187,819 results match your criteria corticosteroid treatment

Oral selenium improved the disease activity in patients with mild Graves' orbitopathy.

J Fr Ophtalmol 2021 Apr 13. Epub 2021 Apr 13.

Instituto de Oftalmologia Conde de Valenciana, IAP, Chimalpopoca # 14, Colonia Obrera, Delegación Cuauhtemoc, 06800, Mexico City, Mexico. Electronic address:

Background: Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD), an autoimmune disorder arising from the activity of T lymphocytes against antigens that infiltrate thyroid tissue, orbital tissue and extraocular muscles. An increase in oxidative stress has been discovered in autoimmune thyroid disease, encouraging investigation into new forms of treatment. Selenium has been described as a treatment option given its antioxidant properties. Read More

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Low-Dose Corticosteroid Combined With Mycophenolate Mofetil for IgA Nephropathy With Stage 3 or 4 CKD: A Retrospective Cohort Study.

Clin Ther 2021 Apr 13. Epub 2021 Apr 13.

Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Purpose: This study assessed the long-term (10-year) tolerability and efficacy of a low-dose corticosteroid combined with mycophenolate mofetil (CS + MMF) in the treatment of immunoglobulin A nephropathy (IgAN) with stage 3/4 chronic kidney disease and proteinuria in clinical practice in China.

Methods: Data from patients with biopsy-proven IgAN, stage 3/4 chronic kidney disease (estimated glomerular filtration rate 15-59 mL/min/1.73 m), and proteinuria (urinary protein excretion ≥1. Read More

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[Prevalence of Arterial Hypertension in a neonatal intensive care unit].

Rev Chil Pediatr 2020 Dec 8;91(6):891-898. Epub 2020 Oct 8.

Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: The prevalence of neonatal hypertension in neonatal intensive care units (NICU) ranges between 3 and 9%. However, there is no current data on Latin America.

Objective: To estimate the prevalence of neonatal hypertension and to assess its association with causes previously related to this condi tion. Read More

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December 2020

Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial.

Pediatr Nephrol 2021 Apr 16. Epub 2021 Apr 16.

Chacha Nehru Bal Chikitsalaya, Delhi, India.

Background: Reduction of steroid exposure in relapses of steroid-sensitive nephrotic syndrome (SSNS) is under-researched.

Methods: In this randomized controlled non-inferiority trial, 1-12-year-old children with relapse of SSNS were randomized to receive prednisolone 1 mg/kg/day (low dose) or 2 mg/kg/day (standard dose) until disease remission or day 15, whichever was earlier. Therapy was switched to 2 mg/kg/day in children in low-dose group not in remission by day 15. Read More

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The incidence and management of shoulder complaints in general practice: a retrospective cohort study.

Fam Pract 2021 Apr 16. Epub 2021 Apr 16.

Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands.

Background: Shoulder pain is the third most common musculoskeletal complaint in primary care. The international guidelines for general practitioners (GPs) recommend a stepwise treatment of shoulder pain. Little is known about the actual distribution of these treatments in current practice. Read More

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IgG4-related kidney disease: Pathogenesis, diagnosis, and treatment.

Clin Nephrol 2021 Apr 16. Epub 2021 Apr 16.

IgG4-related disease (IgG4-RD) is a recently recognized multisystem disease characterized by lymphoplasmacytic inflammation and fibrosis in affected tissues that can affect several organs including the kidney, the involvement of which is often manifested by tubulointerstitial nephritis. The pathogenic mechanisms of IgG4-RD are divided into two sections: one focused on potential initiation mechanisms, particularly genetic, and the other on specific pathological pathways. For the specific pathological pathways, cellular immunity, particularly T-cell mediated immunity, has been implicated in the pathogenesis of IgG4-RD. Read More

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Analysis of the safety of pretransplant corticosteroid therapy in patients with acute liver failure and late-onset hepatic failure in Japan.

JGH Open 2021 Apr 5;5(4):428-433. Epub 2021 Mar 5.

Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine Ube Japan.

Background And Aim: In Japan, corticosteroids have been commonly used as a part of multidisciplinary therapy for patients with acute liver failure and late-onset hepatic failure. However, there is controversy regarding the development of infections and other complications. In this study, the influence of corticosteroids on patient outcomes after liver transplantation was investigated. Read More

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Complications of Cardiovascular Events in Patients Hospitalized with Influenza-Related Pneumonia.

Infect Drug Resist 2021 9;14:1363-1373. Epub 2021 Apr 9.

Department of Pulmonary and Critical Care Medicine, The 2nd People's Hospital of Yunnan Province, Kunming City, People's Republic of China.

