55,014 results match your criteria coumarin derivatives


Review of Pharmacological Properties and Chemical Constituents of .

J Pharmacopuncture 2021 Mar;24(1):14-23

Shahed University of Medical Sciences, Tehran, Iran.

Objectives: (parsnip), is a plant with nutritional and medicinal properties which has been used in all over the world and study about it is rare. In Persian Medicine parsnip is named as and has many uses such as laxative, libido enhancer, kidney stone crusher and diuretic. Because the wide traditional usage of parsnip, in this review the composition and pharmacological properties of this plant are discussed. Read More

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Polarized Helical Coumarins: [1,5] Sigmatropic Rearrangement and Excited-State Intramolecular Proton Transfer.

J Org Chem 2021 Apr 8. Epub 2021 Apr 8.

Institute of Organic Chemistry of Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.

The tandem process of phenol addition to a cyclic α,β-unsaturated ester followed by intramolecular transesterification and [1,5] sigmatropic rearrangement affords a series of helical coumarins based upon a previously unknown 3-amino-7-hydroxybenzo[3,4]cyclohepta[1,2-]chromen-6-one core. These novel polarized coumarins, possessing a β-ketoester moiety, have been employed to synthesize more rigid and helical coumarin-pyrazolones, which display green fluorescence. The enhanced emission of coumarin-pyrazolones in polar solvents depends on the nature of the state. Read More

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A coumarin exudation pathway mitigates arbuscular mycorrhizal incompatibility in Arabidopsis thaliana.

Plant Mol Biol 2021 Apr 6. Epub 2021 Apr 6.

Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, PO Box 800.56, 3508 TB, Utrecht, the Netherlands.

Key Message: Overexpression of genes involved in coumarin production and secretion can mitigate mycorrhizal incompatibility in nonhost Arabidopsis plants. The coumarin scopoletin, in particular, stimulates pre-penetration development and metabolism in mycorrhizal fungi. Although most plants can benefit from mutualistic associations with arbuscular mycorrhizal (AM) fungi, nonhost plant species such as the model Arabidopsis thaliana have acquired incompatibility. Read More

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A Study of the Therapeutic Potential of Lentinus squarrosulus (Agaricomycetes) from Gabon.

Int J Med Mushrooms 2021 ;23(4):39-45

Masuku University of Science and Technology, BP 942 Franceville, Gabon.

Lentinus squarrosulus is a mushroom widely used in Gabon for its culinary and medicinal properties. The bioactive potential of mushrooms might be attributable to the presence of several pharmaceutically important mycocompounds that need to be ascertained scientifically. A study of the therapeutic potential of L. Read More

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January 2021

Anticancer potential of coumarin and its derivatives.

Mini Rev Med Chem 2021 Apr 5. Epub 2021 Apr 5.

Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu. Nepal.

Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different biological properties viz antimicrobial, antibacterial, antifungal, antioxidant, antitumor, anti-HIV, antihypertension, anticoagulant, anticancer, antiviral, anti-inflammatory, analgesics, antidiabetic, anti-depressive, and other bioactive properties. Coumarin and its derivatives possess anticancer activity against different types of cancers such as prostate, renal, breast, laryngeal, lung, colon, CNS, leukemia, malignant melanoma. Read More

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Existing knowledge on Euphorbia fischeriana Steud. (Euphorbiaceae): Traditional uses, clinical applications, phytochemistry, pharmacology and toxicology.

J Ethnopharmacol 2021 Apr 2:114095. Epub 2021 Apr 2.

School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing 100029, P. R. China. Electronic address:

Ethnopharmacological Relevance: Euphorbia fischeriana Steud. (Euphorbiaceae) is a perennial herb distributed in grassland, hill slopes or gravel hillside, with average altitude of 100-600 meters. The whole grass of E. Read More

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Small Molecule Inhibitors of White Spot Syndrome Virus: Promise in Shrimp Seedling Culture.

Int J Mol Sci 2021 Mar 26;22(7). Epub 2021 Mar 26.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo 315211, China.

Rapid production of prawn () under artificial pressure can result in a series of obvious challenges and is vulnerable to serious losses related to aquatic environmental issues and the unrestrained outbreak of white spot syndrome (WSS). However, to date, there are no therapeutic strategies to contain the spread of the virus. Here, we synthesized 27 coumarin derivatives and evaluated their anti-white spot syndrome virus (WSSV) activity in larvae. Read More

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Synthesis and Biological Activity Evaluation of Coumarin-3-Carboxamide Derivatives.

Molecules 2021 Mar 16;26(6). Epub 2021 Mar 16.

Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand.

