136,322 results match your criteria coronavirus


The age-standardized incidence, mortality, and case fatality rates of COVID-19 among 79 countries: cross-sectional comparison and their correlation with associated factors.

Epidemiol Health 2021 Sep 8:e2021061. Epub 2021 Sep 8.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objectives: During the coronavirus disease 2019 (COVID-19) pandemic, crude incidence and mortality rates have been widely reported; however, age-standardized rates are more suitable for comparison. In this study, we estimated and compared the age-standardized incidence, mortality, and case fatality rates among countries and investigated the relationship between these rates and factors associated with healthcare resources: gross domestic product per capita, number of hospital beds per population, and number of doctors per population.

Methods: The incidence, mortality, and case fatality rates of 79 countries were age-standardized using the WHO standard population. Read More

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September 2021

Autopsy-Based Pulmonary and Vascular Pathology: Pulmonary Endotheliitis and Multi-Organ Involvement in COVID-19 Associated Deaths.

Respiration 2021 Sep 15:1-11. Epub 2021 Sep 15.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Background: Findings from autopsies have provided evidence on systemic microvascular damage as one of the underlying mechanisms of Coronavirus disease 2019 (CO-VID-19). The aim of this study was to correlate autopsy-based cause of death in SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients with chest imaging and severity grade of pulmonary and systemic morphological vascular pathology.

Methods: Fifteen SARS-CoV-2 positive autopsies with clinically distinct presentations (age 22-89 years) were retrospectively analyzed with focus on vascular, thromboembolic, and ischemic changes in pulmonary and in extrapulmonary sites. Read More

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September 2021

Acceptance Rates and Beliefs toward COVID-19 Vaccination among the General Population of Pakistan: A Cross-Sectional Survey.

Am J Trop Med Hyg 2021 Sep 3. Epub 2021 Sep 3.

11World Health Organization, Zhob, Pakistan.

Developing countries like Pakistan have previously suffered from barriers to acceptance of vaccination by the public because of financial and belief barriers. This study aims to explore these beliefs and highlight concerns regarding vaccine hesitancy in the general population of Pakistan since they are a hindrance to an effective coronavirus disease-19 (COVID-19) immunization in the country. A cross-sectional study was performed involving 1,778 participants from all four provinces of Pakistan. Read More

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September 2021

Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells.

Stem Cell Reports 2021 Sep 1. Epub 2021 Sep 1.

Department of Cellular and Molecular Medicine and Sarver Heart Center Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ, USA; Department of Physiology, The University of Arizona, Tucson, AZ, USA; BIO5 Institute, The University of Arizona, Tucson, AZ, USA. Electronic address:

The pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been attributed to its ability to enter through the membrane-bound angiotensin-converting enzyme 2 (ACE2) receptor. Therefore, it has been heavily speculated that angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy may modulate SARS-CoV-2 infection. In this study, exposure of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and human endothelial cells (hECs) to SARS-CoV-2 identified significant differences in protein coding genes involved in immunity, viral response, and cardiomyocyte/endothelial structure. Read More

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September 2021

Social interaction is a catalyst for adult human learning in online contexts.

Curr Biol 2021 Sep 7. Epub 2021 Sep 7.

Institute of Cognitive Neuroscience, University College London, Queen Square, London WC1N 3AZ, UK.

Human learning is highly social. Advances in technology have increasingly moved learning online, and the recent coronavirus disease 2019 (COVID-19) pandemic has accelerated this trend. Online learning can vary in terms of how "socially" the material is presented (e. Read More

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September 2021

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months.

N Engl J Med 2021 Sep 15. Epub 2021 Sep 15.

From the State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., S.B., W.V.K., D.C., Q.Y., P.L., P.R.D., W.C.G., K.U.J.) - both in New York; Associação Obras Sociais Irmã Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and iTrials-Hospital Militar Central (G.P.M.) and Fundacion INFANT, Buenos Aires (F.P.P.) - all in Brazil; Centro Paulista de Investigação Clinica, São Paulo (C.Z.); Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.); Vaccine Research and Development (J.L.P., X.X.) and Worldwide Safety, Safety Surveillance, and Risk Management (D.B.T., S.M.), Pfizer, Collegeville, PA; Global Product Development, Pfizer, Peapack, NJ (S.R.); Cincinnati Children's Hospital, Cincinnati (R.W.F.); Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.); BioNTech, Mainz (Ö.T., U.Ş.) and Medizentrum Essen Borbeck, Essen (A.S.) - both in Germany; Tiervlei Trial Centre, Karl Bremer Hospital, Cape Town, South Africa (H.N.); Hacettepe University, Ankara, Turkey (S.Ü.); and Worldwide Safety, Safety Surveillance, and Risk Management, Pfizer, Groton, CT (D.B.T., S.M.).

