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Smoking status links habenular volume to glycated hemoglobin: Findings from the Human Connectome Project-Young Adult.

Psychoneuroendocrinology 2021 Jun 10;131:105321. Epub 2021 Jun 10.

Center for Depression Research and Clinical Care, UT Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Background: The habenula-pancreas axis regulates the stimulatory effects of nicotine on blood glucose levels and may participate in the emergence of type 2 diabetes in human tobacco smokers. This secondary analysis of young adults from the Human Connectome Project (HCP-YA) evaluated whether smoking status links the relationship between habenular volume and glycated hemoglobin (HbA1c), a marker of long-term glycemic control.

Methods: Habenula segmentation was performed using a fully-automated myelin content-based approach in HCP-YA participants and the results were inspected visually (n = 693; aged 22-37 years). Read More

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Nitrogen-cycling gene pool shrunk by species interactions among denser bacterial and archaeal community stimulated by excess organic matter and total nitrogen in a eutrophic bay.

Mar Environ Res 2021 Jun 17;169:105397. Epub 2021 Jun 17.

College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China. Electronic address:

Microbial densities, functional genes, and their responses to environment factors have been studied for years, but still a lot remains unknown about their interactions with each other. In this study, the abundances of 7 nitrogen cycling genes in the sediments from Hangzhou Bay were analyzed along with bacterial and archaeal 16S rRNA abundances as the biomarkers of their densities. The amount of organic matter (OM) and total nitrogen (TN) strongly positively correlated with each other and microbial densities, while total phosphate (TP) and ammonia-nitrogen (NH-N) did not. Read More

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Spatial and temporal variations of Cu and Cd mobility and their controlling factors in pore water of contaminated paddy soil under acid mine drainage: A laboratory column study.

Sci Total Environ 2021 Jun 17;792:148523. Epub 2021 Jun 17.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China; The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, South China University of Technology, Guangzhou 510006, PR China; Guangdong Provincial Key Lab of Solid Wastes Pollution Control and Recycling, South China University of Technology, Guangzhou 510006, PR China.

Acid mine drainage (AMD) poses a potential threat to human health worldwide, due to its high content of inorganic contaminants including heavy metals. Nevertheless, AMD is commonly used for irrigation of paddy soils. To determine the extent to which AMD affects contaminant levels in such practices, the effect of continuous AMD flooding on pH, redox potential Eh and the migration of Cu and Cd in contaminated paddy soil was studied in column experiments. Read More

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Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.

EBioMedicine 2021 Jun 19;69:103436. Epub 2021 Jun 19.

Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China. Electronic address:

Background: Due to the molecular mechanism complexity and heterogeneity of gastric cancer (GC), mechanistically interpretable biomarkers were required for predicting prognosis and discovering therapeutic targets for GC patients.

Methods: Based on a total of 824 GC-specific fitness genes from the Project Score database, LASSOCox regression was performed in TCGA-STAD cohort to construct a GC Prognostic (GCP) model which was then evaluated on 7 independent GC datasets. Targets prioritization was performed in GC organoids. Read More

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Imaging correlates of serum enzyme-linked immunoelectrotransfer blot (EITB) positivity in patients with parenchymal neurocysticercosis: results from 521 patients.

Trans R Soc Trop Med Hyg 2021 Jun 22. Epub 2021 Jun 22.

Department of Neurological Sciences, Christian Medical College, Vellore 632004, Tamilnadu, India.

Background: The presence of perilesional edema among patients with parenchymal neurocysticercosis (pNCC) of various lesion subtypes has not been correlated with results of serum enzyme-linked immunotransfer blot (EITB) for cysticercal antibodies.

Methods: In total, 521 patients with pNCC were classified into solitary cysticercus granuloma (SCG), multiple lesions, at least one of which was an enhancing granuloma (GMNCC), solitary calcified cysticercal lesion (SCC) and multiple calcified cysticercal lesions (CMNCC). The proportion of EITB positivity among each lesion subtype and its association with perilesional edema were determined. Read More

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The Influence of Implantoplasty on Surface Roughness, Biofilm Formation, and Biocompatibility of Titanium Implants: A Systematic Review.

