10,367 results match your criteria correlates outcomes

Using immunotherapy in prostate cancer patients: more than sipuleucel-T.

Endocr Relat Cancer 2021 Jun 1. Epub 2021 Jun 1.

E Parkes, Department of Oncology, University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland.

The landscape of cancer treatment has been transformed over the past decade by the success of immune-targeting therapies. However, despite sipuleucel-T being the first ever approved vaccine for cancer and the first immunotherapy licensed for prostate cancer in 2010, immunotherapy has since seen limited success in the treatment of prostate cancer. The tumour microenvironment of prostate cancer presents particular barriers for immunotherapy. Read More

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Exposure to combat incidents within military and civilian populations as possible correlates of potentially morally injurious events and moral injury outcomes among Israeli combat veterans.

Clin Psychol Psychother 2021 Jun 14. Epub 2021 Jun 14.

The Lior Tsfaty Center for Suicide and Mental Pain Studies, Ruppin Academic Center, Emek Hefer, Israel.

Objectives: Exposure to potentially morally injurious events (PMIEs) is considered a necessary but insufficient determinant of Moral Injury (MI) outcomes. However, a question remains regarding possible acts and the necessary features of PMIEs that should be considered transgressive and might lead to MI psychopathological outcomes. We aim to examine the links between exposure to combat incidents within civilian Palestinian populations (CPP), PMIEs and MI related outcomes of PTSD symptoms (PTSS), trauma-related guilt and shame. Read More

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Enhanced Sensitivity to Optimistic Cues is Manifested in Brain Structure: A Voxel-Based Morphometry Study.

Soc Cogn Affect Neurosci 2021 Jun 15. Epub 2021 Jun 15.

Institute of Psychology, University of Bern, Bern, Switzerland.

Recent research shows that congruent outcomes are more rapidly (and incongruent less rapidly) detected when individuals receive optimistic rather than pessimistic cues, an effect that was termed optimism robustness. In the current voxel-based morphometry study, we examined whether optimism robustness has a counterpart in brain structure. The participants' task was to detect two different letters (symbolizing monetary gain or loss) in a visual search matrix. Read More

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'Ice' flavoured e-cigarette use among young adults.

Tob Control 2021 Jun 14. Epub 2021 Jun 14.

Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Background: 'Ice' e-cigarette flavours-marketed as a combination of fruity/sweet and cooling flavours (eg, 'blueberry ice' or 'melon ice')-recently entered the US market. The prevalence and correlates of ice flavoured e-cigarette use in young adults are unknown.

Methods: This cross-sectional study of a Los Angeles, California, USA, cohort analysed data from the past 30-day e-cigarette (current) users (n=344; M (SD)=21. Read More

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Serum uric acid, disease severity and outcomes in COVID-19.

Crit Care 2021 06 14;25(1):212. Epub 2021 Jun 14.

Division of Nephrology, Cliniques universitaires Saint-Luc, 1200, Brussels, Belgium.

Background: The severity of coronavirus disease 2019 (COVID-19) is highly variable between individuals, ranging from asymptomatic infection to critical disease with acute respiratory distress syndrome requiring mechanical ventilation. Such variability stresses the need for novel biomarkers associated with disease outcome. As SARS-CoV-2 infection causes a kidney proximal tubule dysfunction with urinary loss of uric acid, we hypothesized that low serum levels of uric acid (hypouricemia) may be associated with severity and outcome of COVID-19. Read More

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Efficacy and safety of treatment modalities across EGFR selected/unselected populations with non-small cell lung cancer and brain metastases: A systematic review and Bayesian network meta-analysis.

Lung Cancer 2021 Feb 27;158:74-84. Epub 2021 Feb 27.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China; State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:

Objective: To compare the efficacy and safety of treatment modalities across different populations with non-small cell lung cancer and brain metastases.

Methods: A comprehensive search for randomized controlled trials was conducted in databases including PubMed, Embase, the Cochrane library, the ClinicalTrials.gov, and major international conferences. Read More

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February 2021

Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy.

Front Oncol 2021 27;11:640910. Epub 2021 May 27.

Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Glioblastoma is the most common and lethal brain cancer globally. Clinically, this cancer has heterogenous molecular and clinical characteristics. Studies have shown that UBE2S is highly expressed in many cancers. Read More

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Insomnia Disorder in Adult Attention-Deficit/Hyperactivity Disorder Patients: Clinical, Comorbidity, and Treatment Correlates.

Front Psychiatry 2021 26;12:663889. Epub 2021 May 26.

Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Several investigations have been performed on insomnia symptoms in adult attention-deficit/hyperactivity disorder (ADHD). However, the relationship between insomnia disorder and adult ADHD has been neglected in research. The main objective of the current study is to analyze the differences between adult ADHD patients with and without insomnia disorder, in terms of ADHD clinical severity, medical and psychiatric comorbidity, psychopharmacological treatment, and quality of life. Read More

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Amplitude integrated EEG: how much it helps in prognostication in neonatal encephalopathy?

