525 results match your criteria correlation measles

A Case of Nephrotic Syndrome that Resolved with Influenza B Infection.

Case Rep Nephrol Dial 2021 Jan-Apr;11(1):103-109. Epub 2021 Apr 21.

Department of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

It has been postulated that measles virus infection is associated with remission of idiopathic nephrotic syndrome (INS) in childhood. There are few reports on the correlation of INS remission with other infections. Previously, there have been two case reports suggesting an association between influenza B virus infection and the remission of INS. Read More

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Seasonality, molecular epidemiology, and virulence of Respiratory Syncytial Virus (RSV): A perspective into the Brazilian Influenza Surveillance Program.

PLoS One 2021 18;16(5):e0251361. Epub 2021 May 18.

Laboratory of Respiratory Viruses and Measles, WHO NIC, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Respiratory Syncytial Virus (RSV) is the main cause of pediatric morbidity and mortality. The complex evolution of RSV creates a need for worldwide surveillance, which may assist in the understanding of multiple viral aspects.

Objectives: This study aimed to investigate RSV features under the Brazilian Influenza Surveillance Program, evaluating the role of viral load and genetic diversity in disease severity and the influence of climatic factors in viral seasonality. Read More

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Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens.

bioRxiv 2021 May 4. Epub 2021 May 4.

T cells are critical for control of viral infection and effective vaccination. We investigated whether prior Measles-Mumps-Rubella (MMR) or Tetanus-Diphtheria-pertussis (Tdap) vaccination elicit cross-reactive T cells that mitigate COVID-19. Using co-cultures of antigen presenting cells (APC) loaded with antigens and autologous T cells, we found a high correlation between responses to SARS-CoV-2 (Spike-S1 and Nucleocapsid) and MMR and Tdap vaccine proteins in both SARS-CoV-2 infected individuals and individuals immunized with mRNA-based SARS-CoV-2 vaccines. Read More

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Relationship between biochemical markers and measles viral load in patients with immunologically naive cases and secondary vaccine failure -LDH is one of the potential auxiliary indicators for secondary vaccine failure.

Microbiol Immunol 2021 May 5. Epub 2021 May 5.

Osaka Institute of Public Health, 3-69, Nakamichi, 1-chome, Higashinari-ku, Osaka, 537-0025, Japan.

This study investigated the correlation between biochemical markers and viral load among 38 measles cases, including 15 immunologically naive patients and 23 patients with secondary vaccine failure (SVF). We examined four biochemical markers, namely, aspartate aminotransferase, alanine aminotransferase, C-reactive protein, and lactate dehydrogenase (LDH) and their relationship between virus genome copy numbers in peripheral blood mononuclear cells (PBMCs) and throat swabs as well as the concentration of measles-specific IgG. Although viral genome copies in both clinical specimens showed a significant correlation with specific IgG concentration, they had a higher correlation in PBMCs (Pearson's product-moment correlation coefficient, -0. Read More

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Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019.

Euro Surveill 2021 Apr;26(17)

Department of Paediatrics and Adolescent Medicine, The Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

BackgroundHealthcare workers (HCW) have been identified as index cases in disease outbreaks of vaccine-preventable diseases (VPD) in hospitals.AimWe investigated whether Danish paediatric HCW were protected against selected serious VPD.MethodsWe included 90% of staff members from two paediatric departments. Read More

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Current Immunological and Clinical Perspective on Vaccinations in Multiple Sclerosis Patients: Are They Safe after All?

Int J Mol Sci 2021 Apr 8;22(8). Epub 2021 Apr 8.

Division of Neurochemistry and Neuropathology, Department of Neurology, Poznan University of Medical Sciences (PUMS), 60-355 Poznań, Poland.

Vaccines work by stimulating the immune system, and their immunogenicity is key in achieving protection against specific pathogens. Questions have been raised whether in Multiple Sclerosis (MS) patients they could induce disease exacerbation and whether vaccines could possibly act as a trigger in the onset of MS in susceptible populations. So far, no correlation has been found between the vaccinations against influenza, hepatitis B, tetanus, human papillomavirus, measles, mumps, rubella, varicella zoster, tuberculosis, yellow fever, or typhoid fever and the risk of MS. Read More

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Dynamics of maternally transferred antibodies against measles, mumps, and rubella in infants in Sri Lanka.

Int J Infect Dis 2021 Jun 22;107:129-134. Epub 2021 Apr 22.

Malaria Research Unit, Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. Electronic address:

Background: Determining the dynamics of maternally transferred antibodies against measles, mumps, and rubella infections in infants is important for making evidence-based policy decisions regarding the timing of vaccination.