Int J Oral Maxillofac Implants 2021 Jun 22. Epub 2021 Jun 22.

Purpose: A review was done to evaluate the effect of implantoplasty on surface roughness, biofilm formation, and biocompatibility of dental implants.

Materials And Methods: Electronic searches were done in PubMed (OVID), Scopus, Web of Science, and The Cochrane Library to identify all relevant articles published until April 2020. All publications evaluating changes in implant surfaces after implantoplasty were included. Read More

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Clinicopathological significance of the EMT-related proteins and their interrelationships in prostate cancer. An immunohistochemical study.

PLoS One 2021 22;16(6):e0253112. Epub 2021 Jun 22.

Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Toruń, Poland.

The chronic inflammation influences a microenvironment, where as a result of losing control over tissue homeostatic mechanisms, the carcinogenesis process may be induced. Inflammatory response cells can secrete a number of factors that support both initiation and progression of cancer and also they may consequently induct an epithelial-mesenchymal transition (EMT), the process responsible for development of distant metastasis. Macrophage migration inhibitory factor (MIF) acts as a pro-inflammatory cytokine that is considered as a link between chronic inflammation and tumor development. Read More

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The clinical correlates of the chair sit to stand performance in people with multiple sclerosis.

Physiother Theory Pract 2021 Jun 22:1-12. Epub 2021 Jun 22.

Faculty of Medicine, Department of Neurosciences, Jordan University of Science and Technology, Irbid, Jordan.

: This study aimed to evaluate the motor and non-motor factors associated with sit-to-stand performance in people with Multiple Sclerosis (PwMS). : Observational cross-sectional study. : A total of 88 individuals with MS participated in this study. Read More

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Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011).

J Clin Oncol 2021 Jun 22:JCO2100068. Epub 2021 Jun 22.

Department of Haematology, University Hospital F Mitterrand and Inserm UMR1231, Dijon, France.

Purpose: The prospective, randomized AHL2011 trial demonstrated that the use of the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) in early responders on the basis of a positron emission tomography (PET)-driven strategy was safe and minimized toxicity compared with standard 6 BEACOPP cycles. This substudy investigated the benefit of this strategy in gonadal function and fertility in patients under 45 years old.

Methods: Ovarian function was assessed by serum measurement of follicle-stimulating hormone (FSH), estradiol, and anti-müllerian hormone in women, and semen analysis, FSH, and testosterone levels were used to evaluate testicular function in men at baseline, end of treatment, and during 5 years of follow-up. Read More

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Vigilance: the behavioral impact of quantitative monitoring on administration and antagonism of neuromuscular blocking agents.

J Clin Monit Comput 2021 Jun 22. Epub 2021 Jun 22.

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.

Purpose: The aim of this study was to determine whether use of acceleromyography (1) changes dosing of neuromuscular blocking agents (NMBAs), and (2) increases the time between neostigmine administration and extubation, when compared with subjective assessment of neuromuscular blockade.

Methods: For this retrospective study, data were collected from patient electronic medical records. Patients were included if they had received an NMBA as part of a general anesthetic in 2013 and 2014. Read More

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Depression, anxiety, and drug usage history indicators among institutionalized juvenile offenders of Brasilia.

Psicol Reflex Crit 2021 Jun 22;34(1):17. Epub 2021 Jun 22.

Faculty of Psychology, University of Lisbon, 1649-013, Lisbon, Portugal.

Introduction: One of the most serious socio-educational measures for children and adolescents in conflict with the law in Brazil is their internment. This measure may represent an additional source of stress to this population and present significant impacts in the mental health context. This study aims to describe anxiety levels, depression, and addictive consumption, as well as to estimate the causalities and interactions of these variables. Read More

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Elevated basal serum levels of calcitonin and simultaneous surgery of MEN2A-specific tumors.