J Matern Fetal Neonatal Med 2021 Jun 13:1-8. Epub 2021 Jun 13.

Sir Ganga Ram Hospital, New Delhi, India.

Introduction: Neonatal encephalopathy (NE) is associated with a high risk of adverse neurological outcomes. Several neurodiagnostic tests have been evaluated to predict the prognosis. Amplitude integrated Electroencephalogram (aEEG) is now being commonly used for bedside evaluation of cerebral function. Read More

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Interpretation of familiar metaphors and proverbs by Polish people in middle and late adulthood.

Int J Lang Commun Disord 2021 Jun 14. Epub 2021 Jun 14.

Department of Clinical Psychology and Neuropsychology, Maria Curie-Skłodowska University in Lublin, Lublin, Poland.

Background: The ability to understand figurative language, including metaphors and proverbs, decreases with age, although the phenomenon is not universal. Cognitive capacities and education play an important role in the competence connected with figurative language use and comprehension in people during the second half of life.

Aims: To identify possible similarities and differences in task performance by subjects representing middle adulthood (40-49 and 50-59 years old) and late adulthood (60-69 and 70-92 years old). Read More

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Correlates of blood pressure and blood glucose screenings in Cameroon: insights from the 2018 Demographic and Health Survey.

Int Health 2021 Jun 12. Epub 2021 Jun 12.

Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, CA, USA.

Background: Hypertension and diabetes, two major risk factors for cardiometabolic diseases, are associated with high morbidity and mortality rates. Early detection through screening can initiate early treatment to reduce adverse outcomes. The current study sought to investigate the correlates of blood pressure and blood glucose screenings in Cameroon. Read More

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Immune correlates of therapy outcomes in women with cervical cancer treated with chemoradiotherapy: A systematic review.

Cancer Med 2021 Jun 12. Epub 2021 Jun 12.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Immune markers have been correlated with prognosis in a variety of solid tumors, including cervical cancer.

Objective: To review the literature on hematologic and immune markers and their association with recurrence and survival among patients with cervical cancer treated with chemoradiation.

Evidence Review: This systematic review was conducted in accordance with PRISMA guidelines via searches of Ovid MEDLINE, Ovid Embase, and the Cochrane Library using keywords regarding cervical cancer, immune markers, and HIV. Read More

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Patterns and Effects of Admission Hyperglycemia and Inflammatory Response in Trauma Patients: A Prospective Clinical Study.

World J Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, Trauma Surgery, Hamad General Hospital, Doha, Qatar.

Background: The constellation of the initial hyperglycemia, proinflammatory cytokines and severity of injury among trauma patients is understudied. We aimed to evaluate the patterns and effects of on-admission hyperglycemia and inflammatory response in a level 1 trauma center. We hypothesized that higher initial readings of blood glucose and cytokines are associated with severe injuries and worse in-hospital outcomes in trauma patients. Read More

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Interpretation of anatomic correlates of outer retinal bands in optical coherence tomography.

Exp Biol Med (Maywood) 2021 Jun 10:15353702211022674. Epub 2021 Jun 10.

Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

By providing the sectioning capability to differentiate individual retinal layers, optical coherence tomography (OCT) is revolutionizing eye disease diagnosis and treatment evaluation. A better understanding of the hyper- and hypo-reflective bands in retinal OCT is essential for accurate interpretation of clinical outcomes. In this article, we summarize the interpretations of clinical OCT and adaptive optics (AO) OCT (AO-OCT) of the outer retina in the human eye, and briefly review OCT investigation of the outer retina in animal models. Read More

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Anhedonia in tobacco withdrawal among African-American smokers.

Exp Clin Psychopharmacol 2021 Jun 10. Epub 2021 Jun 10.

Department of Preventive Medicine.

Anhedonia-diminished interest and pleasure in response to rewards-may be a symptom of tobacco withdrawal that is understudied in priority populations. This experiment investigated the magnitude and correlates of various dimensions of anhedonia during tobacco withdrawal among African-American (AA) smokers-a population subject to health disparities. AA smokers ( = 607; ≥ 10 cigarettes/day, 37. Read More

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Post-earthquake Self-Reported Depressive Symptoms and Post-Traumatic Stress Disorder and their Correlates among College-Youths in Kathmandu, Nepal.

Psychiatr Q 2021 Jun 9. Epub 2021 Jun 9.

College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd, MDC 56, Tampa, FL, 33612, USA.