Purpose: Influenza virus infections are a key cause of community-acquired pneumonia (CAP). Cardiovascular events (CVEs) are common among CAP and influenza patients, but there have been few population-based studies of influenza-related pneumonia (Flu-p) patients published to date.

Methods: A retrospective analysis of 1191 immunocompetent hospitalized adult Flu-p patients from January 2012 to December 2018 in five teaching hospitals in China was conducted. Read More

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Optimal inflammatory bowel disease management during the global coronavirus disease 2019 pandemic.

Curr Opin Gastroenterol 2021 Apr 14. Epub 2021 Apr 14.

Digestive Diseases Institute, Cleveland Clinic Abu Dhabi, United Arab Emirates Department of Gastroenterology, Hepatology & Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Purpose Of Review: This review aims to summarize the current evidence regarding the risks and implications of coronavirus disease 2019 (COVID-19) in patients with inflammatory bowel disease (IBD) and discuss optimal management of IBD during this pandemic.

Recent Findings: Patients with IBD are not at increased risk of COVID-19 but several risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection) have been identified, such as active IBD, obesity, and corticosteroid use. COVID-19 outcomes are similar among patients with IBD and the overall population. Read More

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Evaluation of patients diagnosed with psoriasis and multiple myeloma after autologous stem cell transplantation.

Transfus Apher Sci 2021 Apr 8:103137. Epub 2021 Apr 8.

University of Health Sciences, Bozyaka Education and Traing Hospital, Department of Hematology, Izmir, Turkey.

Introduction: The secretion of monoclonal immunoglobulins increase in chronic inflammatory disorders such as chronic infections and autoimmune diseases. This risk is further increased by the biological agents used in the treatment of autoimmune diseases such as psoriasis. Hematological malignancies occurring in patients with psoriasis provides an opportunity to evaluate the effect of autologous or allogeneic stem cell transplantation in this immune-mediated disease. Read More

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The time of postoperative corticosteroid injection can be individualized after arthroscopic rotator cuff repair.

J Orthop Sci 2021 Apr 12. Epub 2021 Apr 12.

Department of Orthopedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background: Intra-articular corticosteroid injection is an effective treatment for pain and to improve the range of motion (ROM) of the shoulder joint. However, consideration of when it would be effective to inject corticosteroids after rotator cuff repair is more limited. The purpose of this study was to compare the outcomes of corticosteroids injection given at 4 and 8 weeks after arthroscopic rotator cuff repair. Read More

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Comparison of the corticosteroid injection and hyaluronate in the treatment of chronic subacromial bursitis: A randomized controlled trial.

Clin Rehabil 2021 Apr 15:2692155211007799. Epub 2021 Apr 15.

Department of Physical Medicine & Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei.

Objective: To analyse the effectiveness of corticosteroid (CS) and hyaluronic acid (HA) subacromial - subdeltoid (SASD) injection compared with normal saline (NS) in patients with chronic subacromial bursitis (CSB).

Design: A prospective three-arm double-blinded randomised controlled trial.

Setting: Rehabilitation department of two teaching hospitals. Read More

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Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis - A study of in vitro, in vivo and clinical trial.

J Ethnopharmacol 2021 Apr 12:114116. Epub 2021 Apr 12.

Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Ethnopharmacological Relevance: Glycyrrhiza glabra, a family of licorice and a traditional Chinese medicine with sweet taste and favorable smell, has anti-inflammatory, anti-allergic and immunomodulatory functions.

Aim Of The Study: We developed a licorice extract (LE) by using glycyrrhiza glabra and administered it through nasal irrigation to treat allergic rhinitis (AR).

Materials And Methods: LE was prepared into extract powder, and the anti-inflammatory effect of the LE was evaluated by calcium ionophore-induced activated mast cell model (in vitro). Read More

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CyberKnife for Recurrent Malignant Gliomas: A Systematic Review and Meta-Analysis.

Front Oncol 2021 29;11:652646. Epub 2021 Mar 29.

Unit of Neurosurgery, University of Brescia and ASST Spedali Civili, Brescia, Italy.

Background And Objective: Possible treatment strategies for recurrent malignant gliomas include surgery, chemotherapy, radiotherapy, and combined treatments. Among different reirradiation modalities, the CyberKnife System has shown promising results. We conducted a systematic review of the literature and a meta-analysis to establish the efficacy and safety of CyberKnife treatment for recurrent malignant gliomas. Read More

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Successful corticosteroid treatment of necrotizing sarcoid granulomatosis associated with tracheal lesion recurred after a surgical lung biopsy.

Respir Med Case Rep 2021 19;33:101402. Epub 2021 Mar 19.

Department of Respiratory Medicine, National Hospital Organization Iwakuni Clinical Center, 1-1-1 Atago-machi, Iwakuni-City, Yamaguchi, 740-8510, Japan.

