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The relationship between mortality and inflammatory markers and the systemic immune inflammatory index in patients in the intensive care unit with a pneumothorax as a complication of COVID-19 disease.

Ir J Med Sci 2021 Sep 18. Epub 2021 Sep 18.

Thoracic Surgery Clinic, Ankara City Hospital, Çankaya, Turkey.

Background: A pneumothorax is common in patients admitted to the intensive care unit (ICU) with coronavirus disease (COVID-19) when non-invasive or invasive mechanical ventilation is performed to maintain adequate oxygenation. The aim of the present study was to investigate the effects of elevated inflammatory markers and an elevated systemic immune inflammatory index (SII) on mortality in this patient population.

Materials And Methods: Between March 2020 and May 2021, 124 patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reacion positviity who were admitted to the ICU in our hospital and diagnosed with and treated for a pneumothorax were evaluated retrospectively. Read More

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September 2021

Low COVID-19 vaccination coverage and high COVID-19 mortality rates in Brazilian elderly.

Emil Kupek

Rev Bras Epidemiol 2021 10;24:e210041. Epub 2021 Sep 10.

Department of Public Health, Center for Health Sciences, Universidade Federal de Santa Catarina - Florianopolis (SC), Brazil.

Objective: To investigate the relation between COVID-19 vaccine coverage and COVID-19-related mortality by age groups in Brazil in 2021.

Methods: Secondary data on COVID-19 deaths and vaccination coverage were retrieved to investigate COVID-19 mortality rate (MR) evolution as the vaccination against COVID-19 advanced in Brazil in 2021. Poisson regression with adjustment for age and Brazilian states was used to calculate the MR. Read More

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September 2021

Extracted features of national and continental daily biweekly growth rates of confirmed COVID-19 cases and deaths via Fourier analysis.

Ray-Ming Chen

Math Biosci Eng 2021 07;18(5):6216-6238

Department of Mathematics and Statistics, Baise University, 21 Zhongshan No. 2 Road, Basie 533000, China.

Aims: By associating features with orthonormal bases, we analyse the values of the extracted features for the daily biweekly growth rates of COVID-19 confirmed cases and deaths on national and continental levels.

Methods: By adopting the concept of Fourier coefficients, we analyse the inner products with respect to temporal and spatial frequencies on national and continental levels. The input data are the global time series data with 117 countries over 109 days on a national level; and 6 continents over 447 days on a continental level. Read More

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"COVID toes": A meta-analysis of case and observational studies on clinical, histopathological, and laboratory findings.

Pediatr Dermatol 2021 Sep 13. Epub 2021 Sep 13.

Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, Brazil.

Background: Coronavirus disease (COVID-19) is related to several extrapulmonary disorders; however, little is known about the clinical, laboratory, and histopathological characteristics of pernio-like skin lesions associated with COVID-19 infection.

Objective: To evaluate and summarize the clinical, laboratory, and histopathological characteristics of pernio-like lesions reported in the literature.

Methods: We conducted a search of the PubMed, SciELO, and ScienceDirect databases for articles published between January 1, 2020 and November 30, 2020, following the PRISMA recommendations (PROSPERO registration ID: CRD42020225055). Read More

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September 2021

Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action.

EClinicalMedicine 2021 Oct 8;40:101111. Epub 2021 Sep 8.

National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China.

Background: Coronavirus disease 2019 (COVID-19) has evolved into a worldwide pandemic, and has been found to be closely associated with mental and neurological disorders. We aimed to comprehensively quantify the association between mental and neurological disorders, both pre-existing and subsequent, and the risk of susceptibility, severity and mortality of COVID-19.

Methods: In this systematic review and meta-analysis, we searched PubMed, Web of Science, Embase, PsycINFO, and Cochrane library databases for studies published from the inception up to January 16, 2021 and updated at July 7, 2021. Read More

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October 2021

Molecular evolutionary characteristics of SARS-CoV-2 emerging in the United States.

J Med Virol 2021 Sep 10. Epub 2021 Sep 10.

National Pathogen Collection Center for Aquatic Animals, Ministry of Agriculture of China, Shanghai, 201306, China.

SARS-CoV-2 is a newly discovered beta coronavirus at the end of 2019, which is highly pathogenic and poses a serious threat to human health. In this paper, 1,875 SARS-CoV-2 whole genome sequences and the sequence coding spike protein (S gene) sampled from the United States were used for the bioinformatics analysis to study the molecular evolutionary characteristics of its genome and spike protein. The MCMC method was used to calculate the evolution rate of the whole genome sequence and the nucleotide mutation rate of S gene. Read More

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September 2021

Dynamics of SARS-CoV-2 mutations reveals regional-specificity and similar trends of N501 and high-frequency mutation N501Y in different levels of control measures.

