129 results match your criteria cortex left-dominant

Speech-Brain Frequency Entrainment of Dyslexia with and without Phonological Deficits.

Brain Sci 2020 Nov 28;10(12). Epub 2020 Nov 28.

Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

Developmental dyslexia is a cognitive disorder characterized by difficulties in linguistic processing. Our purpose is to distinguish subtypes of developmental dyslexia by the level of speech-EEG frequency entrainment (δ: 1-4; β: 12.5-22. Read More

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November 2020

SQSTM1 variant in disorders of the frontotemporal dementia-amyotrophic lateral sclerosis spectrum: identification of a novel heterozygous variant and a review of the literature.

J Neurol 2021 Apr 30;268(4):1351-1357. Epub 2020 Oct 30.

Department of Neurology, Shengjing Hospital of China Medical University, Sanhao Street 36, Shenyang, 110004, Liaoning, China.

Introduction: Accumulating evidence shows that SQSTM1 plays a vital role in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which represent a neurodegenerative disease continuum. Here, we report a novel SQSTM1 variant in a patient presenting with progressive nonfluent aphasia (PNFA) and progressive bulbar palsy (PBP). Relevant literature about FTD and FTD-ALS caused by SQSTM1 mutation was reviewed to better understand its clinical features. Read More

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Global cortical hypoexcitability of the dominant hemisphere in major depressive disorder: A transcranial magnetic stimulation study.

Neurophysiol Clin 2020 Jul 10;50(3):175-183. Epub 2020 Mar 10.

Neuropsychiatry Department, Faculty of Medicine, Assiut University Hospital, 71511 Assiut, Egypt.

Background: Accumulating evidence suggests that major depressive disorders (MDD) are associated with an imbalance of excitation-inhibition within the prefrontal cortex (PFC), generated by a deficit of inhibitory synaptic transmission onto glutamatergic principal neurons. Transcranial magnetic stimulation (TMS) protocols can be used to measure neuronal excitability and GABAergic inhibition and thus provide additional evidence to evaluate this theory.

Objective: In the present study, TMS protocols were used to compare GABAergic function and cortical excitability of dominant hemisphere in unmedicated patients with MDD versus a control group of healthy individuals. Read More

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Prefrontal Cortex Neuromodulation Enhances Frontal Asymmetry and Reduces Caloric Intake in Patients with Morbid Obesity.

Obesity (Silver Spring) 2020 04 6;28(4):696-705. Epub 2020 Mar 6.

Neurosciences Research Program. Integrative Pharmacology and Systems Neuroscience Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.

Objective: The objective of this study was to test the feasibility of a combined intervention involving transcranial direct current stimulation (tDCS) on the dorsolateral prefrontal cortex (dlPFC) and cognitive training (CT). Short-term effects on food consumption, cognition, endocannabinoid (eCB) levels, and electroencephalogram (EEG) markers of future weight loss were explored.

Methods: Eighteen healthy volunteers with morbid obesity were randomized in a double-blind, placebo-controlled, parallel trial. Read More

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Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy.

Neuropathology 2020 Jun 10;40(3):287-294. Epub 2020 Jan 10.

Department of Neurology, Tokyo Teishin Hospital, Tokyo, Japan.

Corticobasal degeneration (CBD) is a rare progressive neurodegenerative disorder characterized by asymmetric presentation of cerebral cortex signs, cortical sensory disturbance and extrapyramidal signs. Herein, we report a case of a 66-year-old Japanese woman who presented with apraxia of the right hand. She subsequently developed postural instability and cognitive impairments that rapidly worsened. Read More

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Eye dominance modulates visuospatial attention.

Neuropsychologia 2020 04 21;141:107314. Epub 2019 Dec 21.

Integrative Multisensory Perception Action & Cognition Team (ImpAct), INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center (CRNL), Lyon, France; University of Lyon 1, Lyon, France; Hospices Civils de Lyon, Mouvement & Handicap, Neuro-Immersion Platforms, Lyon, France; Center for Mind/Brain Sciences (CIMeC), University of Trento, Italy.

