4,527 results match your criteria correlation attenuation

A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).

Int Immunopharmacol 2021 Sep 14;100:108137. Epub 2021 Sep 14.

Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

A growing body of evidence indicates that neutrophil elastase (NE) is involved in the pathogenesis of respiratory infectious diseases, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to analyze the dynamic changes in serum levels of NE associated with inflammation, disease activity, and mortality rate in patients with COVID-19. We measured the serum concentrations of NE, C-Reactive protein (CRP), interleukin (IL)- 4, IL-6, IL-8, IL-10, and vitamin D levels in 83 ICU and 69 non-ICU patients compared with 82 healthy subjects (HS) in three-time points (T1-T3). Read More

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September 2021

Retinal degeneration in mice and humans with neuronal ceroid lipofuscinosis type 8.

Ann Transl Med 2021 Aug;9(15):1274

Department of Ophthalmology & Vision Science, School of Medicine, University of California, Davis, Sacramento, California, USA.

Background: Ceroid lipofuscinosis type 8 belongs to a heterogenous group of vision and life-threatening neurodegenerative diseases, neuronal ceroid lipofuscinosis (NCL). Effective therapy is limited to a single drug for treatment of ceroid lipofuscinosis type 2, necessitating animal disease models to facilitate further therapeutic development. Murine models are advantageous for therapeutic development due to easy genetic manipulation and rapid breeding, however appropriate genetic models need to be identified and characterized before being used for therapy testing. Read More

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Association of quantitative computed tomography ındices with lung function and extent of pulmonary fibrosis in patients with systemic sclerosis.

Clin Rheumatol 2021 Sep 16. Epub 2021 Sep 16.

Department of Rheumatology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Objectives: The aim was to investigate the discriminative value of a wide range of quantitative computed tomography (qCT) parameters in systemic sclerosis (SSc) patients with and without pulmonary fibrosis (PF) and their association with pulmonary function tests (PFTs) and visual fibrosis scores (VFS).

Method: Thoracic high-resolution computed tomography (HRCT) images of SSc patients with and without PF were analyzed with Vitrea® Advanced Visualization software. The mean lung attenuation (MLA), skewness, kurtosis, and threshold-based volumes [low-density volume (LDV), medium-density volume (MDV), and high-density volume (HDV)] derived from the attenuation histograms of the right and left lungs were evaluated separately. Read More

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September 2021

COVID-19 Infection in Octagenarian Patients: Imaging Aspects and Clinical Correlations.

Gerontology 2021 Aug 5:1-11. Epub 2021 Aug 5.

Department of Radiology and Diagnostic Imaging at Prevent Senior, São Paulo, Brazil.

Introduction: Computed tomography (CT) of the chest, although not a screening test or diagnosis of infection with the new coronavirus, has a fundamental role in assessing the extent of lung involvement and complications such as pleural effusion. Considering the higher morbidity and mortality of elderly patients due to this infection, the objective of this study was to evaluate the imaging aspects and clinical correlations of an extreme age (≥80 years) with a confirmed diagnosis for COVID-19.

Methods: This was a retrospective and single-center cohort study. Read More

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Noninvasive OCT angiography-based blood attenuation measurements correlate with blood glucose level in the mouse retina.

Biomed Opt Express 2021 Aug 6;12(8):4680-4688. Epub 2021 Jul 6.

State Key Lab of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.

In this study, we investigated the correlation of the blood optical attenuation coefficient (OAC) and the blood glucose concentration (BGC). The blood OAC was measured in mouse retina in vivo by analyzing the depth attenuation of backscattered light under the guidance of OCT angiography (OCTA) vascular mapping, and then its correlation to the BGC was further investigated. The optical attenuation of the blood components presented a more reliable correlation to BGC than that of the background tissues. Read More

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Quantification of Liver Fat by MRI-PDFF Imaging in Patients with Suspected Non-alcoholic Fatty Liver Disease and Its Correlation with Metabolic Syndrome, Liver Function Test and Ultrasonography.

J Clin Exp Hepatol 2021 Sep-Oct;11(5):586-591. Epub 2020 Dec 1.

Institute of Gastrosciences & Liver, Apollo Gleneagles Hospital, 58, Canal Circular Road, Kolkata, West Bengal, 700054, India.

Background: Magnetic resonance imaging (MRI)-estimated proton density fat fraction (PDFF) has emerged to be a promising tool in quantification of liver fat. Aim of this study was to quantify liver fat using MRI-PDFF in patients with suspected non-alcoholic fatty liver disease (NAFLD) and to correlate it with the presence of metabolic syndrome (MetS), ultrasonography (USG) and liver function test (LFT).