Neoplasma 2021 Jun 23. Epub 2021 Jun 23.

Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Wenzhou Medical University, Hangzhou, Zhejiang, China.

Multiple endocrine neoplasia type 2A (MEN2A) is a rare syndrome caused almost by germline RET mutation, and characterized by medullary thyroid carcinoma (MTC), in combination or not with pheochromocytoma (PHEO), hyperparathyroidism (HPTH), cutaneous lichen amyloidosis (CLA), and Hirschsprung's disease (HD). The basal serum calcitonin (Ctn)/carcinoembryonic antigen (CEA) levels are significantly correlated with the MTC stage. Metachronous surgery of MEN2A-specific tumors is a routine procedure. Read More

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Performance of Residents During Laparoscopic Cholecystectomy: Is Self-assessment Reliable?

Surg Laparosc Endosc Percutan Tech 2021 May 24. Epub 2021 May 24.

*Department of General Surgery, Faculty of Medicine, Gaziosmanpasa University, Tokat †General Surgery Department, Çankiri State Hospital, Çankiri, Turkey.

Background: To compare the self-assessment of surgical residents and observers (faculty members and nurses) during laparoscopic cholecystectomy (LC).

Materials And Methods: A prospective observational study was conducted between February 2020 and July 2020 at a medical school hospital. Seventy-four LC surgeries were performed by surgical residents in the presence of faculty members. Read More

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Are all antral follicles the same? Size of antral follicles as a key predictor for response to controlled ovarian stimulation.

J Obstet Gynaecol 2021 Jun 22:1-6. Epub 2021 Jun 22.

Department of Obstetrics and Gynecology, Bursa Uludag University School of Medicine, Bursa, Turkey.

The aim of this study was to evaluate whether antral follicle size has any value with respect to antral follicle count (AFC) in predicting ovarian response to controlled ovarian stimulation. Patients who were considered to be normal responders based on their ovarian reserve markers were consecutively recruited. Total AFC was the number of 2-10 mm follicles in both ovaries. Read More

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Hepatocellular adenoma in men: a nationwide assessment of pathology and correlation with clinical course.

Liver Int 2021 Jun 22. Epub 2021 Jun 22.

Department of Pathology, UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Background & Aims: Hepatocellular adenomas (HCA) rarely occur in males, and if so, are frequently associated with malignant transformation. Guidelines are based on small numbers of patients and advise resection of HCA in male patients, irrespective of size or subtype. This nationwide retrospective cohort study is the largest series of HCA in men correlating (immuno)histopathological and molecular findings with the clinical course. Read More

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P-MRS of healthy human brain: Measurement of guanosine diphosphate mannose at 7 T.

NMR Biomed 2021 Jun 21:e4576. Epub 2021 Jun 21.

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Guanosine diphosphate mannose (GDP-Man) is the donor substrate required for mannosylation in the synthesis of glycoproteins, glycolipids and the newly discovered glycoRNA. Normal GDP-Man biosynthesis plays a crucial role in support of a variety of cellular functions, including cell recognition, cell communication and immune responses against viruses. Here, we report the detection of GDP-Man in human brain for the first time, using P MRS at 7 T. Read More

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Nutrition quality of pregnant women based on body mass index and the content of selected nutrients and energy in the daily diet.

Ginekol Pol 2021 Jun 22. Epub 2021 Jun 22.

Department of Nursing in Gynecology and Obstetrics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland.

Objectives: BMI of pregnant women is influenced by the percentage of energy and the content of individual nutrients in the daily diet. The aim of the study was to evaluate nutrition quality based on BMI values of women with physiological course of pregnancy and to determine correlations between BMI and the content of selected nutrients and energy in the daily diet.