Methods: The levels of serum immunoglobulin G (IgG) developed against measles, mumps, and rubella infections were assessed using commercial ELISA kits in mother-newborn pairs (n = 294) and 6-12-month-old infants (n = 280) recruited from Colombo District, Sri Lanka. Antibody levels of mothers and their newborns were assessed with respect to sex and parity. Read More

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Correlation of Vaccine Responses.

Front Immunol 2021 2;12:646677. Epub 2021 Apr 2.

Murdoch Children's Research Institute, Parkville, VIC, Australia.

Introduction: The humoral response to vaccinations varies widely between individuals. There is no data available on the correlation between responses to different vaccines. In this study, we investigated the correlation of antibody responses between routine vaccine antigens in infants. Read More

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Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein.

mSphere 2021 04 14;6(2). Epub 2021 Apr 14.

Division of Experimental Clinical Research, DCR-VPH, Vetsuisse Faculty, University of Bern, Bern, Switzerland

The multimeric matrix (M) protein of clinically relevant paramyxoviruses orchestrates assembly and budding activity of viral particles at the plasma membrane (PM). We identified within the canine distemper virus (CDV) M protein two microdomains, potentially assuming α-helix structures, which are essential for membrane budding activity. Remarkably, while two rationally designed microdomain M mutants (E89R, microdomain 1 and L239D, microdomain 2) preserved proper folding, dimerization, interaction with the nucleocapsid protein, localization at and deformation of the PM, the virus-like particle formation, as well as production of infectious virions (as monitored using a membrane budding-complementation system), were, in sharp contrast, strongly impaired. Read More

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["If there is a risk, I should have a choice:" Risk management and risk perception in Italian vaccine hesitancy movements].

Salud Colect 2021 Feb 10;17:e3231. Epub 2021 Feb 10.

Licenciada en Antropología Médica y Salud Global. Magíster en Antropología Médica y Salud Global, Universitat Rovira i Virgili, Tarragona, Cataluña, España.

In Italy, the passing of mandatory pediatric vaccinations in 2017 was a consequence of increasing vaccine hesitancy in the country, a phenomenon that has largely spread on social networks. This article examines risk management and risk perception regarding pediatric vaccinations through an analysis of online content shared by Italian vaccine hesitancy movements between December of 2019 and April of 2020. Results show that these movements carry out a reinterpretation of risk, scientific evidence, and parental responsibility, especially with regard to the alleged correlation between the measles vaccine and autism. Read More

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February 2021

Correlation of protection against varicella in a randomized Phase III varicella-containing vaccine efficacy trial in healthy infants.

Vaccine 2021 Jun 16;39(25):3445-3454. Epub 2021 Mar 16.

GSK, Avenue Fleming 20, 1300 Wavre, Belgium. Electronic address:

Background: Varicella vaccination confers high and long-lasting protection against chickenpox and induces robust immune responses, but an absolute correlate of protection (CoP) against varicella has not been established. This study models the relationship between varicella humoral response and protection against varicella.

Methods: This was a post-hoc analysis of data from a Phase IIIb, multicenter, randomized trial (NCT00226499) conducted in ten varicella-endemic European countries. Read More

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Development of a Measles and Rubella Multiplex Bead Serological Assay for Assessing Population Immunity.

J Clin Microbiol 2021 May 19;59(6). Epub 2021 May 19.

Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Viral Vaccine Preventable Diseases Branch, Atlanta, Georgia, USA.

Serosurveys are important tools for estimating population immunity and providing immunization activity guidance. The measles and rubella multiplex bead assay (MBA) offers multiple advantages over standard serological assays and was validated by comparison with the enzyme-linked immunosorbent assay (ELISA) and the measles plaque reduction neutralization (PRN) assay. Results from a laboratory-produced purified measles virus whole-virus antigen MBA (MeV WVA) correlated better with ELISA and PRN than results from the baculovirus-expressed measles nucleoprotein (N) MBA. Read More

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Seroprevalence against the measles virus after vaccination or natural infection in an adult population in Madinah, Saudi Arabia.

Hum Vaccin Immunother 2021 Feb 11:1-8. Epub 2021 Feb 11.

Department of Medical Laboratory Technology, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.

: Over the past few years, measles cases have increased worldwide, despite the availability of a safe and highly effective vaccine. Numerous countries have eliminated measles or have made substantial advancements toward elimination.: This study investigated the seroprevalence of anti-measles antibodies and vaccination status among 362 men and 81 women in Madinah. Read More

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February 2021

Air Passenger Travel and International Surveillance Data Predict Spatiotemporal Variation in Measles Importations to the United States.

Pathogens 2021 Feb 3;10(2). Epub 2021 Feb 3.

Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.