Methods: We included 111 consecutive patients who were suspected to have NAFLD on the basis of clinical, laboratory or USG findings. Read More

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December 2020

Prognostic value of brain tissues' volumes in patients with essential tremor treated with MRgFUS thalamotomy.

J Clin Neurosci 2021 Oct 3;92:33-38. Epub 2021 Aug 3.

Department of Biotechnological and Applied Clinical Science, University of L'Aquila AQ, Via Vetoio 1 AQ, 67100, Italy. Electronic address:

MRgFUS Vim thalamotomy is a novel, effective, minimally invasive therapeutic option for patients with essential tremor (ET). Among the selection criteria, some parameters related to the patient's anatomy, such as the skull density ratio (SDR), are well recognized. The role of brain tissue interposed between the target and the ultrasound transducers has never been explored. Read More

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October 2021

Objective Evaluation of Cerebral Venous Sinus Attenuation on Plain CT Brain and Detecting Anemia. Noticing the "Unnoticed".

Neurol India 2021 Jul-Aug;69(4):874-878

Department of Radio-Diagnosis, Kasturba Medical College (KMC), Manipal, Karnataka, India.

Context: Plain computed tomography (CT) of the brain is an important first-line investigation of choice in an acute neurologic setup. Unless clinically suspected concealed areas like the confluence of venous sinuses often go unnoticed. Diagnosing anemia, thrombosis, or polycythemia correlating the CT attenuation values might prove to be fruitful in early patient management where the mode of varied clinical presentations causes a clinical dilemma. Read More

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September 2021

Convolutional neural network based attenuation correction forI-FP-CIT SPECT with focused striatum imaging.

Phys Med Biol 2021 Sep 7. Epub 2021 Sep 7.

Radiation, Science and Technology, Technische Universiteit Delft, Delft, NETHERLANDS.

SPECT imaging with 123I-FP-CIT is used for diagnosis of neurodegenerative disorders like Parkinson's disease. Attenuation correction (AC) can be useful for quantitative analysis of 123I-FP-CIT SPECT. Ideally, AC would be performed based on attenuation maps (μ-maps) derived from perfectly registered CT scans. Read More

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September 2021

Genome-Wide Association Studies Provide Insights into the Genetic Determination of Flower and Leaf Traits of .

Front Plant Sci 2021 20;12:730890. Epub 2021 Aug 20.

College of Agronomy, Jiangxi Agricultural University/Kiwifruit institute of Jiangxi Agricultural University, Nanchang, China.

Kiwifruit () is a dioecious vine, and the pollen of its male cultivars has a direct effect on the quality of its fruits. In this study, to facilitate molecular breeding and gene identification, we performed genome-wide association studies (GWAS) on 11 traits of flower and leaf. A total of 946,337 highly consistent SNP markers were obtained in the whole genome. Read More

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Attenuation of rheumatoid arthritis through the inhibition of caspase3/GSDME-mediated pyroptosis induced by TNF-α.

Arthritis Rheumatol 2021 Sep 4. Epub 2021 Sep 4.

Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.

Objectives: To determine the role of gasdermin E (GSDME)-mediated pyroptosis in the pathogenesis and progression of rheumatoid arthritis (RA), and explore the potential therapeutic targets for RA.

Methods: The expression and activation of caspase3 and GSDME in the synovium, macrophages, and monocytes of RA patients was detected by immunohistochemistry, immunofluorescence, and western blot analysis. The correlation of activated GSDME with RA disease activity was evaluated. Read More

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September 2021

Evaluation of the Correction Methods Using Age and BMI for Estimating CT Organ Dose Using a Radiophotoluminescence Glass Dosimeter and a Monte Carlo-based Dose Calculator.

Health Phys 2021 Aug 31. Epub 2021 Aug 31.

Department of Radiological Sciences, Faculty of Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashiogu, Arakawa-ku, Tokyo 116-8551, Japan Center for Radiation Protection Knowledge, National Institute of Radiological Sciences, QST, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555, Japan.

Abstract: The size-specific dose estimates (SSDE) have been recommended to replace the volume computed tomography dose index (CTDIvol) because it takes patient size into account. On the other hand, organ dose is thought to be a more appropriate quantity in the radiation protection field due to its correlation with radiation risk. The web-based computed tomography (CT) dose calculator WAZA-ARIv2 only offers organ doses for adults with four different body shapes and for children with five different ages. Read More

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Influence of nonlinear soft tissue modeling on the external and internal forces during lateral hip impacts.

