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Population Pharmacokinetic Analysis of Ulotaront in Subjects with Schizophrenia.

CPT Pharmacometrics Syst Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Sunovion Pharmaceuticals Inc, Marlborough, MA, USA.

Ulotaront (SEP-363856) is a trace amine-associated receptor 1 (TAAR1) agonist with 5-HT agonist activity in Phase 3 development for the treatment of schizophrenia. The efficacy of ulotaront is not mediated by blockade of D or 5-HT receptors. The aim of this study was to evaluate the population PK of ulotaront in adult subjects using pooled data from seven Phase 1 studies, one Phase 2 acute study, and one 6-month extension study. Read More

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Approaching Efficient and Narrow RGB Electroluminescence from D-A-Type TADF Emitters Containing an Identical Multiple Resonance Backbone as the Acceptor.

ACS Appl Mater Interfaces 2021 Jul 21. Epub 2021 Jul 21.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, P. R. China.

Highly twisted electron donor (D)-electron acceptor (A)-type thermally activated delayed fluorescence (TADF) emitters can achieve high efficiency while suffering from serious structural relaxations and broad emissions. Multiple resonance (MR)-type TADF emitters can realize narrow emission. However, until now, only a few efficient MR-emitting cores are reported and custom tunning of their emission color remains a major challenge in their wider applications. Read More

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Bioenergy Crops for Low Warming Targets Require Half of the Present Agricultural Fertilizer Use.

Environ Sci Technol 2021 Jul 21. Epub 2021 Jul 21.

Ministry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing 100084, China.

Bioenergy with carbon capture and storage (BECCS) is a key option for removing CO from the atmosphere over time to achieve climate mitigation. However, an overlooked impact of BECCS is the amount of nutrients required to sustain the production. Here, we use an observation-driven approach to estimate the future bioenergy biomass production for land-use scenarios maximizing BECCS and the pertaining nutrient requirements. Read More

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Prediction of An(III)/Ln(III) Separation by 1,2,4-Triazinylpyridine Derivatives.

J Phys Chem A 2021 Jul 21. Epub 2021 Jul 21.

Department of Chemistry and Biochemistry, The University of Alabama, Shelby Hall, Tuscaloosa, Alabama 35487-0336, United States.

The effect of frustrated Lewis donors on metal selectivity between actinides and lanthanides was studied using a series of novel organic ligands. Structures and thermodynamic energies were predicted in the gas phase, in water, and in butanol using 9-coordinate, explicitly solvated (HO) Eu, Gd, Am, and Cm in the +III oxidation state as reactants in the formation of complexes with 2-(6-[1,2,4]-triazin-3-yl-pyridin-2-yl)-1-indole (Core 1), 3-[6-(2-pyrazol-3-yl)pyridin-2-yl]-1,2,4-triazine (Core 2), and several derivatives. These complexations were studied using density functional theory (DFT) incorporating scalar relativistic effects on the actinides and lanthanides using a small core pseudopotential and corresponding basis set. Read More

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Genetic analysis of egg production traits in turkeys (Meleagris gallopavo) using a single-step genomic random regression model.

Genet Sel Evol 2021 Jul 20;53(1):61. Epub 2021 Jul 20.

Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, N1G 2W1, Canada.

Background: Egg production traits are economically important in poultry breeding programs. Previous studies have shown that incorporating genomic data can increase the accuracy of genetic prediction of egg production. Our objective was to estimate the genetic and phenotypic parameters of such traits and compare the prediction accuracy of pedigree-based random regression best linear unbiased prediction (RR-PBLUP) and genomic single-step random regression BLUP (RR-ssGBLUP). Read More

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Broadband, Enhanced, and Antithermally Quenched Near-Infrared Phosphors via a Cosubstitution Approach.

Inorg Chem 2021 Jul 20. Epub 2021 Jul 20.

College of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China.

Wearable biosensing and food safety inspection devices with high thermal stability, high brightness, and broad near-infrared (NIR) phosphor-converted light-emitting diodes (pc-LEDs) could accelerate the next-generation NIR light applications. In this work, NIR LaGdGaGeO:Cr ( = 0 to 1.5) phosphors were successfully fabricated by a high-temperature solid-state method. Read More

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Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs.

