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Dynamic curve analysis of indicators related to lumbar cistern drainage for postoperative meningitis.

World Neurosurg 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, 110022, China. Electronic address:

Objective: The purpose of this work was two-fold: to analyze the dynamic curve of cerebrospinal fluid (CSF) related indices in cases of postoperative meningitis after selective craniotomy and to provide reference data for the clinical treatment with lumbar cisterna drainage (LCD).

Methods: We conducted a retrospective study of LCD placement in 51 patients. Primary outcomes measured included pre-intervention and post-intervention dynamic changes of body temperature, and CSF biochemical parameters over the course of 13 days of catheter placement. Read More

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Association of bioelectrical phase angle with aerobic capacity, complex gait ability and total fitness score in older adults.

Exp Gerontol 2021 Apr 16:111350. Epub 2021 Apr 16.

Department of Physical Activity, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.

Purpose: This study aimed to examine the association between whole-body or segmental phase angle (PhA) based on bioelectrical impedance analysis (BIA) and aerobic capacity (endurance), complex gait ability, and total fitness age score (FAS).

Methods: A total of 426 community-dwelling older adults (332 women and 94 men) aged 60 to 93 years participated in this study. PhA and appendicular skeletal mass index (ASMI) were obtained by an eight-electrode standing BIA. Read More

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Postoperative pelvic incidence (PI) change may impact sagittal spinopelvic alignment (SSA) after instrumented surgical correction of adult spine deformity (ASD).

Spine Deform 2021 Apr 19. Epub 2021 Apr 19.

Department of Orthopedics, University of Colorado Anschutz Medical Campus, 12631 E. 17th Ave., Mail Stop B202, Aurora, CO, 80045, USA.

Objectives: To study factors causing postoperative change of PI after surgical correction of ASD and to assess the effect of this variability on postoperative PI-LL mismatch.

Background: PI is used as an individual constant to define lumbar lordosis (LL) correction goal (PI-LL < 10). Postoperative changes of PI were shown but with opposite vectors. Read More

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Correlation between symptoms and imaging findings including pelvic floor ultrasound to improve the symptom-based diagnosis of female urethral diverticulum (CHECK-UD study).

Int Urogynecol J 2021 Apr 19. Epub 2021 Apr 19.

Department of Urology and Pediatric Urology, University Hospital Essen, Essen, Germany.

Introduction And Hypothesis: The objective was to establish a model to predict the presence of a female urethral diverticulum (UD) based on symptoms.

Methods: A prospective CHECK-UD study (check of female urethral diverticulum) was conducted. Female patients presenting with symptoms such as lower urinary tract symptoms (LUTS), postmicturition dribble or urinary incontinence (UI), dyspareunia or pain in the pelvic area, and recurrent urinary tract infection (UTI) treated between 2015 and 2020 were included. Read More

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Skill level and the free moment during a pistol aiming task.

Sports Biomech 2021 Apr 19:1-10. Epub 2021 Apr 19.

Department of Kinesiology, University of Georgia, Athens, GA, USA.

The present study investigated the transversal rotation of body and its relation to the horizontal movement for expert shooters and novices in a pistol aiming task. Participants stood on a force plate with an air pistol and aimed it to the centre of a target, positioned 1.4 m above the floor and 10 m away from the force plate, for 30 s as accurately as possible. Read More

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Variations in athletic performance with occlusal splint in track and field athletes: a randomized clinical trial.

J Sports Med Phys Fitness 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgical Sciences, CIR Dental School, University of Turin, Turin, Italy.

Background: Several studies have been proposed with the aim to demonstrate correlations between the dento-mandibular apparatus and the skeletal muscle system of the human body even in regions distant from the oral cavity. However, a definite conclusion cannot be drawn. The aim of this paper is to demonstrate a possible correlation between dental occlusion and sport performances in track and field athletes. Read More

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Carotid intima-media thickness and epicardial fat thickness predict precoronary artery disease status in psoriasis.

Indian J Dermatol Venereol Leprol 2021 Mar 9:1-7. Epub 2021 Mar 9.

Department of Cardiology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.

Background: Carotid intima-media thickness test is a surrogate marker of subclinical atherosclerosis. Epicardial fat thickness is an early marker of coronary artery disease. Several studies have noted that psoriasis patients have an increased risk of coronary artery disease. Read More

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Differential effects by sex with Kmt5b loss.

Autism Res 2021 Apr 19. Epub 2021 Apr 19.

Department of Pharmacology & Neuroscience, School of Medicine, Creighton University, Omaha, Nebraska, USA.