Exposure to earthquake has previously been associated with adverse mental health outcomes, however, evidence is limited among youth in resource-limited settings. This study explored the association of retrospective extent of exposure on current day depressive symptoms and post-traumatic stress disorder (PTSD) symptoms among 125 youth attending a college in Kathmandu, Nepal. A self-administered survey including socio-demographic variables, scale for earthquake exposure and Nepali language validated standardized scales for depressive and PTSD symptoms was used. Read More

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Frequency and correlates of Mycoplasma genitalium antimicrobial resistance mutations and their association with treatment outcomes: findings from a national sentinel surveillance pilot in England.

Sex Transm Dis 2021 Jun 10. Epub 2021 Jun 10.

National Infection Service, Public Health England, 61 Colindale Avenue, London, UK Guy's and St Thomas' NHS Foundation Trust, London, UK Leeds Teaching Hospitals NHS Trust, Leeds, UK Central and North West London NHS Foundation Trust, London, UK Chelsea and Westminster Healthcare NHS Foundation Trust, London, UK UCLH NHS Foundation Trust, London, UK North Cumbria University Hospitals NHS Trust, Cumbria, UK University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK Imperial College Healthcare NHS Trust, London, UK North Cumbria Integrated Care NHS Foundation Trust, Cumbria, UK North Bristol NHS Trust, Bristol, UK Locala Community Partnerships CIC, Yorkshire, UK.

Background: Mycoplasma genitalium infection is a public health concern due to extensive antimicrobial resistance (AMR). Using data from a pilot of M. genitalium AMR surveillance, we determined the prevalence and risk factors for resistance among specimens from sexual health clinic attendees and assessed treatment outcomes. Read More

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Gene expression signature correlates with outcomes in metastatic renal cell carcinoma patients treated with everolimus alone or with a vascular disrupting agent.

Mol Cancer Ther 2021 Jun 9. Epub 2021 Jun 9.

Department of Medical Oncology, Dana-Farber/Harvard Cancer Center.

Everolimus monotherapy use for metastatic clear cell-RCC (mRCC) has diminished due to recent approvals of immune checkpoint and VEGF inhibitors. We hypothesized that gene expression associated with everolimus benefit may provide rationale to select appropriate patients. To address this hypothesis, tumors from a phase I/II trial that compared everolimus alone or with BNC105P, a vascular disrupting agent (VDA), were profiled using Nanostring as a discovery cohort. Read More

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Upadacitinib Treatment Improves Symptoms of Bowel Urgency and Abdominal Pain, and Correlates With Quality of Life Improvements in Patients With Moderate to Severe Ulcerative Colitis.

J Crohns Colitis 2021 Jun 9. Epub 2021 Jun 9.

Istituto Clinico Humanitas, Department of Gastroenterology, Milan, Italy.

Background And Aims: Bowel urgency and abdominal pain are impactful, yet underappreciated ulcerative colitis symptoms and not commonly assessed in clinical trials. We evaluated how these symptoms may improve with upadacitinib treatment and correlate with clinical and health-related quality of life (HRQOL) outcomes in the phase 2b U-ACHIEVE study.

Methods: Patients aged 18-75 years with moderately to severely active ulcerative colitis were randomised to receive placebo or upadacitinib (7. Read More

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Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly's midgut environment.

PLoS Pathog 2021 Jun 9;17(6):e1009475. Epub 2021 Jun 9.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America.

Tsetse flies are vectors of parasitic African trypanosomes, the etiological agents of human and animal African trypanosomoses. Current disease control methods include fly-repelling pesticides, fly trapping, and chemotherapeutic treatment of infected people and animals. Inhibiting tsetse's ability to transmit trypanosomes by strengthening the fly's natural barriers can serve as an alternative approach to reduce disease. Read More

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A critical threshold for global pediatric surgical workforce density.

Pediatr Surg Int 2021 Jun 9. Epub 2021 Jun 9.

Division of Pediatric Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL, 60611, USA.

Purpose: 1.7 billion children lack access to surgical care, particularly in low- and middle-income countries (LMIC). The pediatric surgical workforce density (PSWD), an indicator of surgical access, correlates with survival of complex pediatric surgical problems. Read More

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A Review of the Evidence Base for Nutrition and Nutritional Supplements in Older Adults with Bipolar Disorder: A report from the OABD task force.

J Frailty Aging 2021 ;10(3):241-246

Andrew T. Olagunju, Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, 100 West 5th Street, Hamilton, ON, L8N 3K7 Canada,

Objectives: To better understand the role of nutrition in older adults (aged 50 years or older) with bipolar disorders (OABD), we conducted a systematic review of the literature and appraise existing evidence.

Methods: Following PRISMA guidelines, we searched databases including Medline/PubMed, PsychINFO, EMBASE, CINAHL, Scopus, Web of Science, Cochrane Register, FDA website, and clinical trial registries through 2019 for eligible reports. The search string combined MeSH terms for bipolar disorder, nutrition and older adults. Read More

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A Systematic Review of the Biological Correlates and Consequences of Childhood Maltreatment and Adverse Childhood Experiences.

