928,722 results match your criteria correlation analyses

[Translation, Adaptation, Reliability and Validity of the German Version of the Prosthesis Mobility Questionnaire 2.0 (PMQ) on Patients with Major Lower Limb Amputation].

Rehabilitation (Stuttg) 2021 Jul 22. Epub 2021 Jul 22.

Klinik für Rehabilitationsmedizin, Medizinische Hochschule Hannover.

Purpose: The aim of this prospective validation study was to translate the Prosthesis Mobility Questionnaire 2.0 (PMQ) into German based on a guideline, following by psychometric testing for its validity and reliability using classical test theory.

Methods: The PMQ was translated into German according to ISPOR guidelines using double forward and double backward translations, finalized by pilot testing (N=10). Read More

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Deep neural network-based approach to improving radiomics analysis reproducibility in liver cancer: effect on image resampling.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Nuclear & Radiological Engineering and Medical Physics Programs, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA, Atlanta, Georgia, UNITED STATES.

Objectives: To test the effect of traditional up-sampling slice thickness (ST) methods on the reproducibility of CT radiomics features of liver tumors and investigate the improvement using a deep neural network (DNN) scheme.

Methods: CT images with ≤ 1 mm ST in the public dataset were converted to low resolution (3 mm, 5 mm) CT images. A DNN model was trained for the conversion from 3 mm-ST and 5 mm-ST to 1 mm-ST and compared with conventional interpolation-based methods (cubic, linear, nearest) using structural similarity (SSIM) and peak-signal-to-noise-ratio (PSNR). Read More

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Synthetic pulmonary perfusion images from 4DCT for functional avoidance using deep learning.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Radiation Oncology, Beaumont Health System, Royal Oak, Michigan, UNITED STATES.

Purpose: To develop and evaluate the performance of a deep learning model to generate synthetic pulmonary perfusion images from clinical 4DCT images for patients undergoing radiotherapy for lung cancer.

Methods: A clinical data set of 58 pre- and post-radiotherapy 99mTc-labelled MAA-SPECT perfusion studies (32 patients) each with contemporaneous 4DCT studies was collected. Using the inhale and exhale phases of the 4DCT, a 3D-Residual Network was trained to create synthetic perfusion images utilizing the MAA-SPECT as ground truth. Read More

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Spin-to-charge conversion and interface-induced spin Hall magnetoresistance in yttrium iron garnet/metallic bilayers.

J Phys Condens Matter 2021 Jul 22. Epub 2021 Jul 22.

Departamento de Física, Universidade Federal de Pernambuco, Av. Jorn. Aníbal Fernandes, s/n - Cidade Universitária, Recife - PE, Recife, PE, 50670-901, BRAZIL.

We report the investigation of spin-to-charge current interconversion process in hybrid structures of yttrium iron garnet (YIG)/metallic bilayers by means of two different experimental techniques: spin pumping effect (SPE) and spin Hall magnetoresistance (SMR). We demonstrate the evidence of a correlation between spin-to-charge conversion and spin Hall magnetoresistance in bilayers of YIG/Pd, YIG/Pt, and YIG/IrMn. The correlation was verified directly in the spin Hall angles and the amplitudes of the voltage signals measured by the SPE and SMR techniques. Read More

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A lacto-ovo-vegetarian dietary pattern is protective against sarcopenic obesity: A cross-sectional study of elderly Chinese people.

Nutrition 2021 Jun 7;91-92:111386. Epub 2021 Jun 7.

Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University. Electronic address:

Objectives: The purpose of this study was to investigate the correlation between dietary patterns and the risk of sarcopenic obesity (SO) in community-dwelling elderly people.

Methods: SO was defined as the coexistence of sarcopenia and obesity. Participants with low skeletal muscle index, low muscle strength, or low physical performance were diagnosed with sarcopenia, whereas obesity was defined as waist circumference ≥85 cm in men and ≥80 cm in women. Read More

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Prediction of chemotherapy response in breast cancer patients at pre-treatment using second derivative texture of CT images and machine learning.