Visuospatial attention has an inherent asymmetry: the leftward bias called pseudoneglect. In typical line bisection tasks, healthy individuals tend to judge the center of a line leftward of the true center, an effect attributed to the right hemisphere dominance in visuospatial attention. Since it has been shown that information perceived by the dominant eye strongly activates the ipsilateral visual cortex, we hypothesized that eye dominance may modulate visuospatial attention bias. Read More

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Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: A Pilot MRI/MRS Study at 7 T.

Front Neurosci 2019 27;13:1260. Epub 2019 Nov 27.

Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation method commonly used in the disciplines of neuroscience, neurology, and neuropsychiatry to examine or modulate brain function. Low frequency rTMS (e.g. Read More

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November 2019

Complete resolution of postherpetic neuralgia following pallidotomy: case report.

J Neurosurg 2019 Sep 27:1-6. Epub 2019 Sep 27.

1Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

The authors report on a female patient with left-dominant Parkinson's disease with motor fluctuations and levodopa-induced dyskinesias and comorbid postherpetic neuralgia (PHN), who underwent a right-sided pallidotomy. Besides a substantial improvement in her Parkinson's symptoms, she reported an immediate and complete disappearance of PHN. This neuralgia had been long-standing, pharmacologically refractory, and severe (preoperative Brief Pain Inventory [BPI] pain severity score of 8. Read More

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September 2019

Auditory T-Complex Reveals Reduced Neural Activities in the Right Auditory Cortex in Musicians With Absolute Pitch.

Front Neurosci 2019 6;13:809. Epub 2019 Aug 6.

Center for Integrated Human Brain Science, Brain Research Institute, Niigata University, Niigata, Japan.

Absolute pitch (AP) is the ability to identify the pitch names of arbitrary musical tones without being given a reference pitch. The acquisition of AP typically requires early musical training, the critical time window for which is similar to that for the acquisition of a first language. This study investigated the left-right asymmetry of the auditory cortical functions responsible for AP by focusing on the T-complex of auditory evoked potentials (AEPs), which shows morphological changes during the critical period for language acquisition. Read More

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Speech network regional involvement in bulbar ALS: a multimodal structural MRI study.

Amyotroph Lateral Scler Frontotemporal Degener 2019 08 14;20(5-6):385-395. Epub 2019 May 14.

a Department of Speech Language Pathology , University of Toronto , Ontario , Canada.

To examine gray (GM) and white matter (WM) structural changes in regions of the speech network (SpN) in ALS patients with varying degree of bulbar disease. T1 and DTI images were obtained for 19 ALS participants and 13 neurologically-intact controls. Surface-based, volumetric, and DTI metrics were obtained for 6 regions-of-interest (ROIs) including the primary motor cortex (PMC), pars triangularis (parsT), pars opercularis (ParsO), posterior superior temporal gyrus (pSTG), and transverse temporal (TT). Read More

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Clinically Significant Gains in Skillful Grasp Coordination by an Individual With Tetraplegia Using an Implanted Brain-Computer Interface With Forearm Transcutaneous Muscle Stimulation.

Arch Phys Med Rehabil 2019 07 20;100(7):1201-1217. Epub 2019 Mar 20.

Department of Physical Medicine & Rehabilitation, Ohio State University, Columbus, Ohio; Neurological Institute, Ohio State University Wexner Medical Center, Columbus, Ohio.

Objective: To demonstrate naturalistic motor control speed, coordinated grasp, and carryover from trained to novel objects by an individual with tetraplegia using a brain-computer interface (BCI)-controlled neuroprosthetic.

Design: Phase I trial for an intracortical BCI integrated with forearm functional electrical stimulation (FES). Data reported span postimplant days 137 to 1478. Read More

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Implicit representation of the auditory space: contribution of the left and right hemispheres.

Brain Struct Funct 2019 May 8;224(4):1569-1582. Epub 2019 Mar 8.

Service de neuropsychologie et de neuroréhabilitation, Centre Hospitalier Universitaire Vaudois (CHUV), Université de Lausanne, Lausanne, Switzerland.

