1,637,170 results match your criteria coronary heart


Impact of sound levels on physiological and consciousness state of cardiovascular patients.

Nurs Crit Care 2022 Jan 20. Epub 2022 Jan 20.

Department of Nursing, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain.

Background: Patients treated in intensive care units (ICUs) experience life-threatening medical conditions but some external factors in ICUs do not help or even adversely affect and complicate their evolution. Among others, such factors include noise pollution due to alarms and medical clinical equipment, as well as the activities of the health care personnel themselves.

Aim: This study aimed to evaluate the influence of elevated sound levels on physiological variables and the consciousness state of patients treated in a cardiovascular area in an ICU. Read More

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January 2022

Novel GNE Gene Variants Associated with Severe Congenital Thrombocytopenia and Platelet Sialylation Defect.

Thromb Haemost 2022 Jan 20. Epub 2022 Jan 20.

Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, Wisconsin, United States.

The gene encodes an enzyme that initiates and regulates the biosynthesis of -acetylneuraminic acid, a precursor of sialic acids. GNE mutations are classically associated with Nonaka myopathy and sialuria, following an autosomal recessive and autosomal dominant inheritance pattern. Reports show that single GNE variants cause severe thrombocytopenia without muscle weakness. Read More

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January 2022

Reducing Opioid-Induced Constipation Post-Cardiac Surgery: An Improvement Project in a Pediatric Cardiac Intensive Care Unit.

J Nurs Care Qual 2022 Jan 19. Epub 2022 Jan 19.

Heart Center (Dr Rodrigues) and Cardiac Intensive Care Unit (Drs Tume and Lemming), Texas Children's Hospital, Houston; and Talent Management, Mobile Infirmary Medical Center, Mobile, Alabama (Dr Lofton).

Background: Pain management with opioids and underutilization of prophylaxis for constipation can prolong a patient's hospital length of stay and impede pain management efforts.

Problem: In pediatric postoperative cardiac patients, opioid therapy is a common approach to pain management but often places them at greater risk for constipation due to anatomy and age.

Methods: A retrospective review of 50 patients' medical records for baseline data was conducted, and a survey evaluated providers' current knowledge and practice. Read More

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January 2022

Histological Prognostic Factors of Endometrial Cancer in Patients with Adenomyosis: A Systematic Review and Meta-Analysis.

Pathobiology 2022 Jan 20:1-8. Epub 2022 Jan 20.

Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, Italy.

Background: A better endometrial cancer (EC) prognosis in patients with coexistent adenomyosis has been hypothesized based on a different prevalence of favorable EC histological prognostic factors. However, pooled risk of EC unfavorable histological prognostic factors in patients with adenomyosis has never been calculated.

Objectives: We aimed to assess the risk of EC unfavorable histological prognostic factors in patients with adenomyosis. Read More

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January 2022

Neonatal Resuscitation Practices in Europe: A Survey of the Union of European Neonatal and Perinatal Societies.

Neonatology 2022 Jan 20:1-9. Epub 2022 Jan 20.

Union of European Neonatal and Perinatal Societies (UENPS), Pisa, Italy.

Background: We aimed to evaluate the policies and practices about neonatal resuscitation in a large sample of European hospitals.

Methods: This was a cross-sectional electronic survey. A 91-item questionnaire focusing on the current delivery room practices in neonatal resuscitation domains was individually sent to the directors of 730 European neonatal facilities or (in 5 countries) made available as a Web-based link. Read More

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January 2022

Clinical characteristics, time course, and outcomes of major bleeding according to bleeding site in patients with venous thromboembolism.

Thromb Res 2022 Jan 14;211:10-18. Epub 2022 Jan 14.

Department of Internal Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, Universidad Autónoma de Barcelona, Spain.

Background: Bleeding is the most dreaded complication of anticoagulant therapy for acute venous thromboembolism (VTE). Limited data exist about patient characteristics, time course and outcomes of major bleeding, according to the bleeding site.

Methods: We used the data from the Registro Informatizado Enfermedad TromboEmbólica (RIETE) registry (03/2001-07/2018) and identified patients who suffered from major bleeding during anticoagulation. Read More

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January 2022

Potential ameliorative effect of dietary quercetin against lead-induced oxidative stress, biochemical changes, and apoptosis in laying Japanese quails.

Ecotoxicol Environ Saf 2022 Jan 17;231:113200. Epub 2022 Jan 17.

Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Firat University, Elazig 23119, Turkey.

Lead (Pb) is a widespread environmental pollutant which is a toxic threat to human and animal health. The present study was designed to evaluate the ameliorative role of quercetin in laying quails exposed to Pb. A total of 112 birds were randomly divided into four groups. Read More

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January 2022

Transcriptome analysis of molecular response to UVC irradiation in zebrafish embryos.

