30,060 results match your criteria corresponding period


Tympanostomy Tubes or Medical Management for Recurrent Acute Otitis Media.

N Engl J Med 2021 May;384(19):1789-1799

From the Departments of Pediatrics (A.H., J.L.P., M.H., D.H.K., S.B., G.B.M.P., T.R.S., J.M.M., M.K.-L., H.L., K.Y., J.P.N., N.S.) and Otolaryngology (D.H.C., J.E.D.), University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, the Department of Biostatistics, University of Pittsburgh Graduate School of Public Health (J.-H.J.), and Children's Community Pediatrics (N.L.C., B.C.) - all in Pittsburgh; Children's National Medical Center, Washington, DC (D.P., D.E.F.); and Kentucky Pediatric and Adult Research, Bardstown (S.L.B.).

Background: Official recommendations differ regarding tympanostomy-tube placement for children with recurrent acute otitis media.

Methods: We randomly assigned children 6 to 35 months of age who had had at least three episodes of acute otitis media within 6 months, or at least four episodes within 12 months with at least one episode within the preceding 6 months, to either undergo tympanostomy-tube placement or receive medical management involving episodic antimicrobial treatment. The primary outcome was the mean number of episodes of acute otitis media per child-year (rate) during a 2-year period. Read More

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Concentration-QTc analysis with two or more correlated baselines.

J Pharmacokinet Pharmacodyn 2021 May 12. Epub 2021 May 12.

Clinical Trial Center, Kitasato University Hospital, Sagamihara, Kanagawa, 252-0375, Japan.

The relationship between drug concentration and QTc interval is typically evaluated by applying the standard analysis model proposed in a scientific whitepaper by Garnett et al. ( https://doi.org/10. Read More

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Skin and soft tissue infections, active component, U.S. Armed Forces, January 2016-September 2020.

MSMR 2021 Apr;28(4):27-38

During 1 January 2016-30 September 2020, there were 210,914 incident cases of skin and soft tissue infections (SSTIs) among active component U.S. military members, corresponding to a crude overall incidence rate of 352. Read More

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Interhemispheric Auditory Cortical Synchronization in Asymmetric Hearing Loss.

Ear Hear 2021 Mar 26. Epub 2021 Mar 26.

1Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California, USA 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.

Objectives: Auditory cortical activation of the two hemispheres to monaurally presented tonal stimuli has been shown to be asynchronous in normal hearing (NH) but synchronous in the extreme case of adult-onset asymmetric hearing loss (AHL) with single-sided deafness. We addressed the wide knowledge gap between these two anchoring states of interhemispheric temporal organization. The objectives of this study were as follows: (1) to map the trajectory of interhemispheric temporal reorganization from asynchrony to synchrony using magnitude of interaural threshold difference as the independent variable in a cross-sectional study and (2) to evaluate reversibility of interhemispheric synchrony in association with hearing in noise performance by amplifying the aidable poorer ear in a repeated measures, longitudinal study. Read More

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"Long-term incidence of upper extremity venous obstruction in implantable cardioverter defibrillator patients".

Pacing Clin Electrophysiol 2021 May 11. Epub 2021 May 11.

Department of Therapeutic and Interventional Cardiology, Beta Clinic Bonn, Germany.

Background: Very little is known about the long-term prevalence of severe venous obstruction and occlusion in patients with transvenous implantable cardioverter-defibrillator leads. The objective of the current investigation was to elucidate the incidence and prevalence and to identify predisposing conditions in an ICD cohort over a long follow-up period.

Methods: Based on a prospective database, we analyzed consecutive patients who received an ICD implantation in our hospital between 06/1988 and 2009 as well as all corresponding follow-up data until 02/2018. Read More

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Worldwide trend in human papillomavirus-attributable cancer incidence rates between 1990 and 2012 and Bayesian projection to 2030.

Cancer 2021 May 11. Epub 2021 May 11.