Transl Oncol 2021 Jul 19;14(10):101183. Epub 2021 Jul 19.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Physical Sciences Platform, Sunnybrook Research Institute, Sunnybrook Health Sciences Center, Toronto, ON, Canada; Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Center, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic address:

Although neoadjuvant chemotherapy (NAC) is a crucial component of treatment for locally advanced breast cancer (LABC), only about 70% of patients respond to it. Effective adjustment of NAC for individual patients can significantly improve survival rates of those resistant to standard regimens. Thus, the early prediction of NAC outcome is of great importance in facilitating a personalized paradigm for breast cancer therapeutics. Read More

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Differences in SCN1A intronic variants result in diverse aberrant splicing patterns and are related to the phenotypes of epilepsy with febrile seizures.

Epilepsy Res 2021 Jul 7;176:106711. Epub 2021 Jul 7.

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, GX, China. Electronic address:

Objective: Intronic variants of the SCN1A gene are detected in patients with epilepsy with febrile seizures (EFS), which includes a series of phenotypes with different severities. However, the pathogenicity of intronic variants and their genotype-phenotype correlation remain under characterized. The purpose of this study was to determine the changes in mRNA splicing caused by SCN1A intronic variants associated with EFS and their association with phenotypes. Read More

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Insights for applying erythrosine B as a green fluorescence probe for estimation of anticancer tamoxifen and its analog; clomiphene in nanogram concentration.

M M Tolba M M Salim

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 12;263:120156. Epub 2021 Jul 12.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University - Egypt, New Damietta 34511, Egypt. Electronic address:

The growth of tumor tissue is extremely pervasive among post-menopausal women. Commonly, from the clinical application, adjuvant selective estrogen receptor modulators such as tamoxifen are prescribed for prohibiting metastatic breast cancer, while its analog, clomiphene, is used to treat infertility in women. Lately, the significance of green chemistry on our environment was through reducing the influence of hazardous chemicals. Read More

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Diagnostic potential of trace metals concentration in expressed prostatic secretion and serum of patients with category IV prostatitis.

J Trace Elem Med Biol 2021 Jul 8;68:126819. Epub 2021 Jul 8.

Scientific Research Center, Guilin Medical University, Guilin, Guangxi, China; Guangxi Health Commission Key Laboratory of Disease Proteomics Research, China. Electronic address:

Background: The National Institutes of Health (NIH) category IV prostatitis is a painless prostate gland inflammation, just as its name implies, this type of prostatitis is related with inflammation of the prostate, but most men are not conscious of it. However, category IV prostatitis is fairly common in general populations and reported having indirect relationships with prostate cancer.

Method: We analyzed the concentration of zinc (Zn), copper (Cu), calcium (Ca) and magnesium (Mg) in expressed prostatic secretion (EPS) and serum of patients with category IV prostatitis and healthy controls, investigating the diagnostic potential of different metals in category IV prostatitis using a flame atomic absorption spectrometer (FAAS). Read More

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Structural insights in galectin-1-glycan recognition: Relevance of the glycosidic linkage and the N-acetylation pattern of sugar moieties.

Bioorg Med Chem 2021 Jul 14;44:116309. Epub 2021 Jul 14.

Laboratorio de Bioquímica, Departamento de Biociencias, Facultad de Química, UdelaR, Gral. Flores, 2124, 11800 Montevideo, Uruguay. Electronic address:

Galectins, soluble lectins widely expressed intra- and extracellularly in different cell types, play major roles in deciphering the cellular glycocode. Galectin-1 (Gal-1), a prototype member of this family, presents a carbohydrate recognition domain (CRD) with specific affinity for β-galactosides such as N-acetyllactosamine (β-d-Galp-(1 → 4)-d-GlcpNAc), and mediate numerous physiological and pathological processes. In this work, Gal-1 binding affinity for β-(1 → 6) galactosides, including β-d-Galp-(1 → 6)-β-d-GlcpNAc-(1 → 4)-d-GlcpNAc was evaluated, and their performance was compared to that of β-(1 → 4) and β-(1 → 3) galactosides. Read More

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Aging microplastics in wastewater pipeline networks and treatment processes: Physicochemical characteristics and Cd adsorption.

