11,032 results match your criteria correlate loss

Loss of expression of both miR-15/16 loci in CML transition to blast crisis.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210;

Despite advances that have improved the treatment of chronic myeloid leukemia (CML) patients in chronic phase, the mechanisms of the transition from chronic phase CML to blast crisis (BC) are not fully understood. Considering the key role of miR-15/16 loci in the pathogenesis of myeloid and lymphocytic leukemia, here we aimed to correlate the expression of miR-15a/16 and miR-15b/16 to progression of CML from chronic phase to BC. We analyzed the expression of the two miR-15/16 clusters in 17 CML patients in chronic phase and 22 patients in BC and in 11 paired chronic phase and BC CML patients. Read More

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Visualizing the in-vivo application of zinc in sensitive skin using reflectance confocal microscopy.

Sci Rep 2021 Apr 8;11(1):7738. Epub 2021 Apr 8.

Department of Medicine, Graduate School, Kyung Hee University, Seoul, South Korea.

Findings obtained on objective assessments to evaluate sensitive skin do not correlate well with the symptomatology. We utilized reflectance confocal microscopy (RCM) to compare transepidermal application of zinc in sensitive and non-sensitive skin. Thirty-six subjects participated in this study. Read More

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Can a Higher Protein/Low Glycemic Index vs. a Conventional Diet Attenuate Changes in Appetite and Gut Hormones Following Weight Loss? A 3-Year PREVIEW Sub-study.

Front Nutr 2021 22;8:640538. Epub 2021 Mar 22.

School of Human Sciences, Faculty of Science, The University of Western Australia, Crawley, WA, Australia.

Previous research showed that weight-reducing diets increase appetite sensations and/or circulating ghrelin concentrations for up to 36 months, with transient or enduring perturbations in circulating concentrations of the satiety hormone peptide YY. This study assessed whether a diet that is higher in protein and low in glycemic index (GI) may attenuate these changes. 136 adults with pre-diabetes and a body mass index of ≥25 kg/m underwent a 2-month weight-reducing total meal replacement diet. Read More

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Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma.

Acta Neuropathol Commun 2021 Apr 7;9(1):61. Epub 2021 Apr 7.

Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Retinoblastoma is a childhood cancer of the retina involving germline or somatic alterations of the RB Transcriptional Corepressor 1 gene, RB1. Rare cases of sellar-suprasellar region retinoblastoma without evidence of ocular or pineal tumors have been described. A nine-month-old male presented with a sellar-suprasellar region mass. Read More

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ARID1A regulates R-loop associated DNA replication stress.

PLoS Genet 2021 Apr 7;17(4):e1009238. Epub 2021 Apr 7.

Terry Fox Laboratory, BC Cancer, Vancouver, Canada.

ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in about 50% of cases. While the impact of ARID1A loss on the function of the BAF chromatin remodeling complexes is likely to drive oncogenic gene expression programs in specific contexts, ARID1A also binds genome stability regulators such as ATR and TOP2. Read More

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Motor unit number index (MUNIX) in children and adults with 5q-spinal muscular atrophy: Variability and clinical correlations.

Neuromuscul Disord 2021 Feb 28. Epub 2021 Feb 28.

Department of Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Spinal muscular atrophy (SMA) is a motor neuron disease associated with progressive muscle weakness and motor disability. The motor unit number index (MUNIX) is a biomarker used to assess loss of motor units in later-onset SMA patients. Twenty SMA patients (SMA types 3 and 4), aged between 7 and 41 years, were clinically evaluated through the Hammersmith Motor Functional Scale Expanded and the Spinal Muscular Atrophy-Functional Rating Scale. Read More

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February 2021

When do children learn how to select a portion size?

Appetite 2021 Apr 2:105247. Epub 2021 Apr 2.

Nutrition and Behaviour Unit, School of Psychological Science, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK.

The reduction of portion sizes supports weight-loss. This study looks at whether children have a conceptual understanding of portion size, by studying their ability to manually serve a portion size that corresponds to what they eat. In a clinical setting, discussion around portion size is subjective thus a computerised portion size tool is also trialled, with the portion sizes chosen on the screen being compared to amounts served manually. Read More

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Assessment and Trends in the Methodological Quality of the Top 50 Most Cited Articles in Shoulder Instability.

Orthop J Sports Med 2020 Dec 15;8(12):2325967120967082. Epub 2020 Dec 15.

Department of Orthopaedic Surgery, Loma Linda University Medical Center, Loma Linda, California, USA.

Background: Citation counts have often been used as a surrogate for the scholarly impact of a particular study, but they do not necessarily correlate with higher-quality investigations. In recent decades, much of the literature regarding shoulder instability is focused on surgical techniques to correct bone loss and prevent recurrence.

