1,153 results match your criteria correspondingly increases

Advanced trophectoderm quality increases the risk of a large for gestational age baby in single frozen-thawed blastocyst transfer cycles.

Hum Reprod 2021 May 6. Epub 2021 May 6.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Study Question: Does trophectoderm (TE) quality affect birthweight after single frozen-thawed blastocyst transfer?

Summary Answer: Transfer of single blastocyst with advanced TE quality was associated with higher birthweight and increased risk of a large for gestational age (LGA) baby.

What Is Known Already: Transfer of blastocysts with advanced TE quality results in higher ongoing pregnancy rates and a lower miscarriage risk. However, data on the relationship between TE quality and birthweight are still lacking. Read More

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Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.

Basic Res Cardiol 2021 Apr 30;116(1):31. Epub 2021 Apr 30.

Department of Cardiology, Cardiology I-Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Building 605, Langenbeckstr. 1, 55131, Mainz, Germany.

Aircraft noise induces vascular and cerebral inflammation and oxidative stress causing hypertension and cardiovascular/cerebral dysfunction. With the present studies, we sought to determine the role of myeloid cells in the vascular vs. cerebral consequences of exposure to aircraft noise. Read More

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Geometrically defined environments direct cell division rate and subcellular YAP localization in single mouse embryonic stem cells.

Sci Rep 2021 Apr 29;11(1):9269. Epub 2021 Apr 29.

Zoological Institute, Cell- and Neurobiology, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.

Mechanotransduction via yes-associated protein (YAP) is a central mechanism for decision-making in mouse embryonic stem cells (mESCs). Nuclear localization of YAP is tightly connected to pluripotency and increases the cell division rate (CDR). How the geometry of the extracellular environment influences mechanotransduction, thereby YAP localization, and decision-making of single isolated mESCs is largely unknown. Read More

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Purification of Wastewater from Biomass-Derived Syngas Scrubber Using Biochar and Activated Carbons.

Int J Environ Res Public Health 2021 Apr 16;18(8). Epub 2021 Apr 16.

Department of Environmental and Chemical Engineering, University of Calabria, via P. Bucci, 44a, I-87036 Rende, Italy.

Phenol is a major component in the scrubber wastewater used for syngas purification in biomass-based gasification plants. Adsorption is a common strategy for wastewater purification, and carbon materials, such as activated carbons and biochar, may be used for its remediation. In this work, we compare the adsorption behavior towards phenol of two biochar samples, produced by pyrolysis and gasification of lignocellulose biomass, with two commercial activated carbons. Read More

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ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments.

J Cell Mol Med 2021 Apr 16;25(8):4014-4027. Epub 2021 Mar 16.

Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

The ADP-ribosylation factor-like proteins (ARLs) have been proved to regulate the malignant phenotypes of several cancers. However, the exact role of ARLs in gastric cancer (GC) remains elusive. In this study, we systematically investigate the expression status, interactive relations, potential pathways, genetic variations and clinical values of ARLs in GC. Read More

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On the impact of absorbed dose specification, tissue heterogeneities, and applicator heterogeneities on Monte Carlo-based dosimetry of Ir-192, Se-75, and Yb-169 in conventional and intensity-modulated brachytherapy for the treatment of cervical cancer.

Med Phys 2021 Feb 22. Epub 2021 Feb 22.

Medical Physics Unit, Department of Oncology, McGill University, Montreal, QC, Canada.

Purpose: The purpose of this study was to evaluate the impact of dose reporting schemes and tissue/applicator heterogeneities for Ir-, Se-, and Yb-based MRI-guided conventional and intensity-modulated brachytherapy.

Methods And Materials: Treatment plans using a variety of dose reporting and tissue/applicator segmentation schemes were generated for a cohort (n = 10) of cervical cancer patients treated with Ir-based Venezia brachytherapy. Dose calculations were performed using RapidBrachyMCTPS, a Geant4-based research Monte Carlo treatment planning system. Read More

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February 2021

Why comparative epidemiological indicators suggest that New Zealand is unlikely to experience a severe opioid epidemic.

