108,340 results match your criteria cost-effectiveness analysis


A Cost Effectiveness Analysis of Intravitreal Aflibercept for the Prevention of Progressive Diabetic Retinopathy.

Ophthalmol Retina 2021 Sep 18. Epub 2021 Sep 18.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: To calculate costs required to prevent center-involved diabetic macular edema (CI-DME) or proliferative diabetic retinopathy (PDR), and to improve the diabetic retinopathy severity score (DRSS) with intravitreal anti-VEGF injections as reported for aflibercept in two randomized control trials.

Design: Cost-effectiveness analysis modeling based on published data SUBJECTS: None METHODS: Results from PANORAMA and the Diabetic Retinopathy Clinical Research Network (DRCR.net) Protocol W were analyzed. Read More

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September 2021

Retrospective analysis of interventions to epidemics using dynamic simulation of population behavior.

Math Biosci 2021 Sep 18:108712. Epub 2021 Sep 18.

Division of Applied Mechanics, U.S. FDA/CDRH Silver Spring, MD 20993, USA. Electronic address:

Retrospective analyses of interventions to epidemics, in which the effectiveness of strategies implemented are compared to hypothetical alternatives, are valuable for performing the cost-benefit calculations necessary to optimize infection countermeasures. SIR (susceptible-infected-removed) models are useful in this regard but are limited by the challenge of deciding how and when to update the numerous parameters as the epidemic changes in response to population behaviors. Behaviors of particular interest include facemasks adoption (at various levels) and social distancing. Read More

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September 2021

Cost-effectiveness Analysis of the 2019 ASCCP Risk-Based Management Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors.

Am J Obstet Gynecol 2021 Sep 18. Epub 2021 Sep 18.

Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA.

Background: Guidelines for managing abnormal cervical cancer screening tests changed from a results-based approach in 2012 to a risk-based approach in 2019. We estimated the cost-effectiveness and changes in resource utilization of the 2012 and 2019 guidelines.

Methods: We utilized a previously published model of cervical cancer natural history and screening to estimate and compare the lifetime costs and number of screens, colposcopies, precancer treatments, cancer cases, and cancer deaths associated with the 2012 versus 2019 management guidelines. Read More

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September 2021

Short-term and pathologic outcomes of robotic versus open pancreatoduodenectomy for periampullary and pancreatic head malignancy: an early experience.

J Robot Surg 2021 Sep 21. Epub 2021 Sep 21.

Department of Surgical Gastroenterology and General Surgery, Narayana Health City, Bengaluru, Karnataka, India.

Open pancreatoduodenectomy (OPD) is associated with high perioperative morbidity. Adoption of robot-assisted pancreatoduodenectomy (RAPD) has been slow despite ergonomic advantages, improved visualization and dexterity. We aim to report our experience comparing operative and short-term outcomes following RAPD and OPD. Read More

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September 2021

Cost-effectiveness analysis of vaborem for the treatment of carbapenem-resistant Enterobacteriaceae-Klebsiella pneumoniae carbapenemase (CRE-KPC) infections in the UK.

Eur J Health Econ 2021 Sep 21. Epub 2021 Sep 21.

Public Health England, Manchester, UK.

Objective: The study objective of this analysis was to determine the cost-effectiveness of vaborem (meropenem-vaborbactam) compared to the best available therapy (BAT) in adult patients with carbapenem-resistant Enterobacteriaceae-Klebsiella pneumoniae carbapenemase (CRE-KPC) infections from the perspective of the UK National Health Service (NHS) and Personal Social Services (PSS).

Methods: A decision tree model was developed to conduct a cost-effectiveness analysis for Vaborem compared to BAT in CRE-KPC patients over a 5 year time horizon. The model structure for Vaborem simulated the clinical pathway of patients with a confirmed CRE-KPC infection. Read More

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September 2021

Cost-effectiveness analysis of endovascular coiling and neurosurgical clipping for aneurysmal subarachnoid hemorrhage in Thailand.

J Neurointerv Surg 2021 Sep 20. Epub 2021 Sep 20.

Division of Social and Administrative Pharmacy, Khon Kaen University Faculty of Pharmaceutical Sciences, Khon Kaen, Thailand.