A series of novel coumarin-3-carboxamide derivatives were designed and synthesized to evaluate their biological activities. The compounds showed little to no activity against gram-positive and gram-negative bacteria but specifically showed potential to inhibit the growth of cancer cells. In particular, among the tested compounds, 4-fluoro and 2,5-difluoro benzamide derivatives ( and , respectively) were found to be the most potent derivatives against HepG2 cancer cell lines (IC = 2. Read More

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Comprehensive Phenolic and Free Amino Acid Analysis of Rosemary Infusions: Influence on the Antioxidant Potential.

Antioxidants (Basel) 2021 Mar 23;10(3). Epub 2021 Mar 23.

REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, R. J. Viterbo Ferreira, 4050-313 Porto, Portugal.

The phenolics profile, free amino acids composition, and antioxidant potential of rosemary infusions were studied. Forty-four compounds belonging to nine different groups (hydroxybenzoic acids, hydroxycinnamic acids, flavan-3-ols, flavanones, flavones, phenolic diterpenes, hydroxybenzaldehydes, coumarins, and pyranochromanones) were identified by UHPLC-ESI-Q-TOF-MS. Of these, seven were firstly described in rosemary infusions: a rosmanol derivative, two dihydroxycoumarin hexosides, a hydroxybenzaldehyde, a dihydroxybenzoic acid hexoside, coumaric acid hexoside, and isocalolongic acid. Read More

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The Common Cichory ( L.) as a Source of Extracts with Health-Promoting Properties-A Review.

Molecules 2021 Mar 23;26(6). Epub 2021 Mar 23.

Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.

Natural products are gaining more interest recently, much of which focuses on those derived from medicinal plants. The common chicory ( L.), of the Astraceae family, is a prime example of this trend. Read More

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Identification and Quantification of Coumarins by UHPLC-MS in Natural Populations.

Molecules 2021 Mar 23;26(6). Epub 2021 Mar 23.

Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland.

Coumarins are phytochemicals occurring in the plant kingdom, which biosynthesis is induced under various stress factors. They belong to the wide class of specialized metabolites well known for their beneficial properties. Due to their high and wide biological activities, coumarins are important not only for the survival of plants in changing environmental conditions, but are of great importance in the pharmaceutical industry and are an active source for drug development. Read More

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A Comparative Study of the Antioxidative Effects of and Infusions.

Antioxidants (Basel) 2021 Mar 3;10(3). Epub 2021 Mar 3.

Faculty of Health Sciences, University of Primorska, 6310 Izola, Slovenia.

(L.) Moench (abbrev. as HA) has a long tradition in European ethnomedicine and its inflorescences are approved as a herbal medicinal product. Read More

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Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency.

Molecules 2021 Mar 2;26(5). Epub 2021 Mar 2.

Department of Chemistry, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.

A tailored series of coumarin-based ferrocenyl 1,3-oxazine hybrid compounds was synthesized and investigated for potential antiparasitic activity, drawing inspiration from the established biological efficacy of the constituent chemical motifs. The structural identity of the synthesized compounds was confirmed by common spectroscopic techniques: NMR, HRMS and IR. Biological evaluation studies reveal that the compounds exhibit higher in vitro antiparasitic potency against the chemosensitive malarial strain (3D7 ) over the investigated trypanosomiasis causal agent ( 427) with mostly single digit micromolar IC values. Read More

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3-Carboxylic Acid and Formyl-Derived Coumarins as Photoinitiators in Photo-Oxidation or Photo-Reduction Processes for Photopolymerization upon Visible Light: Photocomposite Synthesis and 3D Printing Applications.

Molecules 2021 Mar 21;26(6). Epub 2021 Mar 21.

CNRS, IS2M UMR 7361, Université de Haute-Alsace, F-68100 Mulhouse, France.

In this paper, nine organic compounds based on the coumarin scaffold and different substituents were synthesized and used as high-performance photoinitiators for free radical photopolymerization (FRP) of meth(acrylate) functions under visible light irradiation using LED at 405 nm. In fact, these compounds showed a very high initiation capacity and very good polymerization profiles (both high rate of polymerization (Rp) and final conversion (FC)) using two and three-component photoinitiating systems based on coum/iodonium salt (0.1%/1% /) and coum/iodonium salt/amine (0. Read More

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Transcriptome Signatures in WCS417 Shed Light on Role of Root-Secreted Coumarins in -Mutualist Communication.

Microorganisms 2021 Mar 11;9(3). Epub 2021 Mar 11.

Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

WCS417 is a root-colonizing bacterium with well-established plant-beneficial effects. Upon colonization of roots, WCS417 evades local root immune responses while triggering an induced systemic resistance (ISR) in the leaves. The early onset of ISR in roots shows similarities with the iron deficiency response, as both responses are associated with the production and secretion of coumarins. Read More

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Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential.