Spatial cues contribute to the ability to segregate sound sources and thus facilitate their detection and recognition. This implicit use of spatial cues can be preserved in cases of cortical spatial deafness, suggesting that partially distinct neural networks underlie the explicit sound localization and the implicit use of spatial cues. We addressed this issue by assessing 40 patients, 20 patients with left and 20 patients with right hemispheric damage, for their ability to use auditory spatial cues implicitly in a paradigm of spatial release from masking (SRM) and explicitly in sound localization. Read More

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Ahead of time: Early sentence slow cortical modulations associated to semantic prediction.

Neuroimage 2019 04 6;189:192-201. Epub 2019 Jan 6.

Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Spain; Department of Social Psychology, Universidad de Málaga, Spain. Electronic address:

According to prediction-based accounts of language comprehension, incoming contextual information is constantly used to guide the pre-activation of the most probable continuations to the unfolding sentences. However, there is still scarce evidence of the build-up of these predictions during sentence comprehension. Using event-related brain potentials, we investigated sustained processes associated to semantic prediction during online sentence comprehension. Read More

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Impaired Spike Timing Dependent Cortico-Cortical Plasticity in Alzheimer's Disease Patients.

J Alzheimers Dis 2018 ;66(3):983-991

Department of Behavioural and Clinical Neurology, Non-invasive Brain Stimulation Unit, Santa Lucia Foundation IRCCS, Rome, Italy.

Background: Mechanisms of cortical plasticity have been recently investigated in Alzheimer's disease (AD) patients with transcranial magnetic stimulation protocols showing a clear impairment of long-term potentiation (LTP) cortical-like plasticity mechanisms.

Objective: We aimed to investigate mechanisms of cortico-cortical spike-timing dependent plasticity (STDP) in AD patients investigating the connections between posterior parietal cortex (PPC) and primary motor cortex (M1).

Methods: We used a cortico-cortical paired associative stimulation (cc-PAS) protocol to repeatedly activate the connection between PPC and M1 of the left-dominant hemisphere in a sample of fifteen AD patients and ten age-matched healthy subjects. Read More

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November 2019

Relation Between Asymmetry of Prefrontal Activity and Autonomic Nervous System in Post-stroke Patients with a Disorder of Consciousness.

M Moriya K Sakatani

Adv Exp Med Biol 2018;1072:53-58

Department of Electrical and Electronic Engineering, NEWCAT Research Institute, College of Engineering, Fukushima, Japan.

Early mobilization and rehabilitation of stroke patients can improve functional recovery. However, effects of mobilization on the responses of the autonomic nervous system (ANS) and emotions in post-stroke patients are not yet clear, particularly in patients with disorders of consciousness. We evaluated the effects of standing load on the ANS and emotions of post-stroke patients (n = 8, 70. Read More

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January 2019

Preoperative functional magnetic resonance imaging in patients undergoing surgery for tumors around left (dominant) inferior frontal gyrus region.

Surg Neurol Int 2018 26;9:126. Epub 2018 Jun 26.

Department of Neuroradiology, NIMHANS, Bengaluru, Karnataka, India.

Background: Preoperative functional magnetic resonance imaging (fMRI) helps to preserve neurological function and ensure maximal tumor tissue excision. We studied the lateralization and localization of speech centers in select cases of tumors around the left (dominant) inferior frontal gyrus (IFG).

Methods: Twenty-three right-handed patients, harboring tumors involving the left (dominant) IFG or causing mass effect or edema extending onto the left IFG, were recruited over 17 months. Read More

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Laterality of Poststroke Cortical Motor Activity during Action Observation Is Related to Hemispheric Dominance.

Neural Plast 2018 28;2018:3524960. Epub 2018 May 28.

University of Southern California, Los Angeles, CA, USA.

Background: Increased activity in the lesioned hemisphere has been related to improved poststroke motor recovery. However, the role of the dominant hemisphere-and its relationship to activity in the lesioned hemisphere-has not been widely explored.

Objective: Here, we examined whether the dominant hemisphere drives the lateralization of brain activity after stroke and whether this changes based on if the lesioned hemisphere is the dominant hemisphere or not. Read More

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December 2018

Correlations between clinical characteristics and neuroimaging in Chinese patients with subtypes of frontotemporal lobe degeneration.

Medicine (Baltimore) 2017 Sep;96(37):e7948

Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute Department of Neurology, Tianjin Huanhu Hospital PET-CT Center, General Hospital of Tianjin Medical University Department of Neuroimaging, Tianjin Huanhu Hospital, Tianjin, China.

