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INFLAMMATION IN CHILDHOOD EPILEPSY SYNDROMES.

Georgian Med News 2021 Mar(312):88-92

Tbilisi State Medical University, Department of Paediatric Neurology, Georgia.

Epilepsy is one of the most common neurological disorder affecting up to 1% of the world population. It is a heterogeneous disorder and includes genetic, structural, metabolic causes, sometimes reason is unknown. In recent 20 years inflammation has been considered as a possible etiologic factor in angiogenesis and epileptogenesis in experimental models but there is still lack of evidence if inflammation could be seen in clinical cases of children with different forms of epilepsy. Read More

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CORRELATION OF CD4+Т LYMPHOCYTES ACTIVATION WITH INTERLEUKIN IL-9, IL-17, IL- 22 PROFILES IN THE PERIPHERAL BLOOD OF PATIENTS WITH PLAQUE PSORIASIS.

Georgian Med News 2021 Mar(312):75-78

3Ilia State University, School of Natural Sciences and Medicine, Tbilisi, Georgia.

Psoriasis is a T cell mediated chronic inflammatory skin disease affecting about 2% of the population worldwide. Recently has established the central role of IL-23/Th17 immune axis in the pathogenesis of psoriasis and different subclasses of T cells including Th1 and Th17 cells are involved in initiation and amplification of the skin inflammation process, in addition, in cases of recurrent psoriasis, Th22 cells play the role of memory cells with the help of Th9 cells, which are also important in this process. The main goal was to evaluate the ratio of T cell profile and IL23/Th17 axis by evaluating IL17A, IL22, IL9 in peripheral blood of persons with moderate to severe plaque psoriasis. Read More

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APE1 facilitates PD-L1-mediated progression of laryngeal and hypopharyngeal squamous cell carcinoma.

Int Immunopharmacol 2021 May 5;97:107675. Epub 2021 May 5.

Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Electronic address:

Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HSCC) seriously affect the life quality of patients. Nowadays, immunotherapy is widely used in the treatment of cancer. Tumor-infiltrating lymphocytes (TILs), programmed cell death 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) play key roles in the immunotherapy of cancer. Read More

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A method for measuring dynamic respiratory sinus arrhythmia (RSA) in infants and mothers.

Infant Behav Dev 2021 May 5;63:101569. Epub 2021 May 5.

Department of Psychological and Brain Sciences, Indiana University, United States.

The measurement of respiratory sinus arrythmia (RSA) in infants, children and adults is critical to the study of physiological regulation, and more recently, interpersonal physiological covariation, but it has been impeded by methods that limit its resolution to 30 s or longer. Recent analytical developments have suggested methods for studying dynamic RSA in adults, and we have extended this work to the study of infants and mothers. In the current paper, we describe a new analytical strategy for estimating RSA time series for infants and adults. Read More

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Single layered hollow NiO-NiS catalyst with large specific surface area and highly efficient visible-light-driven carbon dioxide conversion.

Chemosphere 2021 May 3;280:130759. Epub 2021 May 3.

Department of Chemistry, College of Natural Sciences, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. Electronic address:

A sea urchin-shaped, single-layer, and hollow NiO-NiS photocatalyst with a large surface area was designed for carbon dioxide (CO) conversion in this study. A d-glucose polymeric hollow frame was fabricated using a d-glucose monomer, and NiO particles were stably grown on it using the hydrothermal method to form a hollow NiO surface. The d-glucose frame was removed by heat treatment to create hollowed NiO; hollowed NiO-NiS (h-NiO-NiS) was subsequently obtained through ion exchange between the O ions in NiO and S ions in the sulfur powder. Read More

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Polyethylene mesh knitted fabrics mulching the soil to mitigate China's haze: A potential source of PBDEs.

Chemosphere 2021 Apr 30;280:130689. Epub 2021 Apr 30.

Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, 300134, China.

