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Comparative analysis of the main medicinal substances and applications of Echium vulgare L. and Echium plantagineum L.: A review.

J Ethnopharmacol 2021 Dec 3:114894. Epub 2021 Dec 3.

School of Life Sciences, Changchun University of Technology, No.7186 Weixing Road, Changchun City, Jilin Province, 130022, China. Electronic address:

Ethnopharmacological Relevance: Echium vulgare L. and Echium plantagineum L. originated in the Mediterranean, and were later domesticated in Africa, America, Asia, Europe and Oceania, where they were widely used to treat many diseases including cough, urinary tract infection, fever, inflammation and muscle strain. Read More

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December 2021

Current Status of Studies Investigating Asthma-Chronic Obstructive Pulmonary Disease Overlap in Korea: A Review.

Yong Suk Jo

Tuberc Respir Dis (Seoul) 2021 Dec 6. Epub 2021 Dec 6.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.

A considerable number of individual exhibit features of both asthma and chronic obstructive pulmonary disease (COPD), defined as asthma-COPD overlap (ACO). Many studies have reported that these patients are known to have a greater burden of symptoms, including cough and dyspnea, and experience more exacerbations and hospitalizations than those with non-ACO COPD or asthma. Although diagnostic criteria for ACO have not yet been clearly established, their clinical significance remains to be determined. Read More

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December 2021

The limited value of triage vital signs in predicting influenza infection in children aged 5 years and under in the emergency department: A single-center retrospective cross-sectional study.

Medicine (Baltimore) 2021 Nov;100(44):e27707

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

Abstract: Diagnosing influenza in children aged 5 years and under can be challenging because of their difficulty in verbalizing symptoms. This study aimed to explore the value of the triage heart rate (HR), respiratory rate (RR), and temperature, either alone or when combined with individual symptoms and signs, in predicting influenza infection in this age group.This was a retrospective study covering 4 influenza seasons from 2017 to 2019 in an emergency department (ED) in Hong Kong. Read More

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November 2021

A retrospective study of azithromycin and ceftizoxime for the management of children with Mycoplasma pneumoniae pneumonia.

Medicine (Baltimore) 2021 Nov;100(44):e27564

Department of Pediatrics, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, China.

Abstract: The aim of this study was to compare the clinical efficacy of azithromycin and ceftizoxime (AC) and erythromycin and amoxicillin/sulbactam (EAS) in the treatment of children with Mycoplasma pneumoniae pneumonia (MPP).In this retrospective study, a total of 92 eligible children with MPP were included, and they were divided into a treatment group (n = 46) and a control group (n = 46). All patients were treated with intravenous ambroxol, and nebulized inhalation of budesonide and terbutaline. Read More

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November 2021

Association between clinical characteristics and CT findings in patients with coronavirus disease-2019.

Medicine (Baltimore) 2021 Nov;100(44):e27435

Department of Radiology, Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

Abstract: This retrospective study was to investigate the association between clinical characteristics and computerized tomography (CT) findings in patients with coronavirus disease-2019 (COVID-19). The clinical data of COVID-19 patients were retrospectively analyzed. Spearman correlation analysis was used to identify the correlation. Read More

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November 2021

COVID-19 in Pediatric Patients: A Systematic Review.

J Neurosurg Anesthesiol 2022 Jan;34(1):141-147

Departments of Anesthesiology.

Introduction: The coronavirus disease (COVID)-19 pandemic has been an enormous global health burden, resulting in hundreds of millions of documented infections and more than 3 million deaths. Increasing reports characterizing the effects of COVID-19 in pediatric populations have been published during the course of the pandemic. We performed a systematic review to assess the scope of diagnosis, treatment, and management of COVID-19 in pediatric patients. Read More

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January 2022

Gestational Psittacosis With Secondary Hemophagocytic Syndrome: A Case Report and Literature Review.