Background: For patients with aneurysmal subarachnoid hemorrhage (aSAH), the Universal Coverage Scheme in Thailand covers the full costs of surgical and endovascular procedures except for those of embolization coils and assisting devices. Costs and effectiveness were compared between endovascular coiling and neurosurgical clipping to inform reimbursement policy decisions.

Methods: Costs and quality-adjusted life years (QALYs) were compared between coiling and clipping using the decision tree and Markov models. Read More

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September 2021

Examining the cost-effectiveness of personal protective equipment for formal healthcare workers in Kenya during the COVID-19 pandemic.

BMC Health Serv Res 2021 Sep 20;21(1):992. Epub 2021 Sep 20.

Health Economics Research Unit, Kenya Medical Research Institute -Wellcome Trust, P.O Box 43640-0010, Nairobi, Kenya.

Background: Healthcare workers are at a higher risk of COVID-19 infection during care encounters compared to the general population. Personal Protective Equipment (PPE) have been shown to protect COVID-19 among healthcare workers, however, Kenya has faced PPE shortages that can adequately protect all healthcare workers. We, therefore, examined the health and economic consequences of investing in PPE for healthcare workers in Kenya. Read More

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September 2021

Cost-effectiveness analysis of domiciliary topical sevoflurane for painful leg ulcers.

PLoS One 2021 20;16(9):e0257494. Epub 2021 Sep 20.

Department of Anesthesiology, Complejo Hospitalario Universitario, Albacete, Spain.

Objectives: The general anesthetic sevoflurane is being repurposed as a topical analgesic for painful chronic wounds. We conducted a Bayesian cost-effectiveness analysis (CEA) comparing the addition of domiciliary topical sevoflurane to conventional analgesics (SEVOFLURANE, n = 38) versus conventional analgesics alone (CONVENTIONAL, n = 26) for the treatment of nonrevascularizable painful leg ulcers in an outpatient Pain Clinic of a Spanish tertiary hospital.

Methods: We used real-world data collected from charts to conduct this CEA from a public healthcare perspective and with a one-year time horizon. Read More

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September 2021

Economic evaluation of the Happy Talk pilot effectiveness trial: A targeted selective speech, language and communication intervention for children from areas of social disadvantage.

Int J Speech Lang Pathol 2021 Sep 20:1-12. Epub 2021 Sep 20.

Department of Economics, University College Cork, Cork, Ireland.

This study presents a cost-effectiveness analysis of a targeted selective pre-school intervention programme, "Happy Talk", which focuses on language development, by simultaneously enhancing parental interaction and the pre-school environment. Happy Talk (delivered to 77 children) is an add on intervention, and is compared to usual care, adopting a healthcare perspective. Cost-effectiveness analyses were carried out using the Pre-school Language Scale 5- Total (PLS-5) for baseline analysis and the Child Health Utility Instrument (CHU9D) in a secondary analysis. Read More

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September 2021

Recycling Nutrients and Reducing Carbon Emissions in the Baltic Sea Region-Sustainable or Economically Infeasible?

Environ Manage 2021 Sep 20. Epub 2021 Sep 20.

Stockholm Environment Institute, Linnégatan 87D, 104 51, Stockholm, Sweden.

Ecotechnologies have the potential to reduce the use of finite resources while providing a variety of co-benefits to society, though they often lack in market competitiveness. In this study, we investigate the sustainability of ecotechnologies for recovering carbon and nutrients, and demonstrate how a so-called "bottom-up" approach can serve as a decision-making instrument. Based on three case study catchments with a focus on domestic wastewater in Sweden and Poland, and on manure, grass and blackwater substrates in Finland, we apply a cost-benefit analysis (CBA) on system alternatives derived from a participatory process. Read More

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September 2021

Why are we vaccinating children against COVID-19?

Toxicol Rep 2021 14;8:1665-1684. Epub 2021 Sep 14.

Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003, Heraklion, Greece.

This article examines issues related to COVID-19 inoculations for children. The bulk of the official COVID-19-attributed deaths per capita occur in the elderly with high comorbidities, and the COVID-19 attributed deaths per capita are negligible in children. The bulk of the normalized post-inoculation deaths also occur in the elderly with high comorbidities, while the normalized post-inoculation deaths are small, but not negligible, in children. Read More

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September 2021

The Positive Value of Rotation-Specific Guides for Resident Education and Patient Care: A Process Improvement Study.

Cureus 2021 Aug 17;13(8):e17262. Epub 2021 Aug 17.