Purpose: To determine (1) the top 50 most cited articles in shoulder instability and (2) if there is a correlation between the number of citations and level of evidence or methodological quality. Read More

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December 2020

Evaluating Awareness and Practices Towards Diabetes and Diabetic Retinopathy in Adult Patients Attending the Eye Clinic in a Tertiary Academic Hospital in Jordan.

Clin Ophthalmol 2021 26;15:1309-1316. Epub 2021 Mar 26.

School of Medicine, The University of Jordan, Amman, Jordan.

Aim And Background: Awareness of diabetes mellitus (DM) and its complications, particularly diabetic retinopathy (DR), is one of the main factors of early detection and improved management. This study aims to assess the level of awareness of DM type 2 complications in a cohort of Jordanian patients, with special emphasis on DR.

Methods: A total of 176 consecutive patients with DM type 2 attending the ophthalmology clinic at Jordan University Hospital were included in the study. Read More

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Number of screws in the articular segment of distal humerus AO/OTA C-type fractures treated with open reduction internal fixation is associated with complication rate.

SICOT J 2021 1;7:25. Epub 2021 Apr 1.

Department of Orthopedic Surgery, Columbia University Irving Medical Center, 622 W. 168th St. PH-11, New York, 10032 NY, USA.

Introduction: Surgical treatment of distal humerus fractures can lead to numerous complications. Data suggest that the number of screws in the distal (articular) segment may be associated with complication rate. The purpose of this study is to evaluate the association between a number of screws in the distal segment and complication rate for surgical treatment of distal humerus fractures. Read More

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Sleeve Gastrectomy Is Associated with a Greater Reduction in Plasma Liver Enzymes Than Bypass Surgeries-A Registry-Based Two-Year Follow-Up Analysis.

J Clin Med 2021 Mar 9;10(5). Epub 2021 Mar 9.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem 91120, Israel.

Bariatric surgeries may lead to an improvement in metabolic fatty liver disease, and a reduction in the levels of the hepatic enzyme Alanine Aminotransferase (ALT). We compared the effects of Sleeve Gastrectomy (SG), Roux en Y Gastric Bypass (RYGB) and One Anastomosis Gastric Bypass (OAGB) on the levels of ALT by analysis of two-year follow-up data from 4980 patients in the Israeli Bariatric Registry that included laboratory tests and demographic information. Pre-operative characteristics of patients, and particularly levels of liver enzymes, were similar across surgery types. Read More

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Characterization of Nanoparticle Adsorption on Polydimethylsiloxane-Based Microchannels.

Sensors (Basel) 2021 Mar 11;21(6). Epub 2021 Mar 11.

Human Augmentation Research Center, National Institute of Advanced Industrial Science and Technology, Chiba 277-0882, Japan.

Nanoparticles (NPs) are used in various medicinal applications. Exosomes, bio-derived NPs, are promising biomarkers obtained through separation and concentration from body fluids. Polydimethylsiloxane (PDMS)-based microchannels are well-suited for precise handling of NPs, offering benefits such as high gas permeability and low cytotoxicity. Read More

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Autoimmune dysautonomia in women with silicone breast implants.

J Autoimmun 2021 Mar 31;120:102631. Epub 2021 Mar 31.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat- Gan, 52621, Israel; Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Importance And Objectives: There is unmet medical need to understand the pathogenic mechanism of the panoply of clinical manifestations associated with silicone breast implants (SBIs) such as severe fatigue, widespread pain, palpitations, dry mouth and eyes, depression, hearing loss etc. We aimed to determine whether autoantibodies against the autonomic nervous system receptors can explain the enigmatic and subjective clinical manifestation reported by women with SBIs.

Results: Circulating level of autoantibodies against G protein-coupled receptors (GPCRs) of the autonomic nervous system (adrenergic, muscarinic, endothelin and angiotensin receptors) have been evaluated in symptomatic women with SBIs using an ELISA method. Read More

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Magnetization Transfer Ratio in Lower Limbs of Late Onset Pompe Patients Correlates With Intramuscular Fat Fraction and Muscle Function Tests.

Front Neurol 2021 16;12:634766. Epub 2021 Mar 16.

Neuromuscular Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Magnetization transfer (MT) imaging exploits the interaction between bulk water protons and protons contained in macromolecules to induce signal changes through a special radiofrequency pulse. MT detects muscle damage in patients with neuromuscular conditions, such as limb-girdle muscular dystrophies or Charcot-Marie-Tooth disease, which are characterized by progressive fiber loss and replacement by fatty tissue. In Pompe disease, in which there is, in addition, an accumulation of glycogen inside the muscle fibers, MT has not been tested yet. Read More

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Flow virometry for process monitoring of live virus vaccines-lessons learned from ERVEBO.