Front Med (Lausanne) 2021 18;8:755669. Epub 2021 Nov 18.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Gestational psittacosis and hemophagocytic syndrome (HPS) are rare clinical diseases. In this article, a case of gestational psittacosis concomitant with secondary HPS was reported. An analysis was performed on the clinical characteristics, signs, laboratory findings, progression, diagnosis, and treatment of a patient with gestational psittacosis concomitant with secondary HPS. Read More

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November 2021

Three Novel and One Potential Hotspot Variants in Chinese Patients With Carnitine Palmitoyltransferase 1A Deficiency.

Front Pediatr 2021 12;9:771922. Epub 2021 Nov 12.

Center of Neonatal Disease Screening, Quanzhou Maternity and Children's Hospital, Quanzhou, China.

Carnitine palmitoyltransferase 1A (CPT1A) deficiency is an inherited disorder of mitochondrial fatty acid β-oxidation that impairs fasting ketogenesis and gluconeogenesis in the liver. Few studies implementing newborn screening (NBS) for CPT1A deficiency in the Chinese population have been reported. This study aimed to determine the biochemical, clinical, and genetic characteristics of patients with CPT1A deficiency in China. Read More

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November 2021

Guillain-Barré Syndrome in an Elderly Patient as a Complication of COVID-19 Infection.

Cureus 2021 Oct 30;13(10):e19154. Epub 2021 Oct 30.

Department of Medicine, Faculty of Medicine, Umm Al Qura University, Makkah, SAU.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an infection that mainly affects the respiratory system. It may present with fever, fatigue, dry cough, and dyspnea. In addition, numerous studies and case reports discussed those viruses showing their effects on the nervous system. Read More

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October 2021

Follow Your Nose: A Key Clue to Understanding and Treating COVID-19.

Front Endocrinol (Lausanne) 2021 18;12:747744. Epub 2021 Nov 18.

Hammersmith Hospital, Imperial College, London, United Kingdom.

This paper suggests that ATP release induced by the SARS-CoV-2 virus plays a key role in the genesis of the major symptoms and complications of COVID-19. Infection of specific cells which contain the Angiotensin-Converting Enzyme 2 (ACE2) receptor results in a loss of protection of the Mineralocorticoid Receptor (MR). Local activation by cortisol stimulates the release of ATP initially into the basolateral compartment and then by lysosomal exocytosis from the cell surface. Read More

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November 2021

Endobronchial Therapy With Gentamicin and Dexamethasone After Airway Clearance by Bronchoscopy in Exacerbation of Non-Cystic Fibrosis Bronchiectasis: A Real-World Observational Study.

Front Pharmacol 2021 11;12:773241. Epub 2021 Nov 11.

Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

The exacerbation of non-cystic fibrosis bronchiectasis (NCFB) may lead to poor prognosis. The objective of this study was to retrospectively analyze the clinical efficacy and safety of endobronchial therapy with gentamicin and dexamethasone after airway clearance by bronchoscopy in the exacerbation of NCFB. We retrospectively reviewed 2,156 patients with NCFB between January 2015 and June 2016 and 367 consecutive patients with exacerbation of bronchiectasis who had complete data and underwent airway clearance (AC) by bronchoscopy. Read More

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November 2021

Comparison of Five Prophylactically Intravenous Drugs in Preventing Opioid-Induced Cough: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.

Front Pharmacol 2021 17;12:684276. Epub 2021 Nov 17.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Due to the absence of direct comparisons of different therapeutic drugs in preventing opioid-induced cough (OIC) during the induction of general anesthesia, clinicians often faced difficulties in choosing the optimal drug for these patients. Hence, this network meta-analysis was conducted to solve this problem. Online databases, including Pubmed, Embase, Web of Science, Cochrane, and Google Scholar, were searched comprehensively to identify eligible randomized controlled trials (RCTs), up to March 15th, 2021. Read More

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November 2021

Isolated Dextrocardia with Situs Solitus - Dextroversion in a Ugandan Baby: A Case Report.

