69 results match your criteria correlates lsd

LSD use in the United States: Trends, correlates, and a typology of us.

Drug Alcohol Depend 2021 Jun 20;223:108715. Epub 2021 Apr 20.

School of Social Work, Boston College, Chestnut Hill, MA, 02467, United States.

Background: Recent years have witnessed an increased interest in LSD. This study investigates current information on the trends and correlates of LSD use from years 2002-2018 and seeks to develop an initial typology of use and misuse.

Methods: Data is taken from the NSDUH (National Survey on Drug Use and Health) collected between 2002 and 2018 and trends and correlates of LSD use were analyzed with a survey adjusted logistic regression. Read More

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LSD alters dynamic integration and segregation in the human brain.

Neuroimage 2021 02 15;227:117653. Epub 2020 Dec 15.

Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.

Investigating changes in brain function induced by mind-altering substances such as LSD is a powerful method for interrogating and understanding how mind interfaces with brain, by connecting novel psychological phenomena with their neurobiological correlates. LSD is known to increase measures of brain complexity, potentially reflecting a neurobiological correlate of the especially rich phenomenological content of psychedelic-induced experiences. Yet although the subjective stream of consciousness is a constant ebb and flow, no studies to date have investigated how LSD influences the dynamics of functional connectivity in the human brain. Read More

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February 2021

The Epidemiology of Cocaine Use Among Hispanic Individuals: Findings From the 2015-2018 National Survey of Drug Use and Health.

Hisp Health Care Int 2021 Jun 24;19(2):105-111. Epub 2020 Nov 24.

Department of Family and Community Medicine, 12303College of Medicine, University of Cincinnati, OH, USA.

Cocaine use disproportionately affects several social groups, including ethnic and sexual minorities. The present study sought to identify the epidemiology of cocaine use among a national sample of Hispanic young adults using pooled data from the 2015-2018 National Survey of Drug Use and Health. Weighted analyses were used to identify correlates to past-year cocaine use. Read More

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Virtual raves and happy hours during COVID-19: New drug use contexts for electronic dance music partygoers.

Int J Drug Policy 2020 Aug 26:102904. Epub 2020 Aug 26.

New York University Grossman School of Medicine, Department of Population Health, 180 Madison Avenue, Room 1752, New York 10016, NY, USA.

Background: The popularity of virtual raves and happy hours has increased during the COVID-19 pandemic. While nightlife settings are often associated with drug use, it is unknown whether virtual events are associated with use.

Methods: Electronic dance music (EDM) partygoers who live in New York and reported recent drug use were recruited online and screened for eligibility throughout April and May 2020. Read More

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Diffusion of Ecstasy in the Electronic Dance Music Scene.

Joseph J Palamar

Subst Use Misuse 2020 30;55(13):2243-2250. Epub 2020 Jul 30.

Department of Population Health, New York University Grossman School of Medicine, New York, NY.

Background: Ecstasy (MDMA, Molly) is among the most prevalent drugs used by people who attend electronic dance music (EDM) events; however, little recent research has examined diffusion of ecstasy in this high-risk population. 1,020 EDM event-attending adults (aged 18-40) were surveyed in NYC in 2018 using time-spacing sampling. Participants were asked about past-year ecstasy use, and those reporting use were asked where they initiated use and whether their first use was planned. Read More

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LSD-induced increases in social adaptation to opinions similar to one's own are associated with stimulation of serotonin receptors.

Sci Rep 2020 07 22;10(1):12181. Epub 2020 Jul 22.

Neuropsychopharmacology and Brain Imaging, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital for Psychiatry Zurich, Lenggstrasse 31, 8032, Zürich, Switzerland.

Adapting one's attitudes and behaviors to group norms is essential for successful social interaction and, thus, participation in society. Yet, despite its importance for societal and individual functioning, the underlying neuropharmacology is poorly understood. We therefore investigated its neurochemical and neural correlates in a pharmacological functional magnetic resonance imaging study. Read More

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Use of "Poppers" among Adults in the United States, 2015-2017.