Measles incidence in the United States has grown dramatically, as vaccination rates are declining and transmission internationally is on the rise. Because imported cases are necessary drivers of outbreaks in non-endemic settings, predicting measles outbreaks in the US depends on predicting imported cases. To assess the predictability of imported measles cases, we performed a regression of imported measles cases in the US against an inflow variable that combines air travel data with international measles surveillance data. Read More

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February 2021

Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy.

Viruses 2021 01 28;13(2). Epub 2021 Jan 28.

Laboratory of Viral Immunology, Fundação Oswaldo Cruz, Rio de Janeiro 1040-900, Brazil.

There have been reports of neurological abnormalities associated with the Zika virus (ZIKV), such as congenital Zika syndrome (CZS) in children born to mothers infected during pregnancy. We investigated how the immune response to ZIKV during pregnancy is primed and conduct a thorough evaluation of the inflammatory and cytotoxic profiles as well as the expression of CCR5 and CX3CR1. We compared the reactivity of T cells to ZIKV peptides in convalescent mothers infected during pregnancy. Read More

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January 2021

Can Google Trends and Wikipedia help traditional surveillance? A pilot study on measles.

Acta Biomed 2020 11 12;91(4):e2020190. Epub 2020 Nov 12.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.

Introduction: Cases of measles in some European countries are increasing. The aim of this study is to find the correlation between Google Trends and Wikipedia searches and the real number of cases notified.

Materials And Methods: The data on Internet searches have been obtained from Google Trends and Wikipedia. Read More

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November 2020

Network theoretic analysis of JAK/STAT pathway and extrapolation to drugs and viruses including COVID-19.

Sci Rep 2021 01 28;11(1):2512. Epub 2021 Jan 28.

Department of Mathematics and Statistics, Aliah University, Kolkata, India.

Whenever some phenomenon can be represented as a graph or a network it seems pertinent to explore how much the mathematical properties of that network impact the phenomenon. In this study we explore the same philosophy in the context of immunology. Our objective was to assess the correlation of "size" (number of edges and minimum vertex cover) of the JAK/STAT network with treatment effect in rheumatoid arthritis (RA), phenotype of viral infection and effect of immunosuppressive agents on a system infected with the coronavirus. Read More

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January 2021

Predicting epidemics using search engine data: a comparative study on measles in the largest countries of Europe.

BMC Public Health 2021 01 21;21(1):100. Epub 2021 Jan 21.

Computer Science Department, Polytechnic Building, University of Alcalá, Ctra. De Barcelona km. 33.6, 28871, Alcalá de Henares (Madrid), Spain.

Background: In recent years new forms of syndromic surveillance that use data from the Internet have been proposed. These have been developed to assist the early prediction of epidemics in various cases and diseases. It has been found that these systems are accurate in monitoring and predicting outbreaks before these are observed in population and, therefore, they can be used as a complement to other methods. Read More

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January 2021

The Importance of Vitamin D Level in Subacute Thyroiditis Disease and the Effect of Vitamin D on Disease Prognosis.

Endocr Pract 2020 Oct;26(10):1062-1069

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Objective: Subacute thyroiditis (SAT) is an inflammatory thyroid disease that manifests with severe pain. The presence of the vitamin D receptor in immune system cells shows that vitamin D deficiency can trigger inflammatory diseases. The aim of the present study was to determine the prevalence of vitamin D deficiency in SAT patients, and the relationship between vitamin D level and permanent hypothyroidism and recurrence rate. Read More

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October 2020

Factors associated with measles resurgence in the United States in the post-elimination era.

Sci Rep 2021 01 8;11(1):51. Epub 2021 Jan 8.

College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, USA.

There have been growing concerns of a potential re-establishment of measles transmission in the United States (US) in the years to come. This study aims to explore potential factors underlying the resurgence of measles in the US by objectively assessing the associations between annual incidence rates (AIR), case importation, vaccination status and disease outbreaks. Data on measles transmission between January 1st, 2001 and December 31st, 2019 were obtained from the national centres for disease control and prevention (CDC) surveillance databases and other published reports. Read More

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January 2021

Impact of complement and difference of cell-based assay and ELISA in determination of neutralization capacity against mumps and measles virus.

J Immunol Methods 2021 Mar 4;490:112957. Epub 2021 Jan 4.

University of Zagreb, Centre for Research and Knowledge Transfer in Biotechnology, Rockefellerova 10, HR-10000 Zagreb, Croatia.