Vascular Surgery, Detroit Medical Center, Detroit, USA.

Introduction Providing high-quality cost-effective patient care requires knowledge of treatment protocols as well as an understanding of the institution's procedures, e.g., what orders to place and how to effectively place them. Read More

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Nonlinear Dynamical Analysis and Optimal Control Strategies for a New Rumor Spreading Model with Comprehensive Interventions.

Qual Theory Dyn Syst 2021 15;20(3):84. Epub 2021 Sep 15.

School of Science, Guilin University of Technology, Guilin, 541004 Guangxi People's Republic of China.

In the current era, information dissemination is more convenient, the harm of rumors is more serious than ever. At the beginning of 2020, COVID-19 is a biochemical weapon made by a laboratory, which has caused a very bad impact on the world. It is very important to control the spread of these untrue statements to reduce their impact on people's lives. Read More

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September 2021

Cost-effectiveness of routine catch-up hepatitis a vaccination in the United States: Dynamic transmission modeling study.

Vaccine 2021 Sep 17. Epub 2021 Sep 17.

Merck & Co., Inc, Kenilworth, NJ, USA.

Background: Despite routine vaccination of children against hepatitis A (HepA), a large segment of the United States population remains unvaccinated, imposing a risk of hepatitis A virus (HAV) to adolescents and adults. In July of 2020, the Advisory Committee on Immunization Practices recommended that all children and adolescents aged 2-18 years who have not previously received a HepA vaccine be vaccinated. We evaluated the public health impact and cost-effectiveness of this HepA catch-up vaccination strategy. Read More

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September 2021

A pilot randomized trial of CBT4CBT for women in residential treatment for substance use disorders.

J Subst Abuse Treat 2021 Sep 13:108622. Epub 2021 Sep 13.

Department of Psychology and Institute of Women's Health, Virginia Commonwealth University, Richmond, VA, United States of America.

Introduction: Despite the effectiveness of cognitive behavioral therapy (CBT) for treatment of substance use disorder, dissemination to clinical practice is limited due to a range of barriers (e.g., time, cost). Read More

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September 2021

Respiratory physiotherapy interventions focused on exercise training and enhancing physical activity levels in people with chronic obstructive pulmonary disease are likely to be cost-effective: a systematic review.

J Physiother 2021 Sep 15. Epub 2021 Sep 15.

Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerp, Belgium.

Question: What is the cost-effectiveness of respiratory physiotherapy interventions for people with chronic obstructive pulmonary disease?

Design: Systematic review of full economic evaluations alongside clinical trials published between 1997 and 2021. Reviewers independently screened studies for inclusion, extracted data and assessed methodological quality.

Participants: People with chronic obstructive pulmonary disease. Read More

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September 2021

Economic evaluations and costing studies of lung transplantation: A scoping review.

J Heart Lung Transplant 2021 Aug 26. Epub 2021 Aug 26.

Institute of Health Policy, Management and Evaluation, University of Toronto, ON, Canada; Toronto Health Economics and Technology Assessment Collaborative, Toronto, ON, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; Department of Medicine, University Health Network, Toronto, ON, Canada.

Background: Evaluation of the joint clinical and economic impacts of lung transplant and associated technologies is crucial for evidence-informed decision-making and wise allocation of scarce healthcare resources. We performed a scoping review to summarize and categorize the available evidence of the costs and cost-effectiveness of lung transplantation.

Methods: A systematic search of MEDLINE, EMBASE, NHS EED, and EconLit was performed to identify studies involving lung transplantation for adults that measured costs, cost-effectiveness, or which described themselves as economic evaluations. Read More

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Cost-benefit analysis of calibration model maintenance strategies for process monitoring.

Anal Chim Acta 2021 Oct 27;1180:338890. Epub 2021 Jul 27.

Radboud University, Institute for Molecules and Materials, P.O. Box 9010, 6500 GL, Nijmegen, the Netherlands. Electronic address:

The long-term prediction performance of spectroscopic calibration models is a critical factor to monitor or control many production processes. Over time, new variations may emerge that deteriorate prediction performance. Therefore, models have to be maintained to retain or improve their prediction performance through time, requiring considerable resources and data. Read More

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October 2021

Cost-effectiveness analysis for SilAtro-5-90 adjuvant treatment in the management of recurrent tonsillitis, compared with usual care only.