Int J Drug Policy 2021 Feb 16;93:103166. Epub 2021 Feb 16.

Schools of Population Health and Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. Electronic address:

North America (i.e., the United States and Canada) and select other wealthy Commonwealth countries (e. Read More

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February 2021

Evaluating humidity sensing response of graphene quantum dots synthesized by hydrothermal treatment of glucose.

Nanotechnology 2021 Apr 27;32(29). Epub 2021 Apr 27.

Institute of Advanced Materials, Bahauddin Zikria University, Multan, 60800, Punjab, Pakistan.

Graphene quantum dots (GQDs) were prepared using a single-step hydrothermal treatment of glucose (CHO) powder. X-ray diffraction patterns confirmed the random stacking or amorphous character of GQDs. Additionally, the UV-vis spectra confirmed the formation of GQDs with evident absorption peaks at 237 and 305 nm, which is attributed to-* and-* transitions correspondingly. Read More

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Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells.

Am J Physiol Lung Cell Mol Physiol 2021 05 10;320(5):L726-L738. Epub 2021 Feb 10.

Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Pulmonary arterial hypertension (PAH) refers to a set of heterogeneous vascular diseases defined by elevation of pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR), leading to right ventricular (RV) remodeling and often death. Early increases in pulmonary artery stiffness in PAH drive pathogenic alterations of pulmonary arterial endothelial cells (PAECs), leading to vascular remodeling. Dysregulation of microRNAs can drive PAEC dysfunction. Read More

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The Role of Waste Management in Control of Rabies: A Neglected Issue.

Viruses 2021 02 1;13(2). Epub 2021 Feb 1.

Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0001, South Africa.

Despite being vaccine preventable, the global burden of dog rabies remains significant, and historically it is the rural and marginalized communities in developing countries of Africa and Asia that are most threatened by the disease. In recent years, the developing world has been experiencing unprecedented increases in urbanization, with a correspondingly massive increase in municipal solid waste generation, among other things. Inefficient and inadequate waste collection and management, due to lack of resources and planning, led to significant increases in the volumes of waste on the streets and in open dumps, where it serves as food sources for free-roaming dogs. Read More

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February 2021

Characterization of Progesterone Receptor Expression in Intracranial Meningiomas of Patients Treated in a High-Complexity Hospital in Bogota, Colombia.

Cureus 2020 Dec 29;12(12):e12355. Epub 2020 Dec 29.

Department of Neurosurgery, Subred Integrada de Servicios de Salud Sur Occidente, Bogota, COL.

Background Meningiomas are the single most common brain tumor. The incidence of these tumors increases with age; different studies have shown that meningiomas usually appear after the age of 50. These tumors are more common in women than in men, and women are twice as likely to suffer from the condition. Read More

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December 2020

Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation.

Cell Microbiol 2021 May 10;23(5):e13313. Epub 2021 Feb 10.

Institut für Mikrobiologie, Technische Universität Braunschweig, Braunschweig, Germany.

ProA is a secreted zinc metalloprotease of Legionella pneumophila causing lung damage in animal models of Legionnaires' disease. Here we demonstrate that ProA promotes infection of human lung tissue explants (HLTEs) and dissect the contribution to cell type specific replication and extracellular virulence mechanisms. For the first time, we reveal that co-incubation of HLTEs with purified ProA causes a significant increase of the alveolar septal thickness. Read More

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Responses of Lotus corniculatus to environmental change. 4: Root carbohydrate levels at defoliation and regrowth climatic conditions are major drivers of phenolic content and forage quality.

Planta 2021 Jan 19;253(2):38. Epub 2021 Jan 19.

Institute of Grassland and Environmental Research, Plas Gogerddan, Ceredigion, Aberystwyth, SY23 3EB, UK.