Lysine methyl transferase 5B (KMT5B) has been recently highlighted as a risk gene in genetic studies of neurodevelopmental disorders (NDDs), specifically, autism spectrum disorder (ASD) and intellectual disability (ID); yet, its role in the brain is not known. The goal of this work was to neurodevelopmentally characterize the effect(s) of KMT5B haploinsufficiency using a mouse model. A Kmt5b gene-trap mouse line was obtained from the Knockout Mouse Project. Read More

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Whole genome transcriptome analysis of the stomach resected in human vertical sleeve gastrectomy: cutting more than calories.

Physiol Genomics 2021 Apr 19. Epub 2021 Apr 19.

Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, United States.

Background: Vertical sleeve gastrectomy (VSG) is a surgical weight loss procedure that resects 80% of the stomach, creating a tube linking the esophagus to the duodenum. Because of the efficacy and relative simplicity of VSG, it is preferred in the U.S with VSG currently at >61% of bariatric surgeries performed. Read More

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Characteristics, Accumulation, and Potential Health Risks of Antimony in Atmospheric Particulate Matter.

ACS Omega 2021 Apr 1;6(14):9460-9470. Epub 2021 Apr 1.

State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China.

Antimony (Sb), a priority pollutant listed by the U.S. Environmental Protection Agency (USEPA), can cause adverse effects on human health, with particular impacts on skin, eyes, gastrointestinal tract, and respiratory system. Read More

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Comparative lipid and uric acid suppressing properties of four common herbs in high fat-induced obese mice with their total phenolic and flavonoid index.

Biochem Biophys Rep 2021 Jul 30;26:100990. Epub 2021 Mar 30.

Faculty of Science, Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.

Our present study was designed to investigate the comparative anti-obesity efficacy of ethanolic extract of , , L. and in high fat-induced mice with their total phenolic and flavonoid profile. Total phenolic and flavonoid content were determined by Folin-Ciocalteu's and Aluminium chloride UV method respectively. Read More

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The Association of Hemoglobin A1c and Fasting Glucose Levels with hs-CRP in Adults Not Diagnosed with Diabetes from the KNHANES, 2017.

J Diabetes Res 2021 1;2021:5585938. Epub 2021 Apr 1.

Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Republic of Korea.

Purpose: High sensitivity C-reactive protein (hs-CRP) has been used as a biomarker to assess the risk of cardiovascular accidents (CVA) and to measure general inflammation in the body. This study investigated the relationship and extent of correlation between serum glucose level markers and hs-CRP as a means to assess CVA risk through hemoglobin A1c (HbA1c) and fasting glucose levels.

Methods: This cross-sectional, population-based study used data from the 2017 Korea National Health and Nutrition Examination Survey (KNHANES). Read More

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Perioperative Hidden Blood Loss in Elderly Cervical Spondylosis Patients With Anterior Cervical Discectomy Fusion and Influencing Factors.

Geriatr Orthop Surg Rehabil 2021 31;12:21514593211002164. Epub 2021 Mar 31.

Department of Orthopedics, Clinical Medical College of Yangzhou University, Yangzhou, China.

Introduction: To analyze the perioperative hidden blood loss (HBL) and its influencing factors in elderly cervical spondylosis patients treated with anterior cervical discectomy fusion (ACDF).

Materials And Methods: From January 2017 to December 2018, 128 elderly cervical spondylosis patients (age > 65 y) treated with ACDF were selected. The patients' height, weight, duration of symptoms, previous medical history and other basic information were routinely recorded. Read More

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Quantitative measurements of prostatic zones by MRI and their dependence on prostate size: possible clinical implications in prostate cancer.

Ther Adv Urol 2021 Jan-Dec;13:17562872211000852. Epub 2021 Mar 31.

Department of Urology, Texas Tech University Health Sciences Center - School of Medicine, 3601 4th Street, Lubbock, TX 79430-7260, USA.

Aim: Many studies support an inverse relationship between benign prostate hypertrophy (BPH) size and incidence of prostate cancer (PCa), but the causal link between these conditions is poorly understood. Recent studies suggest that a growing transition zone (TZ) in the prostate may induce pressure on the outer peripheral zone (PZ), leading to atrophy of the glandular tissue where PCa often originates, providing a possible explanation for this interaction. To further investigate this phenomenon, our pilot study uses magnetic resonance imaging (MRI) to examine quantitative zonal changes in a consecutive cohort of prostates. Read More

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Age-Related Decline in Vertical Jumping Performance in Masters Track and Field Athletes: Concomitant Influence of Body Composition.

Front Physiol 2021 1;12:643649. Epub 2021 Apr 1.

German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.

Vertical jumping power declines with advancing age, which is theoretically explicable by loss of muscle mass and increases in body fat. However, the results of previous cross-sectional studies remain inconsistent on these relationships. The present study included 256 masters athletes who competed at the 2018 track and field world championships in Málaga, Spain. Read More

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Characterization of Chicken Skin Yellowness and Exploration of Genes Involved in Skin Yellowness Deposition in Chicken.