Sci Rep 2021 Jul 19;11(1):14647. Epub 2021 Jul 19.

Ferdinand-Braun-Institut gGmbH, Leibniz-Institut für Höchstfrequenztechnik, Gustav-Kirchhoff-Str. 4, 12489, Berlin, Germany.

Multiresistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) cause serious postoperative infections. A skin tolerant far-UVC (< 240 nm) irradiation system for their inactivation is presented here. It uses UVC LEDs in combination with a spectral filter and provides a peak wavelength of 233 nm, with a full width at half maximum of 12 nm, and an irradiance of 44 µW/cm. Read More

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Photonic Floquet topological insulators in a fractal lattice.

Light Sci Appl 2020 Jul 20;9(1):128. Epub 2020 Jul 20.

Physics Department and Solid State Institute, Technion-Israel Institute of Technology, Haifa, 32000, Israel.

We present Floquet fractal topological insulators: photonic topological insulators in a fractal-dimensional lattice consisting of helical waveguides. The helical modulation induces an artificial gauge field and leads to a trivial-to-topological phase transition. The quasi-energy spectrum shows the existence of topological edge states corresponding to real-space Chern number 1. Read More

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Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag.

J Med Chem 2021 Jul 19. Epub 2021 Jul 19.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, United States.

Chemical biology tools to modulate protein levels in cells are critical to decipher complex biology. Targeted protein degradation offers the potential for rapid and dose-dependent protein depletion through the use of protein fusion tags toward which protein degraders have been established. Here, we present a newly developed protein degradation tag BRD4L94V along with the corresponding cereblon (CRBN)-based heterobifunctional degrader based on a "bump-and-hole" approach. Read More

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Who Called Team Europe? The European Union's Development Policy Response During the First Wave of COVID-19.

Eur J Dev Res 2021 Jul 12:1-16. Epub 2021 Jul 12.

Deutsches Institut Für Entwicklungspolitik, Tulpenfeld 6, 53113 Bonn, Germany.

The COVID-19 pandemic is a critical juncture for global development. Under the label of "Team Europe", the EU has sought to mobilize rapid development assistance to support partners in addressing the impacts of the crisis, while promoting joined-up approaches among European actors to assert itself in a changing and competitive geopolitical context. This article assesses how substantive and process-oriented EU development policy norms are reflected in the Union's global COVID-19 response. Read More

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Evolutionary history of Hemerocallis in Japan inferred from chloroplast and nuclear phylogenies and levels of interspecific gene flow.

Mol Phylogenet Evol 2021 Jul 14:107264. Epub 2021 Jul 14.

Department of Biology, Faculty of Science, Kyushu University, 744 Motooka, Fukuoka, 819-0395, Japan.

The perennial herb genus Hemerocallis (Asphodelaceae) shows four flowering types: diurnal half-day, diurnal one-day, nocturnal half-day, and nocturnal one-day flowering. These flowering types are corresponding to their main pollinators, and probably act as a primary mechanism of reproductive isolation. To examine how the four flowering types diverged, we reconstructed the phylogeny of the Japanese species of Hemerocallis using 1,615 loci of nuclear genome-wide SNPs and 2,078 bp sequences of four cpDNA regions. Read More

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Pharmacokinetics and Bioequivalence of a Generic Fixed-Dose Combination Tablet of Metformin Hydrochloride/Vildagliptin Versus a Branded Product in Healthy Chinese Subjects Under Fed and Fasting Conditions.

Clin Pharmacol Drug Dev 2021 Jul 17. Epub 2021 Jul 17.

Phase I Clinical Trial Unit, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.

The purpose of this study was to compare the bioequivalence and safety of test and reference preparations of fixed-dose combination tablets of metformin hydrochloride/vildagliptin 850 mg/50 mg in healthy volunteers under fasting and fed conditions for marketing authorization in China. A single-dose, randomized, open-label, 2-way crossover study was conducted. Blood samples were collected up to 36 hours after dosing in each period with a 7-day washout. Read More

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Full field-of-view, high-resolution, photon-counting detector CT: technical assessment and initial patient experience.