Sci Rep 2021 Apr 1;11(1):7432. Epub 2021 Apr 1.

Vaccines Process Development and Commercialization, Merck & Co., Inc., 770 Sumneytown Pike, WP 42-3, West Point, PA, 19486, USA.

Direct at line monitoring of live virus particles in commercial manufacturing of vaccines is challenging due to their small size. Detection of malformed or damaged virions with reduced potency is rate-limited by release potency assays with long turnaround times. Thus, preempting batch failures caused by out of specification potency results is almost impossible. Read More

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Breast cancer patients' insurance status and residence zip code correlate with early discontinuation of endocrine therapy: An analysis of the ECOG-ACRIN TAILORx trial.

Cancer 2021 Apr 1. Epub 2021 Apr 1.

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.

Background: Early discontinuation is a substantial barrier to the delivery of endocrine therapies (ETs) and may influence recurrence and survival. The authors investigated the association between early discontinuation of ET and social determinants of health, including insurance coverage and the neighborhood deprivation index (NDI), which was measured on the basis of patients' zip codes, in breast cancer.

Methods: In this retrospective analysis of a prospective randomized clinical trial (Trial Assigning Individualized Options for Treatment), women with hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer who started ET within a year of study entry were included. Read More

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Disentangling the Drivers of Obesity: An Analytical Framework Based on Socioeconomic and Intrapersonal Factors.

Front Nutr 2021 3;8:585318. Epub 2021 Mar 3.

Center for Agro-Food Economics and Development (CREDA-UPC-IRTA), University Polytechnic of Catalonia, Barcelona, Spain.

Obesity is increasing at exponential rates in developed economies despite the numerous policy interventions being implemented. The causes of obesity are multifactorial demanding a holistic review for targeted intervention. This study, therefore, provides a holistic overview of multiple factors affecting body weights i. Read More

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A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease.

Nature 2021 Mar 31. Epub 2021 Mar 31.

The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Crohn's disease (CD) is a chronic inflammatory intestinal disease, with frequent aberrant healing and stricturing complications. Crosstalk between activated myeloid and stromal cells is critical in pathogenicity with increases in intravasating monocytes correlated to anti-TNF treatment non-response. The highest effect risk alleles are loss-of-function NOD2 mutations, which increase risk for stricturing. Read More

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Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction.

PLoS Pathog 2021 Mar 31;17(3):e1009468. Epub 2021 Mar 31.

Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom.

Peptidoglycan is the major structural component of the Staphylococcus aureus cell wall, in which it maintains cellular integrity, is the interface with the host, and its synthesis is targeted by some of the most crucial antibiotics developed. Despite this importance, and the wealth of data from in vitro studies, we do not understand the structure and dynamics of peptidoglycan during infection. In this study we have developed methods to harvest bacteria from an active infection in order to purify cell walls for biochemical analysis ex vivo. Read More

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Head movement kinematics are altered during gaze stability exercises in vestibular schwannoma patients.

Sci Rep 2021 Mar 30;11(1):7139. Epub 2021 Mar 30.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA.

Gaze stability is the ability of the eyes to fixate a stable point when the head is moving in space. Because gaze stability is impaired in peripheral vestibular loss patients, gaze stabilization exercises are often prescribed to facilitate compensation. However, both the assessment and prescription of these exercises are subjective. Read More

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Exercise training has morph-specific effects on telomere, body condition and growth dynamics in a color-polymorphic lizard.

J Exp Biol 2021 Mar 30. Epub 2021 Mar 30.

School of Earth, Atmospheric and Life Sciences, University of Wollongong, Wollongong, NSW 2522, Australia.

Alternative reproductive tactics (ARTs) are correlated suites of sexually selected traits that are likely to impose differential physiological costs on different individuals. While moderate activity might be beneficial, animals living in the wild often work at the margins of their resources and performance limits. Individuals using ARTs may have divergent capacities for activity. Read More

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The Use of Clinical Parameters as Adjuncts to Endoscopic Evaluation of Mural Thickening on Conventional Computed Tomography in Diagnosing Malignancy.

Dig Surg 2021 Mar 30:1-7. Epub 2021 Mar 30.

Department of General Surgery, Mayo University Hospital, Mayo, Castlebar, Ireland.

Background: Mural thickening (MT) on computed tomography (CT) poses a diagnostic dilemma in the absence of clear reporting guidelines. The aim of this study was to analyse CT reports, identifying patients in whom gastrointestinal wall MT was observed, and to correlate these reports with subsequent endoscopic evaluation.