Material And Methods: The study was carried out among healthy women between the first and fourth day after childbirth. Read More

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miR-181d promotes pancreatic beta cell dysfunction by targeting IRS2 in gestational diabetes mellitus.

Ginekol Pol 2021 Jun 22. Epub 2021 Jun 22.

Shanghai Public Health Clinical Center, Shanghai, China.

Objectives: Hyperglycemia that develops during pregnancy is a diagnostic criterion of gestational diabetes mellitus (GDM). Current studies have shown that the expression of miRNA-181d is significantly enhanced in the glomeruli of type 2 diabetic. However, the relationship between miR-181d and GDM has never been reported before. Read More

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Effects of continuous cucumber cropping on crop quality and soil fungal community.

Environ Monit Assess 2021 Jun 21;193(7):436. Epub 2021 Jun 21.

Institute of Vegetables and FlowersShandong Branch of National Improvement Center for VegetablesShandong Key Laboratory of Greenhouse Vegetable Biology, Ministry of Agriculture and Rural Affairs, Shandong Academy of Agricultural Sciences, Huang-Huai-Hai Region Scientific Observation and Experimental Station of Vegetables, Jinan, Shandong, 250100, People's Republic of China.

Long-term continuous cropping is a common practice in facility vegetable production, which has an adverse effect on cucumber yield and quality. Soil fungi are of great significance for creating a normal soil ecological environment. However, the impact of continuous cropping on cucumber quality and soil fungal community has yet to be understood. Read More

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In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients.

Infect Dis Ther 2021 Jun 16:1-14. Epub 2021 Jun 16.

Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, Leopoldstr. 5, 80802 Munich, Germany.

Background: Quantitative serological assays detecting response to SARS-CoV-2 are needed to quantify immunity. This study analyzed the performance and correlation of two quantitative anti-S1 assays in oligo-/asymptomatic individuals from a population-based cohort.

Methods: In total, 362 plasma samples (108 with reverse transcription-polymerase chain reaction [RT-PCR]-positive pharyngeal swabs, 111 negative controls, and 143 with positive serology without confirmation by RT-PCR) were tested with quantitative assays (Euroimmun Anti-SARS-CoV-2 QuantiVac enzyme-linked immunosorbent assay [EI-S1-IgG-quant]) and Roche Elecsys Anti-SARS-CoV-2 S [Ro-RBD-Ig-quant]), which were compared with each other and confirmatory tests, including wild-type virus micro-neutralization (NT) and GenScriptcPass™. Read More

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Tsunami detection by GPS-derived ionospheric total electron content.

Sci Rep 2021 Jun 21;11(1):12978. Epub 2021 Jun 21.

National Research Center for Integrated Natural Disaster Management, Santiago, Chile.

To unravel the relationship between earthquake and tsunami using ionospheric total electron content (TEC) changes, we analyzed two Chilean tsunamigenic subduction earthquakes: the 2014 Pisagua M 8.1 and the 2015 Illapel M 8.3. Read More

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Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study.

Sci Rep 2021 Jun 21;11(1):12943. Epub 2021 Jun 21.

Department of Ophthalmology and Radiology, Jiangxi Center of Natural Ocular Disease Clinical Research Center, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's Republic of China.

This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matched healthy control (HC) subjects (10 males and 18 females in each group) were enrolled. fMRI scans were performed in both groups. Read More

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Body Fat Composition Enhances the Predictive Ability of Changes in White Blood Cell Levels Associated with the Risk of Chronic Disease Development.

J Immunol 2021 Jun 21. Epub 2021 Jun 21.

National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Republic of Korea;

The study aimed to revalidate the influence of WBCs on chronic disease risk factors and to verify which markers are independently involved in WBC level changes in a Korean population. A total of 80 Korean subjects were divided into three groups, according to the WBC count: mild decrease in WBC, normal WBC, and mild increase in WBC. Fasting blood samples for analyzing biochemical parameters and inflammatory markers were obtained from the subjects, and their body fat composition was evaluated by dual energy x-ray absorptiometry and computed tomography. Read More

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Quality of life among relatives of patients with amyotrophic lateral sclerosis: A prospective and longitudinal study.