Phys Med Biol 2021 Jul 16. Epub 2021 Jul 16.

Department of Radiology, Mayo Clinic, Rochester, Minnesota, UNITED STATES.

We report a comprehensive evaluation of a full field-of-view (FOV) photon-counting detector (PCD) CT system using phantoms, and qualitatively assess image quality in patient examples. A whole-body PCD-CT system with 50 cm FOV, 5.76 cm z-detector coverage and two acquisition modes (standard: 144 × 0. Read More

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Spinning objects and partial occlusion: Smart neural responses to symmetry.

Vision Res 2021 Jul 13;188:1-9. Epub 2021 Jul 13.

Department of Psychology, University of Liverpool, Eleanor Rathbone Building, L697ZA Liverpool, UK; Department of General Psychology, Via Venezia, 8 - 35131, University of Padova, Padova, Italy.

In humans, extrastriate visual areas are strongly activated by symmetry. However, perfect symmetry is rare in natural visual images. Recent findings showed that when parts of a symmetric shape are presented at different points in time the process relies on a perceptual memory buffer. Read More

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Soft Viscoelastic Particles in Contact with a Quartz Crystal Microbalance (QCM): A Frequency-Domain Lattice Boltzmann Simulation.

Anal Chem 2021 Jul 16. Epub 2021 Jul 16.

Institute of Physical Chemistry, Clausthal University of Technology, D-38678 Clausthal-Zellerfeld, Germany.

Shifts of frequency and bandwidth of a quartz crystal microbalance (QCM) in contact with a structured, viscoelastic sample have been computed with a linearized version of the lattice Boltzmann method (LBM). The algorithm operates in the frequency domain and covers viscoelasticity. The different domains are characterized by different values of the complex viscosity, η, equivalent to different values of the shear modulus, . Read More

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Production of Homozygous Red Beet (Beta vulgaris L. subsp. vulgaris) Plants by Ovule Culture.

Methods Mol Biol 2021 ;2289:301-312

Department of Applied Biology, The National Institute of Horticultural Research, Skierniewice, Poland.

Hybrid varieties dominate the red beet market. The breeding process necessary to produce these cultivars is very difficult and time consuming. The application of in vitro gynogenesis can reduce the time needed to produce the corresponding homozygous pure lines to a few months. Read More

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January 2021

assessment of the efficiency of the PIM-1 kinase pharmacological inhibitor as a potential treatment for Burkitt's lymphoma.

Oncol Lett 2021 Aug 29;22(2):622. Epub 2021 Jun 29.

Cell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, Riyadh 11481, Saudi Arabia.

Burkitt's lymphoma is an aggressive form of lymphoma affecting B lymphocytes. It occurs endemically in Africa and sporadically in the rest of the world. Due to the high proliferation rate of this tumor, intensive multi-drug treatment is required; however, the risk of tumor syndrome lysis is high. Read More

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Wavelength selection of terahertz time-domain spectroscopy based on a partial least squares model for quantitative analysis.

Appl Opt 2021 Jul;60(19):5638-5642

Terahertz spectroscopy, combined with chemometric methods, has proved to be an effective tool in the quantitative analysis of many substances. However, current research has mainly focused on comparing different algorithms under the full spectrum. In fact, the full spectrum is not only composed of characteristic features of the samples, but also many types of noises. Read More

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Computational modeling of microfluidic data provides high-throughput affinity estimates for monoclonal antibodies.

Comput Struct Biotechnol J 2021 17;19:3664-3672. Epub 2021 Jun 17.

GSK, Siena, Italy.

Affinity measurement is a fundamental step in the discovery of monoclonal antibodies (mAbs) and of antigens suitable for vaccine development. Innovative affinity assays are needed due to the low throughput and/or limited dynamic range of available technologies. We combined microfluidic technology with quantum-mechanical scattering theory, in order to develop a high-throughput, broad-range methodology to measure affinity. Read More

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Different Trends in Excess Mortality in a Central European Country Compared to Main European Regions in the Year of the COVID-19 Pandemic (2020): a Hungarian Analysis.