Background: BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA vaccine encoding a prefusion-stabilized, membrane-anchored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length spike protein. BNT162b2 is highly efficacious against coronavirus disease 2019 (Covid-19) and is currently approved, conditionally approved, or authorized for emergency use worldwide. At the time of initial authorization, data beyond 2 months after vaccination were unavailable. Read More

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September 2021

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel.

N Engl J Med 2021 Sep 15. Epub 2021 Sep 15.

From the Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot (Y.M.B.-O., R.M.), Technion-Israel Institute of Technology, Haifa (Y.G.), Hebrew University of Jerusalem (M.M.) and Israel Ministry of Health (O.B., S.A.-P., N.A.), Jerusalem, the Biostatistical and Biomathematical Unit, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat Gan (L.F., A.H.), KI Research Institute, Kfar Malal (N.K., B.M.), and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv (A.H.) - all in Israel.

Background: On July 30, 2021, the administration of a third (booster) dose of the BNT162b2 messenger RNA vaccine (Pfizer-BioNTech) was approved in Israel for persons who were 60 years of age or older and who had received a second dose of vaccine at least 5 months earlier. Data are needed regarding the effect of the booster dose on the rate of confirmed coronavirus 2019 disease (Covid-19) and the rate of severe illness.

Methods: We extracted data for the period from July 30 through August 31, 2021, from the Israeli Ministry of Health database regarding 1,137,804 persons who were 60 years of age or older and had been fully vaccinated (i. Read More

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September 2021

Can closed-off management in communities alleviate the psychological anxiety and stress caused by the COVID-19 pandemic?

Int J Health Plann Manage 2021 Sep 15. Epub 2021 Sep 15.

School of Government, Central University of Finance and Economics, Beijing, China.

Since the outbreak of the novel coronavirus (COVID-19) pandemic, the number of individuals infected with the COVID-19 has been increasing worldwide, posed a substantial threat to mental health. Therefore, discovering the means for blocking the transmission path of COVID-19 and improving mental health is of great significance. Based on a survey on the life of urban and rural residents in China (in 2020), the study applied the least squares method to analyse the effect of closed-off management on the psychological anxiety and psychological stress caused by the COVID-19 pandemic. Read More

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September 2021

Relationship between Chest CT scan Findings with SOFA score, CRP, Comorbidity, and Mortality in ICU Patients with COVID-19.

Int J Clin Pract 2021 Sep 15:e14869. Epub 2021 Sep 15.

Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: This study aimed to investigate the relationship between chest computed tomography (CT) scan findings with sequential organ failure assessment (SOFA) score, C-reactive protein (CRP), comorbidity, and mortality in intensive care unit (ICU) patients with coronavirus disease 19 (COVID-19).

Method: Adult patients (≥18 years old) with COVID-19 who were consecutively admitted to the Imam-Reza Hospital, Tabriz, East-Azerbaijan Province, North-West of Iran between March 2020 and August 2020 were screened and total of 168 patients were included. Demographic, clinical, and mortality data were gathered. Read More

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September 2021

The International Anesthesia Research Society Coronavirus Disease 2019 Pandemic Scientific Advisory Board: Supporting a Pandemic of Positivity.

Anesth Analg 2021 Oct;133(4):903-905

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

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October 2021

The Association of Delayed Care With Depression Among US Middle-Aged and Older Adults During the COVID-19 Pandemic: Cross-sectional Analysis.

Authors:
Yan Luo

JMIR Aging 2021 Jul 31. Epub 2021 Jul 31.

The University of Alabama, 2106 Forest Lake Dr., Tuscaloosa, US.

Background: During the Coronavirus Disease 2019 (COVID-19) pandemic, the depression level among US adults has significantly increased. Age disparity in depression during the pandemic was also reported in recent studies. Delay or avoidance of medical care is one of the collateral damages caused by the COVID-19 pandemic and it can lead to increased morbidity and mortality. Read More

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Evaluation of biocidal properties of biodegradable nanofiber filters and their use in face masks.

Environ Technol 2021 Sep 15:1-23. Epub 2021 Sep 15.