J Psychoactive Drugs 2020 Nov-Dec;52(5):433-439. Epub 2020 Jul 15.

Department of Population Health, New York University Grossman School of Medicine , New York, NY, USA.

We sought to estimate the prevalence as well as demographic and drug use-related correlates of poppers use among adults in the United States. Data were analyzed from adult participants (ages 18-64) in the 2015-2017 National Survey on Drug Use and Health (N115,744), a nationally representative survey of non-institutionalized adults in the US. An estimated 3. Read More

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Increasing Willingness to Use Synthetic Drugs if Offered among Electronic Dance Music Party Attendees, 2017-2019.

Joseph J Palamar

J Psychoactive Drugs 2020 Sep-Oct;52(4):324-333. Epub 2020 May 19.

Department of Population Health, New York University Grossman School of Medicine , New York, NY, USA.

Intention and willingness to use drugs are proximal predictors of drug use; however, willingness to use requires more research to inform prevention efforts. This study examines willingness to use drugs among electronic dance music (EDM) party attendees, a population at high risk for drug use. Data were examined from a repeated cross-sectional study of 2,426 adult EDM party attendees surveyed entering nightclubs and festivals in New York City from 2017 to 2019 using time-space sampling. Read More

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Survey of subjective "God encounter experiences": Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT.

PLoS One 2019 23;14(4):e0214377. Epub 2019 Apr 23.

Council on Spiritual Practices, Occidental, California, United States of America.

Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been systematically compared. In this study, five groups of individuals participated in an online survey with detailed questions characterizing the subjective phenomena, interpretation, and persisting changes attributed to their single most memorable God encounter experience (n = 809 Non-Drug, 1184 psilocybin, 1251 lysergic acid diethylamide (LSD), 435 ayahuasca, and 606 N,N-dimethyltryptamine (DMT)). Analyses of differences in experiences were adjusted statistically for demographic differences between groups. Read More

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December 2019

Planned and Unplanned Drug Use during a Night out at an Electronic Dance Music Party.

Subst Use Misuse 2019 1;54(6):885-893. Epub 2019 Mar 1.

b Center for Drug Use and HIV/HCV Research, New York University Rory Meyers College of Nursing , New York , NY , USA.

Background: Electronic dance music (EDM) parties at nightclubs and festivals are high-risk scenes for drug use. Although intention to use drugs (such as ecstasy) has been shown to be the most proximal determinant of use, little is known regarding the extent to which drug use is unplanned in this high-risk scene.

Methods: We surveyed 954 adults entering EDM parties in New York City in 2017 and asked about planned drug use that night. Read More

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January 2020

Advances and challenges in neuroimaging studies on the effects of serotonergic hallucinogens: Contributions of the resting brain.

Prog Brain Res 2018 28;242:159-177. Epub 2018 Sep 28.

Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. Electronic address:

The effects of hallucinogenic drugs on the human brain have been studied since the earliest days of neuroimaging in the 1990s. However, approaches are often hard to compare and results are heterogeneous. In this chapter, we summarize studies investigating the effects of hallucinogens on the resting brain, with a special emphasis on replicability and limitations. Read More

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Trends in DMT and other tryptamine use among young adults in the United States.

Am J Addict 2018 10;27(7):578-585

Department of Population Health, New York University Langone Medical Center, New York, New York.

Background And Objectives: The popularity of tryptamines such as N,N-dimethyltryptamine (DMT) appears to be increasing in the United States (US), but epidemiologic literature on prevalence of use is scant. This paper aims to determine trends in prevalence and correlates of past-year tryptamine use among a nationally representative sample of young adults in the US.

Methods: Participants in the National Survey on Drug Use and Health survey were queried about past-year use of tryptamines-specifically DMT, α-methyltryptamine (AMT), and 5-MeO-DIPT ("Foxy"). Read More

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October 2018

A pilot study of performance among hospitalised elderly patients on a novel test of visuospatial cognition: the letter and shape drawing (LSD) test.