Front Physiol 2021 31;12:585089. Epub 2021 Mar 31.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, China.

Skin color is an important economic trait in meat-type chickens. A uniform bright skin color can increase the sales value of chicken. Chickens with bright yellow skin are more popular in China, especially in the broiler market of South China. Read More

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Cytokines and Water Distribution in Anorexia Nervosa.

Mediators Inflamm 2021 2;2021:8811051. Epub 2021 Apr 2.

Section of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.

In patients with anorexia nervosa (AN), decreased intracellular (ICW), extracellular (ECW), and total body water (TBW) as well as changes in serum cytokine concentrations have been reported. In this exploratory study, we measured body composition and serum cytokine levels in patients with AN ( = 27) and healthy controls (HCs; = 13). Eating disorder symptom severity was assessed using the Eating Disorder Examination-Questionnaire (EDE-Q). Read More

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Green synthesis of hesperidin coated silver nanoparticles for colorimetric detection of gentamicin sulfate in real samples.

Pak J Pharm Sci 2020 Nov;33(6):2667-2677

Centre of Excellence in Marine Biology, University of Karachi, Karachi, Pakistan.

Gentamicin sulfate (GEN), a well-known broad-spectrum antibiotic is mostly administered through intramuscular injections and entirely excreted in un-metabolized form through urination from patient's body. Quantitative detection of GEN by direct UV absorption is usually challenging due to lack of chromophores and fluorophores in structure. The current study described the hesperidin coated silver nanoparticles (HSPAgNPs) based novel colorimetric quantitative assay for GEN. Read More

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November 2020

Adiponectin involved in portal flow hepatic extraction of 13C-metacethin in obesity and non-alcoholic fatty liver.

Eur J Intern Med 2021 Apr 15. Epub 2021 Apr 15.

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari 70124, Italy. Electronic address:

Obesity and non-alcoholic fatty liver disease (NAFLD) are high prevalence, inter-related conditions at increased risk for advanced liver diseases and related mortality. Adiponectin and leptin have divergent roles in the pathogenesis of fat accumulation and NAFLD. However, the relationships between body and liver fat accumulation, early modification of liver function and unbalanced adipokine levels are still scarcely explored. Read More

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Preoperative cephalhematoma size measured with computed tomography predicts intraoperative bleeding in pediatric patients undergoing cranioplasty.

Anesth Pain Med (Seoul) 2021 Apr 15. Epub 2021 Apr 15.

Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Cranioplasty for the treatment of cephalhematomas in small infants with limited blood volume is challenging because of massive bleeding. This study aimed to elucidate the correlation between cephalhematoma size and intraoperative blood loss and identify criteria that can predict large intraoperative blood loss.

Methods: We reviewed the medical records of 120 pediatric patients aged less than 24 months who underwent cranioplasty for treatment of a cephalhematoma. Read More

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Unravelling the Complexity Myth for Minimally Invasive Right Hepatectomy: Liver Parenchymal Features and their Correlation to Objective Outcomes in Major Anatomical Resections.

World J Surg 2021 Apr 17. Epub 2021 Apr 17.

Department of Surgery, Emory University School of Medicine, B206 1364 Clifton Road NE, 30322, Atlanta, USA.

Background: Minimally invasive approaches to major liver resection have been limited by presumed difficulty of the operation. While some concerns arise from mastering the techniques, factors such as tumor size and liver parenchymal features have anecdotally been described as surrogates for operative difficulty. These factors have not been systematically studied for minimally invasive right hepatectomy (MIRH). Read More

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Carotid artery molecular calcification assessed by [F]fluoride PET/CT: correlation with cardiovascular and thromboembolic risk factors.

Eur Radiol 2021 Apr 17. Epub 2021 Apr 17.

Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA, 19104, USA.

Objectives: There is growing evidence that sodium fluoride ([F]fluoride) PET/CT can detect active arterial calcifications at the molecular stage. We investigated the relationship between arterial mineralization in the left common carotid artery (LCC) assessed by [F]fluoride PET/CT and cardiovascular/thromboembolic risk.

Methods: In total, 128 subjects (mean age 48 ± 14 years, 51% males) were included. Read More

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Role of Ga-PSMA PET/CT parameters in treatment evaluation and survival prediction in prostate cancer patients compared with biochemical response assessment.

Hell J Nucl Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Nuclear Medicine, Saglik Bilimleri University, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

Objective: In this study, we aimed to evaluate the concordance of biochemical treatment response with gallium-68-prostate specific membrane antigen (Ga-PSMA) positron emission tomography/computed tomography (PET/CT) treatment response in prostate cancer (PCa) and investigate their prognostic effects on survival.