Trauma Violence Abuse 2021 Jun 9:15248380211021613. Epub 2021 Jun 9.

School of Criminal Justice, 2514University of Cincinnati, OH, USA.

Childhood maltreatment (CM) and adverse childhood experiences (ACEs) are two primary forms of interpersonal victimization that have been associated with a host of deleterious health outcomes. Studies over the past decade have begun to use a range of biologically informed methods to better understand the role biology plays in the relationship between CM, ACEs, and later life outcomes. This line of research has shown that both forms of victimization occur at sensitive periods of development, which can increase the likelihood of "getting under the skin" and influence health and behavior across the life course. Read More

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Prevalence of Probable Shift Work Disorder in Non-Standard Work Schedules and Associations with Sleep, Health and Safety Outcomes: A Cross-Sectional Analysis.

Nat Sci Sleep 2021 31;13:683-693. Epub 2021 May 31.

Flinders Health and Medical Research Institute (Sleep Health)/Adelaide Institute for Sleep Health, Flinders University, Bedford Park, SA, Australia.

Purpose: We aimed to estimate the prevalence of probable shift work disorder (pSWD) in a representative sample of Australian workers and identify sleep, health and safety correlates.

Patients And Methods: In 2019, data were collected from working respondents as part of a cross-sectional national sleep health survey conducted online (n=964 total; n=448 individuals on non-standard work schedules). We established the prevalence of pSWD according to International Classification of Sleep Disorders criteria (ICSD-R, ICSD-2 and ICSD-3). Read More

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Brain injury in preterm infants with surgical necrotizing enterocolitis: clinical and bowel pathological correlates.

Pediatr Res 2021 Jun 8. Epub 2021 Jun 8.

Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.

Background: The objective of this study was to determine the risk factors and outcomes of white matter brain injury (WMBI) on magnetic resonance imaging (MRI) at term-equivalent age in infants with surgical necrotizing enterocolitis (NEC).

Methods: This retrospective study compared clinical/pathological information between infants with and those without WMBI.

Results: Out of 69 infants with surgical NEC, 17 (24. Read More

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Physical Activity and Female Sexual Dysfunction: A Lot Helps, But Not Too Much.

J Sex Med 2021 Jun 5. Epub 2021 Jun 5.

Department of Experimental Clinical and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy; Andrology, Women's Endocrinology and Gender Incongruence Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; I.N.B.B. (Istituto Nazionale Biostrutture e Biosistemi), Rome, Italy. Electronic address:

Background: Research on the relationship between physical activity (PA) and female sexual dysfunction (FSD) is lacking.

Aim: To investigate the clinical, psychological, and sexual correlates of PA in women with FSD.

Methods: A non-selected series of n = 322 pre- and post-menopausal patients consulting for FSD was retrospectively studied. Read More

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Vascular depression in Black Americans: a systematic review of the construct and its cognitive, functional, and psychosocial correlates.

Clin Neuropsychol 2021 Jun 7:1-31. Epub 2021 Jun 7.

Department of Psychology, Georgia State University, Atlanta, USA.

Vascular burden is associated with cognitive deficits and a form of late-life depression, vascular depression (VaDep), which is marked by decreased white matter integrity, executive dysfunction, poor treatment response, and functional disability. Older Black Americans represent a vulnerable population at risk of developing VaDep, but the literature in this group is limited. Thus, the goal of this systematic review is to summarize the existing literature that informs our understanding of VaDep in older Black Americans, including cognitive, functional, and psychosocial outcomes. Read More

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Simple electrophysiological predictor of QRS change induced by cardiac resynchronization therapy: a novel marker of complete left bundle branch block.

Heart Rhythm 2021 Jun 4. Epub 2021 Jun 4.

Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2(nd) Department of Internal Cardiovascular Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: QRS complex shortening by cardiac resynchronization therapy (CRT) has been associated with improved outcomes.

Objective: We hypothesized that the absence of QRS duration (QRSd) prolongation by right ventricular mid-septal pacing (RVP) may indicate a complete left bundle branch block (cLBBB).

Methods: We prospectively collected 12-lead surface ECG and intracardiac electrograms during CRT implant procedures. Read More

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Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel.

J Med Chem 2021 Jun 7. Epub 2021 Jun 7.

Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States.

Paclitaxel (PTX) is a first-line treatment in breast cancer, though resistance develops quickly and frequently. Cytochrome P450 enzymes CYP3A4 and CYP2C8, which metabolically inactivate PTX in hepatic tissue, are overexpressed in malignant breast tissues. CYP3A4 expression correlates with PTX therapy failure and poor outcomes, though no direct evidence of CYP3A4 contributing to PTX sensitivity exists. Read More

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