Ir J Psychol Med 2017 Sep;34(3):169-175

7Graduate Entry Medical School,University of Limerick,Castletroy,Limerick,Ireland.

Objectives: Conventional bedside tests of visuospatial function such as the clock drawing (CDT) and intersecting pentagons tests (IPT) are subject to considerable inconsistency in their delivery and interpretation. We compared performance on a novel test - the letter and shape drawing (LSD) test - with these conventional tests in hospitalised elderly patients.

Methods: The LSD, IPT, CDT and the Montreal Cognitive Assessment (MoCA) were performed in 40 acute elderly medical inpatients at University Hospital Limerick The correlation between these tests was examined as well as the accuracy of the visuospatial tests to identify significant cognitive impairment on the MoCA. Read More

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September 2017

1/f electrophysiological spectra in resting and drug-induced states can be explained by the dynamics of multiple oscillatory relaxation processes.

Neuroimage 2018 10 26;179:582-595. Epub 2018 Jun 26.

Centre for Human Psychopharmacology, School of Health Sciences, Swinburne University of Technology, Melbourne, Australia.

Neurophysiological recordings are dominated by arhythmical activity whose spectra can be characterised by power-law functions, and on this basis are often referred to as reflecting scale-free brain dynamics (1/f). Relatively little is known regarding the neural generators and temporal dynamics of this arhythmical behaviour compared to rhythmical behaviour. Here we used Irregularly Resampled AutoSpectral Analysis (IRASA) to quantify β, in both the high (5-100 Hz, β) and low frequency bands (0. Read More

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October 2018

Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells.

Cancer Cell Int 2018 4;18:53. Epub 2018 Apr 4.

1School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021 People's Republic of China.

Background: Signal transducer and activator of transcription 3 (STAT3) is persistently activated in a wide variety of epithelial cancers. Aberrant activity of STAT3 correlates with tumor growth, invasion and metastasis, which makes it a potential therapeutic target of cancer. To explore the biological role of STAT3 in esophageal cancer, we used small hairpin RNA to knockdown the expression of the STAT3 gene in the esophageal carcinoma ECA109 cell line and the cell apoptosis, cell cycle and cell migration were investigated. Read More

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Altered network hub connectivity after acute LSD administration.

Neuroimage Clin 2018 7;18:694-701. Epub 2018 Mar 7.

University of Basel, Department of Psychiatry (UPK), Basel 4012, Switzerland. Electronic address:

LSD is an ambiguous substance, said to mimic psychosis and to improve mental health in people suffering from anxiety and depression. Little is known about the neuronal correlates of altered states of consciousness induced by this substance. Limited previous studies indicated profound changes in functional connectivity of resting state networks after the administration of LSD. Read More

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January 2019

Role of the 5-HT Receptor in Self- and Other-Initiated Social Interaction in Lysergic Acid Diethylamide-Induced States: A Pharmacological fMRI Study.

J Neurosci 2018 04 19;38(14):3603-3611. Epub 2018 Mar 19.

Neuropsychopharmacology and Brain Imaging.

Distortions of self-experience are critical symptoms of psychiatric disorders and have detrimental effects on social interactions. In light of the immense need for improved and targeted interventions for social impairments, it is important to better understand the neurochemical substrates of social interaction abilities. We therefore investigated the pharmacological and neural correlates of self- and other-initiated social interaction. Read More

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Systemic blockade of LPA lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior.

Neuropharmacology 2018 05 31;133:189-201. Epub 2018 Jan 31.

Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Spain. Electronic address:

The systemic administration of lysophosphatidic acid (LPA) LPA receptor antagonists is a promising clinical tool for cancer, sclerosis and fibrosis-related diseases. Since LPA receptor-null mice engage in increased ethanol consumption, we evaluated the effects of systemic administration of an LPA receptor antagonist (intraperitoneal ki16425, 20 mg/kg) on ethanol-related behaviors as well as on brain and plasma correlates. Acute administration of ki16425 reduced motivation for ethanol but not for saccharine in ethanol self-administering Wistar rats. Read More

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Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases.