Neutralizing antibodies against mumps and measles virus are considered a correlate of protection against these diseases. Measurement of neutralizing antibodies is mostly performed using plaque reduction neutralization assay or 50% cell culture infective dose (CCID) neutralization assay, but there are attempts for measuring neutralizing antibodies using enzyme-linked immunosorbent assay (ELISA) which is simpler, but the literature data regarding its convenience are diverse. The role of complement and antibodies in neutralizing capacity of sera is not completely defined. Read More

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Metabolomic analysis reveals the valuable bioactive compounds of Ardisia elliptica.

Phytochem Anal 2020 Dec 8. Epub 2020 Dec 8.

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Introduction: Ardisia elliptica Thunb. (Primulaceae) is a medicinal herb that is traditionally used for the treatment of fever, diarrhoea, measles and herpes. However, there is limited information regarding the correlation of its phytoconstituents with the bioactivity. Read More

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December 2020

Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients.

mBio 2020 11 20;11(6). Epub 2020 Nov 20.

Stanford University, Stanford, California, USA.

The measles-mumps-rubella (MMR) vaccine has been theorized to provide protection against coronavirus disease 2019 (COVID-19). Our aim was to determine whether any MMR IgG titers are inversely correlated with severity in recovered COVID-19 patients previously vaccinated with MMR II. We divided 80 subjects into two groups, comparing MMR titers to recent COVID-19 severity levels. Read More

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November 2020

Estimation of the unvaccinated among those aged less than 25 years according to aimag and its association with incidence of measles outbreak 2015-2016 in Mongolia.

Nagoya J Med Sci 2020 Aug;82(3):437-447

Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Mongolia had an epidemic of measles in 2015-2016, even though more than 90% of the population have been vaccinated since 1997. This study aimed to examine the associations between unvaccinated proportion and measles incidence according to aimag. Mongolia has 21 provinces (aimag) with Ulaanbaatar as the capital city. Read More

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Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2.

PLoS One 2020 28;15(10):e0241471. Epub 2020 Oct 28.

Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.

Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Read More

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November 2020

Strong spatial embedding of social networks generates nonstandard epidemic dynamics independent of degree distribution and clustering.

Proc Natl Acad Sci U S A 2020 09 8;117(38):23636-23642. Epub 2020 Sep 8.

Medical Research Council Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London W2 1PG, United Kingdom;

Some directly transmitted human pathogens, such as influenza and measles, generate sustained exponential growth in incidence and have a high peak incidence consistent with the rapid depletion of susceptible individuals. Many do not. While a prolonged exponential phase typically arises in traditional disease-dynamic models, current quantitative descriptions of nonstandard epidemic profiles are either abstract, phenomenological, or rely on highly skewed offspring distributions in network models. Read More

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September 2020

Immunization status and re-immunization of childhood acute lymphoblastic leukemia survivors.

Hum Vaccin Immunother 2021 Apr 3;17(4):1132-1135. Epub 2020 Sep 3.

Faculty of Medicine, Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.

Intensive chemotherapy can cause long-lasting immunosuppression in children who survived cancer. The immunosuppression varies according to the type of cancer, intensity of chemotherapy and age of the patient. A sufficient immune reconstruction when has been completed in childhood cancer survivors, the re-vaccination program can achieve sufficient antibody levels for some of the life-threatening vaccine-preventable infectious diseases. Read More

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Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection.

BMC Immunol 2020 09 1;21(1):49. Epub 2020 Sep 1.

Department of Blood Transfusion, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang, China.

Background: Measles outbreaks have threatened the global elimination and eradication of measles in recent years. Measles virus (MeV)-specific antibodies are successful in clearing MeV infection. Follicular helper T (Tfh) cells play a crucial role in promoting antibody production. Read More

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September 2020

Epidemic retinitis and community outbreaks.

Indian J Ophthalmol 2020 Sep;68(9):1916-1919

Department of General Ophthalmology, Narayana Nethralaya, Bangalore, India.

Purpose: The objective of this study was to correlate seasonal variation of epidemic retinitis (ER) with concurrent community outbreaks.

Methods: This is a retrospective, observational, comparative study conducted in a tertiary care eye hospital in south India. Monthly variation in number of ER cases in comparison with reported community outbreaks by Integrated Disease Surveillance Program (IDSP) from 2009 to 2020 in the same region were studied. Read More

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September 2020

Measles Outbreak in a Rural Population in Bahar District, Hamadan Province, West of Iran in 2018.

J Res Health Sci 2020 Feb 27;20(1):e00470. Epub 2020 Feb 27.

Department of Pediatrics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Measles is in elimination phase in Iran. Following occurrence of two cases of measles in two children under six years old with the history of measles immunization in one of the villages affiliated to Bahar District, west of Hamadan Province, northwest of Iran, this study was conducted to determine the immunity status of people living in the village affected by the measles outbreak in spring of 2018.

Study Design: A cross-sectional (descriptive-analytical) study. Read More

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February 2020