Cost Eff Resour Alloc 2021 Sep 19;19(1):60. Epub 2021 Sep 19.

Care Policy and Evaluation Centre, Department of Health Policy, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, UK.

Purpose: Antibiotics are one possible treatment for patients with recurrent acute throat infections (ATI), but effectiveness can be modest. In view of worries over antibiotic resistance, treatment pathways that reduce recurrence of ATI are essential from a public health perspective. Integrative treatment strategies can be an option but there is still a high demand to provide evidence of their cost effectiveness. Read More

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September 2021

Evaluation of the "Let's Get Organized" group intervention to improve time management: protocol for a multi-centre randomised controlled trial.

Trials 2021 Sep 19;22(1):640. Epub 2021 Sep 19.

University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: Time management skills are essential for living in modern society. People with mental or neurodevelopmental disorders typically have cognitive limitations, including affected time management, which might lead to poor occupational balance, low self-efficacy, and poor parental sense of competence. "Let's Get Organized" (LGO) is a recently developed manual-based group intervention to train time management skills. Read More

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September 2021

Cost utility analysis of Remdesivir and Dexamethasone treatment for hospitalised COVID-19 patients - a hypothetical study.

BMC Health Serv Res 2021 Sep 18;21(1):986. Epub 2021 Sep 18.

Department of Business and Economics, University of Cagliari, Viale S. Ignazio 17, Cagliari, 09123, Italy.

Background: Sars-Cov-2 is a novel corona virus associated with significant morbidity and mortality. Remdesivir and Dexamethasone are two treatments that have shown to be effective against the Sars-Cov-2 associated disease. However, a cost-effectiveness analysis of the two treatments is still lacking. Read More

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September 2021

Cost-effectiveness of field trauma triage among injured children transported by emergency medical services.

Am J Emerg Med 2021 Aug 20;50:492-500. Epub 2021 Aug 20.

Center for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health and Science University, Portland, OR, United States of America.

Background: A pediatric field triage strategy that meets the national policy benchmark of ≥95% sensitivity would likely improve health outcomes but increase heath care costs. Our objective was to compare the cost-effectiveness of current pediatric field triage practices to an alternative field triage strategy that meets the national policy benchmark of ≥95% sensitivity.

Study Design: We developed a decision-analysis Markov model to compare the outcomes and costs of the two strategies. Read More

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Comparative Analysis of the Results of Cyanoacrylate Ablation and Radiofrequency Ablation in the Treatment of Venous Insufficiency.

J Vasc Surg Venous Lymphat Disord 2021 Sep 15. Epub 2021 Sep 15.

Professor. Ege University Faculty of Medicine, Department of Cardiovascular Surgery, İzmir, Turkey. Electronic address:

Background: Varicose vein treatment has shifted to less invasive techniques.

Objective: The present study was designed to compare the effectiveness of cyanoacrylate ablation (CAA) with radiofrequency ablation (RFA).

Materials And Methods: Patients undergoing RFA and CAA (634 vs 246 patients respectively) due to great saphenous vein (GSV) insufficiency over 5 years were included in the study. Read More

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September 2021

Induction of labour at 41 weeks of gestation versus expectant management and induction of labour at 42 weeks of gestation: a cost-effectiveness analysis.

BJOG 2021 Sep 17. Epub 2021 Sep 17.

School of Public Health & Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objective: To assess the cost-effectiveness of induction of labour (IOL) at 41 weeks of gestation compared with expectant management until 42 weeks of gestation.

Design: A cost-effectiveness analysis alongside the Swedish Postterm Induction Study (SWEPIS), a multicentre, randomised controlled superiority trial.

Setting: Fourteen Swedish hospitals during 2016-2018. Read More

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September 2021

Cost-effectiveness of a Digital Health Intervention for Acute Myocardial Infarction Recovery.

Med Care 2021 Sep 17. Epub 2021 Sep 17.

Johns Hopkins Bloomberg School of Public Health Johns Hopkins University School of Nursing Digital Health Innovation Laboratory, Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine Johns Hopkins University School of Medicine, Baltimore, MD Department of Pharmaceutical & Health Economics, School of Pharmacy, University of Southern California Leonard D. Schaeffer Center for Health Economics & Policy, University of Southern California, Los Angeles, CA Dimock Center Johns Hopkins University Whiting School of Engineering, Baltimore, MD Massachusetts General Hospital, Boston, MA Reading Hospital, West Reading, PA Harvard Medical School, Boston, MA Johns Hopkins University Krieger School of Arts and Sciences Johns Hopkins Health System, Baltimore, MD.