Main Conclusion: Differential accumulation of root carbohydrates at defoliation have a higher impact than regrowth environmental conditions on the phenolic content and feed quality of the perennial forage legume Lotus corniculatus. The unpredictable nature of proanthocyanidin (condensed tannin) accumulation in regrowth vegetation of the perennial forage legume Lotus corniculatus represents a dilemma to the wider use of this species in agriculture, and a potential problem in the nutritional ecology of some terrestrial herbivores, as variable condensed tannin levels can result in either beneficial or detrimental effects on animal nutrition. However, the source of this variation has not been extensively explored. Read More

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January 2021

NBCn1 Increases NH Reabsorption Across Thick Ascending Limbs, the Capacity for Urinary NH Excretion, and Early Recovery from Metabolic Acidosis.

J Am Soc Nephrol 2021 Jan 7. Epub 2021 Jan 7.

Department of Biomedicine, Aarhus University, Aarhus, Denmark

Background: The electroneutral Na/HCO cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urinary net acid excretion, and systemic acid-base homeostasis has been lacking.

Methods: Metabolic acidosis was induced in wild-type and NBCn1 knockout mice. Read More

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January 2021

Primary care management of allergic rhinitis: a cross-sectional study in four ASEAN countries.

Multidiscip Respir Med 2020 Jan 11;15(1):726. Epub 2020 Dec 11.

Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Background: In primary care, general practitioners (GPs) and pharmacists are tasked with the frontline responsibility of identifying and managing allergic rhinitis (AR) patients. There are currently no consolidated data on current treatment practices, patient compliance, and usage of guidelines within Southeast Asian Nations (ASEAN). Objective: To assess the attitudes and practices on AR of GPs and pharmacists in 4 ASEAN countries (Philippines, Indonesia, Thailand, and Malaysia). Read More

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January 2020

Experimental and theoretical investigation of the enhancement of the photo-oxidation of Hg by CeO-modified morphology-controlled anatase TiO.

J Hazard Mater 2021 Mar 2;406:124535. Epub 2020 Dec 2.

Institute of Environmental Engineering, National Sun Yat-Sen University, No. 70, Lian-Hai Road, Kaohsiung 804, Taiwan. Electronic address:

This study aims to investigate the coeffects of predominantly exposed anatase TiO{001} and {101} and CeO loading on the photo-oxidation of Hg to relieve the adverse effects caused by higher temperatures of 50-250 °C. The effect of loading CeO on the photocatalytic activity of morphology-controlled TiO was not only investigated using DFT with U correction but also experimentally analyzed by characterizing the electrochemical properties and the formation of free radicals. The theoretical calculation showed that CeO loading on TiO{101} was more stable than that on TiO{001}. Read More

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Rhizosphere bacterial and fungal communities succession patterns related to growth of poplar fine roots.

Sci Total Environ 2021 Feb 20;756:143839. Epub 2020 Nov 20.

Taishan Forest Ecosystem Research Station of State Forestry Administration, College of Forestry, Shandong Agricultural University, Tai'an 271018, PR China. Electronic address:

Understanding the succession patterns of microbial community along root growth provides deep insights into interaction between fine roots and microbes. In the study, we investigated this issue using fine roots from poplar trees and grouped these fine roots into three growth stages: newborn white roots (WR), mature yellow roots (YR) and aging brown roots (BR). Root surface traits were observed under a scanning electron microscopy (SEM). Read More

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February 2021

Resveratrol accelerates wound healing by attenuating oxidative stress-induced impairment of cell proliferation and migration.

Burns 2021 02 7;47(1):133-139. Epub 2020 Nov 7.