Sci Total Environ 2021 Jul 8;797:148940. Epub 2021 Jul 8.

Centre for Green Technology, University of Technology Sydney, 15 Broadway, Sydney, NSW 2007, Australia.

Despite a wealth of information on removal of the microplastics (MPs) in wastewater treatment plants (WWTPs), little attention has been paid to how wastewater treatment process affect the MP physicochemical and adsorption characteristics. In this study, changes in physicochemical property of three MPs, i.e. Read More

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Mapping groundwater-dependent ecosystems in arid Central Asia: Implications for controlling regional land degradation.

Sci Total Environ 2021 Jul 14;797:149027. Epub 2021 Jul 14.

Eurasia Institute of Earth Sciences, Istanbul Technical University, Maslak, Istanbul 34469, Turkey.

Groundwater-dependent ecosystems (GDEs) exist all over the world, especially in water-limited regions. To achieve better water management, it is necessary to map and identify GDEs. Central Asia (CA) is one of the most arid regions in the mid-latitudes and one of the major regions with shallow groundwater tables. Read More

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Estradiol correlates with the accumulation of Monocytic Myeloid-Derived Suppressor Cells in Pre-term birth: A possible explanation of immune suppression in pre-term babies.

J Reprod Immunol 2021 Jul 19;147:103350. Epub 2021 Jul 19.

Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. Electronic address:

Synergistic interplay of immune endocrine interaction is prerequisite for an effective maternal fetal tolerance. Pre-term birth (PTB) may be a consequence of altered immune-endocrine crosstalk during third trimester resulting in early breakdown of this tolerance. Myeloid derived suppressor cells (MDSCs), a heterogenous population of immature immune cells are increased in pregnant women and healthy newborns, but their role in PTB still remains obscure. Read More

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The predictive value of segmentation metrics on dosimetry in organs at risk of the brain.

Med Image Anal 2021 Jul 13;73:102161. Epub 2021 Jul 13.

ARTORG Center for Biomedical Research, University of Bern, Bern, Switzerland. Electronic address:

Background: Fully automatic medical image segmentation has been a long pursuit in radiotherapy (RT). Recent developments involving deep learning show promising results yielding consistent and time efficient contours. In order to train and validate these systems, several geometric based metrics, such as Dice Similarity Coefficient (DSC), Hausdorff, and other related metrics are currently the standard in automated medical image segmentation challenges. Read More

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Improving severity scoring of food-induced allergic reactions: a global "Best-Worst Scaling" exercise.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

National Heart & Lung Institute, Imperial College London, London, UK;. Electronic address:

Background: There is no current consensus on assigning severity to food-induced allergic reactions, for example to assess the efficacy of allergen immunotherapy. Existing severity scores lack the capability to discriminate between non-anaphylaxis reactions of different severities. Attempts are ongoing to develop a more discriminatory score, which should ideally be data-driven and validated in multiple cohorts. Read More

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Relationship of proprioception, cutaneous sensitivity, and muscle strength with the balance control among older adults.

J Sport Health Sci 2021 Jul 19. Epub 2021 Jul 19.

Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China; Department of Health Sciences and Kinesiology, Georgia Southern University, Statesboro, GA 30460, USA. Electronic address:

Purpose: Balance impairment is one of the strongest risk factors for falls. Proprioception, cutaneous sensitivity, and muscle strength are 3 important contributors to balance control in older adults. The relationship that dynamic and static balance control has to proprioception, cutaneous sensitivity, and muscle strength is still unclear. Read More

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Int J Pharm 2021 Jul 19:120896. Epub 2021 Jul 19.