Federal University of Technology - Paraná, Av. Dos Pioneiros, 3131, Londrina - PR, 86036-370, Brazil.

Due to the recent coronavirus-2019 pandemic, several studies have emerged looking for new materials, especially with biocidal characteristics. Thus, the present research investigates the antibacterial properties of biodegradable cellulose acetate (CA) / cetylpyridinium bromide (CPB) electrospun nanofibers, their aerosol filtration, and the possible use as a filter media of surgical face masks. To achieve this goal, samples of these nanofibers were produced over a nonwoven substrate, using three different volumes of polymeric solution (0. Read More

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September 2021

Evaluation of the BinaxNOW COVID-19 rapid antigen test in an asymptomatic patient population undergoing pre-procedural screening.

J Clin Microbiol 2021 Sep 15:JCM0165021. Epub 2021 Sep 15.

Department of Laboratory Medicine and Pathology and Division of Infectious Diseases Mayo Clinic, Rochester, MN.

As of September 2021, coronavirus disease 2019 (COVID-19) cases have exceeded 220 million and resulted in over 4 million deaths worldwide, as reported by the Johns Hopkins COVID-19 Resource Center (https://coronavirus.jhu.edu/map. Read More

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September 2021

Comparing immunoassays for SARS-Coronavirus-2 antibody detection in patients with and without laboratory-confirmed SARS-Coronavirus-2 infection.

J Clin Microbiol 2021 Sep 15:JCM0138121. Epub 2021 Sep 15.

Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.

Commercially available SARS-CoV-2-directed antibody assays may assist in diagnosing past exposure to SARS-CoV-2 antigens. We cross-compared eight immunoassays detecting antibodies against SARS-CoV-2 nucleocapsid(N)- or spike(S)-antigens in three cohorts consisting of 859 samples from 622 patients: (#1)EDI™-Novel-Coronavirus-COVID19, Epitope; (#2)RecomWell-SARS-CoV-2, Mikrogen; (#3)COVID19-ELISA, VirCell; (#4)Elecsys-Anti-SARS-CoV-2-N, Roche; (#5)LIAISON®-SARS-CoV-2-S1/S2, Diasorin; (#6)Anti-SARS-CoV-2-ELISA, EuroImmun; (#7)Elecsys-Anti-SARS-CoV-2-S, Roche; and (#8)LIAISON®-SARS-CoV-2-TrimericS, Diasorin. In cross-sectional Cohort-1 (68 sera from 38 patients with documented SARS-CoV-2 infection), agreement between assays #1 to #6 ranged from 75% to 93%, whereby discordance mostly resulted from N-based assays #1 to #4. Read More

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September 2021

Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN.

J Med Chem 2021 Sep 15. Epub 2021 Sep 15.

Laboratoire de Glycochimie des Antimicrobiens et des Agroressources (LG2A-UMR7378-CNRS), Université de Picardie Jules Verne, 10 Rue Baudelocque, Amiens, 80039 Cédex, France.

In addition to a variety of viral-glycoprotein receptors (e.g., heparan sulfate, Niemann-Pick C1, etc. Read More

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September 2021

Clinical and radiological features of severe acute respiratory syndrome coronavirus 2 meningo-encephalitis.

Eur J Neurol 2021 Oct;28(10):3530-3532

Infectious Diseases Service, Hospital Universitário Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background And Purpose: This case illustrates for the first time the clinical and radiological evolution of SARS-CoV-2 meningo-encephalitis.

Methods: A case of a SARS-CoV-2 meningo-encephalitis is reported.

Results: A 65-year-old man with COVID-19 presenting with meningo-encephalitis without respiratory involvement is described. Read More

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October 2021

Genetic drift in the genome of SARS COV-2 and its global health concern.

J Med Virol 2021 Sep 15. Epub 2021 Sep 15.

Department of Microbiology, The University of Haripur, Haripur, 22620, Pakistan.

The outbreak of the current coronavirus disease (COVID-19) occurred in late 2019 and quickly spread all over the world. The Severe Acute Respiratory Syndrome Coronavirus-2 belongs to a genetically diverse group that mutates continuously leading to emergence of multiple variants. Although, few antiviral agents and anti-inflammatory medicines are available, thousands of individuals have passed away due to emergence of new viral variants. Read More

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September 2021

Evaluation of the correlation between the Access SARS-CoV-2 IgM and IgG II antibody tests with the SARS-CoV-2 surrogate virus neutralization test.