Materials And Methods: One hundred and fifty-onepatients with PCa, who underwent Ga-PSMA PET/CT imaging in our clinic between May 2016 and December 2019, were on treatment, and had pre-treatment and post-treatment imaging studies were included in our study. The treatment patients received and prostate-specific antigen (PSA) levels at the time of PET/CT imaging were recorded. Read More

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CYP3A5*3 polymorphism and age affect tacrolimus blood trough concentration in myasthenia gravis patients.

J Neuroimmunol 2021 Apr 9;355:577571. Epub 2021 Apr 9.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

The study aims to identify clinical factors affecting tacrolimus blood trough concentration (C0) in myasthenia gravis (MG) patients and to optimize the initial dose of tacrolimus in MG treatment. A total of 103 MG patients participated in this study, and their clinical factors, medication regimens, C0 values and CYP3A5*3 polymorphisms were collected in detail. We used a linear mixed model to analyze the effect of multiple factors on the dosage-weighted C0 (C0:D) and performed subgroup analyses to investigate the consistency of correlations between influencing factors and the C0:D ratios. Read More

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Interscan measurement error of knee cartilage thickness and projected cartilage area ratio at 9 regions and 45 subregions by fully automatic three-dimensional MRI analysis.

Eur J Radiol 2021 Apr 8;139:109700. Epub 2021 Apr 8.

Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Japan. Electronic address:

Background: We have developed a fully automatic three-dimensional MRI analysis software program for automatic segmentation of knee cartilage using a deep neural network. The purpose of this study was to use this software to clarify the interscan measurement error of the knee cartilage thickness and projected cartilage area ratio at 9 regions and 45 subregions in the knee.

Methods: Ten healthy volunteers underwent MRI twice in the same day. Read More

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Long-term exposure to the fluoride blocks the development of chondrocytes in the ducks: The molecular mechanism of fluoride regulating autophagy and apoptosis.

Ecotoxicol Environ Saf 2021 Apr 14;217:112225. Epub 2021 Apr 14.

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Long-term exposure to excessive fluoride causes chronic damage in the body tissues and could lead to skeletal and dental fluorosis. Cartilage damage caused by excessive fluoride intake has gained wide attention, but how fluoride accumulation blocks the development of chondrocytes is still unclear. Here, we report a negative correlation between the length and growth plate width after NaF treatments via apoptosis and autophagy, with shrinkage of cells, nuclear retraction, dissolution of chondrocytes. Read More

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Clinical Features of Essential Voice Tremor and Associations with Tremor Severity and Response to Octanoic Acid Treatment.

Laryngoscope 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurology, SUNY Upstate Medical University, Syracuse, New York, U.S.A.

Objectives/hypothesis: The purpose of this study was to characterize the clinical features, tremor variability, and factors related to octanoic acid (OA) treatment response in essential voice tremor (EVT).

Study Design: Prospective, double blind, placebo-controlled, crossover study with secondary analysis.

Methods: Clinical tremor features in 16 individuals with EVT were comprehensively assessed, and correlations with acoustic tremor severity were determined. Read More

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Modelling growth curves of the normal infant's mandible: 3D measurements using computed tomography.

Clin Oral Investig 2021 Apr 16. Epub 2021 Apr 16.

Department of Oral and Maxillofacial Surgery, Erasmus University Medical Centre, Sophia's Children's Hospital, 's Gravendijkwal 230, 3015, CE, Rotterdam, The Netherlands.

Objectives: Data on normal mandibular development in the infant is lacking though essential to understand normal growth patterns and to discriminate abnormal growth. The aim of this study was to provide normal linear measurements of the mandible using computed tomography performed in infants from 0 to 2 years of age.

Material And Methods: 3D voxel software was used to calculate mandibular body length, mandibular ramus length, bicondylar width, bigonial width and the gonial angle. Read More

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Reorganization of auditory-visual network interactions in long-term unilateral postlingual hearing loss.

J Clin Neurosci 2021 May 19;87:97-102. Epub 2021 Mar 19.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China; Neurosurgical Institute of Fudan University, China; Shanghai Clinical Medical Center of Neurosurgery, China. Electronic address:

Long-term unilateral hearing loss could reorganize the functional network association between the bilateral auditory cortices, while alterations of other functional networks need to be further explored. We attempted to investigate the pattern of the reorganization of functional network associations between the auditory and visual cortex caused by long-term postlingual unilateral hearing loss (UHI) and its relationship with clinical characteristics. Therefore, 48 patients with hearing loss caused by unilateral acoustic tumors and 52 matched healthy controls were enrolled, and their high-resolution structural MRI and resting-state functional MRI data were also collected to depict the brain network. Read More

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