Ecotoxicol Environ Saf 2022 Jan 17;231:113211. Epub 2022 Jan 17.

Graduate School of Regional Innovation Studies, Mie University, Tsu, Mie 514-8507, Japan; Mie University Zebrafish Drug Screening Center, Tsu, Mie 514-8507, Japan.

Ultraviolet (UV) rays can be both harmful and beneficial to humans. This study aimed to investigate the toxicity and safety of ultraviolet C (UVC) exposure in living organisms and the corresponding biodefense molecular mechanisms. Zebrafish embryos, at an early developmental stage (5-6 h post-fertilization), were irradiated with increasing UVC dosages using high-efficiency deep-ultraviolet light-emitting diodes (278 nm). Read More

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January 2022

In vitro inhibitory effects of components from Salvia miltiorrhiza on catalytic activity of three human AA ω-hydroxylases.

Drug Metab Pharmacokinet 2021 May 4;43:100402. Epub 2021 May 4.

Department of Clinical Pharmacology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China. Electronic address:

CYP4 enzymes are involved in the metabolism of xenobiotics and endogenous molecules. 20-Hydroxyeicosatetraenoic acid (20-HETE), the arachidonic acid (AA) ω-hydroxylation metabolite catalyzed by CYP4A/4F enzymes, is implicated in various biological functions. The goal of this investigation is to examine the inhibitory effects of components from Salvia miltiorrhiza(Danshen) on AA ω-hydroxylation using recombinant CYP4A11, CYP4F2, CYP4F3B, and microsomal systems. Read More

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MANUAL FETAL STIMULATION DURING INTRAPARTUM FETAL SURVEILLANCE: A RANDOMISED CONTROLLED TRIAL: CharacteristicMaternal outcome.

Am J Obstet Gynecol MFM 2022 Jan 17:100574. Epub 2022 Jan 17.

Professor and Head, Paediatrics, Pondicherry Institute of Medical Sciences, Puducherry, India.

Background: Manual fetal stimulation, either by mechanical manipulation or by stimulation of the fetal scalp is known to evoke a fetal heart response in a normal fetus.

Objectives: To assess the clinical effectiveness of manual fetal stimulation in assessment of fetal well-being during labor compared with no stimulation among women with a singleton pregnancy. To study the maternal and neonatal outcomes in the two groups. Read More

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January 2022

Relationship between soluble transferrin receptor and clinical outcomes in patients with Heart Failure According to Ejection Fraction Phenotype: The New Zealand PEOPLE Study.

J Card Fail 2022 Jan 17. Epub 2022 Jan 17.

Dept of Medicine, Faculty of Medical and Health Sciences, University of Auckland, NZ; Greenlane Cardiovascular Service, Auckland District Health Board, NZ.

Background: Iron deficiency (ID) is highly prevalent in patients with heart failure (HF) but its impact on prognosis in HFpEF remains unclear. We assessed whether ID defined by sTfR criteria is independently associated with all-cause mortality in HFpEF patients, and evaluated its comparative prognostic performance to ID definitions in common clinical use.

Methods And Results: Data were analysed from 788 patients (36% HFpEF) in a prospective multi-centre heart failure cohort study. Read More

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January 2022

Cardiac Xenotransplantation: Rebirth Amidst An Uncertain Future.

Authors:
Mandeep R Mehra

J Card Fail 2022 Jan 17. Epub 2022 Jan 17.

Center for Advanced Heart Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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January 2022

Epidemiology of Acute Heart Failure in Critically Ill Patients with COVID-19: An Analysis from the Critical Care Cardiology Trials Network.

J Card Fail 2022 Jan 17. Epub 2022 Jan 17.

Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: Acute heart failure (HF) is an important complication of coronavirus disease 2019 (COVID-19) and has been hypothesized to relate to inflammatory activation.

Methods: We evaluated consecutive intensive care unit (ICU) admissions for COVID-19 across 6 centers in the Critical Care Cardiology Trials Network, identifying patients with vs. without acute HF. Read More

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January 2022

FUNDC1 activates the mitochondrial unfolded protein response to preserve mitochondrial quality control in cardiac ischemia/reperfusion injury.

Cell Signal 2022 Jan 17;92:110249. Epub 2022 Jan 17.

Senior Department of Cardiology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, China. Electronic address:

The mitochondrial unfolded protein response (UPR) is an adaptive transcriptional response involving the activation of proteases, chaperones, and antioxidant enzymes and serves to degrade abnormal or unfolded proteins and restore mitochondrial function. Although the cardioprotective action of the UPR has been verified in myocardial ischemia/reperfusion (I/R) injuries, the upstream signals involved remain unclear. Here, we explored the regulatory mechanisms underlying UPR in the reperfused mouse heart. Read More

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January 2022

Invasive Management of Refractory Angina: Are We There Yet?