Hepatobiliary and Pancreatic Interventional Treatment Center, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: There is a paucity of global comparative trend analyses of all human papillomavirus (HPV)-attributable cancers. In addition, most analyses by international sources only describe past trends; few studies have projected the future trend of HPV-attributable cancers.

Methods: Data were used from the Cancer Incidence in Five Continents (CI5plus) database that contains annual incidence by cancer site, age, and sex, as well as corresponding populations. Read More

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Non-invasive preimplantation genetic testing for putative mosaic blastocysts: a pilot study.

Hum Reprod 2021 May 11. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Reproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Anhui, China.

Study Question: What is the potential of applying non-invasive preimplantation genetic testing (niPGT) for chromosome abnormalities in blastocysts reported with a mosaic trophectoderm (TE) biopsy?

Summary Answer: niPGT of cell-free DNA in blastocyst culture medium exhibited a good diagnostic performance in putative mosaic blastocysts.

What Is Known Already: Advances in niPGT have demonstrated the potential reliability of cell-free DNA as a resource for genetic assessment, but information on mosaic embryos is scarce because the mosaicism may interfere with niPGT. In addition, the high incidence of mosaicism reported in the context of PGT and the viability of mosaic blastocysts raise questions about whether mosaicism really exists. Read More

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Journey-Deuce bicompartmental knee arthroplasty with the addition of computer navigation achieves good clinical outcomes and implant survival at 10 years.

Knee Surg Sports Traumatol Arthrosc 2021 May 11. Epub 2021 May 11.

School of Surgery (Orthopaedics), University of Western Australia, Crawley, Perth, WA, 6009, Australia.

Purpose: To report 10-year outcomes and survivorship in patients undergoing bicompartmental knee arthroplasty (BCKA) using the Journey-Deuce prosthesis in a consecutive prospective case series.

Methods: Between November 2006 and November 2009, 41 patients with a mean age of 69.6 years (range 51-86) underwent 51 bicompartmental knee arthroplasties with the Journey-Deuce knee prosthesis. Read More

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Prolonged care delivery time and reduced rate of electrophysiological procedures during the lockdown period due to Covid-19 Outbreak.

Expert Rev Med Devices 2021 May 10. Epub 2021 May 10.

Cardiology and Electrophysiology Unit, S. Maria Nuova Hospital, Florence, Italy.

: The aim of this study is to demonstrate how Electrophysiology activity has been impacted by the pandemic Coronavirus disease 2019 (COVID-19).: In this multicenter retrospective study, we analyze all consecutive patients admitted for electrophysiological procedures during the Covid-19 lockdown in the Tuscany region of Italy, comparing them to patients hospitalised in the corresponding period of the previous year.: The impact of COVID-19 on cardiac arrhythmia management was impressive, with a reduction of more than 50% in all kinds of procedures. Read More

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Speciation and secondary contact in a fossorial island endemic, the São Tomé caecilian.

Mol Ecol 2021 May 10. Epub 2021 May 10.

Department of Vertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, DC, USA.

A period of isolation in allopatry typically precedes local adaptation and subsequent divergence among lineages. Alternatively, locally adapted phenotypes may arise and persist in the face of gene flow, resulting in strong correlations between ecologically-relevant phenotypic variation and corresponding environmental gradients. Quantifying genetic, ecological, and phenotypic divergence in such lineages can provide insights into the abiotic and biotic mechanisms that structure populations and drive the accumulation of phenotypic and taxonomic diversity. Read More

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Timing of convalescent plasma therapy-tips from curing a 100-year-old COVID-19 patient using convalescent plasma treatment: A case report.

World J Clin Cases 2021 Apr;9(12):2890-2898

Translational Medicine Research Center, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing 100853, China.

Background: Convalescent plasma therapy is used for the treatment of critically ill patients for newly discovered infectious diseases, such as coronavirus disease 2019 (COVID-19) pneumonia, under the premise of lacking specific treatment drugs and corresponding vaccines. But the best timing application of plasma therapy and whether it is effective by antiviral and antibiotic treatment remain unclear.