J Med Virol 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Laboratory, Saitama Medical University Hospital, Saitama, Japan.

Fully automated immunoassays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies that are strongly correlated with neutralization antibodies (nAbs) are clinically important because they enable assessment of humoral immunity after infection and vaccination. Access SARS-CoV-2 IgM and IgG II antibody tests are semi-quantitative, fully automated immunoassays that detect anti-receptor-binding domain (RBD) antibodies and might reflect nAb levels in coronavirus disease 2019 (COVID-19). However, no studies have investigated the clinical utility of these tests in association with nAbs to date. Read More

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September 2021

Severe Acute Respiratory Syndrome Coronavirus 2: The Role of the Main Components of the Innate Immune System.

Inflammation 2021 Sep 15. Epub 2021 Sep 15.

Department of Medical Immunology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

At the end of December 2019, the COVID-19 pandemic began in Wuhan of China. COVID-19 affects different people with a wide spectrum of clinical manifestations, ranging from asymptomatic with recovery without hospitalization up to a severe acute respiratory syndrome (SARS). The innate and adaptive immunity appears responsible for the defense against the virus and recovery from the disease. Read More

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September 2021

Diagnostic evaluation of qRT-PCR-based kit and dPCR-based kit for COVID-19.

Genes Genomics 2021 Sep 15. Epub 2021 Sep 15.

Department of Bio-Convergence Engineering, Dankook University, Jukjeon, 16890, Republic of Korea.

Background: Coronavirus disease of 2019 (COVID-19) is well known as a fatal disease, first discovered at Wuhan in China, ranging from mild to death, such as shortness of breath and fever. Early diagnosis of COVID-19 is a crucial point in preventing global prevalence.

Objective: We aimed to evaluate the diagnostic competency and efficiency with the Allplex™ 2019-nCoV Assay kit and the Dr. Read More

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September 2021

COVID-19: repercussions of nursing, structuring and resolutivity of national health systems.

Rev Gaucha Enferm 2021 13;42(spe):e20200332. Epub 2021 Sep 13.

Universidade Federal do Rio Grande do Sul (UFRGS), Escola de Enfermagem. Porto Alegre, Rio Grande do Sul, Brasil.

Aim: To analyze the repercussions of Nursing, the structuring and resolution of National Health Systems in facing the new coronavirus (SARS-CoV-2) in selected countries.

Method: Reflection article on the confrontation of COVID-19 by the National Health Systems of China, United States of America, Italy, United Kingdom, Portugal, Cuba and Brazil, from information disseminated in different media and in the literature.

Results: The response of health systems depended more on political decisions than on their structuring and organization. Read More

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September 2021

Seroprevalence of anti-SARS-CoV-2 antibodies in the Northern Italy population before the COVID-19 second wave.

Int J Occup Med Environ Health 2021 Aug 27. Epub 2021 Aug 27.

University of Modena and Reggio Emilia, Modena, Italy (Department of Biomedical, Metabolic and Neural Sciences).

Objectives: The COVID-19 pandemic is due to SARS-CoV-2 coronavirus infections. It swept across the world in the spring of 2020, and so far it has caused a huge number of hospitalizations and deaths. In the present study, the authors investigated serum anti-SARS-CoV-2 antibody prevalence in the period of June 1-September 25, 2020, in 7561 subjects in Modena, Northern Italy. Read More

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Coronavirus Disease 2019 Planning and Response: A Tale of 2 Health Workforce Estimator Tools.

Med Care 2021 Oct;59(Suppl 5):S420-S427

Fitzhugh Mullan Institute for Health Workforce Equity, Milken Institute School of Public Health, George Washington University, Washington, DC.

Background: As coronavirus disease 2019 (COVID-19) rapidly progressed throughout the United States, increased demand for health workers required health workforce data and tools to aid planning and response at local, state, and national levels.

Objective: We describe the development of 2 estimator tools designed to inform health workforce planning for COVID-19.

Research Design: We estimated supply and demand for intensivists, critical care nurses, hospitalists, respiratory therapists, and pharmacists, using Institute for Health Metrics and Evaluation projections for COVID-19 hospital care and National Plan and Provider Enumeration System, Provider Enrollment Chain and Ownership System, American Hospital Association, and Bureau of Labor Statistics Occupation Employment Statistics for workforce supply. Read More

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October 2021

Consensus statement and recommendations on the treatment of COVID-19: 2021 update.