Molecules 2021 Mar 14;26(6). Epub 2021 Mar 14.

Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK.

Dihydrofuranocoumarin, chalepin () and furanocoumarin, chalepensin () are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant L. (Fam: Rutaceae) but also distributed in various species of the genera , and . The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. Read More

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In vitro inhibition studies of coumarin derivatives on Bos taurus enolase and elucidating their interaction by molecular docking, molecular dynamics simulations and MMGB(PB)SA binding energy calculation.

Bioorg Chem 2021 Mar 5;110:104796. Epub 2021 Mar 5.

Yıldız Technical University, Faculty of Chemical and Metallurgical Engineering, Department of Bioengineering, Davutpasa campus, 34210, Istanbul, Turkey. Electronic address:

Tropical theileriosis is among the most common vector-borne diseases and caused by Theileria parasites. Theileria annulata is an obligate intracellular protozoan parasite and transmitted to especially Bos taurus and Bos indicus by Hyalomma tick vectors. C8 ([4-(3,4-dimethoxyphenyl)-6,7-dihydroxy-2H-chromen-2-one); C9 (4-(3,4-dihydroxyphenyl)-7,8 dihydroxy-2H-chromen-2-one); C21 (4-(3,4-dihydroxyphenyl)-6,7-dihydroxy-2H-chromen-2 one) were identified as potent Theileria annulata enolase (TaEno) inhibitors in our previous studies. Read More

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Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease.

Bioorg Chem 2021 Mar 6;110:104792. Epub 2021 Mar 6.

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt. Electronic address:

Twenty novel 7-benzyloxycoumarin based compounds were synthesized with a variety of bioactive chemical fragments. The synthesized compounds showed remarkable acetylcholinesterase (AChE) inhibitory activity. In vitro assay revealed that compounds 7-benzyloxy-4-{[(4-phenylthiazol-2(3H)-ylidene)hydrazono]methyl}-2H-chromen-2-one (5b, IC= 0. Read More

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Antileishmanial Activity of Lignans, Neolignans, and Other Plant Phenols.

Prog Chem Org Nat Prod 2021 ;115:115-176

Laboratory of Growth Regulators, The Czech Academy of Sciences, Institute of Experimental Botany & Palacký University, Šlechtitelů 27, CZ-78371, Olomouc, Czech Republic.

Secondary metabolites (SM) from organisms have served medicinal chemists over the past two centuries as an almost inexhaustible pool of new drugs, drug-like skeletons, and chemical probes that have been used in the "hunt" for new biologically active molecules with a "beneficial effect on human mind and body." Several secondary metabolites, or their derivatives, have been found to be the answer in the quest to search for new approaches to treat or even eradicate many types of diseases that oppress humanity. A special place among SM is occupied by lignans and neolignans. Read More

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January 2021

Pictet-Spengler condensations using 4-(2-aminoethyl)coumarins.

New J Chem 2020 Aug 22;44(31):13415-13429. Epub 2020 Jul 22.

Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596 USA.

Androgen-deprivation therapy (ADT) is only a palliative measure, and prostate cancer invariably recurs in a lethal, castration-resistant form (CRPC). Prostate cancer resists ADT by metabolizing weak, adrenal androgens to growth-promoting 5α-dihydrotestosterone (DHT), the preferred ligand for the androgen receptor (AR). Developing small-molecule inhibitors for the final steps in androgen metabolic pathways that utilize 17-oxidoreductases required probes that possess fluorescent groups at C-3 and intact, naturally occurring functionality at C-17. Read More

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Discovery of Novel 3,4-Dichloroisothiazole-Containing Coumarins as Fungicidal Leads.

J Agric Food Chem 2021 Apr 1. Epub 2021 Apr 1.

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.

Natural products are one of the resources for discovering novel fungicidal leads. As a natural fungicide, osthole was used as a coumarin-based lead compound for the development of novel fungicides. Here, a series of 3,4-dichloroisothiazole-containing 7-hydroxycoumarins were rationally designed, synthesized, and characterized by introducing a bioactive substructure, 3,4-dichloroisothiazole, into the coumarin skeleton. Read More

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The phytochemistry and biological diversity of Ferulago genus (Apiaceae): a systematic review.

J Pharm Pharmacol 2021 Mar;73(1):1-21

Department of Biology, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI), Tanjung Malim, Perak, Malaysia.

Objectives: The genus Ferulago belonging to the family Apiaceae is a flora widely distributed in Central Asia and the Mediterranean and used in folk medicine. It is administered as a sedative, tonic, digestive, aphrodisiac, also as a treatment for intestinal worms and haemorrhoids. Herein, we reported a review on phytochemistry and its biological activities reported from 1990 up to early 2020. Read More

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Reaction of 3-Oxa-2-oxobicyclo[4.2.0]oct-4-ene-1-carboxylate with Dimethylsulfoxonium Methylide.