Case Summary: We describe a patient with COVID-19, a 100-year-old, high-risk, elderly male who had multiple underlying diseases such as stage 2 hypertension (very high-risk group) and infectious pneumonia accompanied by chronic obstructive pulmonary disease and emphysema. Read More

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Enhancement of euryhaline biomass production for improving biogas generation through anaerobic co-digestion with carbon rich substrate.

3 Biotech 2021 May 3;11(5):251. Epub 2021 May 3.

Department of Microbiology, Punjab Agricultural University, Ludhiana, Punjab 141004 India.

The microalga was isolated from Muktsar, the southwestern zone of Indian Punjab and identified as BGLR5 (MF661929) by 18S rRNA sequence analysis. The optimization of various cultural factors by the Plackett-Burman and central composite (CCD) designs helped in discerning the significant cultural factors for the increased production of biomass and other functional components (chlorophyll, carbohydrate, lipid and protein). The optimal cultural conditions as per the model were pH 9. Read More

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Improved Aflatoxins and Fumonisins Forecasting Models for Maize (PREMA and PREFUM), Using Combined Mechanistic and Bayesian Network Modeling-Serbia as a Case Study.

Front Microbiol 2021 13;12:643604. Epub 2021 Apr 13.

Wageningen Food Safety Research, Wageningen, Netherlands.

Contamination of maize with aflatoxins and fumonisins is one of the major food safety concerns worldwide. Knowing the contamination in advance can help to reduce food safety risks and related health issues and economic losses. The current study aimed to develop forecasting models for the contamination of maize grown in Serbia with aflatoxins and fumonisins. Read More

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Shared humanity, awareness of socio-economic privilege, and classism during the pandemic as predictors of supporting equal socio-economic policies.

Curr Psychol 2021 Apr 30:1-13. Epub 2021 Apr 30.

Hacettepe University, Ankara, Turkey.

The coronavirus pandemic has caused unemployment to skyrocket, exposed the longstanding inequalities in health care services and working conditions, and mainly affected the poor in different parts of the world. In the current study, we focus on social identity and social class-related factors that are critical during the pandemic to gain insights into what predicts support for policies favoring economic equality in the post-pandemic period. We argue that to the extent that individuals 1) identify with all humanity during the pandemic, 2) are aware of their socio-economic status-based privilege, 3) do not hold classist attitudes, they would support policies favoring economic equality. Read More

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Comparison of staining adequacy between tissues stored in formalin and paraffin embedded blocks for prolonged duration.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):586. Epub 2021 Jan 9.

Department of Prosthodontics, Sri Siddhartha Dental College and Hospital, Sri Siddhartha Academy of Higher Education, Tumakuru, Karnataka, India.

Introduction: Tissues submitted for histopathological diagnoses are routinely fixed in formaldehyde fixative which facilitates tissue storage for the extended period of time for further investigation or research purpose. The literature has reliable data relating to immunohistochemistry and molecular studies done using tissue fixed in formalin for longer duration and in paraffin-embedded tissue blocks. We have attempted to evaluate staining adequacy of archival specimens using hematoxylin and eosin (H&E) and trichrome stains. Read More

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January 2021

Changes in short-lived climate pollutants during the COVID-19 pandemic in Tehran, Iran.

Environ Monit Assess 2021 May 8;193(6):331. Epub 2021 May 8.

School of Environment, College of Engineering, University of Tehran, P.O. Box, 14155-6135, Tehran, Iran.

This study investigates the changes of short-lived climate pollutants and other air pollutants during the COVID-19 pandemic in Tehran, Iran. Concentrations of air pollutants were obtained from 21 monitoring stations for the period from 5 January 2019 to 5 August 2019, representing normal conditions unaffected by COVID-19, and the period 5 January 2020 to 5 August 2020, i.e. Read More

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Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data.

Lancet 2021 May 5. Epub 2021 May 5.