Int Med Case Rep J 2021 23;14:797-800. Epub 2021 Nov 23.

Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Background: Dextrocardia is a rare congenital abnormality in the general population, with an estimated incidence of 1 in 12,000 live births. Isolated dextrocardia, the condition of right-sided heart with situs solitus is most commonly referred to as dextroversion.

Case Presentation: A 2-month-old Ugandan baby boy discovered to have isolated dextrocardia with situs solitus presented with fever, cough, and difficulty in breathing. Read More

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November 2021

Infection in Lung Cancer Patients with Positive AIGAs: A Rare Case Report.

Infect Drug Resist 2021 27;14:5005-5013. Epub 2021 Nov 27.

Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen University, Guangdong, 518000, People's Republic of China.

Background: is considered to commonly cause infection in individuals with human immunodeficiency virus (HIV) infection. However, the epidemiology of has changed, and an increasing number of HIV-negative but immunodeficient patients are infected with . The mechanisms of infection of HIV-negative hosts are complex and diverse. Read More

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November 2021

Acute Exacerbation of Cough as a Precipitating Cause of Hypoxia in COVID-19 Patients.

Indian J Crit Care Med 2021 Nov;25(11):1324-1325

Director, All India Institute of Medical Sciences, Patna, Bihar, India.

Kumar A, Kumar A, Kumar A, Sinha C, Kumar N, Singh PK. Acute Exacerbation of Cough as a Precipitating Cause of Hypoxia in COVID-19 Patients. Indian J Crit Care Med 2021;25(11):1324-1325. Read More

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November 2021

Clinico-virological Profile, Intensive Care Needs, and Outcome of Infants with Acute Viral Bronchiolitis: A Prospective Observational Study.

Indian J Crit Care Med 2021 Nov;25(11):1301-1307

Department of Pediatrics, PGIMER, Chandigarh, India.

Objectives: The objective of the study was to describe the clinico-virological profile, treatment details, intensive care needs, and outcome of infants with acute viral bronchiolitis (AVB).

Methodology: In this prospective observational study, 173 infants with AVB admitted to the pediatric emergency room and pediatric intensive care unit (PICU) of a tertiary care teaching hospital in North India during November 2019 to February 2020 were enrolled. The data collection included clinical features, viruses detected [respiratory syncytial virus (RSV), rhinovirus, influenza A virus, parainfluenza virus (PIV) 2 and 3, and human metapneumovirus (hMPV)], complications, intensive care needs, treatment, and outcomes. Read More

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November 2021

E-cigarette, or vaping, product use Associated Lung Injury (EVALI): new scenarios for physicians and radiologists.

Monaldi Arch Chest Dis 2021 Dec 3. Epub 2021 Dec 3.

Department of Diagnostic Imaging, Monaldi Hospital, Azienda Ospedaliera dei Colli, Naples.

A 59-year-old female ex-smoker with 40 pack year smoking history and a 5-year current e-cigarette (EC) use history, presented with progressive dyspnea on exertion and daily cough for 2 months. A CT scan showed a consolidation area with air bronchogram in the middle lobe and non-calcific bilateral nodules, which could be attributed to community-acquired pneumonia. The patient was treated with empiric antibiotics and systemic steroids for 10 days. Read More

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December 2021

Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis.

Korean J Intern Med 2021 Dec 7. Epub 2021 Dec 7.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background/aims: The prevalence and effects of airway diseases, including asthma, eosinophilic bronchitis (EB), chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) have not been thoroughly studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to evaluate the prevalence of airway diseases in patients with IPF and to identify the differences in symptoms based on the presence of airway diseases.

Methods: This single-institution prospective cohort study was conducted from June 2017 to September 2018, at the Seoul National University Hospital. Read More

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December 2021

[Epidemiology, clinical characteristics and treatment in 278 patients with coronavirus disease 2019 in Guangzhou].

Zhonghua Nei Ke Za Zhi 2020 Aug;59(8):598-604

Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou 510060, China.