Sci Rep 2021 09 7;11(1):17755. Epub 2021 Sep 7.

Facultad de Ciencias Biológicas, Universidad Ricardo Palma, Lima, Peru.

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease has spread globally, causing more than 161.5 million cases and 3. Read More

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September 2021

Coevolution of COVID-19 research and China's policies.

Health Res Policy Syst 2021 Sep 6;19(1):121. Epub 2021 Sep 6.

Department of Digital Communication, Soochow University, Room 5146, Building 1005, No.1 Wenjing Road, Dushu Lake Campus of Soochow University, Suzhou, Jiangsu, China.

Background: In the era of evidence-based policy-making (EBPM), scientific outputs and public policy should engage with each other in a more interactive and coherent way. Notably, this is becoming increasingly critical in preparing for public health emergencies.

Methods: To explore the coevolution dynamics between science and policy (SAP), this study explored the changes in, and development of, COVID-19 research in the early period of the COVID-19 outbreak in China, from 30 December 2019 to 26 June 2020. Read More

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September 2021

SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020-March 2021.

Emerg Infect Dis 2021 Sep 3;27(12). Epub 2021 Sep 3.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020-March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection-case, infection-hospitalization, and infection-fatality ratios in 2 waves of infection. Read More

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September 2021

Anxiety, depression, and stress prevalence among college students during the COVID-19 pandemic: A systematic review and meta-analysis.

J Am Coll Health 2021 Sep 1:1-8. Epub 2021 Sep 1.

Hangzhou Institute of Cardiovascular Diseases, Hangzhou Medical Key Discipline, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Background: Since the end of 2019, the coronavirus disease (COVID-19) outbreak rapidly became a pandemic. The psychological state of people during the COVID-19 pandemic has gained interest. Our aim was to study the prevalence of anxiety, depression, and stress in college students during the COVID-19 pandemic. Read More

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September 2021

Factors associated with chemsex in Portugal during the COVID-19 pandemic.

Rev Lat Am Enfermagem 2021 30;29:e3474. Epub 2021 Aug 30.

Universidade Nova de Lisboa, Instituto de Higiene e Medicina Tropical, Global Health and Tropical Medicine; Lisboa, LS, Portugal.

Objective: to investigate the factors associated with the practice of sex under the influence of drugs (chemsex) among Portuguese men who have sex with men during the period of social distancing to prevent the COVID-19.

Method: online survey applied in May 2020 to a sample of 1,301 participants living in Portugal, recruited according to Respondent Driven Sampling and via social media Facebook®. Descriptive and bivariate analyses were performed along with logistic regression to calculate adjusted Odds Ratio (ORa). Read More

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September 2021

Carbon emission savings and short-term health care impacts from telemedicine: An evaluation in epilepsy.

Epilepsia 2021 Aug 31. Epub 2021 Aug 31.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.

Objective: Health systems make a sizeable contribution to national emissions of greenhouse gases that contribute to global climate change. The UK National Health Service is committed to being a net zero emitter by 2040, and a potential contribution to this target could come from reductions in patient travel. Achieving this will require actions at many levels. Read More

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Analysis of Oxygen Blood Saturation/Respiratory Rate Index, NEWS2, CURB65, and quick Sequential Organ Failure Assessment Scores to Assess Prognosis in Patients with Mild Coronavirus Disease 2019.

Rev Invest Clin 2021 Aug 30. Epub 2021 Aug 30.

Internal Medicine Division, Hospital Juan A. Fernández, Buenos Aires, Argentina.

Background: Hospital bed saturation has been one of the problems to solve during the SARS-CoV-2 pandemic. However, not every patient who is admitted requires close monitoring or specific therapeutics. Mild cases could be managed in the outpatient setting. Read More

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Post-COVID-19 ergonomic school furniture design under fuzzy logic.

Cetin O Incekara

Work 2021 ;69(4):1197-1208

BOTAS, Transit Pipeline Manager, Ankara, Turkey ORCID: 0000-0003-1927-8208; E-mail:

Background: Because of wrong sitting position, children have back-pain and related musculoskeletal pain (MPD). Due to inappropriate designed class furniture by not taking into account the children's anthropometric measurements have negative effect on children musculoskeletal systems. The impact of the COVID-19 pandemic crisis has changed the furniture industry's production trends. Read More

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Nervous and Muscular Adverse Events after COVID-19 Vaccination: A Systematic Review and Meta-Analysis of Clinical Trials.

Vaccines (Basel) 2021 Aug 23;9(8). Epub 2021 Aug 23.

Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, Sun Yat-sen University, Guangzhou 510080, China.

Nervous and muscular adverse events (NMAEs) have garnered considerable attention after the vaccination against coronavirus disease (COVID-19). However, the incidences of NMAEs remain unclear. We aimed to calculate the pooled event rate of NMAEs after COVID-19 vaccination. Read More

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D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19.

PLoS One 2021 26;16(8):e0256744. Epub 2021 Aug 26.

Alka Hospital, Jawalakhel, Lalitpur, Nepal.

Introduction: Coronavirus Disease 2019 is a primarily respiratory illness that can cause thrombotic disorders. Elevation of D-dimer is a potential biomarker for poor prognosis in COVID-19, though optimal cutoff value for D-dimer to predict mortality has not yet been established. This study aims to assess the accuracy of admission D-dimer in the prognosis of COVID-19 and to establish the optimal cutoff D-dimer value to predict hospital mortality. Read More

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September 2021

What can the neurological manifestations of COVID-19 tell us: a meta-analysis.

J Transl Med 2021 08 23;19(1):363. Epub 2021 Aug 23.

Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, 218 jixi road, shushan district, Hefei, Anhui, China.

Background: Covid-19 became a global pandemic in 2019. Studies have shown that coronavirus can cause neurological symptoms, but clinical studies on its neurological symptoms are limited. In this meta-analysis, we aimed to summarize the various neurological manifestations that occurred in COVID-19 patients and calculate the incidence of various neurological manifestations. Read More

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Implementation of a Coronavirus Disease 2019 Vaccination Condition of Employment in a Community Nursing Home.

J Am Med Dir Assoc 2021 Aug 7. Epub 2021 Aug 7.

NewCourtland Center for Transitions and Health, University of Pennsylvania School of Nursing, Philadelphia, PA.

The rate of coronavirus disease 2019 (COVID-19) vaccination uptake by US nursing home staff remains low despite the increased risks of viral transmission and related morbidity and mortality in this setting. This study describes vaccine uptake activities including a COVID-19 vaccination condition of employment (COE) policy in one community nursing home. This case study summarizes the timeline of vaccination uptake activities, staff vaccination rates over time, and stakeholder perspectives around the implementation of a COVID-19 vaccination COE. Read More

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Experimental and Mathematical Optimization of a Pooling Test for Detection of SARS-CoV-2 in a Population with Low Viral Load.

Infect Chemother 2021 Mar;53(1):118-127

Division of Infectious Disease, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.

Background: A pooling test is a useful tool for mass screening of coronavirus disease 2019 (COVID-19) in the pandemic era. We aimed to optimize a simple two-step pooling test by estimating the optimal pool size using experimental and mathematical validation.

Materials And Methods: Experimental pools were created by mixing one positive respiratory sample with various numbers of negative samples. Read More

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SARS-CoV-2 natural infection in animals: a systematic review of studies and case reports and series.

Vet Q 2021 Dec;41(1):250-267

Faculty of Health Sciences, Universidad Científica del Sur, Lima, Perú.

COVID-19 pandemic is essentially a zoonotic disease. In this context, early in 2020, transmission from humans to certain animals began reporting; the number of studies has grown since. To estimate the pooled prevalence of SARS-CoV-2 natural infection in animals and to determine differences in prevalence between countries, years, animal types and diagnostic methods (RT-PCR or serological tests). Read More

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December 2021

Survival of COVID-19 Patients With Respiratory Failure is Related to Temporal Changes in Gas Exchange and Mechanical Ventilation.

J Intensive Care Med 2021 Oct 16;36(10):1209-1216. Epub 2021 Aug 16.

12300Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.

Respiratory failure due to coronavirus disease of 2019 (COVID-19) often presents with worsening gas exchange over a period of days. Once patients require mechanical ventilation (MV), the temporal change in gas exchange and its relation to clinical outcome is poorly described. We investigated whether gas exchange over the first 5 days of MV is associated with mortality and ventilator-free days at 28 days in COVID-19. Read More

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October 2021

Has COVID-19 Changed the Hedge Effectiveness of Bitcoin?

Front Public Health 2021 27;9:704900. Epub 2021 Jul 27.

School of Economics and Management, University of Science and Technology Beijing, Beijing, China.