Krka, d. d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia; University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia. Electronic address:

This study investigates the use of the spatial filtering technique (SFT) to monitor the particle size distribution (PSD) of granules obtained by roller compaction. In the first part of the study, the influence of the selected process and formulation parameters on the PSD of granules is monitored at-line using SFT. The correlation between the PSD obtained by SFT, sieve analysis, laser diffraction, and dynamic image analysis was satisfactory. Read More

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Structural white matter connectometry of reading and dyslexia.

Neuroimage 2021 Jul 19:118411. Epub 2021 Jul 19.

Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, P.O.Box 21, University of Helsinki, Finland.

Current views on the neural network subserving reading and its deficits in dyslexia rely largely on evidence derived from functional neuroimaging studies. However, understanding the structural organization of reading and its aberrations in dyslexia requires a hodological approach, studies of which have not provided consistent findings. Here, we adopted a whole brain hodological approach and investigated relationships between structural white matter connectivity and reading skills and phonological processing in a cross-sectional study of 44 adults using individual local connectome matrix from diffusion MRI data. Read More

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Disrupted Small-world Networks are Associated with Decreased Vigilant Attention after Total Sleep Deprivation.

Neuroscience 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurology, The Second Medical Center, Sleep Medicine Research Center, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; School of Medicine, Nankai University, Tianjin, 300071, China. Electronic address:

Sleep deprivation critically affects vigilant attention. Previous neuroimaging studies have revealed altered inter-regional functional connectivity after sleep deprivation, which may disrupt topological properties of brain functional networks. However, little is known about alterations in the topology of intrinsic connectivity and its involvement in attention performance after sleep deprivation. Read More

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Pan-cancer analysis reveals that neurotrophin signaling correlates positively with anti-tumor immunity, clinical outcomes, and response to targeted therapies and immunotherapies in cancer.

Life Sci 2021 Jul 19;282:119848. Epub 2021 Jul 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Aims: The crosstalk between cancer cells and nerves plays an important role in tumor biology. However, the correlation between the neurotrophin signaling (NS) and anti-tumor immunity and immunotherapy response in cancer remains unexplored.

Materials And Methods: We analyzed associations of NS with anti-tumor immune signatures, tumor immunity-related molecular and genomic features, and clinical features in 33 TCGA cancer types. Read More

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DNA methylation array identifies golli-MBP as a biomarker for the disease severity in childhood atopic dermatitis.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 83301; Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. 83301. Electronic address:

In this study, we investigated the changes in the global methylation status and its functional relevance in childhood atopic dermatitis (AD). Differences in epigenome-scale methylation events in peripheral blood associated with childhood AD were screened using DNA methylation arrays of 24 AD patients compared to 24 control subjects (C). Of the 16,840 differentially methylated CpG regions between AD and C, > 97% CpG loci revealed hypomethylation in childhood AD patients. Read More

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Effect of Lens Vault on the Accuracy of Intraocular Lens Calculation Formulas in Shallow Anterior Chamber Eyes.

Chenxi Yan Ke Yao

Am J Ophthalmol 2021 Jul 19. Epub 2021 Jul 19.

Eye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. Electronic address:

Purpose: To explore the impact of preoperative lens vault (LV) on the accuracy of the Barrett Universal Ⅱ, Haigis, Hoffer Q, Hoffer QST, Holladay 1, Kane, and SRK/T formulas in eyes with shallow anterior chamber.

Design: Retrospective case series METHODS: 409 eyes with anterior chamber depth (ACD) shallower than 3.0 mm that underwent phacoemulsification were included. Read More

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AutoGeneS: Automatic gene selection using multi-objective optimization for RNA-seq deconvolution.

Cell Syst 2021 Jul 7;12(7):706-715.e4. Epub 2021 Jun 7.

Institute of Computational Biology, Helmholtz Centre, Munich, Bayern 85764, Germany; Department of Mathematics, Technical University of Munich, Munich, Bayern 85748, Germany; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany. Electronic address:

Knowing cell-type proportions in a tissue is very important to identify which cells or cell types are targeted by a disease or perturbation. Hence, several deconvolution methods have been proposed to infer cell-type proportions from bulk RNA samples. Their performance with noisy reference profiles and closely correlated cell types highly depends on the set of genes undergoing deconvolution. Read More

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Bridging neuronal correlations and dimensionality reduction.