Pathol Oncol Res 2021 13;27:1609774. Epub 2021 Apr 13.

1st Department of Pulmonology, National Korányi Institute of Pulmonology, Semmelweis University, Budapest, Hungary.

This study examined cumulative excess mortality in European countries in the year of the Covid-19 pandemic and characterized the dynamics of the pandemic in different countries, focusing on Hungary and the Central and Eastern European region. Age-standardized cumulative excess mortality was calculated based on weekly mortality data from the EUROSTAT database, and was compared between 2020 and the 2016-2019 reference period in European countries. Cumulate weekly excess mortality in Hungary was in the negative range until week 44. Read More

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Gamma-ray spectroscopy with anode pulses of NaI(Tl) detector using a low-cost digitizer system.

Appl Radiat Isot 2021 Jul 4;176:109854. Epub 2021 Jul 4.

Unidad Academica de Estudios Nucleares, Universidad Autonoma de Zacatecas, Cipres 10, Fracc. La Penuela, 98068, Zacatecas, Mexico.

Recently, digital gamma-ray spectroscopy employing low-cost and publicly available (Commercial off the shelf) digitizers has been frequently used in different studies worldwide. In this paper, we considered the digital methods for gamma-ray spectroscopy in which the anode pulses of the photomultiplier tube (PMT) output in a NaI(Tl) scintillation detector were immediately digitized by a PC sound card. We introduced and developed the methods for gamma-ray spectroscopy of microCurie gamma-ray sources by a sampling rate of 96 kHz. Read More

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Pharmacokinetics of Polymyxin B in Hospitalized Adults with Cystic Fibrosis.

Antimicrob Agents Chemother 2021 Jul 12:AAC0079221. Epub 2021 Jul 12.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

The optimal polymyxin B dosage needed to achieve an efficacy target of 50-100 mg·h/L when treating multi-drug-resistant bacterial infections in adult cystic fibrosis (CF) patients is unclear. The pharmacokinetics of intravenous polymyxin B were evaluated to better inform dosing. This was a prospective, observational pharmacokinetic (PK) study of nine CF adults receiving intravenous polymyxin B as part of usual clinical care. Read More

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Cost-effectiveness evaluation of mammography screening program in Taiwan: Adjusting different distributions of age and calendar year for real world data.

J Formos Med Assoc 2021 Jul 7. Epub 2021 Jul 7.

Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Background/purpose: We estimated loss-of-life expectancy (LE) and lifetime medical expenditures (LME) stratified by stages to evaluate the cost-effectiveness of breast cancer (BC) screening in Taiwan.

Methods: We interlinked four national databases- Cancer Registry, Mortality Registry, National Health Insurance Claim, and Mammography Screening. A cohort of 123,221 BC was identified during 2002-2015 and followed until December 31, 2017. Read More

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Mortality from external causes among 1-14 years old children in Serbia, 1997-2016.

Cent Eur J Public Health 2021 Jun;29(2):83-89

Medical faculty, University in Nis, Nis, Serbia.

Objectives: Globally, child mortality from external causes is in decline, but it is still among the leading causes of child deaths. The aim of this first national study was to determine trends of mortality rates from external causes among children aged 1-14 years in Serbia.

Methods: Mortality data were collected from the database of the Statistical Office of Serbia. Read More

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Heteroprotein Complex Coacervate Based on β-Conglycinin and Lysozyme: Dynamic Protein Exchange, Thermodynamic Mechanism, and Lysozyme Activity.

J Agric Food Chem 2021 Jul 9;69(28):7948-7959. Epub 2021 Jul 9.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.

Heteroprotein complex coacervate (HPCC) is a liquid-like protein concentrate produced by liquid-liquid phase separation. We revealed the protein dynamic exchange and thermodynamic mechanism of β-conglycinin/lysozyme coacervate, and clarified the effect of HPCC on protein structure and activity. β-conglycinin and lysozyme assembled into coacervate at pH 5. Read More

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Substituted nitrogen-bridged diazocines.

