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Effectiveness of Text Messaging as an Adjuvant to Health Advice in Smoking Cessation Programs in Primary Care. A Randomized Clinical Trial.

Nicotine Tob Res 2017 Aug;19(8):901-907

BIOARABA, Health Research Institute, Integrated Health Organization Araba (university hospital), Álava, Spain.

Introduction: Smoking remains a major risk factor for chronic diseases. Health advice is considered one of the most cost-effective interventions; however, changes produced by counseling tend not to persist over time, it is necessary to implement enforcement mechanisms.

Methods: Randomized clinical trial to evaluate the effectiveness of a combined program that includes health advice and text messaging to mobile phone (SMSalud®). Read More

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Electronic Health Record Availability and Anxiety Treatment in Office-Based Practices.

Psychiatr Serv 2016 10 2;67(10):1152-1155. Epub 2016 May 2.

Dr. Harman is with the Department of Behavioral Sciences and Social Medicine, Florida State University, Tallahassee. Mr. Mills is with the Department of Health Services Research, Management and Policy, and Dr. Cook is with the Department of Epidemiology and Medicine, University of Florida, Gainesville. Dr. Harle is with the Department of Health Policy and Management, Indiana University, Indianapolis. Send correspondence to Mr. Mills (e-mail: ).

Objective: This study compared the probability of receiving anxiety treatment during a physician visit to primary care practices with and without an electronic health record (EHR).

Methods: The 2007-2010 National Ambulatory Medical Care Survey was used to identify visits for anxiety (N=290). The outcome was receipt of anxiety treatment. Read More

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October 2016

A cluster randomised controlled trial of advice, exercise or multifactorial assessment to prevent falls and fractures in community-dwelling older adults: protocol for the prevention of falls injury trial (PreFIT).

BMJ Open 2016 Jan 18;6(1):e009362. Epub 2016 Jan 18.

Warwick Clinical Trials Unit, Division of Health Sciences, University of Warwick, Coventry, UK Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK.

Introduction: Falls are the leading cause of accident-related mortality in older adults. Injurious falls are associated with functional decline, disability, healthcare utilisation and significant National Health Service (NHS)-related costs. The evidence base for multifactorial or exercise interventions reducing fractures in the general population is weak. Read More

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January 2016

[Postnatal visit: Routine and particularity after complicated pregnancy--Guidelines for clinical practice].

M Doret

J Gynecol Obstet Biol Reprod (Paris) 2015 Dec 31;44(10):1118-26. Epub 2015 Oct 31.

Service de gynécologie-obstétrique, hôpital Femme-Mère-Enfant, hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Faculté de médecine et de maïeutique Charles-Mérieux-Lyon Sud, université Lyon 1, 69921 Oullins cedex, France. Electronic address:

Objectives: To propose guidelines for clinical practice for routine postnatal visit and after pathological pregnancies.

Materials And Methods: Bibliographic searches were performed with PubMed and Cochrane databases, and within international guidelines references.

Results: Postpartum visit should be planned 6 to 8 weeks after delivery and can be performed by an obstetrician, a gynecologist, a general practitioner or a midwife, when after normal pregnancy and delivery (Professional consensus). Read More

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December 2015

Next-Generation Methods for HIV Partner Services: A Systematic Review.

Sex Transm Dis 2015 Sep;42(9):533-9

From the *Pritzker School of Medicine, University of Chicago, Chicago, IL; †Department of Medicine, University of Chicago Medical Center, Chicago, IL; ‡Chicago Center for HIV Elimination, Chicago, IL; and §Department of Public Health Sciences, University of Chicago, IL.

Partner notification is a widely accepted method whose intent is to limit onward HIV transmission. With increasing use of new technologies such as text messaging, e-mail, and social network sites, there is growing interest in using these techniques for "next-generation" HIV partner services (PS). We conducted a systematic review to assess the use and effectiveness of these technologies in HIV PS. Read More

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September 2015

[Promote better nutritional behaviours among shift workers with night shift].

Presse Med 2015 May 18;44(5):e191-201. Epub 2015 Feb 18.

Institut interrégional pour la santé, 37521 La Riche cedex, France.

Aim: Shift work, especially including a night shift, is associated with degradation of physical, social and psychosocial health as well as poor well-being. Food imbalance and low physical activity contributed to the negative effects on health. Our objective was to promote a healthier nutritional behaviour according to the French national nutrition and health program recommendations (PNNS). Read More

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Proactive outreach for smokers using VHA mental health clinics: protocol for a patient-randomized clinical trial.

BMC Public Health 2014 Dec 17;14:1294. Epub 2014 Dec 17.

VA New York Harbor Healthcare System, 423 East 23rd Street, New York, NY 10010, USA.

Background: Persons with a mental health diagnosis have high rates of tobacco use and face numerous barriers to cessation including high levels of nicotine dependence, low rates of tobacco treatment referrals from mental health providers, and limited availability of tobacco treatment targeted to their needs. This manuscript describes the rationale and methods of a clinical trial with the following aims: 1) Compare the reach and efficacy of a proactive telephone-based tobacco cessation program for Veterans Health Administration (VHA) mental health clinic patients to VHA usual care and 2) Model longitudinal associations between baseline patient characteristics and long-term abstinence.

Methods/design: We will use the electronic medical record to identify patients across four VHA healthcare facilities who have a clinical reminder code indicating current tobacco use in the past six months and who have had a mental health clinic visit in the past 12 months. Read More

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December 2014

Effects of a TELephone Counselling Intervention by Pharmacist (TelCIP) on medication adherence, patient beliefs and satisfaction with information for patients starting treatment: study protocol for a cluster randomized controlled trial.

BMC Health Serv Res 2014 May 15;14:219. Epub 2014 May 15.

Department of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P,O, Box 80082, Utrecht 3508 TB, The Netherlands.

Background: Adherence to medication is often low. Pharmacists may improve adherence, but a one-size-fits-all approach will not work: different patients have different needs. Goal of the current study is to assess the effectiveness of a patient-tailored, telephone-based intervention by a pharmacist at the start of pharmacotherapy aimed at improving medication adherence, satisfaction with information and counselling and the beliefs about medicines. Read More

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Design of the INTEGRATE study: effectiveness and cost-effectiveness of a cardiometabolic risk assessment and treatment program integrated in primary care.

BMC Fam Pract 2014 May 9;15:90. Epub 2014 May 9.

Netherlands Institute for Health Services Research (NIVEL), P,O, Box 1568, 3500 BN Utrecht, The Netherlands.

Background: The increasing prevalence of cardiometabolic disease (CMD) in combination with an ageing population is a major public health problem. Early detection and management of individuals at risk for CMD is required to prevent future health problems with associated costs. General practice is the optimal health care setting to accomplish this goal. Read More

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