Methods: Patients with MT who had follow-up endoscopy were included in the study (n = 308). Read More

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Effects of hydrocortisone and yohimbine on selective attention to emotional cues.

J Psychopharmacol 2021 Mar 28:269881121997100. Epub 2021 Mar 28.

Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Introduction: Facial expressions contain important affective information, and selective attention to facial expression provides an advantage in the face of loss, stress and danger. In addition, the sympathetic nervous system and hypothalamus-pituitary-adrenal axis mediate the organism's response to loss and danger. Here, we aimed at investigating the influence of sympathetic nervous system and hypothalamus-pituitary-adrenal axis activation on selective attention to affective facial stimuli. Read More

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C-Reactive Protein Apheresis as Anti-inflammatory Therapy in Acute Myocardial Infarction: Results of the CAMI-1 Study.

Front Cardiovasc Med 2021 10;8:591714. Epub 2021 Mar 10.

Medical Clinic, Diakonissenhospital Flensburg, Flensburg, Germany.

C-reactive protein (CRP) is a well-known marker of inflammation. It is less known that CRP mediates tissue damage in acute myocardial infarction (AMI) thus potentially worsening prognosis. A newly developed specific CRP adsorber allows efficient lowering of CRP levels and may improve survival. Read More

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The effects of antiepileptic drugs on bone health: A systematic review.

Epilepsy Res 2021 Mar 19;173:106619. Epub 2021 Mar 19.

Department of Orthopaedic Surgery and Rehabilitation Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, New York, USA. Electronic address:

Purpose: Epilepsy may be treated with antiepileptic drugs (AEDs), which have been reported to decrease bone mineral density (BMD). Current data is conflicting and variable, and little is known with regard to how duration of AED use or specific AEDs, such as CYP-450 enzyme-inducing (EIAEDs) versus non-enzyme inducing (NEIAEDs) drugs affect BMD. We sought to systematically review BMD changes due to AED use to identify trends in reporting. Read More

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Relationship of Maternal and Neonatal Variables With Breastmilk Sodium.

Indian Pediatr 2021 Mar 26. Epub 2021 Mar 26.

Department of Pediatrics, Pondicherry Institute of Medical Sciences, Puducherry, India. Correspondence to: Prof Lalitha Krishnan, Head, Departments of Pediatrics, Pondicherry Institute of Medical Sciences, Puducherry 605 014, India.

Objective: To determine breastmilk sodium changes in the first 72 hours after birth and to correlate maternal and neonatal variables with maternal breastmilk sodium.

Methods: We enrolled 245 mothers and their exclusively breast-fed neonates in this prospective cohort study. Singleton, inborn babies of greater than 34 weeks gestation, who were exclusively breastfed for the first 72 hours were included. Read More

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Cortical microstructural correlates of plasma neurofilament light chain in Huntington's disease.

Parkinsonism Relat Disord 2021 Mar 20;85:91-94. Epub 2021 Mar 20.

Movement Disorders Unit, Neurology Department, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain; Biomedical Research Institute (IIB-Sant Pau), Barcelona, Spain; Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address:

Introduction: Huntington's disease (HD) is a severe neurodegenerative disorder with no effective treatment. Minimally-invasive biomarkers such as blood neurofilament light chain (NfL) in HD are therefore needed to quantitatively characterize neuronal loss. NfL levels in HD are known to correlate with disease progression and striatal atrophy, but whether they also reflect cortical degeneration remains elusive. Read More

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Intermediate monocytes correlate with CXCR3+ Th17 cells but not with bone characteristics in untreated early rheumatoid arthritis.

PLoS One 2021 26;16(3):e0249205. Epub 2021 Mar 26.

Centre for Bone and Arthritis Research, Institute of Medicine, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Rheumatoid arthritis (RA) is associated with development of generalized osteoporosis. Bone-degrading osteoclasts are derived from circulating precursor cells of monocytic lineage, and the intermediate monocyte population is important as osteoclast precursors in inflammatory conditions. T cells of various subsets are critical in the pathogenesis of both RA and associated osteoporosis, but so far, no studies have examined associations between circulating intermediate monocytes, T cell subsets and bone characteristics in patients with RA. Read More

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Neurostructural changes and declining sensorimotor function due to cerebellar cortical degeneration.

J Neurophysiol 2021 Mar 24. Epub 2021 Mar 24.

Kinesiology/Ctr. for Clin. Move. Sci, University of Minnesota, United States.

Neurodegeneration of the cerebellum progresses over years and primarily affects cerebellar cortex. It leads to a progressive loss of control and coordination of gait, posture, speech, fine motor and oculomotor function. Yet, little is known how the cerebro-cerebellar network compensates for the loss in cerebellar cortical neurons. Read More

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