Public Health Services, Israel Ministry of Health, Jerusalem, Israel. Electronic address:

Background: Following the emergency use authorisation of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 (international non-proprietary name tozinameran) in Israel, the Ministry of Health (MoH) launched a campaign to immunise the 6·5 million residents of Israel aged 16 years and older. We estimated the real-world effectiveness of two doses of BNT162b2 against a range of SARS-CoV-2 outcomes and to evaluate the nationwide public-health impact following the widespread introduction of the vaccine.

Methods: We used national surveillance data from the first 4 months of the nationwide vaccination campaign to ascertain incident cases of laboratory-confirmed SARS-CoV-2 infections and outcomes, as well as vaccine uptake in residents of Israel aged 16 years and older. Read More

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A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells.

PLoS One 2021 7;16(5):e0251172. Epub 2021 May 7.

Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada.

Within the classical eye-blink conditioning, Purkinje cells within the cerebellum are known to suppress their tonic firing rates for a well defined time period in response to the conditional stimulus after training. The temporal profile of the drop in tonic firing rate, i.e. Read More

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Effects of Agronomic Practices on Lygus spp. (Hemiptera: Miridae) Population Dynamics in Quinoa.

Environ Entomol 2021 May 7. Epub 2021 May 7.

Department of Entomology, Washington State University, Pullman, WA, USA.

Crop diversification often promotes farm sustainability. However, proper management of newly introduced crops is difficult when pests are unknown. Characterizing herbivore dynamics on new crops, and how they respond to agronomic factors, is crucial for integrated pest management. Read More

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Effects of COVID-2019 on plastic surgery emergencies in Korea.

Arch Craniofac Surg 2021 Apr 20;22(2):99-104. Epub 2021 Apr 20.

Department of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.

Background: To fight the coronavirus disease 2019 (COVID-19) pandemic, many countries have implemented social distancing and lockdowns. We investigated the changes in the trauma patterns of emergency plastic surgeries in the midst of a pandemic.

Methods: A retrospective review of the medical records of all patients treated for emergency plastic surgeries was performed at our hospital in Seoul. Read More

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Effectiveness of proprotein convertase subtilisin/kexin-9 monoclonal antibody treatment on plasma lipoprotein(a) concentrations in patients with elevated lipoprotein(a) attending a clinic.

Clin Cardiol 2021 May 6. Epub 2021 May 6.

School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia.

Background: Lipoprotein(a) (Lp[a]) is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Proprotein convertase subtilisin/kexin-9 monoclonal antibodies (PCSK9mAbs) can lower Lp(a) levels in clinical trials, but their effects in patients with elevated Lp(a) in clinical practice remain unclear.

Aims: To investigate the effectiveness and safety of PCSK9mAbs in lowering plasma Lp(a) in patients with elevated Lp(a) concentrations in a lipid clinic. Read More

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Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian women.

J Pharmacokinet Pharmacodyn 2021 May 5. Epub 2021 May 5.

School of Pharmacy and Pharmaceutical Sciences, State University of New York, University at Buffalo, Buffalo, NY, USA.

Population pharmacokinetic/pharmacodynamic (PK/PD) analysis was performed for extensive data for differing dosage forms and routes for dexamethasone (DEX) and betamethasone (BET) in 48 healthy nonpregnant Indian women in a partial and complex cross-over design. Single doses of 6 mg dexamethasone phosphate (DEX-P), betamethasone phosphate (BET-P), or 1:1 mixture of betamethasone phosphate and acetate (BET-PA) were administered orally (PO) or intramuscularly (IM) where each woman enrolled in a two-period cross-over study. Plasma concentrations collected over 96 h were described with a two-compartment model with differing PO and IM first-order absorption inputs. Read More

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Nationwide study on trends in unplanned hospital attendance and deaths during the 7 weeks after the onset of the COVID-19 pandemic in Denmark.

BMJ Qual Saf 2021 May 5. Epub 2021 May 5.

Department of Emergency Medicine, Sydvestjysk Sygehus Esbjerg, Esbjerg, Denmark

Background: The impact of a pandemic on unplanned hospital attendance has not been extensively examined. The aim of this study is to report the nationwide consequences of the COVID-19 pandemic on unplanned hospital attendances in Denmark for 7 weeks after a 'shelter at home' order was issued.