Palliat Support Care 2021 Jun 22:1-9. Epub 2021 Jun 22.

Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.

Objective: Relatives are often central in caring for patients with amyotrophic lateral sclerosis (ALS), involving considerable physical, emotional, and social challenges. The aim of this study was to describe individual quality of life (iQoL) among relatives of patients with ALS, from diagnosis through disease progression.

Method: A total of 31 relatives were included. Read More

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Relationship between advanced glycated end products and maternal cognition in gestational diabetes: a case control study.

J Matern Fetal Neonatal Med 2021 Jun 21:1-6. Epub 2021 Jun 21.

Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Objective: Gestational diabetes (GDM) is a form of glucose intolerance which manifests during pregnancy. There is lack of literature regarding the study of cognitive functions in GDM. Recent evidences suggests an increase in accumulation of serum Advanced glycated end products (AGE'S) during GDM. Read More

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Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis.

Ann Palliat Med 2021 Jun 11. Epub 2021 Jun 11.

Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China; RICU & MICU, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Background: To explore the relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and the disease condition and prognosis in patients with severe acute pancreatitis (SAP).

Methods: A total of 52 patients with SAP (SAP group) and 50 patients with mild acute pancreatitis (MAP group) admitted to Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China between April 2017 and December 2019 were included in the present study. A further 50 people who had received a healthy physical examination during the same period constituted the healthy control group. Read More

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Accuracy of stroke volume variation and pulse pressure variation to predict fluid responsiveness in patients with thoracic kyphosis.

Ann Palliat Med 2021 Jun 21. Epub 2021 Jun 21.

Department of Anesthesiology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: This study aims to evaluate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in mechanically ventilated patients with thoracic kyphosis.

Methods: A total of 35 patients diagnosed with thoracic kyphosis undergoing corrective surgery were studied. For all patients, the Vigileo/FloTrac system was used for analysis. Read More

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A novel algorithm for the computation of the diastolic pressure ratio in the invasive assessment of the functional significance of coronary artery disease.

Panminerva Med 2021 Jun;63(2):206-213

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University, Latina, Italy -

Background: Invasive functional assessment is a mainstay in the management of patients with coronary artery disease (CAD), but there is uncertainty on the comparative accuracy of diagnostic indices of functional significance. We aimed to validate the diagnostic performance of a novel non-hyperemic diastolic pressure ratio (dPR).

Methods: We performed a retrospective analysis including two separate registries (VERIFY 2, Latina, Italy) of patients in whom functional indices were measured for lesions with angiographically moderate severity. Read More

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[Analysis of factors related to the prognostic benefit of neoadjuvant chemotherapy followed by interval debulking surgery in patients with advanced ovarian cancer].

Zhonghua Fu Chan Ke Za Zhi 2021 Jun;56(6):385-392

Gynecologic Oncology Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.

To explore the prognostic factors of patients with advanced epithelial ovarian cancer (EOC) who received neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). The clinical and pathological data of patients with stage Ⅲc-Ⅳ EOC underwent surgical treatment in Sichuan Cancer Center from January 1st, 2014 to December 31th, 2018 were retrospectively analyzed, and the prognosis was followed up. (1) A total of 216 EOC patients were included in the study, whose age was (52. Read More

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Can Omentin-1 Be a Prognostic Marker in Surgical Intensive Care Patients?

Turk J Med Sci 2021 Jun 22. Epub 2021 Jun 22.

Purpose: A member of the adipokine family, omentin-1 is selectively secreted from visceral fat tissue and the omentum. It has been shown that omentin-1 is involved in the pathogenesis of certain diseases and can be used as a prognostic marker. This study first investigated the prognostic significance of omentin-1 in surgical intensive care patients. Read More

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