Nano Lett 2018 02 17;18(2):1351-1359. Epub 2018 Jan 17.

Department of Physics, ‡Department of Chemistry, and §Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, University of Chicago , Chicago, Illinois 60637, United States.

We describe a new method to measure viscosity within subcellular organelles of a living cell using nanorheology. We demonstrate proof of concept by measuring viscosity in lysosomes in multiple cell types and disease models. The lysosome is an organelle responsible for the breakdown of complex biomolecules. Read More

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February 2018

Polysubstance use profiles among electronic dance music party attendees in New York City and their relation to use of new psychoactive substances.

Addict Behav 2018 03 4;78:85-93. Epub 2017 Nov 4.

Center for Drug Use and HIV Research, New York University Rory Meyers College of Nursing, New York, NY, USA; Department of Population Health, New York University Langone Medical Center, New York, NY, USA.

Background: Electronic Dance Music (EDM) party attendees are often polysubstance users and are at high risk for use of new psychoactive substances (NPS). We sought to identify patterns of use of common illegal drugs among EDM party attendees, sociodemographic correlates, and use of NPS as a function of patterns of use of more common drugs to inform prevention and harm reduction.

Method: Using time-space-sampling, 1045 individuals aged 18-40 were surveyed entering EDM parties in New York City. Read More

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Increased thalamic resting-state connectivity as a core driver of LSD-induced hallucinations.

Acta Psychiatr Scand 2017 Dec 21;136(6):648-657. Epub 2017 Sep 21.

Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.

Objective: It has been proposed that the thalamocortical system is an important site of action of hallucinogenic drugs and an essential component of the neural correlates of consciousness. Hallucinogenic drugs such as LSD can be used to induce profoundly altered states of consciousness, and it is thus of interest to test the effects of these drugs on this system.

Method: 100 μg LSD was administrated orally to 20 healthy participants prior to fMRI assessment. Read More

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December 2017

Synthetic Cannabinoid Use Among High School Seniors.

Pediatrics 2017 Oct 11;140(4). Epub 2017 Sep 11.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.

Objectives: In this study, we examined the prevalence and correlates of current synthetic cannabinoid (SC) use among high school seniors in the United States.

Methods: Monitoring the Future, an annual nationally representative survey of high school seniors, began querying current (30-day) SC use in 2014. Data were examined from the 2 most recent cohorts (2014-2015; = 7805). Read More

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October 2017

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.

Nat Commun 2017 03 7;8:14612. Epub 2017 Mar 7.

Section on Developmental Genetics, PEMG, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1830, USA.

Defective lysosomal acidification contributes to virtually all lysosomal storage disorders (LSDs) and to common neurodegenerative diseases like Alzheimer's and Parkinson's. Despite its fundamental importance, the mechanism(s) underlying this defect remains unclear. The v-ATPase, a multisubunit protein complex composed of cytosolic V1-sector and lysosomal membrane-anchored V0-sector, regulates lysosomal acidification. Read More

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Proton magnetic resonance spectroscopy reveals significant decline in the contents of -acetylaspartylglutamate in the hippocampus of aged healthy subjects.

Arch Med Sci 2017 Feb 19;13(1):124-137. Epub 2016 Dec 19.

Department of Radiology, the Second Hospital of Hebei Medical University, Shijiazhuang, China.

Introduction: To characterize the contents of choline (Cho), creatine (Cr) and N-acetylaspartylglutamate (NAA) in the hippocampus of healthy volunteers, we investigated the contents and their correlationship with age, gender and laterality.

Material And Methods: Volunteers were grouped into a young, a middle and an old age. The Cho, Cr and NAA contents were determined with proton magnetic resonance spectroscopy (1H-MRS), and the correlationship was analyzed with Pearson correlation. Read More

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February 2017

Self-reported use of novel psychoactive substances among attendees of electronic dance music venues.