The aim of the study was to obtain an overview of the clinical and neuroimaging features of Chinese patients with subtypes of frontotemporal lobe degeneration (FTLD).We evaluated the demographic features, clinical presentation, and lobe atrophy depicted by magnetic resonance imaging (MRI) in 133 patients with FTLD. Two positron emission tomography (PET) scans were performed at baseline: [C]Pittsburgh compound B PET to assess amyloid-β plaque load and [F]fluorodeoxyglucose (FDG) PET to assess glucose metabolism. Read More

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September 2017

Evaluation of Pleasure-Displeasure Induced by Use of Lipsticks with Near-Infrared Spectroscopy (NIRS): Usefulness of 2-Channel NIRS in Neuromarketing.

Adv Exp Med Biol 2017 ;977:215-220

NEWCAT Research Institute, Department of Electrical and Electronics Engineering, College of Engineering, 1 Nakagawara, Tokusada, Tamuramachi, Koriyama, Fukushima, 963-8642, Japan.

In order to examine whether near-infrared spectroscopy (NIRS) would be a useful neuromarketing tool, we employed NIRS to evaluate the difference of pleasure-displeasure in women, induced by the use of different types of lipsticks. The subjects used lipsticks A and B; A is softer than B. Concentration changes of oxy-Hb were measured in the bilateral prefrontal cortex (PFC) during use of lipsticks A and B. Read More

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January 2018

You talkin' to me? Communicative talker gaze activates left-lateralized superior temporal cortex during perception of degraded speech.

Neuropsychologia 2017 06 8;100:51-63. Epub 2017 Apr 8.

Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK.

Neuroimaging studies of speech perception have consistently indicated a left-hemisphere dominance in the temporal lobes' responses to intelligible auditory speech signals (McGettigan and Scott, 2012). However, there are important communicative cues that cannot be extracted from auditory signals alone, including the direction of the talker's gaze. Previous work has implicated the superior temporal cortices in processing gaze direction, with evidence for predominantly right-lateralized responses (Carlin & Calder, 2013). Read More

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Three- and four-dimensional mapping of speech and language in patients with epilepsy.

Brain 2017 05;140(5):1351-1370

Department of Pediatrics, Wayne State University, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI, 48201, USA.

We have provided 3-D and 4D mapping of speech and language function based upon the results of direct cortical stimulation and event-related modulation of electrocorticography signals. Patients estimated to have right-hemispheric language dominance were excluded. Thus, 100 patients who underwent two-stage epilepsy surgery with chronic electrocorticography recording were studied. Read More

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Hemispheric asymmetries in the transition from action preparation to execution.

Neuroimage 2017 03 6;148:390-402. Epub 2017 Jan 6.

IRCCS Santa Lucia Foundation, Rome 00179, Italy; Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome 00135, Italy.

Flexible and adaptive behavior requires the ability to contextually stop inappropriate actions and select the right one as quickly as possible. Recently, it has been proposed that three brain regions, i.e. Read More

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Relation Between Prefrontal Cortex Activity and Respiratory Rate During Mental Stress Tasks: A Near-Infrared Spectroscopic Study.

Adv Exp Med Biol 2016 ;923:209-214

Department of Electrical and Electronic Engineering, NEWCAT Research Institute, College of Engineering, Nihon University, Tokyo, Japan.

In order to clarify the central mechanism controlling respiratory rate during mental stress, we examined the relation between prefrontal cortex (PFC) activity and respiratory rate during mental arithmetic (MA) tasks. Employing two-channel near-infrared spectroscopy (NIRS), we measured hemoglobin (Hb) concentration changes in the bilateral PFC during MA tasks in normal adults. To evaluate asymmetry of the PFC activity, we calculated the laterality index (LI); (R-L)/(R + L) of oxy-Hb concentration changes (R = right, L = left); positive LI scores indicate right-dominant activity, while negative scores indicate left-dominant activity. Read More

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November 2017

Mirrored patterns of lateralized neuronal activation reflect old and new memories in the avian auditory cortex.

Neuroscience 2016 08 8;330:395-402. Epub 2016 Jun 8.