Chem Pharm Bull (Tokyo) 2021 ;69(4):391-399

Kyoto Pharmaceutical University.

We have been interested in the reactivities of small-ring compounds and have reported reactions that proceed through cyclopropane intermediates starting from coumarin derivatives bearing an electron-withdrawing group at the 3-position or 2-oxo-2H-pyran-3-carboxylate derivatives and dimethylsulfoxonium methylide. This time, the reaction between 3-oxa-2-oxobicyclo[4.2. Read More

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January 2021

Reconstructable Gradient Structures and Reprogrammable 3D Deformations of Hydrogels with Coumarin Units as the Photolabile Crosslinks.

Adv Mater 2021 Mar 31:e2008057. Epub 2021 Mar 31.

Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

Morphing hydrogels have versatile applications in soft robotics, flexible electronics, and biomedical devices. Controlling component distribution and internal stress within a hydrogel is crucial for shape-changing. However, existing gradient structures of hydrogels are usually non-reconstructable, once encoded by chemical reactions and covalent bonds. Read More

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[Main chemical constituents in aerial parts of Glycyrrhiza uralensis by UPLC-Q-Exactive Orbitrap-MS].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(6):1449-1459

School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488,China Engineering Research Center of Good Agricultural Practice for Chinese Crude Drugs,Ministry of Education Beijing 102488,China.

Chemical constituents from aerial parts of Glycyrrhiza uralensis were analyzed and identified using ultra-high performance liquid chromatography coupled with hybrid quadrupole-orbitrap mass spectrometry(UPLC-Q-Exactive Orbitrap-MS). The chromatographic column of Waters Acquity UPLC BEH-C_(18)(2.1 mm×100 mm, 1. Read More

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[Research advances in chemical constituents and pharmacological activities of Pueraria genus].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(6):1311-1331

Key Laboratory of Modern Chinese Medicine Preparations,Ministry of Education,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China.

Kudzu plants in the subfamily sphenoideae of Leguminosae are commonly used herbs in China, Japan, Korea, India and Thailand, with a long history of medicinal use. They are recorded in Chinese Pharmacopoeia, Japanese Pharmacopeia, Korea Pharmacopeia, Ayurveda Pharmacopoeia of India and Flora of Thailand. There are 15-20 species of Pueraria in the world, including 7 species and 2 varieties in China. Read More

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[Study on fragmentation patterns of coumarins in Notopterygium inchum with ultrahigh performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(5):1179-1190

Institute of Chinese Material Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.

To demonstrate the fragmentation patterns of simple coumarins furanocourmarin(C_7-C_8), furanocourmarin(C_6-C_7) and dihydrofuran coumarin by mass spectrometry, with fraxin, scopoletin, isopsoralen, pimpinellin, isoimperatorin, notopterol and noda-kenin as study subjects, so as to provide a basis for rapid identification of compounds in different subtypes of coumarins. Ultrahigh performance liquid chromatography combined with quardrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) was implemented in both positive and negative ion modes. Masslynx software was employed to provide the elemental constituents of each detected ion based on its accurate molecular weight. Read More

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Non-targeted screening of pyranosides in Rhodiola crenulata using an all ion fragmentation-exact neutral loss strategy combined with liquid chromatography-quadrupole time-of-flight mass spectrometry.

Phytochem Anal 2021 Mar 28. Epub 2021 Mar 28.

The Research Centre of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Introduction: Pyranosides as one kind of natural glycosides contain a pyran ring linked to an aglycone in the structure. They occur widely in plants and possess diverse biological activities. The discovery of new pyranosides not only contributes to research on natural products but also may promote pharmaceutical development. Read More

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Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Genus (Apiaceae).

Front Pharmacol 2020 12;11:608649. Epub 2021 Mar 12.

Laboratory of Phytopathology and Microbial Biotechnology, Department of Botany, Mohanlal Sukhadia University, Udaipur, India.

The genus is the third largest and a well-known genus of the Apiaceae family. It is categorized in the Peucedaneae tribe and Ferulinae subtribe of the Apiaceae family. At present, about 180 species have been reported. Read More

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The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus).

Pestic Biochem Physiol 2021 Mar 9;173:104774. Epub 2021 Jan 9.

Laboratory of Toxicology, Department of Environmental Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan. Electronic address:

Well-known 4-hydroxycoumarin derivatives, such as warfarin, act as inhibitors of the vitamin K epoxide reductase (VKOR) and are used as anticoagulants. Mutations of the VKOR enzyme can lead to resistance to those compounds. This has been a problem in using them as medicine or rodenticide. Read More

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