Methods: We merged data from national registries (Civil Registration System and Patient Registry) to conduct a study of unplanned (excluding outpatient visits and elective surgery) hospital-based healthcare and mortality of all Danes. Read More

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A role for cardiopulmonary exercise testing in detecting physiological changes underlying health status in Idiopathic pulmonary fibrosis: a feasibility study.

BMC Pulm Med 2021 May 5;21(1):147. Epub 2021 May 5.

Academic Respiratory Unit, School of Clinical Sciences, Southmead Hospital, University of Bristol, Learning and Research Building, Bristol, BS10 5NB, UK.

Introduction: There is limited data available on the use of CPET as a predictive tool for disease outcomes in the setting of IPF. We investigated the feasibility of undertaking CPET and the relationship between CPET and quality of life measurements in a well-defined population of mild and moderate IPF patients.

Methods: A prospective, single-centre observational study. Read More

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Stress and hair cortisol concentrations in nurses during the first wave of the COVID-19 pandemic.

Psychoneuroendocrinology 2021 Apr 27;129:105245. Epub 2021 Apr 27.

Department of Psychology, Faculty of Arts, Comenius University, Bratislava, Slovakia.

During the COVID-19 pandemic, frontline healthcare workers have been exposed to very stressful conditions. Measuring hair cortisol concentrations (HCCs), which reflect the integrated long-term cortisol levels, may elucidate the impact of COVID-19 related stress on healthcare professionals. In the current study, we investigated experienced stress in 693 healthcare workers, with hair samples for cortisol analysis collected from a subset of 67 female nurses. Read More

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Appraisal of definition of baseline length for somatosensory evoked magnetic fields.

J Neurosci Methods 2021 May 2:109213. Epub 2021 May 2.

Department of Systems Neuroscience, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo, 060-8556, Japan. Electronic address:

Background: The baseline (BL) segment in the prestimulus period is generally assigned as a reference of evoked activities. However, an experimenter empirically defines its length in each condition. So far, the criterion for the length of a BL segment has not been established. Read More

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Mobile-phone-based e-diary derived patient reported outcomes: Association with clinical disease activity, psychological status and quality of life of patients with multiple sclerosis.

PLoS One 2021 5;16(5):e0250647. Epub 2021 May 5.

Multiple Sclerosis Center & Department of Neurology, Lady Davis Carmel Medical Center, Haifa, Israel.

Background: The applicability of mobile digital technology to promote clinical care of people with multiple sclerosis (pwMS) is gaining increased interest as part of the implementation of patient-centered approaches. We aimed at assessing adherence to a smartphone-based e-diary, which was designed to collect patient-reported outcomes (PROs). Secondary objectives were to evaluate the construct and predictive validity of e-diary derived PROs and to explore the various factors that were associated with changes in PROs over time. Read More

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Cultivation of fractionated cells from a bioactive-alkaloid-bearing marine sponge Axinella sp.

In Vitro Cell Dev Biol Anim 2021 May 4. Epub 2021 May 4.

Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Sponges are among the most primitive multicellular organisms and well-known as a major source of marine natural products. Cultivation of sponge cells has long been an attractive topic due to the prominent evolutionary and cytological significance of sponges and as a potential approach to supply sponge-derived compounds. Sponge cell culture is carried out through culturing organized cell aggregates called 'primmorphs. Read More

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Progress and trends in publication of oral and video presentations at the society of gynecologic oncology annual meeting from 2006 to 2016.

Gynecol Oncol Rep 2021 May 16;36:100758. Epub 2021 Apr 16.

California Pacific Medical Center, San Francisco, CA, United States.

Previous research has identified factors associated with publication of plenary presentations at the Society of Gynecologic Oncology annual meeting. However, there are no detailed comprehensive trends analyses on the publications of these oral and video presentations over time. In this analysis of 11 annual meetings, we found an increase in clinical rather than translational science publications over time. Read More

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