The fate of polybrominated diphenyl ethers (PBDEs) from polyethylene mesh knitted fabrics (PMKFs) to mulched soil and nearby plants was studied. PBDEs in the soil sample collected from Tianjin University of Commerce in April 2019 increased significantly after 6 months of PMKF mulching owing to PMKFs as the main input source. The compositional profiles/congener patterns of the PBDEs in the soil and PMKFs became similar after 6 months. Read More

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Risk assessment of vertebral compressive fracture using bone mass index and strength predicted by computed tomography image based finite element analysis.

Clin Biomech (Bristol, Avon) 2021 Apr 23;85:105365. Epub 2021 Apr 23.

Inazawa Municipal Hospital, Department of Neurosurgery, Inazawa, Aichi 492-8510, Japan.

Background: A main purpose of osteoporosis diagnosis is to evaluate the bone fracture risk. Some bone mass indices evaluated using bone mineral density has been utilized clinically to assess the degree of osteoporosis. On the other hand, Computed tomography image based finite element analysis has been developed to evaluate bone strength of vertebral bodies. Read More

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Conductive hearing loss in large vestibular aqueduct syndrome -clinical observations and proof-of-concept predictive modeling by a biomechanical approach.

Int J Pediatr Otorhinolaryngol 2021 Apr 29;146:110752. Epub 2021 Apr 29.

ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China. Electronic address:

Objective: The purpose of this study was to investigate the effect of a dilated vestibular aqueduct on conductive hearing loss (CHL). A biomechanical method was proposed for modeling the patterns of CHL in patients with large vestibular aqueduct syndrome (LVAS).

Study Design: High resolution computed tomography (CT) scans and pure tone audiometry (PTA) were retrospectively collected from 16 patients who were diagnosed with LVAS. Read More

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Study on structural characterization, physicochemical properties and digestive properties of euryale ferox resistant starch.

Food Chem 2021 Apr 22;359:129924. Epub 2021 Apr 22.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.

At present, the raw materials for industrialized RS3 products are relatively simple and its purity is low. In addition, the correlation between structure and digestion characteristics of RS3 are rarely studied. In this study, euryale ferox, a kind of annual aquatic herb crop with high content of starch was used as a raw material to prepare RS3 by different methods, including autoclaving, enzymolysis-autoclaving and dual enzymolysis, respectively. Read More

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Development of a patient-reported outcome tool for assessing symptom burden during perioperative care in liver surgery: The MDASI-PeriOp-Hep.

Eur J Oncol Nurs 2021 Apr 28;52:101959. Epub 2021 Apr 28.

Institute for Cancer Care Innovation, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: Based on the MD Anderson Symptom Inventory (MDASI), we developed a Patient-reported outcomes tool for hepatectomy perioperative care (MDASI-PeriOp-Hep).

Methods: To establish the content validity, we generated PeriOp-Hep-specific candidate items from qualitative interviews of patients (n = 30), and removed items that lacked clinical relevance on the basis of input from panels of patients, caregivers, and clinicians. The psychometric properties of the MDASI-PeriOp-Hep were validated (n = 150). Read More

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The Venous Occlusion Image Score: A Novel Quantitative Scoring Instrument for Cerebral Venous Sinus Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 5;30(7):105845. Epub 2021 May 5.

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, P R China. Electronic address:

Purpose: This study aims to test the validity of a new quantitative scoring instrument-the Venous Occlusion Image Score (VOIS), and assess the diagnostic and prognostic value of VOIS for cerebral venous sinus thrombosis (CVST).

Methods: The VOIS divided the major cerebral venous sinuses and internal jugular veins into nine parts of interest. CT venography and DSA source images and reconstruction were extracted from the database, then interpreted and scored independently according to VOIS by a panel of three reviewers. Read More

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A semiological marker of emotional insulo-cingulate network activation in epileptic human brain.

Epilepsy Behav 2021 May 5;120:107970. Epub 2021 May 5.

Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China. Electronic address:

There are limited reports on the "chapeau de gendarme" (CDG) sign, which is considered reliable evidence for the verification of frontal epilepsy. However, several recent reports of scattered cases of extra-frontal epilepsy suggest the complexity of the cortical networks underlying CDG generation. The present study aimed to investigate the anatomo-electro-clinical correlations and explore the cortical mechanisms of the generation of CDG via video-stereoelectroencephalography (SEEG). Read More

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Validation of the Health-Related Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) for Brazilian Portuguese.