Neuroscience Program, Wellesley College, 106 Central Street, Wellesley, MA 02481-8203, United States. Electronic address:

In monolingual humans, language-related brain activation shows a distinct lateralized pattern, in which the left hemisphere is often dominant. Studies are not as conclusive regarding the localization of the underlying neural substrate for language in sequential language learners. Lateralization of the neural substrate for first and second language depends on a number of factors including proficiency and early experience with each language. Read More

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Prefrontal left--dominant hemisphere--gamma and delta oscillators in general anaesthesia with volatile anaesthetics during open thoracic surgery.

Neuro Endocrinol Lett 2016 ;37(1):33-40

Objectives: The main objective was to indicate sufficient general anaesthesia (GA) inhibition for negative experience rejection in GA.

Patients And Methods: We investigated the group of patients (n = 17, mean age 63.59 years, 9 male--65. Read More

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A two-level model of interindividual anatomo-functional variability of the brain and its implications for neurosurgery.

Hugues Duffau

Cortex 2017 01 29;86:303-313. Epub 2016 Jan 29.

Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France; National Institute for Health and Medical Research (INSERM), U1051 Laboratory, Team "Brain Plasticity, Stem Cells and Glial Tumors", Institute for Neurosciences of Montpellier, Montpellier University Medical Center, Montpellier, France. Electronic address:

The classical dogma of localizationism implicitly resulted in the principle of a similar brain functional anatomy between individuals, as for example the pars opercularis of the left "dominant" hemisphere corresponding to the speech area. This fixed "single brain" model led neurosurgeons to define a set of "eloquent" areas, for which injury would induce severe and persistent neurological worsening, making their surgical resections impossible. Therefore, numerous patients with a cerebral lesion justifying surgery were a priori not selected for resection and lost a chance to be treated. Read More

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January 2017

Effects of Acupuncture on Anxiety Levels and Prefrontal Cortex Activity Measured by Near-Infrared Spectroscopy: A Pilot Study.

Adv Exp Med Biol 2016 ;876:297-302

Department of Neurological Surgery, School of Medicine, Nihon University, Tokyo, Japan.

There is increasing evidence that acupuncture is useful in treating somatic and psychological disorders caused by stress; however, the physiological basis of the effect remains unclear. In the present study, we evaluated the effect of acupuncture on psychological conditions (i.e. Read More

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Hemispheric specialization in affective responses, cerebral dominance for language, and handedness: Lateralization of emotion, language, and dexterity.

Behav Brain Res 2015 Jul 13;288:11-9. Epub 2015 Apr 13.

FLENI Psychiatry and Neuroimaging, Buenos Aires, Argentina; Department of Mental Health (FLENI Teaching Unit), University of Buenos Aires School of Medicine, Buenos Aires, Argentina; Argentine National Council of Scientific and Technological Research (CONICET), Argentina; Department of Neurophysiology, University of Buenos Aires School of Psychology, Buenos Aires, Argentina. Electronic address:

Hemispheric specialization in affective responses has received little attention in the literature. This is a fundamental variable to understand circuit dynamics of networks subserving emotion. In this study we put to test a modified "valence" hypothesis of emotion processing, considering that sadness and happiness are processed by each hemisphere in relation to dominance for language and handedness. Read More

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Cognitive dysfunction in patients with very mild Alzheimer's disease and amnestic mild cognitive impairment showing hemispheric asymmetries of hypometabolism on ¹⁸F-FDG PET.

Int J Geriatr Psychiatry 2016 Jan 27;31(1):41-8. Epub 2015 Mar 27.

PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo, Japan.

Objective: We investigated cognitive dysfunction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) who present hemispheric asymmetries of cerebral metabolic rate of glucose (CMRglc) decrease on (18) F-fluorodeoxyglucose positron emission tomography.

Methods: Based on the hemispheric asymmetries of CMRglc decrease in the posterior cingulate cortex, precuneus, and parietotemporal cortex, the patients were divided into three groups (a left-dominant hypometabolism group, a right-dominant hypometabolism group, and a non-dominant hypometabolism group). CMRglc decrease in the whole brain was controlled among the three groups. Read More

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January 2016