J Mech Behav Biomed Mater 2021 Aug 21;124:104743. Epub 2021 Aug 21.

Neuronic Engineering, KTH Royal Institute of Technology, Stockholm, Sweden.

Soft tissues in the hip region, which are typically considered the natural shock-absorbers during falls, attenuate the applied forces to the underlying hard tissue. The soft tissue thickness is, therefore, a significant parameter in the force attenuation. Another factor that could affect the assessment of the force attenuation in numerical simulations is the choice of constitutive model and material parameters for the soft tissue. Read More

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4D Bragg Edge Tomography of Directional Ice Templated Graphite Electrodes.

J Imaging 2020 Dec 11;6(12). Epub 2020 Dec 11.

Rutherford Appleton Laboratory, Science and Technology Facilities Council (STFC), ISIS Facility, Harwell OX11 0QX, UK.

Bragg edge tomography was carried out on novel, ultra-thick, directional ice templated graphite electrodes for Li-ion battery cells to visualise the distribution of graphite and stable lithiation phases, namely LiC and LiC. The four-dimensional Bragg edge, wavelength-resolved neutron tomography technique allowed the investigation of the crystallographic lithiation states and comparison with the electrode state of charge. The tomographic imaging technique provided insight into the crystallographic changes during de-/lithiation over the electrode thickness by mapping the attenuation curves and Bragg edge parameters with a spatial resolution of approximately 300 µm. Read More

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December 2020

Optimization of cross-calibration factor for quantitative bone SPECT without attenuation and scatter correction in the lumbar spine: head-to-head comparison with attenuation and scatter correction.

Nucl Med Commun 2021 Aug 26. Epub 2021 Aug 26.

Department of Radiology, Toyohashi Municipal Hospital, Aichi Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa Department of Radiological Technology, Faculty of Medical Technology, Teikyo University, Tokyo, Japan.

Objectives: Quantitative single-photon emission computed tomography (SPECT) with computed tomography (SPECT/CT) is known to improve diagnostic performance. Although SPECT-alone systems are used widely, accurate quantitative SPECT using these systems is challenging. This study aimed to improve the accuracy of quantitative bone SPECT of the lumbar spine with the SPECT-alone system. Read More

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Correlation Between Sex Hormones and Non-alcoholic Fatty Liver Disease Before and After Laparoscopic Sleeve Gastrectomy.

Obes Surg 2021 Aug 28. Epub 2021 Aug 28.

Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.

Objectives: To investigate the cross-sectional and longitudinal correlation between sex hormones and non-alcoholic fatty liver disease (NAFLD) in patients with obesity before and after laparoscopic sleeve gastrectomy (LSG).

Methods: A total of 360 patients with obesity aged 16-48 years (170 men and 190 women) were enrolled between May 2017 and March 2021. Among them, 132 patients (55 men and 77 women) who underwent LSG had follow-up data. Read More

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CT hepatic arterial perfusion index does not allow stratification of the degree of esophageal varices and bleeding risk in cirrhotic patients in Child-Pugh classes A and B.

Abdom Radiol (NY) 2021 Aug 27. Epub 2021 Aug 27.

Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany.

Purpose: To evaluate if the hepatic arterial perfusion index (HPI) in liver parenchyma of cirrhotic patients can serve as a surrogate parameter for stratifying the degree of esophageal varices and related bleeding risks.

Methods: CT image data of sixty-six patients (59 men; mean age 68 years ± 10 years) with liver cirrhosis (Child-Pugh class A (35/66, 53%), B (25/66, 38%), and C (6/66, 9%) who underwent perfusion CT (PCT) for hepatocellular carcinoma (HCC) screening between April 2010 and January 2019 were retrospectively identified. HPI, a parameter calculated by a commercially available CT liver perfusion analysis software that is based on the double maximum slope model, using time attenuation curve to determine perfusion, was correlated with the degree of esophageal varices diagnosed at endoscopy and the number of bleeding events. Read More

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Advanced glycation end product: A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study.

World J Gastroenterol 2021 Aug;27(29):4913-4928

Laboratory of Health and Environment Education, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, Brazil.

Background: Liver diseases are associated with the excess formation of advanced glycation end products (AGEs), which induce tissue inflammation and oxidative damage. However, the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease (NAFLD) is unclear.

Aim: To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil population. Read More

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Nuclear Radiation Shielding Characteristics of Some Natural Rocks by Using EPICS2017 Library.