Institute of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan 430060, PR China. Electronic address:

Background: Impaired wound healing, which is due to various external and internal factors that are involved in wound pathophysiology, leads to high rates of morbidity and mortality worldwide. Oxidative stress injury is an important factor that affects wound healing by changing the whole healing process. So, resveratrol, a dietary fruits polyphenol, which is known for its antioxidant properties, maybe the candidate to accelerate the wound-healing process. Read More

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February 2021

Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders.

J Clin Invest 2020 12;130(12):6739-6753

Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.

BACKGROUNDKisspeptin is a key regulator of hypothalamic gonadotropin-releasing hormone (GnRH) neurons and is essential for reproductive health. A specific kisspeptin receptor (KISS1R) agonist could significantly expand the potential clinical utility of therapeutics targeting the kisspeptin pathway. Herein, we investigate the effects of a KISS1R agonist, MVT-602, in healthy women and in women with reproductive disorders. Read More

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December 2020

Impact of emission reductions and meteorology changes on atmospheric mercury concentrations during the COVID-19 lockdown.

Sci Total Environ 2021 Jan 11;750:142323. Epub 2020 Sep 11.

Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

Controlling anthropogenic mercury emissions is an ongoing effort and the effect of atmospheric mercury mitigation is expected to be impacted by accelerating climate change. The lockdown measures to restrict the spread of Coronavirus Disease 2019 (COVID-19) and the following unfavorable meteorology in Beijing provided a natural experiment to examine how air mercury responds to strict control measures when the climate becomes humid and warm. Based on a high-time resolution emission inventory and generalized additive model, we found that air mercury concentration responded almost linearly to the changes in mercury emissions when excluding the impact of other factors. Read More

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January 2021

Induction of cytotoxic effector cells towards cholangiocellular, pancreatic, and colorectal tumor cells by activation of the immune checkpoint CD40/CD40L on dendritic cells.

Cancer Immunol Immunother 2021 May 12;70(5):1451-1464. Epub 2020 Nov 12.

Department of Internal Medicine I, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53105, Bonn, Germany.

Introduction: Gastrointestinal (GI) malignancies, such as cholangiocarcinoma, pancreatic carcinoma, and metastatic colorectal carcinoma, have a poor prognosis and effective therapeutic approaches are still challenging. Checkpoint inhibition with PD-1 or PDL-1 antibodies revealed promising results in different tumor entities; however, only few patients with GI tumors can potentially benefit from PD1/PDL1 inhibiting immunotherapy. Further immunotherapeutic strategies for GI malignancies are urgently needed. Read More

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The Unintentional Effects on Body Donation Programs of a Competency-Based Curriculum in Postgraduate Medical Education.

Anat Sci Educ 2020 Nov 5. Epub 2020 Nov 5.

Division of Anatomical Sciences, Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

As medical programs place increasing importance on competency-based training and surgical simulations for residents, anatomy laboratories, and body donation programs find themselves in a position of adapting to changing demands. To better assess the demand for "life-like" cadaveric specimens and evaluate the possible impacts that competency-based medical education could have upon the body donation program of McGill University, Canada, the authors tracked, over the course of the last 10 years, the number of soft-embalmed specimens, along with the number of teaching sessions and the residents enrolled in competency-based programs that are using cadaveric material. The results reveal that the number of soft-embalmed specimens used within residency training increased from 5 in 2009 to 35 in 2019, representing an increase from 6% of bodies to 36. Read More

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November 2020

Corticosterone Is Essential for Survival Through Frog Metamorphosis.

Endocrinology 2020 12;161(12)

Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio.

Thyroid hormone (TH) is required for frog metamorphosis, and corticosterone (CORT) increases TH signaling to accelerate metamorphic progression. However, a requirement for CORT in metamorphosis has been difficult to assess prior to the recent development of gene-editing technologies. We addressed this long-standing question using transcription activator-like effector nuclease (TALEN) gene disruption to knock out proopiomelanocortin (pomc) and disrupt CORT production in Xenopus tropicalis. Read More

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December 2020

Antiphotoaging Effect of 3,5-Dicaffeoyl-epi-quinic Acid against UVA-Induced Skin Damage by Protecting Human Dermal Fibroblasts In Vitro.