Can J Cardiol 2022 Jan 17. Epub 2022 Jan 17.

Division of Cardiology, Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, QC H1T 1C8, Canada. Electronic address:

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January 2022

Who to Screen for Thoracic Aortic Aneurysms, and When to Refer for Surgery.

Can J Cardiol 2022 Jan 17. Epub 2022 Jan 17.

Division of Cardiac Surgery - University of Ottawa Heart Institute, Ottawa, ON.

Thoracic aortopathy is a silent but deadly disease affecting people of all ages. In this Practice Paper, we briefly outline clinical considerations guiding screening and prophylactic surgical practices for thoracic aortic aneurysm in adults, and highlight areas of clinical uncertainty that should serve as motivation for future research studies in the field. Read More

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January 2022

Critical Role of Extracellular Matrix Remodeling in Dilated Cardiomyopathy: Lessons from Connective Tissue Disorders.

Can J Cardiol 2022 Jan 17. Epub 2022 Jan 17.

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Electronic address:

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January 2022

Respect versus resect approaches for mitral valve repair: a study-level meta-analysis.

Trends Cardiovasc Med 2022 Jan 17. Epub 2022 Jan 17.

Division of Cardiovascular Surgery of Pronto Socorro Cardiológico de Pernambuco - PROCAPE. Recife, Brazil; University of Pernambuco - UPE. Recife, Brazil.

Mitral valve repair (MVr) restores leaflets coaptation while preserving the patient's own valve. The two main techniques are: (a) chordal replacement ("respect approach"), whereby artificial neochordae are used to resuspend prolapsed segments of the affected leaflet - and (b) leaflet resection ("resect approach"), whereby diseased leaflet segment is resected, and the remaining segments are sutured together. Both techniques of MVr are associated with better long-term results, fewer valve-related complications and lower mortality when compared with mitral valve replacement (MVR). Read More

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January 2022

Age-specific trace element bioaccumulation in grey seals from the Gulf of St. Lawrence.

Chemosphere 2022 Jan 17:133640. Epub 2022 Jan 17.

Mélanie Lemire, Centre de recherche du CHU de Québec -Université Laval, Département de médecine sociale et préventive, Institut de biologie intégrative et des systèmes (IBIS), Université Laval, Québec, G1V 0A6, QC, Canada. Electronic address:

We measured concentrations of 19 trace elements and mercury speciation in grey seals (Halichoerus grypus) from the Gulf of St. Lawrence (GSL), Canada. With interest growing in commercializing grey seal products for human consumption in this region, our goal was to measure essential and non-essential trace elements in grey seals to evaluate health concerns and nutritional benefits. Read More

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January 2022

The prognostic value of time from symptom onset to thrombolysis in patients with pulmonary embolism.

Int J Cardiol 2022 Jan 17. Epub 2022 Jan 17.

Cardiology, Health Sciences University, Sultan II. Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

Background: According to clinical practice guidelines, thrombolysis can be administered during the 14 days after the beginning of symptoms in PE. However, the role of the early thrombolysis in PE has not been comprehensively investigated. In this study we evaluated the effect of short symptom-to-thrombolysis time (STT) in these patients who received the thrombolytic therapy within the 48-h. Read More

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January 2022

Effect of l-carnitine and mildronate on the mitochondrial metabolism of heart and bacterial composition of the gut microbiome in ageing mice.

Life Sci 2022 Jan 18;293:120333. Epub 2022 Jan 18.

Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technology, 394036 Voronezh, Russia.

Ageing is the most significant risk factor for cardiovascular diseases. l-Carnitine has a potent cardioprotective effect and its synthesis decreases during ageing. At the same time, there are pharmaceuticals, such as mildronate which, on the contrary, are aimed at reducing the concentration of l-carnitine in the heart and lead to slows down the oxidation of fatty acids in mitochondria. Read More

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January 2022

Oral fluoxetine treatment changes serotonergic sympatho-regulation in experimental type 1 diabetes.

Life Sci 2022 Jan 18;293:120335. Epub 2022 Jan 18.

Laboratory of Pharmacology, Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain; Research Institute of Salamanca (IBSAL), Paseo San Vicente 58-182, 37007 Salamanca, Spain. Electronic address:

Aims: This study investigated whether fluoxetine treatment changes the 5-HT regulation on vascular sympathetic neurotransmission in type 1 diabetes.

Main Methods: Four-week diabetes was obtained by a single alloxan s.c. Read More

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January 2022

Global, regional, and country estimates of metabolic syndrome burden in children and adolescents in 2020: a systematic review and modelling analysis.

Lancet Child Adolesc Health 2022 Jan 17. Epub 2022 Jan 17.