Epilepsy Behav 2021 May 5;120:107969. Epub 2021 May 5.

Unidade de Pesquisa e Tratamento das Epilepsias (UNIPETE), Universidade Federal de São Paulo - Unifesp, São Paulo, SP, Brazil. Electronic address:

Objective: The present study aimed to validate the 55-item Health-Related Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) in Brazilian Portuguese and evaluate the relation of its results with clinical data and caregiver burden.

Methods: The QOLCE-55 was submitted to translation, back-translation, and cultural adaptation in a pilot sample with 20 subjects. To ensure the psychometric properties of validation, the validation of the QOLCE-55 was carried out in a sample of 45 patients with epilepsy aged between 4 and 18 years and their parents or caregivers and compared with the results of other quality-of-life instruments, namely, the QVCE-50 and QOLIE-AD-48, as well as with the SDQ, abrief behavioral screeningquestionnaire. Read More

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Single-Position Prone Lateral Interbody Fusion Improves Segmental Lordosis in Lumbar Spondylolisthesis.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona. Electronic address:

Objective: Single-position surgery in the prone position is a novel technique for lateral interbody fusion with pedicle screw fixation. We performed a radiographic comparison of patients treated for spondylolisthesis using the prone lateral (PL) transpsoas approach to those treated with the traditional dual-position (DP) strategy (lateral decubitus then prone).

Methods: 30 consecutive patients with spondylolisthesis treated using PL (N=15) were compared to patients treated using DP surgery (N=15). Read More

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Counter-directed leucine gradient promotes amino acid transfer across the human placenta.

J Nutr Biochem 2021 May 5:108760. Epub 2021 May 5.

Institute of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Bern, Switzerland; Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Switzerland. Electronic address:

The developing fetus is highly vulnerable to imbalances in the supply of essential amino acids (AA). Transplacental AA transfer depends on complex interactions between accumulative transporters, exchangers and facilitators, which maintain both intra-extracellular and materno-fetal substrate gradients. We determined physiological AA gradients between maternal and fetal blood and assessed their importance by studying maternal-fetal leucine transfer in human trophoblasts. Read More

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Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study.

Bioorg Med Chem Lett 2021 May 5:128080. Epub 2021 May 5.

Key Laboratory of Animal Model of TCM Syndromes of Depression, Jiangxi Administration of traditional Chinese Medicine, Jiangxi University of Chinese Medicine, 1688 Meiling Road, Nanchang 330006, China; Laboratory Animal Science and Technology Center, Jiangxi University of Chinese Medicine, 1688 Meiling Road, Nanchang 330006, China.

Saponin is an active component of many phytomedicine, which has extensive pharmacology effects. Meanwhile, it is reported that cytotoxicity, especially hemolysis and hepatotoxicity, in pentacyclic triterpenoid saponin (PTS) hindered their further development and application. Surface activity, a unique physical property of saponins, is believed to be related to membrane toxicity. Read More

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Validation of the Bath CRPS Body Perception Disturbance Scale.

J Pain 2021 May 5. Epub 2021 May 5.

Department of Psychology, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom; Centre for Pain Research, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom.

The Bath Complex Regional Pain Syndrome Body Perception Disturbance Scale ("B-CRPS-BPDS") measures alterations in body perception. We assessed its internal consistency, known group validity, construct validity, and associations with demographic and clinical characteristics. We also evaluated changes in, and baseline predictors of B-CRPS-BPDS scores at follow-up. Read More

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Live Observational Objective Assessment of Operative Performance in a Cadaveric Model is Equivalent to Delayed Video-Based Assessment.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Faculty of Life and Health Sciences, Ulster University; Londonderry, UK Prof; Director of Research and Learning, ORSI Academy. Proefhoevestraat 12 | 9090 Melle, Belgium.