Int J Mol Sci 2020 Oct 20;21(20). Epub 2020 Oct 20.

Division of Marine Bioscience, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea.

Cutaneous aging is divided into intrinsic and exogenous aging correspondingly contributing to the complex biological phenomenon in skin. Intrinsic aging is also termed chronological aging, which is the accumulation of inevitable changes over time and is largely genetically determined. Superimposed on this intrinsic process, exogenous aging is associated with environmental exposure, mainly to ultraviolet (UV) radiation and more commonly termed as photoaging. Read More

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October 2020

Oxygen depletion in FLASH ultra-high-dose-rate radiotherapy: A molecular dynamics simulation.

Med Phys 2020 Dec 8;47(12):6551-6561. Epub 2020 Nov 8.

Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, 75031, USA.

Purpose: We present a first-principles molecular dynamics (MD) simulation and expound upon a mechanism of oxygen depletion hypothesis to explain the mitigation of normal tissue injury observed in ultra-high-dose-rate (UHDR) FLASH radiotherapy.

Methods: We simulated damage to a segment of DNA (also representing other biomolecules such as RNA and proteins) in a simulation box filled with O and molecules. Attoseconds physical interactions (ionizations, electronic, and vibrational excitations) were simulated by using the Monte Carlo track structure code Geant4-DNA. Read More

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December 2020

Change in Intraocular Pressure and Ocular Perfusion Pressure Due to Trendelenburg Positioning.

Optom Vis Sci 2020 Oct;97(10):857-864

Veterans Affairs Maryland Health Care System, Baltimore, Maryland.

Significance: This study increases foundational knowledge about the dynamic relationships between intraocular pressure (IOP), blood pressure (BP), and mean ocular perfusion pressure (MOPP) in the setting of steep Trendelenburg positioning and may inform medical decision making for patients in which this positioning is planned.

Purpose: The purpose of this study was to explore the demographic and clinical factors related to IOP, MOPP, and BP change during Trendelenburg positioning in a large sample of subjects.

Methods: A single-cohort interventional study was conducted at the American Academy of Optometry 2017 annual meeting. Read More

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October 2020

Influence of maximum MLC leaf speed on the quality of volumetric modulated arc therapy plans.

J Appl Clin Med Phys 2020 Nov 12;21(11):37-47. Epub 2020 Oct 12.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Purpose: Maximum leaf speed is a configurable parameter of MLC in a treatment-planning system. This study investigated the influence of MLC on the quality of VMAT plans.

Methods: Seven MLCs with different maximum leaf speeds (1. Read More

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November 2020

Time varying methods to infer extremes in dengue transmission dynamics.

PLoS Comput Biol 2020 10 12;16(10):e1008279. Epub 2020 Oct 12.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.

Dengue is an arbovirus affecting global populations. Frequent outbreaks occur, especially in equatorial cities such as Singapore, where year-round tropical climate, large daily influx of travelers and population density provide the ideal conditions for dengue to transmit. Little work has, however, quantified the peaks of dengue outbreaks, when health systems are likely to be most stretched. Read More

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October 2020

Nanoscale patterning at the Si/SiO/graphene interface by focused He beam.

Nanotechnology 2020 Dec;31(50):505302

Institute of Physical Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 2, D-76131, Karlsruhe, Germany.

We have studied the capability of He focused ion beam (He-FIB) patterning to fabricate defect arrays on the Si/SiO/Graphene interface using a combination of atomic force microscopy (AFM) and Raman imaging to probe damage zones. In general, an amorphized 'blister' region of cylindrical symmetry results upon exposing the surface to the stationary focused He beam. The topography of the amorphized region depends strongly on the ion dose, D , (ranging from 10 to 10ions/spot) with craters and holes observed at higher doses. Read More

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December 2020