J Chin Med Assoc 2021 Sep 3. Epub 2021 Sep 3.

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Division of Infectious Disease, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

Many treatments including antiviral and non-antiviral drugs, and critical care are considered for the management of coronavirus disease 2019 (COVID-19). Practice recommendations need to be updated and graded according to critical evaluation of rapidly emerging literature. In June 2020, Research Center for Epidemic Prevention - National Yang Ming Chiao Tung University formed a task group comprising infectious disease clinicians, pulmonologists, and intensivists with varied areas of expertise. Read More

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September 2021

Gastrointestinal manifestations of coronavirus disease 2019.

Curr Opin Infect Dis 2021 Oct;34(5):471-476

Liver Center, Division of Abdominal Transplantation, Michael E DeBakey Department of General Surgery.

Purpose Of Review: The ubiquitous expression of angiotensin-converting enzyme-2 receptors and its significance as the origin of viral entry have assisted in comprehending the pathophysiology of extrapulmonary manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this review, we focus on the clinical significance of gastrointestinal manifestations.

Recent Findings: The global pandemic, a result of the widespread implications of SARS-CoV-2, remains a significant burden to current healthcare systems. Read More

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October 2021

COVID-19 transmission and the safety of air travel during the pandemic: a scoping review.

Curr Opin Infect Dis 2021 Oct;34(5):415-422

Institute of Preventive and Social Medicine, University of Bern, Switzerland.

Purpose Of Review: To examine the literature assessing safety of air travel relating to coronavirus disease 2019 (COVID-19) transmission from January 2020 to May 2021. The COVID-19 pandemic has had an unprecedented impact on air travel and global mobility, and various efforts are being implemented to determine a safe way forward. As the pandemic evolves, so do the challenges that force various stakeholders, including the aviation industry, health authorities, and governments, to reassess and adapt their practices to ensure the safety of travellers. Read More

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October 2021

Right Ventricular Dysfunction and Its Association With Mortality in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Do Not Focus on Not Reliable Markers!

Crit Care Med 2021 Sep 15. Epub 2021 Sep 15.

Medical Intensive Care Unit, Ambroise Paré Hospital, APHP, Boulogne-Billancourt, France, INSERM UMR 1018, Clinical Epidemiology Team, CESP, Université de Paris Saclay, Villejuif, France Joint Research Unit JCL-bioMérieux, EA 7426 « Pathophysiology of Injury-Induced Immunosupression » (Université Claude Bernard Lyon 1-Hospices Civils de Lyon-bioMérieux), Lyon, France Anestesia and Critical Care Medicine Department, Edouard Herriot Hospital, Lyon, France.

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September 2021

Impact of the COVID-19 pandemic on operations in general surgery clinics in Turkey.

Ann Ital Chir 2021 ;92:333-338

Introduction: The Covid-19 pandemic spread rapidly throughout Turkey from March 2020 onward, and despite modified working conditions in the surgical clinics of our hospitals, some surgical patients became infected with the coronavirus during their perioperative period.

Aim: The present study investigates the impact of the novel coronavirus on patients undergoing general surgical operations in our clinics during the Covid-19 pandemic.

Methods: A retrospective analysis was conducted of all surgeries performed in the general surgery clinics of two 'pandemic hospitals' between March 19 and April 30, 2020 - a period when all elective surgeries were suspended in hospitals within Turkey. Read More

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January 2021

Prevalence and molecular characteristics of feline coronavirus in southwest China from 2017 to 2020.

J Gen Virol 2021 Sep;102(9)

College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, PR China.

Feline coronavirus (FCoV) is the causative agent of feline infectious peritonitis and diarrhoea in kittens worldwide. In this study, a total of 173 feline diarrhoeal faecal and ascetic samples were collected from 15 catteries and six veterinary hospitals in southwest China from 2017 to 2020. FCoV was detected in 80. Read More

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September 2021

Higher incidence of Ménière's disease during COVID-19 pandemic: a preliminary report.

Acta Otolaryngol 2021 Sep 15:1-4. Epub 2021 Sep 15.

Department of Neuroscience DNS, Audiology Unit at Treviso Hospital, University of Padova, Treviso, Italy.

Background: Coronavirus disease 2019 (COVID-19) pandemic represented a stressful event.

Objectives: The incidence of newly diagnosed Ménière's disease (MD) patients before and during COVID-19 at our Institution was calculated.

Materials And Methods: The period 2018-2020 was considered. Read More

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September 2021