Purpose: The purpose of our study was to compare real time, live observational scoring with delayed retrospective video review of operative performance, and to determine if the evaluation method affected attainment of proficiency benchmarks.

Methods: Sixteen arthroscopy / sports medicine fellows and two senior residents completed training to perform arthroscopic Bankart (ABR) and rotator cuff repairs (ARCR) using a proficiency-based progression curriculum. Each final operative performance for 15 randomly selected ABRs and 13 ARCRs performed on cadavers were scored live (observation during the operative performance) and on delayed video review (6 - 8 weeks) by one of fifteen trained raters using validated metric-based (step and error) assessment tools. Read More

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The inverse relationship between labral size and acetabular coverage: Does it protect the cartilage in the dysplastic hip?

Arthroscopy 2021 May 5. Epub 2021 May 5.

American Hip Institute Research Foundation, Chicago, IL 60018; American Hip Institute, Chicago, IL 60018; AMITA Health St. Alexius Medical Center, Hoffman Estates, IL 60169. Electronic address:

Purpose: The aims of this study were to confirm the relationship between osseous coverage and labral size, and to investigate the severity of intra-articular damage in borderline dysplastic hips in correlation to labral size.

Methods: Patients treated with primary hip arthroscopy for symptomatic labral tears between 2010 and 2018 were considered for this study. Patients were included if they had preoperative radiographic measures and intraoperative assessments of the labra and cartilage. Read More

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Femoro-Epiphyseal Acetabular Roof (FEAR) index and anterior acetabular coverage correlate with labral length in developmental dysplasia of the hip.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Purpose: The aim of this study was to evaluate the association between labral length and radiographic parameters of lateral and anterior acetabular coverage and the femoro-epiphyseal acetabular roof (FEAR) index in patients with developmental dysplasia of the hip (DDH).

Methods: We retrospectively analyzed data from patients with DDH who visited our hip joint clinic for the first time due to hip symptoms. DDH presence was defined as a lateral center-edge angle (LCEA) ≤ 25°. Read More

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GALNT2/14 overexpression correlate with prognosis and methylation:a potential therapeutic target for lung adenocarcinoma.

Gene 2021 May 5:145689. Epub 2021 May 5.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou, Fujian, China *. Electronic address:

Objective: GALNT2/14 are members of the glycosyltransferase protein family, which initiate mucin-type O-glycosylation of peptides in the Golgi apparatus. However, the correlation between GALNT2/14 and disease prognosis and methylation in lung adenocarcinoma (LUAD) remains unclear. Thus, we sought to identify its potential value in LUAD. Read More

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XRCC2 repairs mitochondrial DNA damage and fuels malignant behavior in hepatocellular carcinoma.

Cancer Lett 2021 May 5. Epub 2021 May 5.

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

The effects of DNA damage repair (DDR) and mitochondrial dysfunction associated with HCC have been investigated, but the functional role of mitochondrial DDR in HCC remains elusive. We studied the DDR genes and identified XRCC2 as a potential prognostic marker for HCC. XRCC2 overexpression was detected in HCC cells and shown to promote the malignant behavior of cancer cells. Read More

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Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy.

Radiother Oncol 2021 May 5. Epub 2021 May 5.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, United States.

This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation- coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement. Read More

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Trichinella spiralis excretory-secretory products downregulate MMP-9 in Dark Agouti rats affected by experimental autoimmune encephalomyelitis.

Exp Parasitol 2021 May 5:108112. Epub 2021 May 5.

Institute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080, Belgrade, Serbia.

Matrix metalloproteinases (MMPs), are implicated in the pathogenesis of multiple sclerosis (MS) and in its animal model, experimental autoimmune encephalomyelitis (EAE). Our aim was to investigate whether amelioration of EAE in Dark Agouti (DA) rats, induced by Trichinella spiralis muscle larvae excretory-secretory products (ES L1), could be related to the level and activity of gelatinases, MMP-9 and MMP-2. Serum levels of MMP-9, MMP-2, NGAL/MMP-9, TIMP-1, and cytokines, evaluated by gel-zymography or ELISA, as well as gelatinases and TIMP-1 expression in the spinal cord (SC), were determined in: i) EAE induced, ii) ES L1-treated EAE induced animals. Read More

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Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease.