To retrospective analyze the epidemiology, clinical characteristics, treatment and prognosis in patients with coronavirus disease 2019 (COVID-19). A total of 278 patients with COVID-19 admitted to Guangzhou Eighth People's Hospital from January 20 to February 10, 2020 were selected. The general demographic data, epidemiological data, clinical symptoms, laboratory examinations, lung CT imaging, treatment and prognosis were analyzed. Read More

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[ pulmonary disease:report of 3 cases and literature review].

Zhonghua Jie He He Hu Xi Za Zhi 2021 May;44(5):474-480

Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.

To analyze the clinical manifestations, radiographic characteristics and prognosis of pulmonary disease, in order to improve diagnosis and treatment of the disease. Using " pulmonary disease" as the search term, from February 15, 2007 to February 21, 2021, a total of 1 264 cases were retrieved in the PubMed database. In the Wanfang database, using " pulmonary disease" as the search term, from February 15, 2007 to February 21, 2021, no related document was retrieved. Read More

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[Pulmonary malignant perivascular epithelioid cell tumor mixed with lung adenocarcinoma components: a case report and literature review].

Zhonghua Jie He He Hu Xi Za Zhi 2021 May;44(5):468-473

Department of Pathology, Affiliated Dongguan People's Hospital, Southern Medical University, Dongguan 523000, China.

To analyze the pathogenesis, clinical manifestations, diagnosis, treatment and prognosis of pulmonary malignant perivascular epithelioid cell tumor (PEComa) with adenocarcinoma. In August 2020, the Department of Pathology, Dongguan People's Hospital of Southern Medical University, diagnosed a case of pulmonary malignant PEComa mixed with adenocarcinoma. The clinical data, pathological diagnosis, treatment plan and prognosis of the patient were analyzed, and the literature was reviewed. Read More

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Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce.

Med J Aust 2021 Dec 5. Epub 2021 Dec 5.

IMPACCT Centre, University of Technology Sydney, Sydney, NSW.

Introduction: Older people living with frailty and/or cognitive impairment who have coronavirus disease 2019 (COVID-19) experience higher rates of critical illness. There are also people who become critically ill with COVID-19 for whom a decision is made to take a palliative approach to their care. The need for clinical guidance in these two populations resulted in the formation of the Care of Older People and Palliative Care Panel of the National COVID-19 Clinical Evidence Taskforce in June 2020. Read More

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December 2021

Prevalence of Mycobacterium tuberculosis in sputum and reported symptoms among clinic attendees compared to a community survey in rural South Africa.

Clin Infect Dis 2021 Dec 3. Epub 2021 Dec 3.

TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Tuberculosis (TB) case finding efforts typically target symptomatic people attending health facilities. We compared the prevalence of Mycobacterium tuberculosis (Mtb) sputum culture-positivity among adult clinic attendees in rural South Africa with a concurrent, community-based estimate from the surrounding demographic surveillance area (DSA).

Methods: Clinic: Randomly-selected adults (≥18 years) attending two primary healthcare clinics were interviewed and requested to give sputum for mycobacterial culture. Read More

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December 2021

The first experience of ultrasound-guided percutaneous microwave ablation for extracranial schwannoma of the cervical vagus nerve in carotid space and treatment response evaluation with contrast-enhanced imaging.

Clin Hemorheol Microcirc 2021 Dec 1. Epub 2021 Dec 1.

Center of Minimally Invasive Treatment for Tumor, Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Shanghai, China.

Schwannoma is a benign tumor that originates from Schwann cells in the nerve sheathing of cranial, other peripheral, or autonomic nerves. Patients often present with painless mass as the chief complaint. The main symptoms of this tumor are related to its size and specific nerve origin. Read More

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December 2021

The value of lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio in differentiating pneumonia from upper respiratory tract infection (URTI) in children: a cross-sectional study.

BMC Pediatr 2021 Dec 3;21(1):545. Epub 2021 Dec 3.