Neuron 2021 Jul 16. Epub 2021 Jul 16.

Carnegie Mellon Neuroscience Institute, Pittsburgh, PA 15213, USA; Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address:

Two commonly used approaches to study interactions among neurons are spike count correlation, which describes pairs of neurons, and dimensionality reduction, applied to a population of neurons. Although both approaches have been used to study trial-to-trial neuronal variability correlated among neurons, they are often used in isolation and have not been directly related. We first established concrete mathematical and empirical relationships between pairwise correlation and metrics of population-wide covariability based on dimensionality reduction. Read More

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Cardinal Electronegativity Values Correlate with Physicochemical Properties.

Gordon Sproul

Inorg Chem 2021 Jul 22. Epub 2021 Jul 22.

University of South Carolina Beaufort, 1 University Boulevard, Bluffton, South Carolina 29909, United States.

The use of the difference in electronegativity (EN) function is shown to be fundamentally untenable for differentiating ionic from covalent bonding in binary compounds. Also, the commonly used parameters of differences and averages of EN values do not provide a direct correlation with metallic, ionic, or covalent chemical bonding types. On the other hand, the cardinal coordinates of lower and higher EN values readily demonstrate such a correlation. Read More

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A Clinical Feasibility Study of Spinal Evoked Compound Action Potential Estimation Methods.

Neuromodulation 2021 Jul 22. Epub 2021 Jul 22.

Medtronic plc, Minneapolis, MN, USA.

Objectives: Spinal cord stimulation (SCS) is a treatment for chronic neuropathic pain. Recently, SCS has been enhanced further with evoked compound action potential (ECAP) sensing. Characteristics of the ECAP, if appropriately isolated from concurrent stimulation artifact (SA), may be used to control, and aid in the programming of, SCS systems. Read More

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The interactions between childhood adversities and recent stress were associated with early-adulthood depression among Chinese undergraduate students.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Background: It is widely acknowledged that childhood adversities (CAs) and recent stress are potential risk factors for adult depression. However, the mechanism(s) by which interactions of CAs with recent stress affect adult depression remain unclear.

Aims: To investigate the predictive association of the interaction among CAs and recent stress with early-adult depression. Read More

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Measuring the difference in natural head position between the standing and sitting positions using an inertial measurement unit.

J Oral Rehabil 2021 Jul 22. Epub 2021 Jul 22.

Division of Orthodontics, University Clinics of Dental Medicine, University of Geneva, Switzerland.

The purpose of this study was to compare the natural head position (NHP) in the sitting position to the NHP in a standing position using inertial measurement unit (IMU) and lateral photographs. Twenty healthy young adult volunteers were asked to look at a mirror located at 1 meter in front of their eyes while being recorded with the IMU system. Lateral photographs were also taken. Read More

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Predicting mutant outcome by combining deep mutational scanning and machine learning.

Proteins 2021 Jul 22. Epub 2021 Jul 22.

Department of Computer Science, Ben-Gurion University of the Negev, Be'er Sheva, Israel.

Motivation: Deep mutational scanning provides unprecedented wealth of quantitative data regarding the functional outcome of mutations in proteins. A single experiment may measure properties (e.g. Read More

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Reproducibility and Validity of Capillary Dried Blood Spot for Diagnosis of Vitamin A Deficiency and Anemia in Children <5 Years Old.

J Nutr 2021 Jul 22. Epub 2021 Jul 22.

Department of Social Nutrition, Nutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Background: Vitamin A deficiency (VAD) and anemia are the most prevalent nutritional deficiency in children globally. The dried blood spot (DBS) method has been used in prevalence studies of VAD and anemia in different age groups. However, it has not yet been validated for children. Read More

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