J Lipid Res 2021 May 5:100085. Epub 2021 May 5.

Research Center, CHU Ste-Justine; Departments of Pharmacology & Physiology,; Nutrition. Electronic address:

Chylomicron retention disease (CRD) is an autosomal recessive disorder associated with biallelic Sar1b mutations leading to defects in intracellular chylomicron (CM) trafficking and secretion. To date, a direct cause-effect relationship between CRD and Sar1b mutation has not been established, but genetically modified animal models provide an opportunity to elucidate unrecognized aspects of these mutations. To examine the physiological role and molecular mechanisms of Sar1b function, we generated mice expressing either a targeted deletion or mutation of human Sar1b using the CRISPR/Cas9 system. Read More

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Lectin-like oxidized low-density lipoprotein receptor-1 related microglial activation in neonatal hypoxic-ischemic encephalopathy: morphological consideration.

Am J Pathol 2021 May 5. Epub 2021 May 5.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira. Electronic address:

Neonatal hypoxic-ischemic encephalopathy (nHIE) is a major neonatal brain injury. Despite therapeutic hypothermia, mortality and sequelae remain severe. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) was associated with the pathophysiology of nHIE. Read More

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Intra- and interobserver agreement of histopathological findings in pediatric patients with eosinophilic esophagitis.

J Pediatr (Rio J) 2021 May 5. Epub 2021 May 5.

Universidade Federal do Paraná, Departamento de Pediatria, Curitiba, PR, Brazil.

Objective: To assess intra- and interobserver agreement among non-expert pathologists in identifying features of the eosinophilic esophagitis histologic scoring system (EoEHSS) in pediatric patients.

Patients And Methods: The authors used 50 slides from patients (aged 1-15 years; 72% male) with EoE. EoEHSS evaluates eosinophilic inflammation and other features including epithelial basal zone hyperplasia, eosinophilic abscesses, eosinophil surface layering, dilated intercellular spaces, surface epithelial alteration, dyskeratotic epithelial cells, and lamina propria fibrosis. Read More

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doTwo loss of function alleles of glutathione-S-transferase (GTS) gene cause anthocyanin deficiency in flowers and fruit skin of peach (Prunus persica).

Plant J 2021 May 8. Epub 2021 May 8.

National Peach and Grape Improvement Center/Key Laboratory of Fruit Breeding Technology of Ministry of Agriculture, Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou, China.

Flower and fruit colors are important agronomic traits. To date, there is no forward genetic evidence that Glutathione-S-transferase (GST) gene is responsible for the white flower color in peach. In this study, genetic analysis indicated white-flower trait was monogenetic, recessive to the non-white, and showed pleiotropic effects with non-white flowered types. Read More

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A randomized controlled trial of manual versus powered tooth brushing during haematopoietic stem cell transplantation.

Oral Dis 2021 May 8. Epub 2021 May 8.

Department of Dentistry, Radboudumc, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Aim: To compare manual and powered tooth brushing (MT and PT) with respect to patient compliance to brushing frequency advice, plaque removal and severity of oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT) after high dose chemotherapy.

Materials & Methods: A randomized controlled trial was conducted. Forty six patients scheduled to receive myelo-ablative conditioning regimen before autologous HSCT were included and randomly assigned to control (MT, n=23) or test (PT, n=23) groups. Read More

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Identification and validation of novel biomarkers and therapeutics for pulpitis using connectivity mapping.

Int Endod J 2021 May 8. Epub 2021 May 8.

School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

Aim: To create an irreversible pulpitis gene signature from microarray data of healthy and inflamed dental pulps, followed by a bioinformatics approach using connectivity mapping to identify therapeutic compounds that could potentially treat pulpitis.

Methodology: The Gene Expression Omnibus (GEO) database, an international public repository of genomics datasets, was searched for human microarray datasets assessing pulpitis. An irreversible pulpitis gene expression signature was generated by differential expression analysis. Read More

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