Department of health management, Hangzhou Normal University, Zhejiang, 310000, Hangzhou, China.

Backgrounds: Early and accurate diagnosis of pediatric pneumonia in primary health care can reduce the chance of long-term respiratory diseases, related hospitalizations and mortality while lowering medical costs. The aim of this study was to assess the value of blood biomarkers, clinical symptoms and their combination in assisting discrimination of pneumonia from upper respiratory tract infection (URTI) in children.

Methods: Both univariate and multivariate logistic regressions were used to build the pneumonia screening model based on a retrospective cohort, comprised of 5211 children (age ≤ 18 years). Read More

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December 2021

Pimavanserin for negative symptoms of schizophrenia: results from the ADVANCE phase 2 randomised, placebo-controlled trial in North America and Europe.

Lancet Psychiatry 2021 Nov 30. Epub 2021 Nov 30.

Acadia Pharmaceuticals, San Diego, CA, USA.

Background: Negative symptoms of schizophrenia are associated with adverse clinical outcomes, but there are few effective treatments. We aimed to assess the effects of pimavanserin, a selective 5-HT inverse agonist and antagonist, on negative symptoms of schizophrenia.

Methods: The ADVANCE study was a phase 2, 26-week, randomised, double-blind, placebo-controlled study of pimavanserin in stable outpatients with schizophrenia aged 18-55 years with predominant negative symptoms. Read More

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November 2021

The relationship between gastroesophageal reflux disease and autism spectrum disorder in adult patients in the United States.

Neurogastroenterol Motil 2021 Dec 3:e14295. Epub 2021 Dec 3.

Division of Gastroenterology & Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Background: Gastroesophageal reflux disease (GERD) has been associated with psychiatric and neurocognitive disorders. Those with autism spectrum disorder (ASD) are prone to gastrointestinal (GI) diseases, but most research has been done on children. Our aim was to determine the relationship between GERD and autism in adults and assess GERD-related complications in those with autism. Read More

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December 2021

Comparison of Effects of Extubation in Prone and Supine Positions in Patients Operated for Lumbar Disk Herniation.

Turk Neurosurg 2021 Nov 10. Epub 2021 Nov 10.

Dokuz Eylul University, School of Medicine, Department of Anesthesiology and Intensive Care, Izmir, Turkey.

Aim: At the end of lumbar disk operations conducted in the prone position, the extubation period can result in serious respiratory and hemodynamic side effects. In this study, we aimed to observe the effects of prone position extubation on respiratory side effects and hemodynamic parameters.

Material And Methods: This prospective observational study included 60 patients extubated in either the prone (n = 30) or supine (n = 30) positions. Read More

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November 2021

Quality of life and long-term results in patients operated on for Esophageal Atresia.

Minerva Pediatr (Torino) 2021 Dec 3. Epub 2021 Dec 3.

Pediatric Surgery Unit, University Hospital of Health and Science, Regina Margherita Children's Hospital, Turin, Italy.

Background: Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) represents the most severe entity among the foregut malformations, with patients at risk of chronic morbidity. This study aims to investigate on health-related quality of life (QoL) and long-term results in patients with EA.

Methods: 50 patients (30M, 20F, mean age: 14-year-old), among 82 patients operated from January 1995 to December 2005, answered the questionnaire. Read More

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December 2021

An comparison of acute toxicities and patient-reported outcomes between intensity-modulated proton therapy and volumetric-modulated arc therapy after ipsilateral radiation for head and neck cancers.

Head Neck 2021 Dec 3. Epub 2021 Dec 3.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Background: Intensity-modulated proton therapy (IMPT) demonstrates superior dose distribution over volumetric-modulated arc therapy (VMAT) for sparing organs-at-risk (OARs) in ipsilateral radiotherapy. To determine a clinical benefit, assessment of patient-reported outcomes (PRO) and physician-reported toxicities alongside a dosimetric analysis is needed.

Methods: Plans were analyzed for dosimetric differences. Read More

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December 2021