Materials (Basel) 2021 Aug 19;14(16). Epub 2021 Aug 19.

Physics Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Radiation leakage is a serious problem in various technological applications. In this paper, radiation shielding characteristics of some natural rocks are elucidated. Mass attenuation coefficients (µ/ρ) of these rocks are obtained at different photon energies with the help of the EPICS2017 library. Read More

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Detection of fibrotic remodeling of epicardial adipose tissue in patients with atrial fibrillation: Imaging approach based on histological observation.

Heart Rhythm O2 2021 Aug 24;2(4):311-323. Epub 2021 May 24.

Department of Cardiology and Clinical Examination.

Background: Fibrotic remodeling of epicardial adipose tissue (EAT) is crucial for proinflammatory atrial myocardial fibrosis, which leads to atrial fibrillation (AF).

Objectives: We tested the hypothesis that the ratio of central to marginal adipocyte diameter in EAT represents its fibrotic remodeling. Based on a similar concept, we also tested whether the percent (%) change in EAT fat attenuation determined using computed tomographic (CT) images can detect this remodeling. Read More

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Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis.

Hepatol Commun 2021 Aug 13;5(8):1362-1372. Epub 2021 May 13.

Division of Pediatric Gastroenterology, Hepatology and Nutrition Emory University School of Medicine/Children's Healthcare of Atlanta Atlanta GA USA.

Methods to identify children with cystic fibrosis (CF) at risk for development of advanced liver disease are lacking. We aim to determine the association between liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) with research ultrasound (US) patterns and conventional hepatic markers as a potential means to follow liver disease progression in children with CF. ELASTIC (Longitudinal Assessment of Transient Elastography in CF) is a nested cohort of 141 patients, ages 7-21, enrolled in the Prediction by US of Risk of Hepatic Cirrhosis in CF (PUSH) Study. Read More

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X-ray Dark-Field Chest Imaging: Qualitative and Quantitative Results in Healthy Humans.

Radiology 2021 Aug 24:210963. Epub 2021 Aug 24.

From the Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum Rechts der Isar, Technical University of Munich, Ismaningerstr 22, 81675 Munich, Germany (F.T.G., A.A.F., A.P.S., M.R.M., D.P., F.P.); Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany (T.U., M.F., K.W., W.N., P.B., R.S., F.P.); and Philips Research, Hamburg, Germany (T.K., J.v.B.).

Background X-ray dark-field radiography takes advantage of the wave properties of x-rays, with a relatively high signal in the lungs due to the many air-tissue interfaces in the alveoli. Purpose To describe the qualitative and quantitative characteristics of x-ray dark-field images in healthy human subjects. Materials and Methods Between October 2018 and January 2020, patients of legal age who underwent chest CT as part of their diagnostic work-up were screened for study participation. Read More

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Sarcopenia and major complications in patients undergoing oncologic colon surgery.

J Cachexia Sarcopenia Muscle 2021 Aug 22. Epub 2021 Aug 22.

Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, Switzerland.

Background: Sarcopenia is a surrogate marker for malnutrition and frailty, which has been linked to higher complication rates and prolonged length of stay (LOS) after surgery. The study aim was to assess the correlation between computed tomography (CT)-based sarcopenia and short-term clinical outcomes after oncologic colon surgery.

Methods: This retrospective study included consecutive patients operated between May 2014 and December 2019. Read More

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Preselection of robust radiomic features does not improve outcome modelling in non-small cell lung cancer based on clinical routine FDG-PET imaging.

EJNMMI Res 2021 Aug 21;11(1):79. Epub 2021 Aug 21.

Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background: Radiomics is a promising tool for identifying imaging-based biomarkers. Radiomics-based models are often trained on single-institution datasets; however, multi-centre imaging datasets are preferred for external generalizability owing to the influence of inter-institutional scanning differences and acquisition settings. The study aim was to determine the value of preselection of robust radiomic features in routine clinical positron emission tomography (PET) images to predict clinical outcomes in locally advanced non-small cell lung cancer (NSCLC). Read More

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Diagnostic accuracy of ultrasound-guided attenuation parameter as a noninvasive test for steatosis in non-alcoholic fatty liver disease.

J Med Ultrason (2001) 2021 Aug 20. Epub 2021 Aug 20.

Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Nishitokuta 2-1-1, Yahaba-cho, Shiwa-gun, Iwate, 028-3694, Japan.