School of Public Health, Faculty of Medicine, University of Paris-Sud, Le Kremlin-Bicêtre, France; Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, Yaoundé, Cameroon. Electronic address:

Background: Halting the rise in cardiometabolic risk factors in children and adolescents is crucial to curb the global burden of cardiovascular diseases. We aim to provide global, regional, and national estimates of the prevalence of metabolic syndrome in children and adolescents to support the development of evidence-based prevention strategies.

Methods: In this systematic review with modelling analysis, we searched PubMed, Embase, Africa Journal Online, and Global Index Medicus from database inception to Jan 30, 2021, with no restriction on language or geographical location. Read More

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January 2022

Ten Tumors in the Heart: Papillary Fibroelastoma with Triple Valve Involvement.

Ann Thorac Surg 2022 Jan 17. Epub 2022 Jan 17.

Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania; Department of Cardiac Surgery, C.C. Iliescu Emergency Institute for Cardiovascular Diseases, Bucharest 022322, Romania.

Cardiac papillary fibroelastoma (CPF) is a benign tumor of endocardial origin, most frequently solitary, which commonly affects the aortic valve. We report the case of a 62-years-old woman with ten separate tumors that developed on the mitral, tricuspid, and pulmonary cusps, atrioventricular valve chordae, and left ventricular endocardium. Surgical treatment included valve-sparring resection of the pulmonary cusp tumors and bioprosthetic replacement of the mitral and tricuspid valves, which exhibited extensive tumor invasion. Read More

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January 2022

A Lifestyle Intervention Program to Improve Knowledge and Health Behaviors in Women.

Nurs Womens Health 2022 Jan 17. Epub 2022 Jan 17.

Objective: To improve health knowledge, facilitate healthy behaviors, and provide social support for a high-risk population of women by implementing a culturally tailored, gender-specific lifestyle intervention program.

Design: Evidence-based practice project.

Setting/local Problem: A Chicago neighborhood in Cook County, Illinois, where there are increased rates of diabetes, heart disease, cancer, stroke, hypertension, obesity, preterm birth, and violent crime. Read More

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January 2022

Internal senses of the vagus nerve.

Neuron 2022 Jan 11. Epub 2022 Jan 11.

Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

The vagus nerve is an indispensable body-brain connection that controls vital aspects of autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes like coughing and swallowing, and survival behaviors like feeding, drinking, and sickness responses. Classical physiological studies and recent molecular/genetic approaches have revealed a tremendous diversity of vagal sensory neuron types that innervate different internal organs, with many cell types remaining poorly understood. Here, we review the state of knowledge related to vagal sensory neurons that innervate the respiratory, cardiovascular, and digestive systems. Read More

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January 2022

Electrostatic Interaction-Based High Tissue Adhesive, Stretchable Microelectrode Arrays for the Electrophysiological Interface.

ACS Appl Mater Interfaces 2022 Jan 20. Epub 2022 Jan 20.

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, National and Local Joint Engineering Laboratory for Synthesis, Transformation and Separation of Extreme Environmental Nutrients, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, P. R. China.

The drift or fall of stretchable neural microelectrodes from the surface of wet and dynamic tissues severely hampers the adoption of microelectrodes for electrophysiological signal monitoring. Endowing the stretchable electrodes with adhesive ability is an effective way to overcome these problems. Current adhesives form tough adhesion to tissues by covalent interaction, which decreases the biocompatibility of the adhesives. Read More

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January 2022

Non-selective beta-blockers in patients with ascites: the complex interplay among the liver, kidney, and heart.

Liver Int 2022 Jan 20. Epub 2022 Jan 20.

Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad de Alcalá, Madrid, Spain.

Non-selective beta-blockers (NSBBs) are the cornerstone of the primary and secondary prophylaxis of variceal bleeding in cirrhotic patients. They additionally prevent ascites development and death in compensated patients with clinically significant portal hypertension. After ascites onset, NSBBs remain beneficial for preventing further decompensations. Read More

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January 2022

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.

Eur Heart J 2022 Jan 20. Epub 2022 Jan 20.

Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.

Aims: Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome).

Methods And Results: FINGER enrolled 1259 individuals aged 60-77 years (ClinicalTrials. Read More

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January 2022

The dawn of a new era of targeted lipid-lowering therapies.

Eur Heart J 2022 Jan 20. Epub 2022 Jan 20.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115,USA.

Lipid risk factors for cardiovascular disease depend in part on lifestyle, but optimum control of lipids often demands additional measures. Low-density lipoprotein (LDL) doubtless contributes causally to atherosclerosis. Recent human genetic findings have substantiated a number of novel targets for lipid-lowering therapy including apolipoprotein C-III, angiopoietin-like protein 3 and 4, apolipoprotein V, and ATP citrate lyase. Read More

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January 2022