Beilstein J Org Chem 2021 25;17:1503-1508. Epub 2021 Jun 25.

Otto Diels-Institute of Organic Chemistry, Christian Albrechts University Kiel, Otto-Hahn-Platz 4, 24118 Kiel, Germany.

Novel nitrogen-bridged diazocines (triazocines) were synthesized that carry a formyl or an acetyl group at the CHNR-bridge and bromo- or iodo-substituents at the distant phenyl ring. The photophysical properties were investigated in acetonitrile and water. As compared to previous approaches the yields of the intramolecular azo cyclizations were increased (from ≈40 to 60%) using an oxidative approach starting from the corresponding aniline precursors. Read More

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[Mechanism of histone deacetylase inhibitor tubastatin A promoting autophagy of Legionella pneumophila infected RAW264.7 cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Aug;37(8):693-701

Department of Pathogenic Biology and Immunology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China. *Corresponding author, E-mail:

Objective To investigate the role of HDAC6 in the interference of Legionella pneumophila on the autophagy of macrophages and its mechanism. Methods RAW264.7 macrophages were treated with 10 μmol/L, 5 μmol/L, and 2. Read More

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Metal-Organic Framework-Derived Trimetallic Nanocomposites as Efficient Bifunctional Oxygen Catalysts for Zinc-Air Batteries.

ACS Appl Mater Interfaces 2021 Jul 6;13(28):33209-33217. Epub 2021 Jul 6.

Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Key Laboratory of Cluster Science, Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.

Transition-metal-based multifunctional catalysts have attracted increasing attention owing to high possibilities of substituting the expensive noble-metal-based catalysts in various scenarios. Multivariate metal-organic frameworks (MTV-MOFs) are ideal precursors to prepare multimetallic nanocomposites with high catalytic activity since the uniform distribution and precise regulation of mixed metal centers, as well as the consequent strong synergistic effect, could be readily achieved. Herein, a Mn/Co/Ni trimetallic catalyst (MnCoNi-C-D) with a hollow rhombic dodecahedron shape was synthesized via pyrolysis of the corresponding trimetallic-based MTV-MOF. Read More

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A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: Clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity.

J Glob Health 2021 Jun 30;11:05018. Epub 2021 Jun 30.

Centre for Global Child Health, the Hospital for Sick Children (SickKids), Toronto, Canada.

Background: We determined the clinical presentation, risk factors, and pregnancy and perinatal outcomes in pregnant women with confirmed COVID-19 and identified if these are different based on COVID-19 severity.

Methods: We included all observational studies on pregnant women with confirmed COVID-19 reporting clinical presentation, risk factors, and pregnancy and perinatal outcomes. We included all studies published between Dec/2019-Feb/2021 in Medline, Embase, the WHO COVID-19 databases, and clinicaltrials. Read More

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Outcomes of off-pump coronary artery bypass grafting in non-dialysis-dependent patients with stage 2 and stage 3 chronic kidney disease.

Indian J Thorac Cardiovasc Surg 2021 Jul 19;37(4):392-401. Epub 2021 Mar 19.

Department of Cardiothoracic & Vascular Surgery, Peerless Hospitex Hospital & B K Roy Research Centre, 360, Pancha Sayar Road, Sahid Smrity Colony, Pancha Sayar, Kolkata, West Bengal 700094 India.

Purpose: To assess the short-term outcomes in non-dialysis-dependent patients with stage 2 and stage 3 chronic kidney disease (CKD), undergoing off-pump coronary artery bypass (OPCAB). To examine whether there was a difference in mortality between stage 2 and stage 3 CKD patients and whether mortality in diabetics was different compared to non-diabetics. Outcomes would be judged on the basis of possible cardiovascular, pulmonary, infective, neurological and renal complications, duration of stay at the intensive therapy unit (ITU), and overall duration of stay at the hospital. Read More

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