Necrotizing sarcoid granulomatosis (NSG) is a rare disease that presents with nodular lung lesions and necrosis. The pathology is consistent with sarcoidosis, but the necrosis can lead to a diagnosis of tuberculosis. Herein, we report a rare case of NSG that recurred four years after the initial diagnosis was made by surgical lung biopsy. Read More

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Transverse myelitis masquerading as cauda equina syndrome, stroke and cervical myelopathy.

Biomedicine (Taipei) 2020 28;10(1):45-50. Epub 2020 Mar 28.

Division of Spine, Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

Transverse myelitis is an uncommon but well-defined neurological syndrome. However, a high index of suspicion is needed to diagnose this condition, especially when it occurs in concomitance with preexisting spinal canal stenosis. We report our patient, a 48 year old male, who initially presented to our spine clinic with acute onset unilateral lower limb weakness associated with urinary retention, which was suspected to be cauda equina syndrome due to a prolapsed intervertebral disc. Read More

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Allergic Rhinitis Therapy Decisions During a Routine Consultation: A Multicenter, Cross-Sectional Survey.

J Asthma Allergy 2021 7;14:335-345. Epub 2021 Apr 7.

Global Medical Affairs, MEDA Pharma GmbH & Co. KG (A Mylan Company), Bad Homburg, Germany.

Background: Allergic rhinitis (AR) is characterized by nasal and ocular symptoms, and substantially impacts the quality of life. Therapy selection for patients with AR depends on several factors, including symptom severity, age, patient preference, patient adherence, and cost.

Methods: The purpose of this multicenter, noninterventional, cross-sectional survey was to evaluate current therapy decisions in routine clinical practice for patients with symptomatic AR, and to determine how these decisions are linked to experiences with previous treatments and current symptom severity as assessed by aVAS. Read More

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Budesonide MMX in the Treatment of Ulcerative Colitis: Current Perspectives on Efficacy and Safety.

Ther Clin Risk Manag 2021 7;17:285-292. Epub 2021 Apr 7.

Gastroenterology Unit, Department of Biomedical and Clinical Sciences FBF - L.Sacco, University Hospital, Milan, Italy.

Budesonide MMX is a low bioavailability corticosteroid oral once-daily formulation, which has a controlled rate of release throughout the colon, thanks to the multimatrix (MMX) formulation. It has been available for a decade in the USA and Europe for the induction of remission in patients with active, mild to moderate ulcerative colitis, particularly for those not responsive to mesalamine. The efficacy of budesonide MMX in this setting has been assessed by registrative randomized controlled trials showing a higher rate of clinical and endoscopic remission at 8 weeks compared with placebo, mostly in patients with proctosigmoiditis and left-side colitis. Read More

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Sarcoidosis during treatment of pulmonary tuberculosis: a rare case report and review of the literature.

J Int Med Res 2021 Apr;49(4):3000605211001632

Department of Radiology, Chungbuk National University Hospital, Cheongju, Korea.

The coexistence of pulmonary tuberculosis and pulmonary sarcoidosis is rare. Further, the morphological features of pulmonary tuberculosis with comorbid pulmonary sarcoidosis are similar to those of tuberculosis alone. There are obvious clinical, histological, and radiological similarities between sarcoidosis and tuberculosis, which makes differential diagnosis very challenging, particularly in countries with a high burden of tuberculosis. Read More

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[Biological Treatments in patients with ABPA].

Tuberk Toraks 2021 Mar;69(1):84-93

Division of İmmunology and Allergy, Department of Chest Diseases, Ankara University Faculty of Medicine, Ankara, Turkey.

Allergic Bronchopulmonary Aspergillosis (ABPA) is a pulmonary disease characterized by recurrent pulmonary opacities and bronchiectasis caused by Type 1 hypersensitivity to A. fumigatus. Asthma is an important part of the disease and is generally in severe form. Read More

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High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status.

Cell Rep 2021 Apr;35(2):108974

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-resistant asthma patients cluster largely into two groups: one enriched in interleukin (IL)-4 innate immune cells and another dominated by interferon (IFN)-γ T cells, including tissue-resident memory cells. In contrast, BAL cells of a healthier population are enriched in IL-10 macrophages. Read More

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Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events.

Cochrane Database Syst Rev 2021 Apr 14;4:CD007694. Epub 2021 Apr 14.

Cochrane Airways, Population Health Research Institute, St George's, University of London, London, UK.