Am J Drug Alcohol Abuse 2016 11 17;42(6):624-632. Epub 2016 Jun 17.

b Center for Drug Use and HIV Research , New York University College of Nursing , New York , NY , USA.

Background: Novel psychoactive substances (NPSs) continue to emerge in the United States and worldwide. Few epidemiological studies have examined the prevalence and correlates of use.

Objective: We examined the extent of NPS use in a high-risk population-attendees of electronic dance music (EDM) parties at nightclubs and festivals. Read More

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November 2016

Angiotensin converting enzyme serum activities: Relationship with Alzheimer's disease.

Brain Res 2016 11 5;1650:196-202. Epub 2016 Sep 5.

Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China. Electronic address:

Objective: To determine serum activities of angiotensin-converting enzyme (ACE) as a marker in diagnosis and determine the severity of Alzheimer's disease (AD), METHODS: We measured serum ACE activities in 59 moderate-severe AD, 19 mild AD, 45 amnestic mild cognitive impairment (aMCI) and 39 controls.

Results: We found that patients in moderate-severe AD stages showed significantly higher ACE in comparison to aMCI and controls (ANOVA, LSD post hoc test: p: 0.02 and p: 0. Read More

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November 2016

Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution.

Curr Biol 2016 04 13;26(8):1043-50. Epub 2016 Apr 13.

Centre for Neuropsychopharmacology, Department of Medicine, Imperial College London, London W12 0NN, UK. Electronic address:

Lysergic acid diethylamide (LSD) is a non-selective serotonin-receptor agonist that was first synthesized in 1938 and identified as (potently) psychoactive in 1943. Psychedelics have been used by indigenous cultures for millennia [1]; however, because of LSD's unique potency and the timing of its discovery (coinciding with a period of major discovery in psychopharmacology), it is generally regarded as the quintessential contemporary psychedelic [2]. LSD has profound modulatory effects on consciousness and was used extensively in psychological research and psychiatric practice in the 1950s and 1960s [3]. Read More

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Neural correlates of the LSD experience revealed by multimodal neuroimaging.

Proc Natl Acad Sci U S A 2016 Apr 11;113(17):4853-8. Epub 2016 Apr 11.

Centre for Neuropsychopharmacology, Department of Medicine, Imperial College London, W12 0NN, London, United Kingdom;

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimaging techniques: arterial spin labeling (ASL), blood oxygen level-dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects. Increased visual cortex cerebral blood flow (CBF), decreased visual cortex alpha power, and a greatly expanded primary visual cortex (V1) functional connectivity profile correlated strongly with ratings of visual hallucinations, implying that intrinsic brain activity exerts greater influence on visual processing in the psychedelic state, thereby defining its hallucinatory quality. Read More

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Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide.

J Psychopharmacol 2016 Apr;30(4):344-53

Centre for Neuropsychopharmacology, Imperial College London, London, UK.

This paper reports on the effects of LSD on mental time travel during spontaneous mentation. Twenty healthy volunteers participated in a placebo-controlled crossover study, incorporating intravenous administration of LSD (75 μg) and placebo (saline) prior to functional magnetic resonance imaging (fMRI). Six independent, blind judges analysed mentation reports acquired during structured interviews performed shortly after the functional magnetic resonance imaging (fMRI) scans (approximately 2. Read More

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New psychoactive substance use among regular psychostimulant users in Australia, 2010-2015.

Drug Alcohol Depend 2016 Apr 3;161:110-8. Epub 2016 Feb 3.

School of Medicine (Psychology), Faculty of Health, University of Tasmania, Hobart, TAS 7001, Australia.

Objective: To examine the rates and patterns of new psychoactive substance (NPS) use amongst regular psychostimulant users (RPU) in Australia.

Method: Data were obtained from the 2010-2015 Ecstasy and related Drugs Reporting System (EDRS), which comprised a total cross-sectional sample of 4122RPU.

Results: Recent use of 'any' NPS increased from 33% in 2010 to 40% in 2015, although trends of use differed significantly across NPS classes. Read More

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