Background: Acute myocardial infarction (AMI) is a common cause of hospital admissions, readmissions, and mortality worldwide. Digital health interventions (DHIs) that promote self-management, adherence to guideline-directed therapy, and cardiovascular risk reduction may improve health outcomes in this population. The "Corrie" DHI consists of a smartphone application, smartwatch, and wireless blood pressure monitor to support medication tracking, education, vital signs monitoring, and care coordination. Read More

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September 2021

Quality of Life in Pediatric Minimally Invasive Surgery. Cost-Utility Analysis of Laparoscopic Versus Open Appendectomy.

J Laparoendosc Adv Surg Tech A 2021 Sep 17. Epub 2021 Sep 17.

Pediatric Surgery Departament, León University Hospital, León, Spain.

Economic evaluation in health care is becoming increasingly important. Laparoscopic appendectomy (LAp) is one of the most frequent minimally invasive procedures in the pediatric population. The increased costs of this approach in any indication could be justified by proving its cost-utility in terms of health-related quality of life (HRQoL). Read More

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September 2021

Using latent class and quantum models to value equity in health care: a tale of 2 stories.

J Manag Care Spec Pharm 2021 Sep;27(9-a Suppl):S14-S18

Department of Health Outcomes Research & Policy, Harrison School of Pharmacy, Auburn University, Auburn, AL.

Cost-effectiveness analysis (CEA) with quality-adjusted life-year (QALY) was introduced to address health equity concerns in value assessment. However, QALY fails to capture patient preference. Stated preference methods (eg, discrete choice experiment [DCE]) have been increasingly used to incorporate patient preference into the value assessment framework in health care. Read More

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September 2021

Clinic price reductions in a tiered total cost benefit design.

Am J Manag Care 2021 Aug 1;27(8):e316-e321. Epub 2021 Aug 1.

Pardee RAND Graduate School, 1776 Main St, Santa Monica, CA 90401. Email:

Objectives: To understand responses of primary care clinics to inclusion in a tiered total cost of care insurance benefit design.

Study Design: We used a qualitative design beginning with longitudinal analysis of administrative data on consumer clinic choice, clinic tier placement, and clinic actions, followed by in-depth interviews with key informants from clinics, administering health plans, and program administrators.

Methods: We collected data via semistructured interviews with purposively sampled key informants selected from clinics that prospectively reduced prices to move to, or remain in, a tier with lower cost sharing. Read More

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Cost-Utility Analysis of Sacubitril-Valsartan Compared with Enalapril Treatment in Patients with Acute Decompensated Heart Failure in Thailand.

Clin Drug Investig 2021 Sep 17. Epub 2021 Sep 17.

Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, 239 Huaykaew Road, Suthep, Chiang Mai, 50200, Thailand.

Background: Sacubitril-valsartan is effective in reducing the N-terminal pro-B-type natriuretic peptide level of hospitalized patients with acute decompensated heart failure, with a high acquisition cost compared with enalapril treatment.

Objective: This study aimed to determine the cost utility of sacubitril-valsartan compared with enalapril for acute decompensated heart failure treatment.

Methods: A Markov model was constructed to project the total costs, life-years, quality-adjusted life-years (QALYs) of early initiation, and a 2-month delay of sacubitril-valsartan treatment and enalapril treatment in hospitalized patients with acute decompensated heart failure over a lifetime horizon from a Thai healthcare system perspective. Read More

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September 2021

Using Acoustic Speech Patterns From Smartphones to Investigate Mood Disorders: Scoping Review.

JMIR Mhealth Uhealth 2021 Sep 17;9(9):e24352. Epub 2021 Sep 17.

Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Background: Mood disorders are commonly underrecognized and undertreated, as diagnosis is reliant on self-reporting and clinical assessments that are often not timely. Speech characteristics of those with mood disorders differs from healthy individuals. With the wide use of smartphones, and the emergence of machine learning approaches, smartphones can be used to monitor speech patterns to help the diagnosis and monitoring of mood disorders. Read More

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September 2021