Background: Asthma is characterised by chronic inflammation of the airways and recurrent exacerbations with wheezing, chest tightness, and cough. Treatment with inhaled steroids and bronchodilators can result in good control of symptoms, prevention of further morbidity, and improved quality of life. However, an increase in serious adverse events with the use of both regular formoterol and regular salmeterol (long-acting beta₂-agonists) compared with placebo for chronic asthma has been demonstrated in previous Cochrane Reviews. Read More

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Management of primary immune thrombocytopenia in a real-world setting in Japan: eltrombopag versus corticosteroids.

Int J Hematol 2021 Apr 13. Epub 2021 Apr 13.

Department of Blood Transfusion, Osaka University Hospital, Suita, Osaka, Japan.

This real-world study in Japan assessed the long-term safety of persistent use of eltrombopag compared to corticosteroids. Overall, 1887 patients with primary immune thrombocytopenia were included in the study cohort, based on hospital claims data. Eltrombopag was frequently used as a second- or third-line therapy (monotherapy: 13. Read More

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Lupus-Like Glomerulonephritis Associated With Regorafenib, a Multikinase Inhibitor.

Kidney Med 2021 Mar-Apr;3(2):294-298. Epub 2021 Feb 5.

Section of Nephrology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.

Drug-induced lupus glomerular diseases have historically been associated with hydralazine, but new drugs that modify the growth, metabolism, and immunity of cells are increasingly found to cause glomerular disease. This includes anti-tumor necrotic factor and other antibody agents used in cancer treatment. Multitarget tyrosine kinases such as regorafenib are increasingly used in metastatic malignancies with good outcomes. Read More

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February 2021

Early rehabilitation after lung transplantation with extracorporeal membrane oxygenation (ECMO) of COVID-19 patient: a case report.

Ann Transl Med 2021 Mar;9(6):512

Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Even when severe acute respiratory syndrome coronavirus 2-related coronavirus disease 2019 (COVID-19) is treated with first-line drugs, it progresses and leads to irreversible loss of lung function in some critically ill patients, and lung transplantation is an effective treatment for end-stage chronic pulmonary disease. This case report mainly describes the rehabilitation of a 66-year-old female patient with severe COVID-19 after bilateral lung transplantation. The old patient had a body mass index of 31. Read More

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Periapical abscess progressing to parotitis and descending necrotizing mediastinitis with thoracic abscess in a patient on etanercept: A case report.

Int J Crit Illn Inj Sci 2020 Oct-Dec;10(4):220-223. Epub 2020 Dec 29.

Department of Emergency Medicine, Vidant Medical Center, East Carolina University Brody School of Medicine, Greenville, NC, USA.

Patients on Type 2 biologics, such as etanercept, are at increased risk for aggressive infections. This may be further exacerbated by concomitant systemic corticosteroid use or comorbidities such as diabetes. We report a case of a patient with rheumatoid arthritis on etanercept with poor dentition and periodontal disease, who developed parotitis with peritonsillar abscess and descending necrotizing mediastinitis (DNM) with periaortic abscess arising from a periapical abscess. Read More

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December 2020

A Randomized Clinical Trial on the Effect of Biofeedback on Pain and Quality of Life of Patients With Chronic Coccydynia.

Basic Clin Neurosci 2020 Nov-Dec;11(6):753-763. Epub 2020 Nov 1.

Neuromusculoskeletal Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Pelvic floor muscles dysfunction is one of the most important etiologies of coccydynia; therefore, manual therapies have been proposed as the first line of treatment. The purpose of this study was to investigate the effect of biofeedback as a new approach in the treatment of coccydynia.

Methods: Thirty women were randomized into two groups. Read More

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November 2020

Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study.

Int J Med Sci 2021 10;18(9):2042-2050. Epub 2021 Mar 10.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

The interaction between hyperuricemia and the cognitive system is still under debate, with studies presenting somewhat conflicting results. This study aimed to investigate the risk of dementia in patients with gout who are administered anti-inflammatory drug treatment. Gouty arthritis patients aged 50 years and older, who received at least one of the background therapy drugs (colchicine, corticosteroids, or nonsteroidal anti-inflammatory drugs for 6 months), were divided into the following groups and compared: patients who had dementia over a period of 5 years (n = 2,292) and matched patients without dementia (n = 2,292). Read More

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Rapid corticosteroid taper versus standard of care for immune checkpoint inhibitor induced nephritis: a single-center retrospective cohort study.

J Immunother Cancer 2021 Apr;9(4)

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

Background: Current guidelines for treatment of immune checkpoint inhibitor (ICI)-induced nephritis are not evidence based and may lead to excess corticosteroid exposure. We aimed to compare a rapid corticosteroid taper to standard of care.

Methods: Retrospective cohort study in patients with ICI-induced nephritis comparing a rapid taper beginning with 60 mg/day prednisone and tapered to 10 mg within 3 weeks to a historical control group that began 60 mg/day tapered to 10 mg within 6 weeks (standard of care). Read More

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