The purpose of this study was to evaluate the diagnostic accuracy of the ultrasound-guided attenuation parameter (UGAP) using the LOGEQ E10 for hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients and directly compare UGAP with attenuation imaging (ATI) and controlled attenuation parameter (CAP). We prospectively analyzed 105 consecutive patients with NAFLD who underwent UGAP, ATI, CAP, and liver biopsy on the same day between October 2019 and April 2021. The diagnostic ability of the UGAP-determined attenuation coefficient (AC) was evaluated using receiver operating characteristic (ROC) curve analysis, and its correlation with ATI-determined AC values or CAP values was investigated. Read More

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The antioncogenic effect of Beclin-1 and FOXP3 is associated with SKP2 expression in gastric adenocarcinoma.

Medicine (Baltimore) 2021 Aug;100(33):e26951

Department of Surgery, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Korea.

Abstract: An overexpression of S-phase kinase-associated protein 2 (SKP2) is frequently observed in human cancer progression and metastasis, and evidence suggests that SKP2 plays a proto-oncogenic role both in vitro and in vivo. However, the function of SKP2 in gastric adenocarcinoma remains largely obscure. We investigated SKP2 expression in human gastric carcinomas. Read More

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Impact of glucose variability on coronary plaque vulnerability in patients with dysglycemia: A whole coronary analysis with multislice computed tomography.

J Cardiol 2021 Aug 16. Epub 2021 Aug 16.

Department of Cardiology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuhocho, Nagoya 4678601, Japan.

Background: Dysglycemia is associated with an increased risk of acute coronary syndrome caused by the disruption of vulnerable plaques. The relationship between glycemic variability (GV), which is a component of impaired glucose metabolism, and coronary plaque vulnerability has not been fully elucidated. This study investigated the impact of GV on whole coronary plaque vulnerability using multislice computed tomography (MSCT). Read More

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Steatosis grading consistency between controlled attenuation parameter and MRI-PDFF in monitoring metabolic associated fatty liver disease.

Ther Adv Chronic Dis 2021 12;12:20406223211033119. Epub 2021 Aug 12.

Department of Gastroenterology of the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China.

Background: The consistency in steatosis grading between magnetic resonance imaging-based proton density fat fraction (MRI-PDFF) and controlled attenuation parameter (CAP) before and after treatment remains unclear. This study aimed to compare the diagnostic accuracy of steatosis grading between MRI-PDFF and CAP using liver biopsy as standard and to evaluate the value of monitoring changes in steatosis grading with CAP during follow-up utilizing MRI-PDFF as a reference.

Methods: Consecutive patients from a biopsy cohort and a randomized controlled trial were included in this study and classified into 3 groups (the biopsy, orlistat treatment, and routine treatment subgroups). Read More

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Muscle-Related Parameters as Determinants of Survival in Patients with Stage I-III Gastric Cancer Undergoing Gastrectomy.

J Cancer 2021 25;12(18):5664-5673. Epub 2021 Jul 25.

College of Nursing Science, Kyung Hee University, Seoul, Republic of Korea.

: This study aimed to evaluate the prognostic potential of muscle-related parameters (MRPs) at the level of the third lumbar vertebra (L3) using computerized tomography (CT) images in patients with stage I-III gastric cancer (GC) who underwent curative gastric resection. : Patients with stage I-III GC who underwent curative gastric resection between October 2006 and June 2014 were enrolled in this study. In addition to demographic and clinical parameters, MRPs, such as skeletal muscle index (SMI), skeletal muscle radiation attenuation (SMRA), paraspinal muscle index (PMI), and paraspinal muscle radiation attenuation (PMRA), at the L3 level using CT images were collected and analyzed. Read More

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Quantitative Evaluation of Renal Cortex Perfusion Using Contrast-Enhanced Ultrasound Imaging Parameters in Ischemia-Reperfusion Injury in Rabbits.

Ultrasound Med Biol 2021 Aug 13. Epub 2021 Aug 13.

Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China; Department of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China; Department of Ultrasound, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China. Electronic address:

The aim of this study was to evaluate blood perfusion of the renal cortex during ischemia-reperfusion (I/R) injury using quantitative contrast-enhanced ultrasound (CEUS) parameters. In this experiment, 24 rabbits were randomly divided into four groups (N = 6): sham-operated group, 24-h post-operation for I/R injury group (24-h I/R), 3-d post-operation for I/R injury group (3-d I/R) and 5 d post-operation for I/R injury group (5 d I/R). All quantitative CEUS parameters were monitored and included the gradient from the start frame to the peak frame (Grad), area under the curve (Area), time-to-peak (TTP), difference between B(intercept intensity at t=0) and A(the intensity attenuation t= 0) and arrival time (AT). Read More

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