The Bitcoin market has become a research hotspot after the outbreak of Covid-19. In this paper, we focus on the relationships between the Bitcoin spot and futures. Specifically, we adopt the vector autoregression-dynamic correlation coefficient-generalized autoregressive conditional heteroskedasticity (VAR-DCC-GARCH) model and vector autoregression-Baba, Engle, Kraft, and Kroner-generalized autoregressive conditional heteroskedasticity (VAR-BEKK-GARCH) models and calculate the hedging effectiveness (HE) value to investigate the dynamic correlation and volatility spillover and assess the risk reduction of the Bitcoin futures to spot. Read More

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Comparing the COVID-19 pandemic in space and over time in Europe, using numbers of deaths, crude rates and adjusted mortality trend ratios.

Sci Rep 2021 08 12;11(1):16443. Epub 2021 Aug 12.

Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.

Comparison of COVID-19 trends in space and over time is essential to monitor the pandemic and to indirectly evaluate non-pharmacological policies aimed at reducing the burden of disease. Given the specific age- and sex- distribution of COVID-19 mortality, the underlying sex- and age-distribution of populations need to be accounted for. The aim of this paper is to present a method for monitoring trends of COVID-19 using adjusted mortality trend ratios (AMTRs). Read More

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Evaluation of accuracy, exclusivity, limit-of-detection and ease-of-use of LumiraDx™: An antigen-detecting point-of-care device for SARS-CoV-2.

Infection 2021 Aug 12. Epub 2021 Aug 12.

Division of Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.

Purpose: Rapid antigen-detecting tests (Ag-RDTs) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can transform pandemic control. Thus far, sensitivity (≤ 85%) of lateral-flow assays has limited scale-up. Conceivably, microfluidic immunofluorescence Ag-RDTs could increase sensitivity for SARS-CoV-2 detection. Read More

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Responses to COVID-19 in South Asian Association for Regional Cooperation (SAARC) countries in 2020, a data analysis during a world of crises.

Chaos Solitons Fractals 2021 Nov 5;152:111311. Epub 2021 Aug 5.

Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.

Coronavirus disease (COVID-19) caused by SARS-CoV-2 was notified from Wuhan city, Hubei province, China in the mid of December 2019. The disease is showing dynamic change in the pattern of confirmed cases and death toll in these low and middle-income countries (LMICs). In this study, exponential growth (EG) method was used to calculate the real-time reproductive number (R) for initial and later stage of epidemic in South Asian Association for Regional Cooperation (SAARC) member countries (April 2020 - December 2020). Read More

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November 2021

Inverse correlates of COVID-19 mortality across European countries during the first versus subsequent waves.

BMJ Glob Health 2021 08;6(8)

Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.

The objectives of the study were to calculate the standardised mortality rates (SMRs) for COVID-19 in European Union/European Economic Area countries plus the UK and Switzerland and to evaluate the correlation between SMRs and selected indicators in the first versus the subsequent waves until 23 June 2021. We used indirect standardisation (using Italy as the reference) to compute SMRs and considered 16 indicators of health and social well-being, health system capacity and COVID-19 response. The highest SMRs were in Belgium, the UK and Spain in the first wave (1. Read More

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Mental Health Symptoms, Binge Drinking, and the Experience of Abuse During the COVID-19 Lockdown in Mexico.

Front Public Health 2021 22;9:656036. Epub 2021 Jul 22.

Sección mexicana de la Comisión de Salud Fronteriza México-Estados Unidos, Mexico City, Mexico.

The health crisis associated with the COVID-19 pandemic is causally linked to negative mental health symptoms in the same way as other diseases such as Ebola. The purpose of this paper is to describe the relationship between mental health symptoms, binge drinking, and the experience of abuse during the COVID-19 lockdown. We surveyed 9,361 participants, all Mexican, with an average age of 33 years old ( = 10. Read More

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Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis.

Am J Kidney Dis 2021 Aug 5. Epub 2021 Aug 5.

Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; Sydney School of Public Health, The University of Sydney, Sydney, Australia.

Rationale & Objective: Coronavirus disease 2019 (COVID-19) disproportionately affects people with chronic diseases such as chronic kidney disease (CKD). We assessed the incidence and outcomes of COVID-19 in people with CKD.

Study Design: Systematic review and meta-analysis by searching MEDLINE, EMBASE, and PubMed through February 2021. Read More

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A Novel Vaccine Selection Decision-Making Model (VSDMM) for COVID-19.

Vaccines (Basel) 2021 Jul 1;9(7). Epub 2021 Jul 1.

Department of Integrative Biology, College of Arts and Sciences, University of South Florida, St. Petersburg, FL 33701, USA.

Selecting a vaccine for fighting a pandemic is one of the serious issues in healthcare. Novel decision models for vaccine selection need to be developed. In this study, a novel vaccine selection decision-making model (VSDMM) was proposed and developed, based on the analytic hierarchy process (AHP) technique, which assesses many alternatives (vaccines) using multi-criteria to support decision making. Read More

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